Physical Sciences and Mathematics Commons^™

Liquid Chromatography-Tandem Mass Spectrometry For The Determination Of Methylprednisolone In Rat Plasma And Liver After Intravenous Administration Of Its Liver-Targeted Dextran Prodrug, Shuang-Qing Zhang, Helen R. Thorsheim, Suman Penugonda, Venkateswaran C. Pillai, Quentin R. Smith, Reza Mehvar

Pharmacy Faculty Articles and Research

A specific and sensitive liquid chromatography (LC)-tandem mass spectrometric method for quantitative determination of methylprednisolone (MP) in rat plasma and liver was developed and validated using triamcinolone acetonide as an internal standard. Liquid-liquid extraction using tert-butyl methyl ether was used to extract the drug and the internal standard from plasma and liver. The separation of MP was performed on a C(18) column with a mobile phase of acetonitrile:0.5% formic acid aqueous solution (85:15, v/v) over 4 min. The assay was based on the selected reaction monitoring transitions at m/z 375 -> 161 for MP in plasma, 375 -> 357 for …

Migration And Gender: The Case Of A Farming Ejido In Calakmul, Mexico, Claudia Radel, Birgit Schmook

Environment and Society Faculty Publications

As one of Mexico’s last agricultural frontiers, southern Mexico’s rural farming municipality of Calakmul has long been marked by rural in-migration. In the last few years this process has given place to an explosive growth of primarily male labor out-migration, particularly to the United States. The authors trace the outlines of the migration process from the perspective of one rural Calakmul community, to explore effects of men’s transnational migration on the household and community status of the women remaining behind. Analysis is based on quantitative data collected in 2004 from 25 households, and on in-depth qualitative interviews in 2005 with …

Los Maridos En El 'Norte'; Las Mujeres ¿Bien Gracias?, B. Schmook, Claudia Radel

Environment and Society Faculty Publications

La migración de mexicanos hacia Estados Unidos ha sido una constante en las relaciones entre ambas naciones desde hace más de siglo y medio, pero se ha intesificado considerablemente en las últimas tres décadas. Factores diversos como la vecindad geográfica, tendencias demográficas y laborales, la creciente integrción económica, la crisis del campo y las intensas relaciones e intercambios entre los dos países, hacen inevitable estos movimientos poblacionales.

Hydrologic Interdependencies And Human Cooperation: The Process Of Adapting To Droughts, Joanna Endter-Wada, Theresa Selfa, Lisa Welsh

Environment and Society Faculty Publications

The Bear River Basin, which includes portions of Idaho, Utah, and Wyoming in the United States, has a dynamic history of human hydrologic adaptations in relation to a highly variable water supply. These adaptations are embedded in a geographical setting highly influenced by the legal, policy, and institutional contexts that govern allocation of water in this generally arid region. In response to several years of drought and a historically low water year in 2004, water users in the Bear River Basin tested the efficacy of the “law of the river” and innovative agreements that they had negotiated in recent years …

Xafs Debye-Waller Factors For Deformed Hemes And Metal Substituted Hemes, N. Dimakis, T. Mion, C. Ramirez, G. Bunker

Physics and Astronomy Faculty Publications and Presentations

We present an efficient and accurate method for calculating XAFS Debye-Waller factors for deformed active sites of hemoproteins and metal substituted hemes. Based on the Normal Coordinate Structural Decomposition scheme, the deformation of the porphyrin macrocycle is expressed as a linear combination of the normal modes of the planar species. In our approach, we identify the modes that contribute most to the deformation. Small metal-porphyrin structures which match the macrocycle structural deformation of the deformed hemoprotein site are used to calculate the Debye-Waller parameters at sample's temperature. The Debye-Waller factors are directly obtained by calculating the normal mode spectrum of …

