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Articles 11791 - 11820 of 12521

Full-Text Articles in Physical Sciences and Mathematics

An Intrinsic Characterization Of Bonnet Surfaces Based On A Closed Differential Ideal, Paul Bracken Jan 2017

An Intrinsic Characterization Of Bonnet Surfaces Based On A Closed Differential Ideal, Paul Bracken

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

The structure equations for a two-dimensional manifold are introduced and two results based on the Codazzi equations pertinent to the study of isometric surfaces are obtained from them. Important theorems pertaining to isometric surfaces are stated and a theorem due to Bonnet is obtained. A transformation for the connection forms is developed. It is proved that the angle of deformation must be harmonic, and that the differentials of many of the important variables generate a closed differential ideal. This implies that a coordinate system exists in which many of the variables satisfy particular ordinary differential equations, and these results can …


Iowa Waste Reduction Center Newsletter, January 2017, University Of Northern Iowa. Iowa Waste Reduction Center. Jan 2017

Iowa Waste Reduction Center Newsletter, January 2017, University Of Northern Iowa. Iowa Waste Reduction Center.

Iowa Waste Reduction Center Newsletter

Inside this Issue:

--- Registration Now Open for Midwest Food Recovery Summit
--- What We’re Looking Forward to at the Midwest Food Recovery Summit
--- 6X Certification and Compliance Report for 2016
--- 2016 Grain Elevator PTE Report
--- SLEIS Training
--- Industry News


Sedimentation Dynamics Of The Cagayan De Oro River Catchment And The Implications For Its Coastal Marine Environments, Mars P. Tan Jan 2017

Sedimentation Dynamics Of The Cagayan De Oro River Catchment And The Implications For Its Coastal Marine Environments, Mars P. Tan

Theses

Declines in coastal environment condition can often be attributed to land-based activities in the uplands. This may be the case in some parts of Macajalar Bay, where river plume is observed almost daily. This present study aims to demonstrate the erosion-sedimentation process along the Cagayan de Oro River Catchment to its river mouth, and its implication for the marine coastal habitats. Highlighted in the study are the various natural factors that have influenced the erosion-sedimentation process: its volume; direction; and effects on the coastal habitats.

In the uplands, to account for the influence of catchment spatial heterogeneity and local rainfall …


Pteropus Voeltzkowi And The Understory: A Study Of The Behavioral Impacts Of The Pemba Flying Fox On The Vegetation And Soil Quality Of Pemba Island, Lea Davidson Jan 2017

Pteropus Voeltzkowi And The Understory: A Study Of The Behavioral Impacts Of The Pemba Flying Fox On The Vegetation And Soil Quality Of Pemba Island, Lea Davidson

Independent Study Project (ISP) Collection

This study examines the impact of Pteropus voeltzkowi , colloquially known as the Pemba Flying Fox, on biodiversity and health of the forest ground layer. Known to serve as reforesters, high concentrations of both fruit seeds and nutrient dense guano are introduced into specific environmental locations due to the bat's behavioral patterns. Working around two roost locations, one in Ngezi Forest and the other at the Kidike conservation site near Mjini Ole, diversity of juvenile vegetation was measured and quantified. In a laboratory setting, soil samples from both sites were analyzed for impacts of guano concentration on soil chemical properties. …


Coincidence Charged-Current Neutrino-Induced Deuteron Disintegration For 2H216O, J. W. Van Orden, T. W. Donnelly, O. Moreno Jan 2017

Coincidence Charged-Current Neutrino-Induced Deuteron Disintegration For 2H216O, J. W. Van Orden, T. W. Donnelly, O. Moreno

Physics Faculty Publications

Semi-inclusive charge-changing neutrino reactions on targets of heavy water are investigated with the goal of determining the relative contributions to the total cross section of deuterium and oxygen in kinematics chosen to emphasize the former. The study is undertaken for conditions where the typical neutrino beam energies are in the few GeV region, and hence relativistic modeling is essential. For this, the previous relativistic approach for the deuteron is employed, together with a spectral function approach for the case of oxygen. Upon optimizing the kinematics of the final-state particles assumed to be detected (typically a muon and a proton) it …


Cryogenic Rf Test Of The First Srf Cavity Etched In An Rf Ar/Cl2 Plasma, J. Upadhyay, A. Palczewski, S. Popovic, A.-M. Valente-Feliciano, Do Im, H. L. Phillips, L. Vuskovic Jan 2017

