Physical Sciences and Mathematics Commons^™

Increased Yields And Simplified Purification With A Second-Generation Cobalt Catalyst For The Oxidative Formation Of Trans-Thf Rings., Cory Palmer, Nicholas A Morra, Andrew C Stevens, Barbora Bajtos, Ben P Machin, Brian L Pagenkopf

Chemistry Publications

The synthesis of a second-generation cobalt catalyst for the formation of trans-THF products via the Mukaiyama aerobic oxidative cyclization is reported. Two procedures have been developed with the new water-soluble catalyst that give superior yields and greatly simplify purification compared to the previous catalysts.

Growth And Geodesics Of Thompson's Group F, Jennifer L. Schofield

Theses and Dissertations

In this paper our goal is to describe how to find the growth of Thompson's group F with generators a and b. Also, by studying elements through pipe systems, we describe how adding a third generator c affects geodesic length. We model the growth of Thompson's group F by producing a grammar for reduced pairs of trees based on Blake Fordham's tree structure. Then we change this grammar into a system of equations that describes the growth of Thompson's group F and simplify. To complete our second goal, we present and discuss a computer program that has led to some …

Random Graphs: From Paul Erdős To The Internet, Michał Karoński

Dalrymple Lecture Series

Paul Erdős, one of the greatest mathematicians of the twentieth century, was a champion of applications of probabilistic methods in many areas of mathematics, such as a graph theory, combinatorics and number theory. He also, almost fifty years ago, jointly with another great Hungarian mathematician Alfred Rényi, laid out foundation of the theory of random graphs: the theory which studies how large and complex systems evolve when randomness of the relations between their elements is incurred. In my talk I will sketch the long journey of this theory from the pioneering Erdős era to modern attempts to model properties of …

Synthesis And Evaluation Of N6,5'-Bis-Ureido-5'-Amino-5'-Deoxyadenosine Derivatives: Novel Nucleosides With Antiproliferative And Protein Kinase Binding Activities, Marcelio Oliveira

Theses and Dissertations

A new series of N6,5'-bis-ureido-5'-amino-5'-deoxyadenosine derivatives was prepared and evaluated for anticancer activities using the NCI 60 panel of human cancers. Certain of the derivatives showed promising activities (low micromolar GI50's) against several of the representative cancers. These included cell lines from the following general cell types in the NCI 60: Leukemia, Breast, Central Nervous System, Non-Small Cell Lung, Ovarian, Prostate, Renal, and Colon cancers. Select compounds were also screened for their affinities for protein kinases. The synthesis of the compounds was straightforward and involved N6 acylation with arylisocyanates, preceded by activation and nucleophilic substitution of the 5'-position to give …

Counting Pattern-Avoiding Permutations, Lara Pudwell

Lara K. Pudwell

No abstract provided.

A Statistical Framework For The Analysis Of Chip-Seq Data, Pei Fen Kuan, Dongjun Chung, Guangjin Pan, James A. Thomson, Ron Stewart, Sunduz Keles

Sunduz Keles

Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has revolutionalized experiments for genome-wide profiling of DNA-binding proteins, histone modifications, and nucleosome occupancy. As the cost of sequencing is decreasing, many researchers are switching from microarray-based technologies (ChIP-chip) to ChIP-Seq for genome-wide study of transcriptional regulation. Despite its increasing and well-deserved popularity, there is little work that investigates and accounts for sources of biases in the ChIP-Seq technology. These biases typically arise from both the standard pre-processing protocol and the underlying DNA sequence of the generated data.

We study data from a naked DNA sequencing experiment, which sequences non-cross-linked DNA after deproteinizing and …

Future Cascadia Megathrust Rupture Delineated By Episodic Tremor And Slip, James S. Chapman, Timothy I. Melbourne

Faculty Scholarship for the Cascadia Hazards Institute

A suite of 15 episodic tremor and slip events imaged between 1997 and 2008 along the northern Cascadia subduction zone suggests future coseismic rupture will extend to 25 km depth, or approximately 60 km inland of the Pacific coast, rather than stopping offshore at 15 km depth. An ETS-derived coupling profile accurately predicts GPS measured interseismic deformation of the overlying North American plate, as measured by approximately 50 continuous GPS stations across western Washington State. When extrapolated over the 550-year average recurrence interval of Cascadia megathrust events, the coupling model also replicates the pattern and amplitude of coseismic coastal subsidence …

Decentralized Control Of Large Scale Interconnected Systems Using Adaptive Neural Network-Based Dynamic Surface Control, Shahab Mehraeen, Sarangapani Jagannathan, Mariesa L. Crow

