Physical Sciences and Mathematics | Open Access Articles

Homologation Of Α-Amino Acids To Β-Amino Acids Via A Modified Arndt-Eistert Synthesis, Brian Brennan, James Carolan, '10

Brian B. Brennan

No abstract provided.

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Utilizing Phage Display To Identify Novel Peptides That Bind To Sickle Cell Hemoglobin, Brian Brennan, Chris Betzle, '10

Brian B. Brennan

No abstract provided.

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The Development Of A Novel Therapeutic For The Treatment Of Sickle Cell Disease, Brian Brennan, Steven Sturlis, '10

Brian B. Brennan

No abstract provided.

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Novel Therapeutics In The Treatment Of Sickle Cell Disease: Expression And Purification Of Hemoglobin And Sickle Cell Hemoglobin, Brian Brennan, Susan Zhong, '11

Brian B. Brennan

No abstract provided.

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Utilizing Phage Display To Identify Novel Peptides That Bind To Sickle Cell Hemoglobin, Brian Brennan, Chris Betzle, '10

Brian B. Brennan

No abstract provided.

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The Synthesis And Characterization Of A Peptide Hemoglobin Ligand, Brian Brennan, Chris Brackett, '11

Brian B. Brennan

No abstract provided.

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The Synthesis Of A Peptoid For Use As A Novel Therapeutic In The Treatment Of Sickle-Cell Disease, Brian Brennan, Michael Chiodo, '11

Brian B. Brennan

No abstract provided.

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Smectic Polymer Vesicles, Mark Bowick, Lin Jia, Xiangjun Xing

Physics - All Scholarship

Polymer vesicles are stable robust vesicles made from block copolymer amphiphiles. Recent progress in the chemical design of block copolymers opens up the exciting possibility of creating a wide variety of polymer vesicles with varying fine structure, functionality and geometry. Polymer vesicles not only constitute useful systems for drug delivery and micro/nano-reactors but also provide an invaluable arena for exploring the ordering of matter on curved surfaces embedded in three dimensions. By choosing suitable liquid-crystalline polymers for one of the copolymer components one can create vesicles with smectic stripes. Smectic order on shapes of spherical topology inevitably possesses topological defects …

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Network Coding For Wdm All-Optical Multicast, Eric D. Manley, Jitender S. Deogun, Lisong Xu, Dennis R. Alexander

CSE Technical Reports

Network coding has become a useful means for achieving efficient multicast, and the optical community has started to examine its application to optical networks. However, a number of challenges, including limited processing capability and coarse bandwidth granularity, need to be overcome before network coding can be effectively used in optical networks. In this paper, we address some of these problems. We consider the problem of finding efficient routes to use with coding, and we study the effectiveness of using network coding for optical-layer dedicated protection of multicast traffic. We also propose architectures for all-optical circuits capable of performing the processing …

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A Semi-Parametric Two-Part Mixed-Effects Heteroscedastic Transformation Model For Correlated Right-Skewed Semi-Continuous Data, Huazhen Lin, Xiao-Hua Zhou

UW Biostatistics Working Paper Series

In longitudinal or hierarchical structure studies, we often encounter a semi-continuous variable that has a certain proportion of a single value and a continuous and skewed distribution among the rest of values. In the paper, we propose a new semi-parametric two-part mixed-effects transformation model to ﬁt correlated skewed semi-continuous data. In our model, we allow the transformation to be non-parametric. Fitting the proposed model faces computational challenges due to intractable numerical integrations. We derive the estimates for the parameter and the transformation function based on an approximate likelihood, which has high order accuracy but less computational burden. We also propose …

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The Spaces Of Encounter Of Female Middle Eastern And Muslim Immigrants In Atlanta, Georgia, Tara Diana Prizito

Geosciences Theses

This study analyzes identity, class, religiosity, and belonging as they affect the experiences of female Middle Eastern and Muslim immigrants in various spaces within the context of the Atlanta, Georgia area and draws attention to the ‘othering’ of immigrants in American society. The exploration of immigrants’ experiences in various spaces includes public and semi-public, employment, educational and organizational spaces. Interviews were conducted on 24 female immigrants in the Atlanta area who possess various backgrounds. While female immigrants who wear the hijab experienced more, and more direct, discrimination than those who wear Western styles, the women who wear hijab were not …