Cryogenic Rf Test Of The First Srf Cavity Etched In An Rf Ar/Cl2 Plasma, J. Upadhyay, A. Palczewski, S. Popovic, A.-M. Valente-Feliciano, Do Im, H. L. Phillips, L. Vuskovic

Physics Faculty Publications

An apparatus and a method for etching of the inner surfaces of superconducting radio frequency (SRF) accelerator cavities are described. The apparatus is based on the reactive ion etching performed in an Ar/Cl2 cylindrical capacitive discharge with reversed asymmetry. To test the effect of the plasma etching on the cavity rf performance, a 1497 MHz single cell SRF cavity was used. The single cell cavity was mechanically polished and buffer chemically etched and then rf tested at cryogenic temperatures to provide a baseline characterization. The cavity's inner wall was then exposed to the capacitive discharge in a mixture of …


Measurement Of The Differential And Total Cross Sections Of The ᵧd→Kºʌ(P) Reaction Within The Resonance Region, N. Compton, C. E. Taylor, K. Hicks, P. Cole, N. Zachariou, Y. Ilieva, P. Nadel-Turonski, E. Klempt, V. A. Nikonov, A. V. Sarantsev, C. E. Hyde, M. Khachatryan, A. Klein, Y. Prok, B. Torayev, J. Zhang Jan 2017

Measurement Of The Differential And Total Cross Sections Of The ᵧd→Kºʌ(P) Reaction Within The Resonance Region, N. Compton, C. E. Taylor, K. Hicks, P. Cole, N. Zachariou, Y. Ilieva, P. Nadel-Turonski, E. Klempt, V. A. Nikonov, A. V. Sarantsev, C. E. Hyde, M. Khachatryan, A. Klein, Y. Prok, B. Torayev, J. Zhang

Physics Faculty Publications

We report the first measurement of differential and total cross sections for the γd →K0 Λ(p)reaction, using data from the CLAS detector at the Thomas Jefferson National Accelerator Facility. Data collected during two separate experimental runs were studied with photon-energy coverage 0.8-3.6 GeV and 0.5-2.6 GeV, respectively. The two measurements are consistent giving confidence in the method and determination of systematic uncertainties. The cross sections are compared with predictions from the KAON-MAID theoretical model (without kaon exchange), which deviate from the data at higher W and at forward kaon angles. These data, along with previously published cross sections for …


Transverse Parton Momenta In Single Inclusive Hadron Production In E+E- Annihilation Process., M. Boglione, J. O. Gonzalez-Hernandez, R. Taghavi Jan 2017

Transverse Parton Momenta In Single Inclusive Hadron Production In E+E- Annihilation Process., M. Boglione, J. O. Gonzalez-Hernandez, R. Taghavi

Physics Faculty Publications

We study the transverse momentum distributions of single inclusive hadron production in e+e annihilation processes. Although the only available experimental data are scarce and quite old, we find that the fundamental features of transverse momentum dependent (TMD) evolution, historically addressed in Drell–Yan processes and, more recently, in Semi-inclusive deep inelastic scattering processes, are visible in e+e annihilations as well. Interesting effects related to its non-perturbative regime can be observed.

We test two different parameterizations for the p⊥ dependence of the cross section: the usual Gaussian distribution and a power-law model. We find the latter …


Exploring The Reasons For The Seasons Using Google Earth, 3d Models, And Plots, Declan G. De Paor, Mladen M. Dordevic, Paul Karabinos, Stephen Burgin, Filis Coba, Steven J. Whitmeyer Jan 2017

Exploring The Reasons For The Seasons Using Google Earth, 3d Models, And Plots, Declan G. De Paor, Mladen M. Dordevic, Paul Karabinos, Stephen Burgin, Filis Coba, Steven J. Whitmeyer

Physics Faculty Publications

Public understanding of climate and climate change is of broad societal importance. However, misconceptions regarding reasons for the seasons abound amongst students, teachers, and the public, many of whom believe that seasonality is caused by large variations in Earth's distance from the Sun. Misconceptions may be reinforced by textbook illustrations that exaggerate eccentricity or show an inclined view of Earth's near-circular orbit. Textbook explanations that omit multiple factors influencing seasons, that do not mesh with students' experiences, or that are erroneous, hinder scientifically valid reasoning. Studies show that many teachers share their students' misconceptions, and even when they understand basic …