Electrical and Computer Engineering Faculty Research & Creative Works

A novel decentralized controller using the dynamic surface control (DSC) is proposed for a class of uncertain large scale interconnected nonlinear systems in strict feedback form while relaxing the "explosion of complexity" problem which is observed in the typical backstepping approach. the matching condition is not assumed when dealing with the interconnection terms. Neural networks (NNs) are utilized to approximate the uncertainties in both subsystem and interconnected terms. by using novel NN weight update laws, it is demonstrated using Lyapunov stability that the closed-loop signals are asymptotically stable in the presence of NN approximation errors in contrast with the uniform …

Adaptive Dynamic Programming-Based Optimal Control Of Unknown Affine Nonlinear Discrete-Time Systems, Travis Dierks, Balaje T. Thumati, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

Discrete time approximate dynamic programming (ADP) techniques have been widely used in the recent literature to determine the optimal or near optimal control policies for nonlinear systems. However, an inherent assumption of ADP requires at least partial knowledge of the system dynamics as well as the value of the controlled plant one step ahead. in this work, a novel approach to ADP is attempted while relaxing the need of the partial knowledge of the nonlinear system. the proposed methodology entails a two-part process: online system identification and offline optimal control training. First, in the identification process, a neural network (NN) …

Feature-Based Interactive Terrain Sketching, Daniel B. Adams

Theses and Dissertations

Procedural generation techniques are able to quickly and cheaply produce large areas of terrain. However, these techniques produce results that are not easily directable and often require artists to edit the results by hand to achieve the desired layout. This paper proposes a sketch-based system for controlling fractal terrain that allows for a wide variety of terrain feature types. Artists sketch features rather than constrained points or elevations. The system is interactive, provides quick on-demand previews of the terrain, and allows for iterative design modifications. Interaction between features is handled in a realistic fashion. An arbitrary vertex insertion order midpoint …

An Introduction To Enumeration Schemes, Lara Pudwell

Lara K. Pudwell

No abstract provided.

Interview With Peter Spendelow, Oregon Deq, 2009 (Audio), Peter Spendelow

All Sustainability History Project Oral Histories

Interview of Peter Spendelow by Angie Yzaguirre in downtown Portland, Oregon on November 17th, 2009.

The interview index is available for download.

A New Class Of Minimum Power Divergence Estimators With Applications To Cancer Surveillance, Nirian Martin, Yi Li

Harvard University Biostatistics Working Paper Series

No abstract provided.

Climate Change Economics 101, Adele C. Morris

Brookings Scholar Lecture Series

Outline of Talk:
- Climate change is a market failure
- Climate and energy facts
- Economically efficient policy design
- Economics of Domestic Legislation

Nmr Multiple Quantum Coherences In Quasi-One-Dimensional Spin Systems: Comparison With Ideal Spin-Chain Dynamics, Wenxian Zhang, Paola Cappellaro, Natania Antler, Brian Pepper, David G. Cory, Viatcheslav V. Dobrovitski, Chandrasekhar Ramanathan, Lorenza Viola

Dartmouth Scholarship

The ¹⁹F spins in a crystal of fluorapatite have often been used to experimentally approximate a one-dimensional spin system. Under suitable multipulse control, the nuclear-spin dynamics may be modeled to first approximation by a double-quantum one-dimensional Hamiltonian, which is analytically solvable for nearest-neighbor couplings. Here, we use solid-state nuclear magnetic resonance techniques to investigate the multiple quantum coherence dynamics of fluorapatite, with an emphasis on understanding the region of validity for such a simplified picture. Using experimental, numerical, and analytical methods, we explore the effects of long-range intrachain couplings, cross-chain couplings, as well as couplings to a spin environment, …

Nonlinear Models In Multivariate Population Bioequivalence Testing, Bassam Dahman

Theses and Dissertations

In this dissertation a methodology is proposed for simultaneously evaluating the population bioequivalence (PBE) of a generic drug to a pre-licensed drug, or the bioequivalence of two formulations of a drug using multiple correlated pharmacokinetic metrics. The univariate criterion that is accepted by the food and drug administration (FDA) for testing population bioequivalence is generalized. Very few approaches for testing multivariate extensions of PBE have appeared in the literature. One method uses the trace of the covariance matrix as a measure of total variability, and another uses a pooled variance instead of the reference variance. The former ignores the correlation …

A La-Icpms Sr Isotope And Trace Element Study Of Plagioclase And Clinopyroxene Of The Higganum Dike, Connecticut: Determining The Magma Source Of The Central Atlantic Magmatic Province, Caprise Steadman Harper

