Physical Sciences and Mathematics Commons^™

Lymphoblastoid Cell Lines As A Tool To Study Inter-Individual Differences In The Response To Glucose., Michael A Grassi, Vidhya R Rao, Siquan Chen, Dingcai Cao, Xiaoyu Gao, Patricia A. Cleary, R Stephanie Huang, Andrew D Paterson, Rama Natarajan, Jalees Rehman, Timothy S Kern

GW Biostatistics Center

BACKGROUND: White blood cells have been shown in animal studies to play a central role in the pathogenesis of diabetic retinopathy. Lymphoblastoid cells are immortalized EBV-transformed primary B-cell leukocytes that have been extensively used as a model for conditions in which white blood cells play a primary role. The purpose of this study was to investigate whether lymphoblastoid cell lines, by retaining many of the key features of primary leukocytes, can be induced with glucose to demonstrate relevant biological responses to those found in diabetic retinopathy.

METHODS: Lymphoblastoid cell lines were obtained from twenty-three human subjects. Differences between high and …

The Complements Of Lower Cones Of Degrees And The Degree Spectra Of Structures, Uri Andrews, Mingzhong Cai, Iskander Sh Kalimullin, Steffen Lempp, Joseph S. Miller, Antonio Montalban

Dartmouth Scholarship

We study Turing degrees a for which there is a countable structure whose degree spectrum is the collection {x : x ≰ a}. In particular, for degrees a from the interval [0′, 0″], such a structure exists if a′ = 0″, and there are no such structures if a″ > 0‴.

Vapor Deposited Cr-Doped Zns Thin Films: Towards Optically Pumped Mid-Infrared Waveguide Lasers, Eric A. Karhu, Charles R. Ildstad, Stefano Poggio, Vedran Furtula, Nikolai Tolstik, Irina T. Sorokina, Joseph J. Belbruno, Ursula J. Gibson

Dartmouth Scholarship

Compact, affordable mid-IR lasers require the development of gain materials in waveguide form. We report on the high vacuum deposition of Cr:ZnS films with concentration ranging from 10¹⁸-10²⁰ dopants/cm³ . At low concentrations, films display well-isolated absorption associated with substitutional Cr²⁺ ions in the lattice. Spatial modulation of the dopant concentration suppresses the absorption associated with this substitution. Lateral crystallite sizes less than 30 nm are associated with the lowest substrate temperatures (<50 °C) used during deposition, and waveguide losses as low as 8dB/cm are observed. These materials are promising candidates as gain media for fabrication of waveguide mid-IR lasers.

บทบรรณาธิการ

Thai Environment

No abstract provided.

แนวทางการฟื้นฟูพื้นที่ปนเปื้อนแคดเมียมด้วยวิธีที่เป็นมิตรกับสิ่งแวดล้อม...จากขวดทดลองสู่พื้นที่จริง, เบญจภรณ์ ประภักดี

Thai Environment

No abstract provided.

ป่าแห่งจิตวิญญาณ : ความหลากหลายและศักยภาพทางนิเวศของพืชในป่าแห่งจิตวิญญาณของชนเผ่าผู้ไทในดินแดนแอ่งสกลนคร ประเทศไทย, ธันวา ใจเที่ยง

Thai Environment

No abstract provided.

ระบบนิเวศนี้ สำคัญไฉน ทำไมอะไรๆ ก็ต้อง Eco?, ฝอยฝา ชุติดำรง

Thai Environment

No abstract provided.

เรื่องเล่าจากคนท้องถิ่น "ตามรอย "เมืองชาละวัน" เมืองน่าอยู่...มุ่งสู่เมืองสิ่งแวดล้อมยั่งยืนอาเซียน", สุจิตรา วาสนาดำรงดี

Thai Environment

No abstract provided.

กลไกของปากใบและบทบาทในการศึกษาผลกระทบทางสิ่งแวดล้อมต่อระบบนิเวศ, พันธนา ตอเงิน

Thai Environment

No abstract provided.

การแก้ปัญหาสิ่งแวดล้อมในมุมมองของนักออกแบบ กรณีศึกษา : การสร้างมูลค่าเพิ่มด้วยกระบวนการย้อมสีทะลายปาล์ม, รุ่งทิพย์ ลุยเลา

Thai Environment

No abstract provided.

วิเคราะห์เปรียบเทียร่างกฎหมายจัดการขยะอิเล็กทรอนิกส์สองฉบับของประเทศไทย, สุจิตรา วาสนาดำรงดี

Thai Environment

No abstract provided.

การศีกษาการปนเปื้อนโลหะหนักในเขตพื้นที่แหล่งแร่ทองคำภูทับฟ้า ตำบลเขาหลวง อำเภอวังสะพุง จังหวัดเลย กรณีศึกษา : น้ำใต้ดิน, อรุบล โชติพงศ์

Thai Environment

No abstract provided.