Search For Gravitational-Wave Bursts In The First Year Of The Fifth Ligo Science Run, B. P. Abbott, R. Abbott, Matthew Benacquista, Teviet Creighton, Mario C. Diaz, R. Grosso, K. Hayama, Hansheng Lei, Soumya Mohanty, S. Mukherjee, Malik Rakhmanov, Joseph D. Romano, Robert Stone, Lappoon R. Tang

Physics and Astronomy Faculty Publications and Presentations

We present the results obtained from an all-sky search for gravitational-wave (GW) bursts in the 64–2000 Hz frequency range in data collected by the LIGO detectors during the first year (November 2005—November 2006) of their fifth science run. The total analyzed live time was 268.6 days. Multiple hierarchical data analysis methods were invoked in this search. The overall sensitivity expressed in terms of the root-sum-square (rss) strain amplitude hrss for gravitational-wave bursts with various morphologies was in the range of 6×10−22  Hz−1/2 to a few×10−21  Hz−1/2. No GW signals were observed and a frequentist upper limit of 3.75 events per …

Computational Techniques For Reducing Spectra Of The Giant Planets In Our Solar System, Holly L. Grimes

Dissertations and Theses

The dynamic atmospheres of Jupiter, Saturn, Uranus, and Neptune provide a rich source of meteorological phenomena for scientists to study. To investigate these planets, scientists obtain spectral images of these bodies using various instruments including the Cooled Mid-Infrared Camera and Spectrometer (COMICS) at the Subaru Telescope Facility at Mauna Kea, Hawaii. These spectral images are two-dimensional arrays of double precision floating point values that have been read from a detector array. Such images must be reduced before the information they contain can be analyzed. The reduction process for spectral images from COMICS involves several steps:

1. Sky subtraction: the …

Why Study Applied/Agricultural Economics, Matt Bogard

Agriculture Department Seminar Series

Agricultural Economics is a very applied field covering many topics beyond those stereotypically thought of as pertaining to agriculture. These may include finance and risk management, environmental and natural resource economics, game theory, or public policy analysis to name a few.

My Trig Book, Bruce Kessler

Mathematics Faculty Publications

This is the MATH 117 Trigonometry text developed by Dr. Bruce Kessler for the Gatton Academy of Math and Science at Western Kentucky University for the Math and Science sections of the course. The text has also been used in two online course offerings.

Comic Books That Teach Mathematics, Bruce Kessler

Mathematics Faculty Publications

During the 2008--2009 academic year, the author embarked on an extremely non-standard curriculum path: developing comic books with embedded mathematics appropriate for 3rd through 6th grade students. With the help of an education professor to measure impact, an elementary-school principal, and talented undergraduate illustrators, this project came to fruition and the comics were implemented in elementary classrooms at Cumberland Trace Elementary in the Warren County School System in Bowling Green, Kentucky. This manuscript gives the history of this idea, the difficulties of developing the content of the comics and getting them illustrated, and the implementation plan in the school.

Thermocapillary Effects In Driven Dewetting And Self-Assembly Of Pulsed Laser-Irradiated Metallic Films, Agegnehu Atena, Mikhail Khenner

Mathematics Faculty Publications

In this paper the lubrication-type dynamical model is developed of a molten, pulsed laser-irradiated metallic film. The heat transfer problem that incorporates the absorbed heat from a single beam or interfering beams is solved analytically. Using this temperature field, we derive the 3D long-wave evolution PDE for the film height. To get insights into dynamics of dewetting, we study the 2D version of the evolution equation by means of a linear stability analysis and by numerical simulations. The stabilizing and destabilizing effects of various system parameters, such as the peak laser beam intensity, the film optical thickness, the Biot and …

The Biscayne Aquifer Of Southeastern Florida, Kevin J. Cunningham, Lee J. Florea

Earth, Environmental, and Atmospheric Sciences Faculty Publications

No abstract provided.

The Southeastern Coastal Plain: An Overview, Lee J. Florea, H. L. Vacher

Earth, Environmental, and Atmospheric Sciences Faculty Publications

No abstract provided.

