Physical Sciences and Mathematics Commons^™

Membrane Inlet Mass Spectrometry Reveals That Ceriporiopsis Subvermispora Bicupin Oxalate Oxidase Is Inhibited By Nitric Oxide, Ellen W. Moomaw, Richard Uberto, Chingkuang Tu

Ellen Moomaw

No abstract provided.

Boundaries Of A Complex World, Isbn 978-3-662-49078-5 (2016), Andrei Ludu

Andrei Ludu

Bias In Estimating The Causal Hazard Ratio Using Two-Stage Instrumental Variable Methods, Fei Wan, Dylan S. Small, Justin E. Bekelman, Nandita Mitra

fei wan

Two stage instrumental variable methods are commonly used to determine the causal effects of treatments on survival in the presence of measured and unmeasured confounding. Two stage residual inclusion (2SRI) has been the method of choice over two stage predictor substitution (2SPS) in clinical studies. We directly compare the bias in the causal hazard ratio estimated by these two methods. Under a principal stratification framework, we derive a closed form solution for asymptotic bias of the causal hazard ratio among compliers for both the 2SPS and 2SRI methods when survival time follows the Weibull distribution with random censoring. When there …

Co-Delivery Of Small Interfering Rna Using A Camptothecin Prodrug As The Carrier, Qiong Tang, Bin Cao, Gang Cheng

Gang Cheng

We have reported the first effort towards directly using an anticancer prodrug (CPTssR5H5) as a carrier to co-deliver camptothecin (CPT) and small interfering RNA for multidrug resistant cancer chemotherapy. The results indicated that CPTssR5H5 is a promising co-delivery system for MDR cancer therapy.

Unpublished Writings From Audio Magazine: Proposed Series Chapter 5, Richard C. Heyser, Douglas R. Jones Ed.

Douglas R Jones

This is the fifth in a series of seven articles written by Richard C. Heyser in 1983. Heyser originally intended to publish this work in AUDIO magazine. This updated version has been edited and annotated by Douglas R. Jones.

Cloud Trader Simulator Overview

Stephen M. Watt

This video presentation complements the article "An Agent-Based Financial Market Simulator for Evaluation of Algorithmic Trading Strategies" by Rui Hu and Stephen Watt.

Some Definitions And Proofs Regarding Romeo, Paul Stansifer, Mitchell Wand

Paul Stansifer

This is intended to accompany Romeo: a system for more flexible binding-safe programming.

Importance Accelerated Robbins-Monro Recursion With Applications To Parametric Confidence Limits, Zdravjko I. Botev, Chris Lloyd

Chris J. Lloyd

Monro (1951) to calculating confidence limits leads to poor efficiency and difficulties in estimating the appropriate governing constants as well as the standard error. We suggest sampling instead from an alternative importance distribu- tion and modifying the Robbins-Monro recursion accordingly. This can reduce the asymptotic variance by the usual importance sampling factor. It also allows the standard error and optimal step length to be estimated from the simulation. The methodology is applied to computing almost exact confidence limits in a generalised linear model.

Shaping Carbon Nanotube Forests For Field Emission, Ben Pound

Ben Pound

No abstract provided.

Advancing Green Economy Through Technology Transfer Experiences From Malawi, Stanley Mubako

Stanley Mubako

No abstract provided.

Double Propensity-Score Adjustment: A Solution To Design Bias Or Bias Due To Incomplete Matching, Peter Austin

Peter Austin

Propensity-score matching is frequently used to reduce the effects of confounding when using observational data to estimate the effects of treatments. Matching allows one to estimate the average effect of treatment in the treated. Rosenbaum and Rubin coined the term "bias due to incomplete matching" to describe the bias that can occur when some treated subjects are excluded from the matched sample because no appropriate control subject was available. The presence of incomplete matching raises important questions around the generalizability of estimated treatment effects to the entire population of treated subjects. We describe an analytic solution to address the bias …

Rheology Of Magnesite, Caleb Holyoke, Andreas Kronenberg, Julie Newman, Christopher Ulrich

Caleb Holyoke

No abstract provided.

Microstructural Evolution During Strain Localization In Dolomite Aggregates, Caleb Holyoke, Julie Newman, Andreas Kronenberg

Caleb Holyoke

No abstract provided.