โลหะหนักในสิ่งแวดล้อมและความเสี่ยงต่อสุขภาพในชุมชนคัดแยกขยะอิเล็กทรอนิกส์ "ชุมชนเสือใหญ่" เขตจตุจักร, ศีลาวุธ ดำรงศิริ

Thai Environment

No abstract provided.

Male Pattern Baldness In Relation To Prostate Cancer–Specific Mortality: A Prospective Analysis In The Nhanes I Epidemiologic Follow-Up Study, Cindy Ke Zhou, Paul H Levine, Sean D. Cleary, Heather J. Hoffman, Barry I Graubard, Michael B. Cook

Epidemiology Faculty Publications

We used male pattern baldness as a proxy for long-term androgen exposure and investigated the association of dermatologist-assessed hair loss with prostate cancer–specific mortality in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. From the baseline survey (1971–1974), we included 4,316 men who were 25–74 years of age and had no prior cancer diagnosis. We estimated hazard ratios and used Cox proportional hazards regressions with age as the time metric and baseline hazard stratified by baseline age. A hybrid framework was used to account for stratification and clustering of the sample design, with adjustment for the variables …

Socioecological Factors Influencing Women's Hiv Risk In The United States: Qualitative Findings From The Women's Hiv Seroincidence Study (Hptn 064)., Paula M Frew, Kimberly Parker, Linda Vo, Danielle Haley, Ann O'Leary, Dazon Dixon Diallo, Carol E Golin, Irene Kuo, Lydia Soto-Torres, Jing Wang, Adaora A Adimora, Laura A Randall, Carlos Del Rio, Sally Hodder, Hiv Prevention Trials Network 064 (Htpn) Study Team.

Epidemiology Faculty Publications

BACKGROUND: We sought to understand the multilevel syndemic factors that are concurrently contributing to the HIV epidemic among women living in the US. We specifically examined community, network, dyadic, and individual factors to explain HIV vulnerability within a socioecological framework.

METHODS: We gathered qualitative data (120 interviews and 31 focus groups) from a subset of women ages 18-44 years (N = 2,099) enrolled in the HPTN 064 HIV seroincidence estimation study across 10 US communities. We analyzed data from 4 diverse locations: Atlanta, New York City (the Bronx), Raleigh, and Washington, DC. Data were thematically coded using grounded theory methodology. …

Interruptions Of Antiretroviral Therapy In Children And Adolescents With Hiv Infection In Clinical Practice: A Retrospective Cohort Study In The Usa., Natella Rakhmanina, Kam S Lam, Jaclyn Hern, Heather A. Young, Alex Walters, Amanda D. Castel

Epidemiology Faculty Publications

INTRODUCTION: Changes in combination antiretroviral therapy (cART) throughout childhood challenge the continuity of paediatric HIV treatment. This study aimed to evaluate the prevalence of treatment interruption (TI), including lamivudine (3TC) monotherapy, and the relationship of TI to virologic and immunologic parameters in HIV-infected paediatric patients.

METHODS: Nested within a prospective observational study of a city-wide cohort of HIV-infected persons in the District of Columbia, this sub-study collected retrospective data on antiretroviral therapy, enrolment (endpoint) and historic (lifelong) CD4 counts and HIV RNA viral load (VL) of the paediatric cohort. TI was defined as interruption of cART ≥4 consecutive weeks. Data …

Detectable Viral Load In Late Pregnancy Among Women In The Rwanda Option B+ Pmtct Program: Enrollment Results From The Kabeho Study., Michelle M Gill, Heather J Hoffman, Emily A Bobrow, Placidie Mugwaneza, Dieudonne Ndatimana, Gilles F Ndayisaba, Cyprien Baribwira, Laura Guay, Anita Asiimwe

Epidemiology Faculty Publications

There are limited viral load (VL) data available from programs implementing "Option B+," lifelong antiretroviral treatment (ART) to all HIV-positive pregnant and postpartum women, in resource-limited settings. Extent of viral suppression from a prevention of mother-to-child transmission of HIV program in Rwanda was assessed among women enrolled in the Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV (Kabeho) Study. ARV drug resistance testing was conducted on women with VL>2000 copies/ml. In April 2013-January 2014, 608 pregnant or early postpartum HIV-positive women were enrolled in 14 facilities. Factors associated with detectable enrollment VL (>20 copies/ml) were examined …

Impairment Of Continuous Insulin Delivery Therapy And Analysis From Graeco-Latin Square Design Model, Norou Diawara, Ayodeji Demuren, Eric Gyuricsko