The Cumberland Plateau Of Eastern Kentucky, Larry C. Simpson, Lee J. Florea

Earth, Environmental, and Atmospheric Sciences Faculty Publications

No abstract provided.

Caves And Karst Of West-Central Florida, Lee J. Florea, David A. Budd, Robert B. Brinkman

Earth, Environmental, and Atmospheric Sciences Faculty Publications

No abstract provided.

My Trig Book, Bruce Kessler

Mathematics Faculty Publications

This is the MATH 117 Trigonometry text developed by Dr. Bruce Kessler for the Gatton Academy of Math and Science at Western Kentucky University for the Academy sections of the course. The text has also been used in two online course offerings.

Thermocapillary Effects In Driven Dewetting And Self-Assembly Of Pulsed Laser-Irradiated Metallic Films, Agegnehu Atena, Mikhail Khenner

Mathematics Faculty Publications

In this paper the lubrication-type dynamical model is developed of a molten, pulsed laser-irradiated metallic film. The heat transfer problem that incorporates the absorbed heat from a single beam or interfering beams is solved analytically. Using this temperature field, we derive the 3D long-wave evolution PDE for the film height. To get insights into dynamics of dewetting, we study the 2D version of the evolution equation by means of a linear stability analysis and by numerical simulations. The stabilizing and destabilizing effects of various system parameters, such as the peak laser beam intensity, the film optical thickness, the Biot and …

Planning For Sea Level Rise And Coastal Flooding, John D. Boon, Harry V. Wang, Jian Shen, Virginia Institute Of Marine Science. Initiative For Coastal Climate Change Research

Reports

VIMS climate change white papers: Planning for sea level rise and coastal flooding

Marine Plankton Food Webs And Climate Change, Walker O. Smith Jr., Deborah K. Steinberg, Deborah A. Bronk, Kam W. Tang, Virginia Institute Of Marine Science. Initiative For Coastal Climate Change Research

Reports

VIMS climate change white papers: Marine plankton food webs and climate change

Land-Coast Connections And Climate Change : Carbon Cycling In Chesapeake Bay And Its Watershed, Elizabeth A. Canuel, James E. Bauer, Virginia Institute Of Marine Science, Initiative For Coastal Climate Change Research

Reports

VIMS climate change white paper: Land-coast connections and climate change : carbon cycling in Chesapeake Bay and its watershed

Workshop On Environmental Research Needs In Support Of Potential Virginia Offshore Oil And Gas Activities, Robert J. Diaz, Richard Brill, Linda C. Schaffner, Kenneth W. Able, Larry Atkinson, Diane Austin, Scott Kraus, Douglas Lipton, United States. Minerals Management Service

Reports

The MMS, a bureau within the Department of the Interior, sponsored a workshop on the environmental research needs in support of potential Virginia offshore oil and gas activities 3 and 4 December 2008, in Williamsburg, Virginia. The focus of the workshop was to assess the existing scientific knowledgebase along the Virginia Coast and the information gaps that need to 2 be addressed should a lease sale for oil and gas activities be held for the Virginia outer continental shelf. This report summarizes the outcome of the workshop.

Virginia Game Fish Tagging Program Annual Report 2008, John A. Lucy, Lewis Gillingham

Reports

Through 2008, the Virginia Game Fish Tagging Program has maintained a database comprised of 14 years of data on tagged and recaptured fish. The program is a cooperative project of the Virginia Saltwater Fishing Tournament (VSFT-under the Marine Resources Commission) and the Virginia Institute of Marine Science (VIMS) of the College of William and Mary (under VIMS Sea Grant Marine Advisory Program).

Local Spectral Analysis Via A Bayesian Mixture Of Smoothing Splines” Journal Of The American Statistical Association, Sally Wood, Ori Rosen, David Stoffer

Sally Wood

No abstract provided.