Theses and Dissertations

The Higganum dike of Connecticut is one of the earliest basaltic dikes of the Central Atlantic Magmatic province and is geochemically representative of the widespread low-Ti basaltic lavas (~1 wt % TiO2) that make up the majority of the province in North America. Liquid compositions calculated from Cr-rich clinopyroxene cores from the Higganum dike are significantly more primitive than the bulk rock with average Mg# s of 0.63 compared to the Higganum dike which has Mg #'s ~ 0.55. However, the negative Nb and positive Pb anomalies that are seen in trace element patterns of the low-Ti group are also …

Reducing Microwave Loss In Superconducting Resonators Due To Trapped Vortices, Britton Plourde, C. Song, M. P. Defeo, Kang Yu

Physics - All Scholarship

Microwave resonators with high quality factors have enabled many recent breakthroughs with superconducting qubits and photon detectors, typically operated in shielded environments to reduce the ambient magnetic field. Insufficient shielding or pulsed control fields can introduce vortices, leading to reduced quality factors, although increased pinning can mitigate this effect. A narrow slot etched into the resonator surface provides a straightforward method for pinning enhancement without otherwise affecting the resonator. Resonators patterned with such a slot exhibited over an order of magnitude reduction in the excess loss due to vortices compared with identical resonators from the same film with no slot.

Observation Of A Helical Self-Organized State In A Compact Toroidal Plasma, C. D. Cothran, Michael R. Brown, Timothy G. Gray , '01, M. J. Schaffer, G. Marklin

Physics & Astronomy Faculty Works

A nonaxisymmetric stable magnetohydrodynamic (MHD) equilibrium within a prolate cylindrical conducting boundary has been produced experimentally. It has m=1 azimuthal symmetry, helical distortion, and flat lambda profile, all in agreement with the computed magnetically relaxed minimum magnetic energy Taylor state. Despite varied initial conditions determined by two helicity injectors on the device, this same equilibrium consistently emerges as the final state. These results therefore describe a new example of self-organization in an MHD plasma.

Nutrient Enrichment Studies Of Natural Phytoplankton Populations In Tampa Bay: A Summary Of Results June 1993 To August 2009, The City Of Tampa Wastewater Department

Reports

The Bay Study Group (BSG) has been conducting nutrient enrichment studies (bioassays) on natural phytoplankton populations at four locations in Tampa Bay since 1993 (Figure 1). This report will summarize findings for all tests that have been performed to date, from June 1993 through August 2009.

Analysis Of Nonequilibrium Hcp Precipitate Growth In Fcc Matrices: Application To Al–Ag, Daniel Finkenstadt, Duane D. Johnson

Duane D. Johnson

Hexagonal-close-packed (hcp) γ-precipitates with large aspect ratios form rapidly in some face-centered cubic (fcc) solid-solutions. No model explains the observed time-dependent increase in aspect ratio, nor irregular intermediate growth shapes. We propose a nonequilibrium process involving trapezoidal offshoots (controlled only by energetics) that governs the growth behavior (kinetics) and yields nonequilibrium structures in agreement with observation. Then, combining nucleation theory and diffusion-limited growth both of secondary nuclei and ledges, we derive a general growth equation for γ-precipitates due to solute-segregation to precipitate–matrix interfaces that includes our modification of the Jones–Trivedi model for thickening to account for the slow growth of …

Homological Dimensions And Regular Rings, Alina Iacob, Srikanth B. Iyengar

Alina Iacob

A question of Avramov and Foxby concerning injective dimension of complexes is settled in the affirmative for the class of noetherian rings. A key step in the proof is to recast the problem on hand into one about the homotopy category of complexes of injective modules. Analogous results for flat dimension and projective dimension are also established.

Determination Of 6-Benzylthioinosine In Mouse And Human Plasma By Liquid Chromatography–Tandem Mass Spectrometry, Lan Li, Yan Xu, David N. Wald, William Tse

Chemistry Faculty Publications

This paper described the development and validation of a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the quantitative determination of 6-benzylthioinosine (6BT), a novel myeloid leukemia differentiation-inducing agent, in mouse and human plasma. In this method, 2-amino-6-benzylthioinosine (2A6BT) was used as internal standard and ethyl acetate was used as organic solvent for the extraction of 6BT and internal standard from plasma samples. The extracted samples were separated on YMC ODS-AQ® column (2.0 mm × 50 mm), and the eluates from the column were monitored by the positive-electrospray-ionization tandem mass spectrometer (ESI+-MS/MS). Quantification of 6BT by internal calibration with 2A6BT was …