Mathematics & Statistics Faculty Publications

The desire to deliver measured amount of insulin continuously to patients with type I diabetes, for glycemic control, has attracted a lot of attention. Continuous subcutaneous insulin infusion has seen some success in recent years. However, occlusion of insulin delivery may prevent the patient from receiving the prescribed dosage, with adverse consequence. An in vitro study of insulin delivery is performed, using different insulin pumps, insulin analogs and operating conditions. The aim is to identify incidences of occlusion due to bubble formation in the infusion line. A detailed statistical analysis was performed on the data collected to determine any significant …

Combining Harmonic Generation And Laser Chirping To Achieve High Spectral Density In Compton Sources, Balša Terzić, Cody Reeves, Geoffrey A. Krafft

Physics Faculty Publications

Recently various laser-chirping schemes have been investigated with the goal of reducing or eliminating ponderomotive line broadening in Compton or Thomson scattering occurring at high laser intensities. As a next level of detail in the spectrum calculations, we have calculated the line smoothing and broadening expected due to incident beam energy spread within a one-dimensional plane wave model for the incident laser pulse, both for compensated (chirped) and unchirped cases. The scattered compensated distributions are treatable analytically within three models for the envelope of the incident laser pulses: Gaussian, Lorentzian, or hyperbolic secant. We use the new results to demonstrate …

Comment On "Controlling The Spectral Shape Of Nonlinear Thomson Scattering With Proper Laser Chirping", Balša Terzić, Geoffrey A. Krafft

Physics Faculty Publications

Rykovanov, Geddes, Schroeder, Esarey and Leemans [Phys. Rev. Accel. Beams 19, 030701 (2016); hereafter RGSEL] have recently reported on the analytic derivation for the laser pulse frequency modulation (chirping) which controls spectrum broadening for high laser pulse intensities. We demonstrate here that their results are the same as the exact solutions reported in Terzic, Deitrick, Hofler and Krafft [Phys. Rev. Lett. 112, 074801 (2014); hereafter TDHK]. While the two papers deal with circularly and linearly polarized laser pulses, respectively, the difference in expressions for the two is just the usual factor of 1/2 present from going from circular to linear …

Electroexcitation Of The Δ+ (1232) At Low Momentum Transfer, A. Blomberg, D. Anez, N. Sparveris, A. J. Sarty, M. Paolone, S. Gilad, D. Higinbotham, Z. Ahmed, H. Albataineh, K. Allada

Physics Faculty Publications

We report on new p(e, e' p)π°. measurements at the Δ⁺(1232) resonance at the low momentum transfer region, where the mesonic cloud dynamics is predicted to be dominant and rapidly changing, offering a test bed for chiral effective field theory calculations. The new data explore the Q² dependence of the resonant quadrupole amplitudes and for the first time indicate that the Electric and the Coulomb quadrupole amplitudes converge as Q² -> 0. The measurements of the Coulomb quadrupole amplitude have been extended to the lowest momentum transfer ever reached, and suggest that more than half of …

Ab Initio Calculation Of The Electromagnetic And Neutral Weak Response Functions Of 4He And 12C, A. Lovato, O. Benhar, J. Carlson, S. Gandolfi, Steven C. Pieper, N. Rocco, R. Schiavilla

Physics Faculty Publications

Precise measurement of neutrino oscillations, and hence the determination of their masses demands a quantitative understanding of neutrino-nucleus interactions. To this aim, two-body meson-exchange currents have to be accounted for along within realistic models of nuclear dynamics. We summarize our progresses towards the construction of a consistent framework, based on quantum Monte Carlo methods and on the spectral function approach, that can be exploited to accurately describe neutrino interactions with atomic nuclei over the broad kinematical region covered by neutrino experiments.

Structure Constant Of Twist-2 Light Ray Operators In The Regge Limit, Ian Balitsky, Vladimir Kazakov, Evgeny Sobko

Physics Faculty Publications

We compute the normalized structure constant of three twist-2 operators in N =4 SYM in the leading Balitsky-Fadin-Kuraev-Lipatov (BFKL) approximation at any N_c . The result is applicable to other gauge theories including QCD.