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Patterns Of Abundance Across An Urban-Rural Gradient For Commonly Found Indigenous Arthropods, David Jones

Theses and Dissertations

Abstract Proof of concept for a continuous environmental sampling methodology that employs common terrestrial arthropods as environmental samplers was tested by analyzing pitfall, malaise and black light captures over a six month period over a replicated urban-suburban-rural gradient in Central Virginia. All arthropods captured at the nine sites were identified and assigned to aquatic, vegetation, or soil groups based on their association with these microhabitats. To offset variability in arthropod life history patterns and species abundance within habitat types, arthropod categories based on presence/absence data over the six month period were constructed to provide for sampling reliability within each microhabitat …

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Progressive Spatial Networks, Samuel Curren

Theses and Dissertations

Digital street and trail maps are typically represented by an interconnected network of path segments. These spatial networks are used in map creation, route planning, and geo-location. Consumer GPS devices have become popular as a method of collecting data for use in spatial networks. Existing methods for creating spatial networks either require extensive hand editing or use inefficient algorithms that require re-computation when adding new data to an existing network. I demonstrate a method for creating and maintaining spatial networks that allows for incremental updates without complete re-computation. I also demonstrate how spatial limits on data set growth allows networks …

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Synthesis Of 2,4,5-Triaminocyclohexane Carboxylic Acid As A Novel 2-Deoxystreptamine Mimetic, Sarah Elizabeth Roberts

Theses and Dissertations

RNAs have become increasingly recognized as possible drug targets due to their involvement in important biochemical functions, as well as their unique but well-defined structures. Recently published crystal structures depict the binding of a series of aminoglycosides- or more specifically- 2-deoxystretamine (2-DOS), the most preserved central scaffold of aminoglycosides, to a conserved 5'-GU-3'region on their target RNAs. A novel unnatural γ-amino acid, 1, has been synthesized using 2-deoxystreptamine as a template through structure-based rational design. The unnatural amino acid has been designed to replace a glycosidic linkage with an amide bond, which may limit the promiscuous binding characteristics of aminoglycosides …

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Ccsd(T) Complete Basis Set Limit Relative Energies For Low-Lying Water Hexamer Structures, Desiree M. Bates, Gregory S. Tschumper

Chemistry Faculty Research & Creative Works

MP2 and CCSD(T) complete basis set (CBS) limit relative electronic energies (ΔE e) have been determined for eight low-lying structures of the water hexamer by combining explicitly correlated MP2-R12 computations with higher-order correlation corrections from CCSD(T) calculations. Higher-order correlation effects are quite substantial and increase ΔE e by at least +0.19 kcalmol^-1 and as much as +0.59 kcalmol^-1. The effects from zero-point vibrational energy (ZPVE) have been assessed from unsealed harmonic vibrational frequencies computed at the MP2 level with a correlation consistent triple-̌ basis set (cc-pVTZ for H and aug-cc-pVTZ for O). ZPVE effects are even more …

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Multisite Photometry Of The Pulsating Herbig Ae Star V346 Ori, S. Bernabei, Terry D. Oswalt, V. Ripepi, A. Ruoppo, Et Al.

Publications

The study of pulsation in Pre--Main--Sequence intermediate-mass stars represents an important tool for deriving information on fundamental stellar parameters and internal structure, as well as for testing current theoretical models. Interest in this class of variable stars has significantly increased during the last decade and about 30 members are presently known in the literature. AIMS: We have constructed the frequency spectrum of the oscillations in V346 Ori. We apply asteroseismic tools to these data to estimate the intrinsic parameters (mass, luminosity, effective temperature) of V346 Ori and to obtain information on its internal structure. METHODS: CCD time series photometry in …

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State Of Secure Application Development For 802.15.4, Janell Armstrong

Theses and Dissertations

A wireless sensor network consists of small, limited-resource embedded systems exchanging environment data and activating controls. These networks can be deployed in hostile environments to monitor wildlife habitats, implemented in factories to locate mobile equipment, and installed in home environments to optimize the use of utilities. Each of these scenarios requires network security to protect the network data. The IEEE 802.15.4 standard is designed for WSN communication, yet the standard states that it is not responsible for defining the initialization, distribution, updating, or management of network public keys. Individuals seeking to research security topics will find that there are many …

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Xprime: A Method Incorporating Expert Prior Information Into Motif Exploration, Rachel Lynn Poulsen