The Design Of The Open Prototype For Educational Nanosats, Jeremy Straub

Jeremy Straub

No abstract provided.

Atmospheric Methane Over The Arctic Ocean: Thermal Ir Satellite And Ship- Based Observations, Leonid Yurganov

Leonid Yurganov

Recent warming of the Arctic stimulated speculations about dissociation of methane hydrates in the Arctic seabed and a new climatic positive feedback. Here, for the first time, methane low tropospheric satellite retrievals over the Arctic from two instruments: AIRS (Atmospheric IR Sounder) and IASI (Infrared Atmospheric Sounding Interferometer) were analyzed. Analyzed are data for areas over open water with high values of the vertical thermal contrast (ThC, defined here as the temperature difference between the surface and altitude of 4 km); they have been found to be reliable. The seasonal cycles of the data well correlate with the cycles measured …

R Codes For "Multilevel Sparse Functional Principal Component Analysis" (Stat), Chongzhi Di

Chongzhi Di

No abstract provided.

Change Point Testing In Logistic Regression Models With Interaction Term, Y Fong, Cz Di, S Permar

Chongzhi Di

From Amazon To Apple: Modeling Online Retail Sales, Purchase Incidence And Visit Behavior, Anastasios Panagiotelis, Michael S. Smith, Peter Danaher

Michael Stanley Smith

In this study we propose a multivariate stochastic model for website visit duration, page views, purchase incidence and the sale amount for online retailers. The model is constructed by composition from carefully selected distributions, and involves copula components. It allows for the strong nonlinear relationships between the sales and visit variables to be explored in detail, and can be used to construct sales predictions. The model is readily estimated using maximum likelihood, making it an attractive choice in practice given the large sample sizes that are commonplace in online retail studies. We examine a number of top-ranked U.S. online retailers, …

Air Concentrations Of Volatile Compounds Near Oil And Gas Production: A Community-Based Exploratory Study, Gregg P. Macey

Gregg P. Macey

Background: Horizontal drilling, hydraulic fracturing, and other drilling and well stimulation technologies are now used widely in the United States and increasingly in other countries. They enable increases in oil and gas production, but there has been inadequate attention to human health impacts. Air quality near oil and gas operations is an underexplored human health concern for five reasons: (1) prior focus on threats to water quality; (2) an evolving understanding of contributions of certain oil and gas production processes to air quality; (3) limited state air quality monitoring networks; (4) significant variability in air emissions and concentrations; and (5) …

Infrared Cross-Sections And Integrated Band Intensities Of Propylene: Temperature-Dependent Studies, Et-Touhami Es-Sebbar, Majed Alrefae, Aamir Farooq

Dr. Et-touhami Es-sebbar

Propylene, a by-product of biomass burning, thermal cracking of hydrocarbons and incomplete combustion of fossil fuels, is a ubiquitous molecule found in the environment and atmosphere. Accurate infrared (IR) cross-sections and integrated band intensities of propylene are essential for quantitative measurements and atmospheric modeling. We measured absolute IR cross-sections of propylene using Fourier Transform Infrared (FTIR) Spectroscopy over the wavenumber range of 400–6500 cm−1 and at gas temperatures between 296 and 460 K. We recorded these spectra at spectral resolutions ranging from 0.08 to 0.5 cm−1 and measured the integrated band intensities for a number of vibrational bands in certain …

Outer Median Triangles, Árpád Bényi, Branko Ćurgus

Branko Ćurgus

We define the notions of outer medians and outer median triangles. We show that outer median triangles enjoy similar properties to that of the median triangle.

Birds Of A Feather Deceive Together: The Chicanery Of Multiplied Metadata, David M. Cook

Dr. David M Cook

Xena: An Automated 'Open-Source' 129xe Hyperpolarizer For Clinical Use, Panayiotis Nikolaou, Aaron M. Coffey, Laura L. Walkup, Brogan M. Gust, Nicholas Whiting, Hayley Newton, Iga Muradyan, Mikayel Dabaghyan, Kaili Ranta, Gregory D. Moroz, Matthew S. Rosen, Samuel Patz, Michael J. Barlow, Eduard Y. Chekmenev, Boyd M. Goodson

Nicholas Whiting

Spectral Density Shrinkage For High-Dimensional Time Series, Mark Fiecas, Rainer Von Sachs