A Finite Volume Method For Solving Parabolic Equations On Logically Cartesian Curved Surface Meshes, Donna Calhoun, Christiane Helzel

Donna Calhoun

We present a second-order, finite-volume scheme for the constant-coefficient diffusion equation on curved, parametric surfaces described via smooth or piecewise smooth mappings on logically Cartesian meshes. Our method does not require analytic metric terms, shows second-order accuracy, can be easily coupled to existing finite-volume solvers for logically Cartesian meshes and handles general mixed boundary conditions. We present numerical results demonstrating the accuracy of the scheme, and then use the scheme to solve advection-reaction-diffusion equations modeling biological pattern formation on surfaces.

Balancing The R With The E In Reu Programs, Sarah Spence Adams, Rick Gillman, Darren Narayan

Sarah Spence Adams

Externally or internally funded Research Experience for Undergraduates (REU) programs offer students the opportunity to work with faculty on unsolved problems and can serve as a highlight of their undergraduate career. The overall goal of these formative programs is that students and faculty have an enjoyable experience as they investigate the horizon of knowledge. However, there is a question on how much a program should focus on research and how much emphasis should be placed on the experience. In the end, both aspects should be given considerable weight.

Target Finding Time For Microtubules In A Confined Geometry, Mitra Shojania-Feizabadi

Mitra Shojania-Feizabadi

Dynamic instability of microtubules may reach the steady state with exponentially growing or decaying length distribution in a confined geometry such as a cell-like environment. In this brief communication, the target finding time for these microtubules with the stochastic polymerization in a confined geometry is compared with the reversible polymerization. It is shown that the efficiency of microtubules with increasing length distribution at the steady state depends on the location of a target. They are very efficient in finding a target located at the cell cortex, which confirms the significant biological role they play in rapidly reaching the cell cortex …

Amphipathic Small Molecules Mimic The Binding Mode And Function Of Endogenous Transcription Factors, Brian Brennan, Sara Buhrlage, Caleb Bates, Steven Rowe, Aaron Minter, Chinmay Majmudar, David Wemmer, Hashim Al-Hashimi, Anna Map

Brian B. Brennan

Small molecules that reconstitute the binding mode(s) of a protein and in doing so elicit a programmed functional response offer considerable advantages in the control of complex biological processes. The development challenges of such molecules are significant, however. Many protein–protein interactions require multiple points of contact over relatively large surface areas. More significantly, several binding modes can be superimposed upon a single sequence within a protein, and a true small molecule replacement must be preprogrammed for such multimodal binding. This is the case for the transcriptional activation domain or TAD of transcriptional activators as these motifs utilize a poorly characterized …

Identification Of Yeast Transcriptional Regulation Networks Using Multivariate Random Forests, Yuanyuan Xiao, Mark Segal

Mark R Segal

The recent availability of whole-genome scale data sets that investigate complementary and diverse aspects of transcriptional regulation has spawned an increased need for new and effective computational approaches to analyze and integrate these large scale assays. Here, we propose a novel algorithm, based on random forest methodology, to relate gene expression (as derived from expression microarrays) to sequence features residing in gene promoters (as derived from DNA motif data) and transcription factor binding to gene promoters (as derived from tiling microarrays). We extend the random forest approach to model a multivariate response as represented, for example, by time-course gene expression …

Large Area, Continuous, Few-Layered Graphene As Anodes In Organic Photovoltaic Devices, Y Wang, Xh Chen, Yl Zhong, F.R. Zhu, Kp Loh

Professor ZHU, Fu Rong

No abstract provided.

Ethically Notable Videogames: Moral Dilemmas And Gameplay, Jose Zagal

Jose P Zagal

In what ways can we use games to make moral demands of players and encouraging them to reflect on ethical issues? In this article we propose an ethically notable game as one that provides opportunities for encouraging ethical reasoning and reflection. Our analysis of the videogames Ultima IV, Manhunt, and Fire Emblem: Radiant Dawn highlights the central role that moral dilemmas can play towards creating ethically notable games. We discuss the different ways that these are implemented, such as placing players in situations in which their understanding of an ethical system is challenged, or by creating moral tension between the …