Electron-Ion Collider: The Next Qcd Frontier, A. Accardi, J. L. Albacete, M. Anselmino, N. Armesto, E. C. Aschenauer, A. Bacchetta, D. Boer, W. K. Brooks, T. Burton, N.-B. Chang, C. E. Hyde

Physics Faculty Publications

This White Paper presents the science case of an Electron-Ion Collider (EIC), focused on the structure and interactions of gluon-dominated matter, with the intent to articulate it to the broader nuclear science community. It was commissioned by the managements of Brookhaven National Laboratory (BNL) and Thomas Jefferson National Accelerator Facility (JLab) with the objective of presenting a summary of scientific opportunities and goals of the EIC as a follow-up to the 2007 NSAC Long Range plan. This document is a culmination of a community-wide effort in nuclear science following a series of workshops on EIC physics over the past decades …

Harmonically Resonant Cavity As A Bunch-Length Monitor, B. Roberts, F. Hannon, M. M. Ali, E. Forman, J. Grames, R. Kazimi

Physics Faculty Publications

A compact, harmonically resonant cavity with fundamental resonant frequency 1497 MHz was used to evaluate the temporal characteristics of electron bunches produced by a 130 kV dc high voltage spin-polarized photoelectron source at the Continuous Electron Beam Accelerator Facility (CEBAF) photoinjector, delivered at 249.5 and 499 MHz repetition rates and ranging in width from 45 to 150 picoseconds (FWHM). A cavity antenna attached directly to a sampling oscilloscope detected the electron bunches as they passed through the cavity bore with a sensitivity of ∼1  mV/μA . The oscilloscope waveforms are a superposition of the harmonic modes excited by the beam, …

"Hammer" Events, Neutrino Energies, And Nucleon-Nucleon Correlations, L. B. Weinstein, O. Hen, Eli Piasetzky

Physics Faculty Publications

Background: Accelerator-based neutrino oscillation measurements depend on observing a difference between the expected and measured rate of neutrino-nucleus interactions at different neutrino energies or different distances from the neutrino source. Neutrino-nucleus scattering cross sections are complicated and depend on the neutrino beam energy, the neutrino-nucleus interaction, and the structure of the nucleus. Knowledge of the incident neutrino energy spectrum and neutrino-detector interactions are crucial for analyzing neutrino oscillation experiments. The ArgoNeut liquid argon time projection chamber (lArTPC) observed charged-current neutrino-argon scattering events with two protons back-to-back in the final state ("hammer" events) which they associated with short-range correlated (SRC) nucleon-nucleon …

Laser Pulsing In Linear Compton Scattering, G. A. Krafft, E. Johnson, K. Deitrick, B. Terzić, R. Kelmar, T. Hodges, J. R. Delayen

Physics Faculty Publications

Previous work on calculating energy spectra from Compton scattering events has either neglected considering the pulsed structure of the incident laser beam, or has calculated these effects in an approximate way subject to criticism. In this paper, this problem has been reconsidered within a linear plane wave model for the incident laser beam. By performing the proper Lorentz transformation of the Klein-Nishina scattering cross section, a spectrum calculation can be created which allows the electron beam energy spread and emittance effects on the spectrum to be accurately calculated, essentially by summing over the emission of each individual electron. Such an …

Rosenbluth Separation Of The Πᵒ Electroproduction Cross Section, M. Defurne, M. Canan, C. E. Hyde, S. Koirala, M.N.H. Rashad, Jefferson Lab Hall A Collaboration

Physics Faculty Publications

We present deeply virtual πᵒ electroproduction cross-section measurements at x_B = 0.36 and three different Q² values ranging from 1.5 to 2 GeV2, obtained from Jefferson Lab Hall A experiment E07-007. The Rosenbluth technique is used to separate the longitudinal and transverse responses. Results demonstrate that the cross section is dominated by its transverse component and, thus, is far from the asymptotic limit predicted by perturbative quantum chromodynamics. Nonetheless, an indication of a nonzero longitudinal contribution is provided by the measured interference term σ_LT. Results are compared with several models based on the leading-twist approach of …

Target And Beam Target Spin Asymmetries In Exclusive Π+ And Π- Electroproduction With 1.6 To 5.7 Gev Electrons, P. E. Bosted, S. Careccia, G. Dodge, S. E. Kuhn, Y. Prok, M. J. Amaryan, B. Torayev, L. B. Weinstein, Z. W. Zhao, Clas Collaboration

Physics Faculty Publications

Beam-target double-spin asymmetries and target single-spin asymmetries in exclusive π⁺ and quasiexclusive π^- electroproduction were obtained from scattering of 1.6- to 5.7-GeV longitudinally polarized electrons from longitudinally polarized protons (for π⁺) and deuterons (for π^-) using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. The kinematic range covered is 1.1 < W < 2.6 GeV and 0.05 < Q² < 5 GeV², with good angular coverage in the forward hemisphere. The asymmetry results were divided into approximately 40 000 kinematic bins for π⁺ from free protons and 15 000 bins for π^- production from bound nucleons in the deuteron. The …

Gluon Tmd In Particle Production From Low To Moderate X, I. Balitsky, A. Tarasov

Physics Faculty Publications

We study the rapidity evolution of gluon transverse momentum dependent distributions appearing in processes of particle production and show how this evolution changes from small to moderate Bjorken x.