Measurements Of Ep → E′Π+Π-P′ Cross Sections With Clas At 1.40 Gev < W < 2.0 Gev And 2.0 Gev² < Q² < 5.0 Gev², E.L. Isupov, V.D. Burkert, D.S. Carman, R. W. Gothe, R. Hicks, B. S. Ishkhanov, V. I. Mokeev, K. P. Adhikari, S. Adhikari, D. Adikaram, M. J. Amaryan, G. Charles, A. Klein, Y. Prok, B. Torayev Jan 2017

Measurements Of Ep → E′Π+Π-P′ Cross Sections With Clas At 1.40 Gev < W < 2.0 Gev And 2.0 Gev² < Q² < 5.0 Gev², E.L. Isupov, V.D. Burkert, D.S. Carman, R. W. Gothe, R. Hicks, B. S. Ishkhanov, V. I. Mokeev, K. P. Adhikari, S. Adhikari, D. Adikaram, M. J. Amaryan, G. Charles, A. Klein, Y. Prok, B. Torayev

Physics Faculty Publications

This paper reports new exclusive cross sections for ep → e′π+π-p′ using the CLAS detector at Jefferson Laboratory. These results are presented for the first time at photon virtualities 2.0GeV2 2 < 5.0GeV2 in the center-of-mass energy range 1.4 GeV < W < 2.0 GeV, which covers a large part of the nucleon resonance region. Using a model developed for the phenomenological analysis of electroproduction data, we see strong indications that the relative contributions from the resonant cross sections at W < 1.74 GeV increase with Q2. These data considerably extend the kinematic reach of previous measurements. Exclusive ep → e′π+π-p′ cross section measurements are of particular importance for the extraction of resonance electrocouplings in the mass range above 1.6 GeV.


Deep Neural Networks With Confidence Sampling For Electrical Anomaly Detection, Norman L. Tasfi, Wilson A. Higashino, Katarina Grolinger, Miriam A. M. Capretz Jan 2017

Deep Neural Networks With Confidence Sampling For Electrical Anomaly Detection, Norman L. Tasfi, Wilson A. Higashino, Katarina Grolinger, Miriam A. M. Capretz

Electrical and Computer Engineering Publications

The increase in electrical metering has created tremendous quantities of data and, as a result, possibilities for deep insights into energy usage, better energy management, and new ways of energy conservation. As buildings are responsible for a significant portion of overall energy consumption, conservation efforts targeting buildings can provide tremendous effect on energy savings. Building energy monitoring enables identification of anomalous or unexpected behaviors which, when corrected, can lead to energy savings. Although the available data is large, the limited availability of labels makes anomaly detection difficult. This research proposes a deep semi-supervised convolutional neural network with confidence sampling for …


Fire, Ice, Water, And Dirt: A Simple Climate Model, John Kroll Jan 2017

Fire, Ice, Water, And Dirt: A Simple Climate Model, John Kroll

Mathematics & Statistics Faculty Publications

A simple paleoclimate model was developed as a modeling exercise. The model is a lumped parameter system consisting of an ocean (water), land (dirt), glacier, and sea ice (ice) and driven by the sun (fire). In comparison with other such models, its uniqueness lies in its relative simplicity yet yielding good results. For nominal values of parameters, the system is very sensitive to small changes in the parameters, yielding equilibrium, steady oscillations, and catastrophes such as freezing or boiling oceans. However, stable solutions can be found, especially naturally oscillating solutions. For nominally realistic conditions, natural periods of order 100kyrs are …


Multiplicative Noise Removal With A Sparsity-Aware Optimization Model, Jian Lu, Lixin Shen, Chen Xu, Yuesheng Xu Jan 2017

Multiplicative Noise Removal With A Sparsity-Aware Optimization Model, Jian Lu, Lixin Shen, Chen Xu, Yuesheng Xu

Mathematics & Statistics Faculty Publications

Restoration of images contaminated by multiplicative noise (also known as speckle noise) is a key issue in coherent image processing. Notice that images under consideration are often highly compressible in certain suitably chosen transform domains. By exploring this intrinsic feature embedded in images, this paper introduces a variational restoration model for multiplicative noise reduction that consists of a term reflecting the observed image and multiplicative noise, a quadratic term measuring the closeness of the underlying image in a transform domain to a sparse vector, and a sparse regularizer for removing multiplicative noise. Being different from popular existing models which focus …


Multipliers Of Sequence Spaces, Raymond Cheng, Javad Mashreghi, William T. Ross Jan 2017

Multipliers Of Sequence Spaces, Raymond Cheng, Javad Mashreghi, William T. Ross

Mathematics & Statistics Faculty Publications

This paper is selective survey on the space l(A)(p)and its multipliers. It also includes some connections of multipliers to Birkhoff-James orthogonality.