Theses and Dissertations

One of the primary goals of active research in molecular biology is to better understand the process of transcription regulation. An important objective in understanding transcription is identifying transcription factors that directly regulate target genes. Identifying these transcription factors is a key step toward eliminating genetic diseases or disease susceptibilities that are encoded inside deoxyribonucleic acid (DNA). There is much uncertainty and variation associated with transcription factor binding sites, requiring these sites to be represented stochastically. Although typically each transcription factor prefers to bind to a specific DNA word, it can bind to different variations of that DNA word. In …

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Water Embodied In Bioethanol In The United States, Yi-Wen Chiu, Brian Walseth, Sangwon Suh

Natural Resources Management and Environmental Sciences

Prior studies have estimated that a liter of bioethanol requires 263−784 L of water from corn farm to fuel pump, but these estimates have failed to account for the widely varied regional irrigation practices. By using regional time-series agricultural and ethanol production data in the U.S., this paper estimates the state-level field-to-pump water requirement of bioethanol across the nation. The results indicate that bioethanol’s water requirements can range from 5 to 2138 L per liter of ethanol depending on regional irrigation practices. The results also show that as the ethanol industry expands to areas that apply more irrigated water than …

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Strategies For The Characteristic Extraction Of Gravitational Waveforms, Maria C. Babiuc-Hamilton, N. T. Bishop, B´Ela Szila´Gyi, Jeffrey Winicour

Physics Faculty Research

We develop, test, and compare new numerical and geometrical methods for improving the accuracy of extracting waveforms using characteristic evolution. The new numerical method involves use of circular boundaries to the stereographic grid patches which cover the spherical cross sections of the outgoing null cones. We show how an angular version of numerical dissipation can be introduced into the characteristic code to damp the high frequency error arising form the irregular way the circular patch boundary cuts through the grid. The new geometric method involves use of the Weyl tensor component Ψ₄ to extract the waveform as opposed to …

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A Search For Multi-Planet Systems Using The Hobby–Eberly Telescope, Robert A. Wittenmyer, Michael Endl, William D. Cochran, Harold F. Levison, Gregory W. Henry

Information Systems and Engineering Management Research Publications

Extrasolar multiple-planet systems provide valuable opportunities for testing theories of planet formation and evolution. The architectures of the known multiple-planet systems demonstrate a fascinating level of diversity, which motivates the search for additional examples of such systems in order to better constrain their formation and dynamical histories. Here we describe a comprehensive investigation of 22 planetary systems in an effort to answer three questions: (1) are there additional planets? (2) where could additional planets reside in stable orbits? and (3) what limits can these observations place on such objects? We find no evidence for additional bodies in any of these …

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Structure–Mutagenicity Relationships And Energies Of 1-, And 2-Nitrotriphenylenes [Abstract], Kefa Karimu Onchoke

Faculty Publications

No abstract provided.

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Grünbaum Colorings Of Toroidal Triangulations, Michael O. Albertson, Hannah Alpert, Sarah-Marie Belcastro, Ruth Haas

Mathematics Sciences: Faculty Publications

We prove that if G is a triangulation of the torus and χ(G) 6 ≠ 5, then there is a 3-coloring of the edges of G so that the edges bounding every face are assigned three different colors.

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Development And Testing Of The Gait Assessment And Intervention Tool (G.A.I.T.): A Measure Of Coordinated Gait Components, J. J. Daly, J. Nethery, J. P. Mccabe, I. Brenner, J. Rogers, J. Gansen, K. Butler, R. Burdsall, K. Roenigk, John Holcomb

Mathematics and Statistics Faculty Publications

Recent neuroscience methods have provided the basis upon which to develop effective gait training methods for recovery of the coordinated components of gait after neural injury. We determined that there was not an existing observational measure that was, at once, adequately comprehensive, scored in an objectively-based manner, and capable of assessing incremental improvements in the coordinated components of gait. Therefore, the purpose of this work was to use content valid procedures in order to develop a relatively inexpensive, more comprehensive measure, scored with an objectively-based system, capable of incrementally scoring improvements in given items, and that was both reliable and …

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Monitoring Relative Abundance Of American Shad In Virginia Rivers 2008 Annual Report, John E. Olney, Brian Watkins

Reports

Concern about the decline in landings of American shad (Alosa sapidissima) along the Atlantic coast prompted the development of an interstate fisheries management plan (FMP) under the auspices of the Atlantic States Marine Fisheries Management Program (AS

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Frequency Doubling And Memory Effects In The Spin Hall Effect, Yuriy V. Pershin Dr, Massimiliano Di Ventra

Faculty Publications

We predict that when an alternating voltage is applied to a semiconducting system with inhomogeneous electron density in the direction perpendicular to main current flow, the spin Hall effect results in a transverse voltage containing a double-frequency component. We also demonstrate that there is a phase shift between applied and transverse-voltage oscillations, related to the general memristive behavior of semiconductor spintronic systems. A different method to achieve frequency doubling based on the inverse spin Hall effect is also discussed.