Mark Fiecas

Stereoselective Synthesis Of 3,7-Diarylaminocholestanes By Titanium-Mediated Reductive Amination, Md Wasi Ahmad, Hong Seok Kim

Dr. Mohammad Wasi Ahmad (Md Wasi Ahmad)

An efficient method for the synthesis of aryl aminocholestanes, using a chlorotriisopropoxytitanium (IV)-mediated reductive amination reaction of 5a-cholestane-3,7-dione, is reported. A series of 3, 7-diarylaminocholestane derivatives were prepared according to this methodology in up to 98% yield. These compounds were primarily characterized by 1H NMR, 13C NMR, and mass spectrometry.

Selective Fluorescence Sensing Of Salicylic Acid Using A Simple Pyrene Appended Imidazole Receptor, Md Wasi Ahmad, Bo Yeon Kim, Hong Seok Kim

Dr. Mohammad Wasi Ahmad (Md Wasi Ahmad)

A simple salicylic acid selective fluorescence receptor 1 was designed by combining 1-pyrenecarboxaldehyde and 1-(3-aminopropyl)imidazole. The selective sensing of salicylic acid resulted in a significant increase in monomer emissions due to the p–p interactions between the benzene and pyrene rings. The nature of the interactions between receptor 1 and salicylic acid was investigated further by 1H NMR spectroscopy, and the energy minimised structure of the complex between receptor 1 and salicylic acid was optimised. Receptor 1 showed the highest binding constant with 5-nitrosalicylic acid among all the aromatic carboxylic acids tested. 5-Nitrosalicylic acid formed a complex with receptor 1 at …

Bovine Serum Albumin (Bsa) And Cleaved-Bsa Conjugated Ultrasmallgd2o3nanoparticles: Synthesis, Characterization, And Application To Mri Contrast Agents, Md Wasi Ahmad, Cho Rong Kim, Jong Su Baeck, Yongmin Chang, Tae Jeong Kim, Ji Eun Bae, Kwon Seok Chae, Gang Ho Lee

Dr. Mohammad Wasi Ahmad (Md Wasi Ahmad)

No abstract provided.

A Serial Risk Score Approach To Disease Classification That Accounts For Accuracy And Cost, Ron Brookmeyer, Dat Huynh, Oliver Laeyendecker

Ron Brookmeyer

The performance of diagnostic tests for disease classification is often measured by accuracy (e.g., sensitivity or specificity); however, costs of the diagnostic test are a concern as well. Combinations of multiple diagnostic tests may improve accuracy, but incur additional costs. Here, we consider serial testing approaches that maintain accuracy while controlling costs of the diagnostic tests. We present a serial risk score classification approach. The basic idea is to sequentially test with additional diagnostic tests just until persons are classified. In this way, it is not necessary to test all persons with all tests. The methods are studied in simulations …

Modeling The Longitudinality Of User Acceptance Of Technology With An Evidence-Adaptive Clinical Decision Support System, Michael P. Johnson Jr., Kai Zheng, Rema Padman

Michael P. Johnson

This paper presents multiple innovations associated with an electronic health record system developed to support evidence-based medicine practice, and highlights a new construct, based on the technology acceptance model, to explain end users' acceptance of this technology through a lens of continuous behavioral adaptation and change. We show that this new conceptualization of technology acceptance reveals a richer level of detail of the developmental course whereby individuals adjust their behavior gradually to assimilate technology use. We also show that traditional models such as technology acceptance model (TAM) are not capable of delineating this longitudinal behavioral development process. Our TAM-derived analysis …

Fluctuations In Transient Response Of Adsorption-Based Plasmonic Sensors, Zeljko D. Cupic

Zeljko D Cupic

The basic parameters of a sensor element defining its ultimate performance are sensitivity and intrinsic noise. In plasmonic gas sensors both are determined by refractive index changes due to adsorption and desorption (a–d) of target analyte particles to the sensor active area. In this paper we present a general model that can be simultaneously used to determine sensitivity and intrinsic noise of a plasmonic sensor both during transients and in steady-state and is valid for multi-analyte environments. The model utilizes the conventional probabilistic approach. It is derived without any assumptions about the stochastic nature of the fundamental (a–d) process. It …