Synthesis Of New Fullerene Derivatives For Photovoltaic And Biological Applications, Edison Castro Jan 2017

Synthesis Of New Fullerene Derivatives For Photovoltaic And Biological Applications, Edison Castro

Open Access Theses & Dissertations

Functionalized fullerenes exhibit improved solubility and different chemical and physical properties that allow applications in multiple fields such as photovoltaic and biological applications. Currently, perovskite solar cells (PSCs) are the most rapidly developing type of solar cells with certified efficiencies rising from 3.8% in 2009 to 22.1% in 2016. The good electron transporting and solution processable properties of most fullerene derivatives make them the most popular electron transporting materials (ETMs) in inverted perovskite solar cells (PSCs).

The work is reported in 11 chapters. We start with a fullerene overview followed by cleaver and elegant methodologies that allow the synThesis of …


Airborne Lead In El Paso, Texas, Usa, Lisa Marie Paz Jan 2017

Airborne Lead In El Paso, Texas, Usa, Lisa Marie Paz

Open Access Theses & Dissertations

Despite significant strides to minimize lead in our air, water, soil, food, homes, workplaces, and consumer products, sporadic and systemic lead poisoning persists in industrial societies, e.g., the contemporary Flint (Michigan, USA) municipal water tragedy. Because lead exposure is cumulative, the sum of exposure from all sources, it is important to document and update potential community or neighborhood exposure levels from such environmental compartments as air, water, and housing. Here we present ambient airborne lead levels in El Paso, Texas, USA, parsed by particulate matter (PM) size fraction, geography, and season. Dichotomous samplers at 8 stations collected particulate matter continuously …


Combining Interval, Probabilistic, And Other Types Of Uncertainty In Engineering Applications, Andrew Martin Pownuk Jan 2017

Combining Interval, Probabilistic, And Other Types Of Uncertainty In Engineering Applications, Andrew Martin Pownuk

Open Access Theses & Dissertations

In many practical application, we process measurement results and expert estimates. Measurements and expert estimates are never absolutely accurate, their result are slightly different from the actual (unknown) values of the corresponding quantities. It is therefore desirable to analyze how this measurement and estimation inaccuracy affects the results of data processing.

There exist numerous methods for estimating the accuracy of the results of data processing under different models of measurement and estimation inaccuracies: probabilistic, interval, and fuzzy. To be useful in engineering applications, these methods should provide accurate estimate for the resulting uncertainty, should not take too much computation time, …


Study Of Electron Gas On A Neutron-Rich Nuclear Pasta, Enrique Ramirez-Homs Jan 2017

Study Of Electron Gas On A Neutron-Rich Nuclear Pasta, Enrique Ramirez-Homs

Open Access Theses & Dissertations

This study used a classical molecular dynamics model to observe the role of electron gas on the formation of nuclear structures at subsaturation densities (Ï?<0.015 fm^-3) and low temperatures (T< 1MeV ). The simulations were performed by varying the Coulomb interaction strength on systems of isospin symmetric and asymmetric matter with periodic boundary conditions. The effect was quantified on the fragment size multiplicity, the inter-particle distance, the isospin content of the clusters, the nucleon mobility and cluster persistence, and on the nuclear structure shapes. The existence of the nuclear pasta structures was observed even with the absence of the Coulomb interaction but with a modication of the shapes formed. It was found that the presence of the electron gas tends to distribute matter more evenly, forms less compact objects, decreases the isospin content of clusters, modies the nucleon mobility, reduces the persistence and the fragment size multiplicity, but does not alter the inter-particle distance in clusters. The degree of these effects also varied on the nuclear structures and depended on their isospin content, temperature, and density.