Inhibitors Of Bacterial N-Succinyl-L,L-Diaminopimelic Acid Desuccinylase (Dape) And Demonstration Of In Vitro Antimicrobial Activity, Danuta Gillner, Nicola Armoush, Richard C. Holz, Daniel P. Becker

Chemistry: Faculty Publications and Other Works

The dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) is a critical bacterial enzyme for the construction of the bacterial cell wall. A screen biased toward compounds containing zinc-binding groups (ZBG’s) including thiols, carboxylic acids, boronic acids, phosphonates and hydroxamates has delivered a number of micromolar inhibitors of DapE from Haemophilus influenzae, including the low micromolar inhibitor l-captopril (IC50 = 3.3 μM, Ki = 1.8 μM). In vitro antimicrobial activity was demonstrated for l-captopril against Escherichia coli.

Homological Dimensions And Regular Rings, Alina Iacob, Srikanth B. Iyengar

Department of Mathematical Sciences Faculty Publications

A question of Avramov and Foxby concerning injective dimension of complexes is settled in the affirmative for the class of noetherian rings. A key step in the proof is to recast the problem on hand into one about the homotopy category of complexes of injective modules. Analogous results for flat dimension and projective dimension are also established.

Inhibitors Of Bacterial N-Succinyl-L,L-Diaminopimelic Acid Desuccinylase (Dape) And Demonstration Of In Vitro Antimicrobial Activity, Danuta Gillner, Nicola Armoush, Richard C. Holz, Daniel P. Becker

Chemistry Faculty Research and Publications

The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is a critical bacterial enzyme for the construction of the bacterial cell wall. A screen biased toward compounds containing zinc-binding groups (ZBG’s) including thiols, carboxylic acids, boronic acids, phosphonates and hydroxamates has delivered a number of micromolar inhibitors of DapE from Haemophilus influenzae, including the low micromolar inhibitor L-captopril (IC₅₀ = 3.3 μM, K_i = 1.8 μM). In vitro antimicrobial activity was demonstrated for l-captopril against Escherichia coli.

Non-Commutative Desingularization Of Determinantal Varieties, I, Ragnar-Olaf Buchweitz, Graham J. Leuschke, Michel Van Den Bergh

Mathematics - All Scholarship

We show that determinantal varieties defined by maximal minors of a generic matrix have a non-commutative desingularization, in that we construct a maximal Cohen-Macaulay module over such a variety whose endomorphism ring is Cohen-Macaulay and has finite global dimension. In the case of the determinant of a square matrix, this gives a non-commutative crepant resolution.

Two-Stage Decompositions For The Analysis Of Functional Connectivity For Fmri With Application To Alzheimer's Disease Risk, Brian S. Caffo, Ciprian M. Crainiceanu, Guillermo Verduzco, Stewart H. Mostofsky, Susan Spear-Bassett, James J. Pekar

COBRA Preprint Series

Functional connectivity is the study of correlations in measured neurophysiological signals. Altered functional connectivity has been shown to be associated with numerous diseases including Alzheimer's disease and mild cognitive impairment. In this manuscript we use a two-stage application of the singular value decomposition to obtain data driven population-level measures of functional connectivity in functional magnetic resonance imaging (fMRI). The method is computationally simple and amenable to high dimensional fMRI data with large numbers of subjects. Simulation studies suggest the ability of the decomposition methods to recover population brain networks and their associated loadings. We further demonstrate the utility of these …

Rigid And Non-Rigid Point-Based Medical Image Registration, Nestor Andres Parra

FIU Electronic Theses and Dissertations

The primary goal of this dissertation is to develop point-based rigid and non-rigid image registration methods that have better accuracy than existing methods. We first present point-based PoIRe, which provides the framework for point-based global rigid registrations. It allows a choice of different search strategies including (a) branch-and-bound, (b) probabilistic hill-climbing, and (c) a novel hybrid method that takes advantage of the best characteristics of the other two methods. We use a robust similarity measure that is insensitive to noise, which is often introduced during feature extraction. We show the robustness of PoIRe using it to register images obtained with …

A Privacy Framework For Mobile Health And Home-Care Systems, David Kotz, Sasikanth Avancha, Amit Baxi

Dartmouth Scholarship

In this paper, we consider the challenge of preserving patient privacy in the context of mobile healthcare and home-care systems, that is, the use of mobile computing and communications technologies in the delivery of healthcare or the provision of at-home medical care and assisted living. This paper makes three primary contributions. First, we compare existing privacy frameworks, identifying key differences and shortcomings. Second, we identify a privacy framework for mobile healthcare and home-care systems. Third, we extract a set of privacy properties intended for use by those who design systems and applications for mobile healthcare and home-care systems, linking them …