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The Nebraska Sand Hills – Mid- To Late-Holocene Drought Variation And Landscape Stability Based On High-Resolution Lake Sediment Records, Jens Schmieder

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

A high-resolution multi-proxy analysis was used to reconstruct moisture balance fluctuations spanning the last 6500 years and to investigate the origins of interdunal lakes in the central Sand Hills of Nebraska. Detailed paleoecological data from Beaver Lake, plus analyses from two nearby lakes, were integrated to reconstruct regional climate history. Six episodes of multi-centennial droughts occurred, with a dramatic change in overall mean state between 4000 and 3800 yr BP. An extensive low lake stand between 6500-5750 yr BP was likely predominantly climatically driven rather than geomorphically induced.

Paleohydrological reconstructions of five lakes in the Nebraska Sand Hills were compared …

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Open Library, William Osei-Poku

William Osei-Poku

No abstract provided.

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Clay Mineralogy And Illite Crystallinity In The Late Devonian To Early Mississippian Woodford Shale In The Arbuckle Mountains, Oklahoma, Usa, Richard Allen Whittington Ii

Geosciences Theses

Commonly the thermal maturity of the Late Devonian to Early Mississippian Woodford shale found on the flanks of the Arbuckle Mountains of Oklahoma is determined by vitrinite reflectance, values ranging from 0.3-1.5%. Using phyllosilicate minerals, specifically diagenetic mixed layer illite/smectite and diagenetic illite, an understanding of the extent and processes leading to the thermal maturation may be developed. Analysis by XRD of the clay mineralogy of the Woodford shale found kaolinite and mixed layer illite/smectite with <5% smectite and R≥3 stacking order. Modeling of the Woodford shale also suggests the percentage of smectite present in mixed layer illite/smectite to be <5% and commonly <2.5%. Deconvolution of the illite (001) peak supports the low smectite content and high illite crystallinity. The long range ordered illite, R≥3, and high illite crystallinity values are indicative of diagenesis to anchizone conditions suggesting a higher thermal maturity relative to previously measured values of vitrinite reflectance.

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Implementing Energy-Saving Improvements To The Ieee 802.15.4 Mac Protocol, Marco Valero

Computer Science Theses

IEEE 802.15.4 is a standard designed for low data rate wireless personal area networks (WPANs) intended to provide connectivity to mobile devices. Such devices present considerable storage, energy, and communication constraints. However, they can be used in a variety of applications like home/office automation, environmental control and more. In order to extend the lifetime of the WPAN, we propose some changes to the standard including modifications to the Superframe Guaranteed Time Slot (GTS) distribution which can be optimized to reduce energy consumption. We implemented the proposed improvements to the IEEE 802.15.4 protocol using real sensor nodes. Specifically, we conducted an …

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Full-Text Articles in Physical Sciences and Mathematics

Homologation Of Α-Amino Acids To Β-Amino Acids Via A Modified Arndt-Eistert Synthesis, Brian Brennan, James Carolan, '10

Brian B. Brennan

Utilizing Phage Display To Identify Novel Peptides That Bind To Sickle Cell Hemoglobin, Brian Brennan, Chris Betzle, '10

Brian B. Brennan

The Development Of A Novel Therapeutic For The Treatment Of Sickle Cell Disease, Brian Brennan, Steven Sturlis, '10

Brian B. Brennan

Novel Therapeutics In The Treatment Of Sickle Cell Disease: Expression And Purification Of Hemoglobin And Sickle Cell Hemoglobin, Brian Brennan, Susan Zhong, '11

Brian B. Brennan

Utilizing Phage Display To Identify Novel Peptides That Bind To Sickle Cell Hemoglobin, Brian Brennan, Chris Betzle, '10