The Former Asarco Demolition Fallout, A Post Study On Lead Soil Concentrations And Environmental Agents Of Redistribution In El Paso, Texas, Stephanie A. Robinson Jan 2017

The Former Asarco Demolition Fallout, A Post Study On Lead Soil Concentrations And Environmental Agents Of Redistribution In El Paso, Texas, Stephanie A. Robinson

Open Access Theses & Dissertations

The former El Paso ASARCO Smelting and Refining Co. operated between 1877 and 1999, the pyrometallurgic activity was estimated to have discharged excess of a 1,000 tons of lead (Pb) into the atmosphere from 1969-71. It was estimated 96 tons of (Pb) were emitted on an annual basis from the standing ore and fluid beds. The Environmental Protection Agency (EPA) determined that lead (Pb) is the heavy metal of the highest concentration within the vicinity of the smelter. After the smelter production ceased, flash flooding common to the southwest, such as the 2006 historic flood, increased transportation of superficial contaminants …


Eco Friendly: Ecology Meets Economy, Neal Shannon Jan 2017

Eco Friendly: Ecology Meets Economy, Neal Shannon

A with Honors Projects

Sustainability is a word that gets used a lot, but it’s important to properly define how we are using it. In general, sustainability is the ability to continue an activity indefinitely. Environmental sustainability is defined as using environmental sciences to manage the rates of renewable resource harvest vs consumption; limit pollution creation vs natural sink potential; and slow non-renewable resource depletion; in a way that our behaviors can be continued indefinitely (Harich). An environmentally sustainable society would prioritize processing waste efficiently and promoting the regeneration of resources, just as a business would prioritize efficient use of equipment to lower costs …


The Keystone Pipeline: Is This Black Gold Worth It?, Claudia Salazar Jan 2017

The Keystone Pipeline: Is This Black Gold Worth It?, Claudia Salazar

A with Honors Projects

In this persuasive essay, the student describes the negative impacts of the Keystone XL pipeline, and argues that it is culturally threatening, socially unethical, economically unwise, and environmentally dangerous. Lists the negative consequences that may arise from the construction and operation of the pipeline, and concludes that the pipeline should not be constructed, since the danger it represents is greater than the benefits it may have.


Using The Pert Exponential Growth Model: Predicting Past And Future Chinese Populations Involving Their Famous Population Control Policies, Greg Gancarz Jan 2017

Using The Pert Exponential Growth Model: Predicting Past And Future Chinese Populations Involving Their Famous Population Control Policies, Greg Gancarz

A with Honors Projects

This project serves to examine the hypothetical effects of the implementation and repeal of China’s famous One Child Policy on the rate of population growth in that country through the use and applications of the basic exponential growth model. Calculates growth in three different scenarios and estmates the population for China in the year 2045.


Desalination Of Ocean Water, Daniel Wright Jan 2017

Desalination Of Ocean Water, Daniel Wright

A with Honors Projects

This honors project compares two methods of desalination of ocean water: hollow fiber membranes and porous nano-graphine sheets.


Electric Ion Dispersion As A New Type Of Mass Spectrometer, Michael R. Lindstrom, Iain Moyles, Kevin Ryczko Jan 2017

Electric Ion Dispersion As A New Type Of Mass Spectrometer, Michael R. Lindstrom, Iain Moyles, Kevin Ryczko

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

At the 2014 Fields-MPrime Industrial Problem Solving Workshop, PerkinElmer presented a design problem for mass spectrometry. Traditionally, mass spectrometry is done via three methods: using magnetic fields to deflect charged particles whereby different masses bend differently; using a time-of-flight procedure where particles of different mass arrive at different times at a target; and using an electric quadrupole that filters out all masses except for one very narrow band. The challenge posed in the problem was to come up with a new design for mass spectrometry that did not involve magnetic fields and where mass fractions could be measured in an …


Using Technology To Determine Factorability Or Non-Factorability Of Quadratic Algebraic Trinomials, John E. T. Bernard, Olga Ramirez, Cristina Villalobos Jan 2017

Using Technology To Determine Factorability Or Non-Factorability Of Quadratic Algebraic Trinomials, John E. T. Bernard, Olga Ramirez, Cristina Villalobos

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

This paper is aimed for mathematics educators who teach algebra, more specifically, the factoring of quadratic algebraic expressions, and who want to enhance student learning of this topic using technology in conjunction with the Middle Term Splitting Method (Donnell, 2010; MTSM 2016a; MTSM 2016b). We will use technology-based algebra and geometry connections to help determine factorability or nonfactorability of quadratic algebraic trinomials over the integers, over the real numbers, and over the complex numbers, both with clarity, certainty and with understanding by using two equations, one derived from the coefficients of the outer terms and the other from the middle …


Hamiltonian Models For The Propagation Of Irrotational Surface Gravity Waves Over A Variable Bottom, Alan Compelli, Rossen Ivanov, Michail D. Todorov Jan 2017

Hamiltonian Models For The Propagation Of Irrotational Surface Gravity Waves Over A Variable Bottom, Alan Compelli, Rossen Ivanov, Michail D. Todorov

Articles

A single incompressible, inviscid, irrotational fluid medium bounded by a free surface and varying bottom is considered. The Hamiltonian of the system is expressed in terms of the so-called Dirichlet-Neumann operators. The equations for the surface waves are presented in Hamiltonian form. Specific scaling of the variables is selected which leads to approximations of Boussinesq and KdV types taking into account the effect of the slowly varying bottom. The arising KdV equation with variable coefficients is studied numerically when the initial condition is in the form of the one soliton solution for the initial depth.


The Last Best Hope: Are Voluntary Conservation Agreements Effective Tools For Protecting Imperiled Species?, Sophie B. Tsairis Jan 2017

The Last Best Hope: Are Voluntary Conservation Agreements Effective Tools For Protecting Imperiled Species?, Sophie B. Tsairis

Graduate Student Theses, Dissertations, & Professional Papers

Candidate Conservation Agreements with Assurances, or CCAAs, are little known, voluntary conservation agreements that protect imperiled wildlife on private lands. These agreements have emerged over the past decade and have had mixed results in providing adequate protections for candidate species.

Landowners, private industries, state and federal agencies, and environmental nonprofits, are using CCAAs as tools to eliminate the need for an endangered species listing. An Endangered Species Act listing can lead to land-use uncertainty for private landowners and this threat is the main incentive to enroll in a CCAA. When landowners enroll in CCAAs they are agreeing to provide specific …


Structural Analysis Of A Triangle Zone Culmination, Comb Rock, Lewis And Clark County, Montana, Shane S. Fussell Jan 2017

Structural Analysis Of A Triangle Zone Culmination, Comb Rock, Lewis And Clark County, Montana, Shane S. Fussell

Graduate Student Theses, Dissertations, & Professional Papers

A triangle zone is a structure commonly found at the leading edge of a thrust belt, characterized by a triangular cross-section of thrust faults. In the Montana triangle zone, west-dipping thrust faults intersect east-dipping ones above a regional detachment fault. Most studies of triangle zones focus on the structure in a cross-sectional sense, but little work addresses variations along the trend. The Canadian Rocky Mountain triangle zone has long been a productive petroleum province, so understanding the southern extent of this zone, where it enters Montana, is of interest for economic purposes as well as geologic understanding. Previous studies have …


Stream Restoration Effects On Hydraulic Exchange, Storage And Alluvial Aquifer Discharge, Christine M. Brissette Jan 2017

Stream Restoration Effects On Hydraulic Exchange, Storage And Alluvial Aquifer Discharge, Christine M. Brissette

Graduate Student Theses, Dissertations, & Professional Papers

Stream restoration is increasingly being considered as a climate change mitigation tool, altering the storage and exchange capacities of streams and their adjacent alluvial aquifers. While previous research has shown that added geomorphic complexity and increased width-to-depth ratios can enhance hydraulic exchange and alluvial aquifer storage, few studies have used field data to link these changes in form to baseflow generation. In this paper, we quantify the effect of stream restoration on nested scales of hydraulic exchange and temporal patterns of alluvial aquifer recharge and discharge. Our work compares a restored and degraded reach on Ninemile Creek, Montana following extensive …


Study Of Biologically Important Macromolecules By Nuclear Magnetic Resonance, Christopher Michael Demott Jan 2017

Study Of Biologically Important Macromolecules By Nuclear Magnetic Resonance, Christopher Michael Demott

Legacy Theses & Dissertations (2009 - 2024)

Intrinsically disordered proteins or unstructured segments within proteins play an important role in cellular physiology and pathology. A combination of peptide aptamers selected by using the yeast-two-hybrid scheme, and in-cell NMR identified high affinity binders to a transiently structured intrinsically disordered proteins (IDP). This method was validated using the prokaryotic ubiquitin-like protein, Pup, of the Mycobacterium proteasome. We discover two peptide aptamers that bind to opposite sites of a transient helix in Pup, an intrinsically disordered protein, that have vastly different effects on the survival of Mycobacterium bovis BCG.