Brian B. Brennan

The Synthesis And Characterization Of A Peptide Hemoglobin Ligand, Brian Brennan, Chris Brackett, '11

Brian B. Brennan

The Synthesis Of A Peptoid For Use As A Novel Therapeutic In The Treatment Of Sickle-Cell Disease, Brian Brennan, Michael Chiodo, '11

Brian B. Brennan

Smectic Polymer Vesicles, Mark Bowick, Lin Jia, Xiangjun Xing

Physics - All Scholarship

Network Coding For Wdm All-Optical Multicast, Eric D. Manley, Jitender S. Deogun, Lisong Xu, Dennis R. Alexander

CSE Technical Reports

A Semi-Parametric Two-Part Mixed-Effects Heteroscedastic Transformation Model For Correlated Right-Skewed Semi-Continuous Data, Huazhen Lin, Xiao-Hua Zhou

UW Biostatistics Working Paper Series

The Spaces Of Encounter Of Female Middle Eastern And Muslim Immigrants In Atlanta, Georgia, Tara Diana Prizito

Geosciences Theses

Patterns Of Abundance Across An Urban-Rural Gradient For Commonly Found Indigenous Arthropods, David Jones

Theses and Dissertations

Progressive Spatial Networks, Samuel Curren

Theses and Dissertations

Synthesis Of 2,4,5-Triaminocyclohexane Carboxylic Acid As A Novel 2-Deoxystreptamine Mimetic, Sarah Elizabeth Roberts

Theses and Dissertations

Ccsd(T) Complete Basis Set Limit Relative Energies For Low-Lying Water Hexamer Structures, Desiree M. Bates, Gregory S. Tschumper

Chemistry Faculty Research & Creative Works

Multisite Photometry Of The Pulsating Herbig Ae Star V346 Ori, S. Bernabei, Terry D. Oswalt, V. Ripepi, A. Ruoppo, Et Al.

Publications

State Of Secure Application Development For 802.15.4, Janell Armstrong

Theses and Dissertations

Xprime: A Method Incorporating Expert Prior Information Into Motif Exploration, Rachel Lynn Poulsen

Theses and Dissertations

Water Embodied In Bioethanol In The United States, Yi-Wen Chiu, Brian Walseth, Sangwon Suh

Natural Resources Management and Environmental Sciences

Strategies For The Characteristic Extraction Of Gravitational Waveforms, Maria C. Babiuc-Hamilton, N. T. Bishop, B´Ela Szila´Gyi, Jeffrey Winicour

Physics Faculty Research

A Search For Multi-Planet Systems Using The Hobby–Eberly Telescope, Robert A. Wittenmyer, Michael Endl, William D. Cochran, Harold F. Levison, Gregory W. Henry

Information Systems and Engineering Management Research Publications

Structure–Mutagenicity Relationships And Energies Of 1-, And 2-Nitrotriphenylenes [Abstract], Kefa Karimu Onchoke

Faculty Publications

Grünbaum Colorings Of Toroidal Triangulations, Michael O. Albertson, Hannah Alpert, Sarah-Marie Belcastro, Ruth Haas

Mathematics Sciences: Faculty Publications

Development And Testing Of The Gait Assessment And Intervention Tool (G.A.I.T.): A Measure Of Coordinated Gait Components, J. J. Daly, J. Nethery, J. P. Mccabe, I. Brenner, J. Rogers, J. Gansen, K. Butler, R. Burdsall, K. Roenigk, John Holcomb

Mathematics and Statistics Faculty Publications

Monitoring Relative Abundance Of American Shad In Virginia Rivers 2008 Annual Report, John E. Olney, Brian Watkins

Reports

Frequency Doubling And Memory Effects In The Spin Hall Effect, Yuriy V. Pershin Dr, Massimiliano Di Ventra

Faculty Publications

The Nebraska Sand Hills – Mid- To Late-Holocene Drought Variation And Landscape Stability Based On High-Resolution Lake Sediment Records, Jens Schmieder

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Open Library, William Osei-Poku

William Osei-Poku

Clay Mineralogy And Illite Crystallinity In The Late Devonian To Early Mississippian Woodford Shale In The Arbuckle Mountains, Oklahoma, Usa, Richard Allen Whittington Ii

Geosciences Theses

Implementing Energy-Saving Improvements To The Ieee 802.15.4 Mac Protocol, Marco Valero

Computer Science Theses