Physical Sciences and Mathematics Commons^™

Niclosamide Induces Protein Ubiquitination And Inhibits Multiple Pro-Survival Signaling Pathways In The Human Glioblastoma U-87 Mg Cell Line, Benxu Cheng, Liza Doreen Morales, Yonghong Zhang, Shizue Mito, Andrew Tsin

Chemistry Faculty Publications and Presentations

Glioblastoma is the most common and lethal malignant primary brain tumor for which the development of efficacious chemotherapeutic agents remains an urgent need. The anti-helminthic drug niclosamide, which has long been in use to treat tapeworm infections, has recently attracted renewed interest due to its apparent anticancer effects in a variety of in vitro and in vivo cancer models. However, the mechanism(s) of action remains to be elucidated. In the present study, we found that niclosamide induced cell toxicity in human glioblastoma cells corresponding with increased protein ubiquitination, ER stress and autophagy. In addition, niclosamide treatment led to down-regulation of …

An Efficient Image Segmentation Algorithm Using Neutrosophic Graph Cut, Florentin Smarandache, Yanhui Guo, Yaman Akbulut, Abdulkadir Sengur, Rong Xia

Branch Mathematics and Statistics Faculty and Staff Publications

Segmentation is considered as an important step in image processing and computer vision applications, which divides an input image into various non-overlapping homogenous regions and helps to interpret the image more conveniently. This paper presents an efficient image segmentation algorithm using neutrosophic graph cut (NGC). An image is presented in neutrosophic set, and an indeterminacy filter is constructed using the indeterminacy value of the input image, which is defined by combining the spatial information and intensity information. The indeterminacy filter reduces the indeterminacy of the spatial and intensity information. A graph is defined on the image and the weight for …

Nonlinear Optical Studies Of Defects And Domain Structures In Perovskite-Type Dielectric Ceramics, David J. Ascienzo

Dissertations, Theses, and Capstone Projects

In order to improve future generations of dielectric capacitors a deeper understanding of voltage-induced dielectric breakdown and electrical energy storage limitations is required. This dissertation presents the use of far-field optical second harmonic generation (SHG) polarimetry for probing structural defects and polar domains in linear and nonlinear perovskite dielectric ceramics. We investigated the formation of electric field-induced structural distortions at pristine Fe-doped SrTiO₃ (Fe:STO) electrode interfaces, structural defect and strain formation due to oxygen vacancy migration in electrodegraded Fe:STO single crystals, and mixed tetragonal and rhombohedral phase domains in ferroelectric Zr-doped BaTiO₃ (BZT) films exhibiting excellent …

Stereospecific Electrophilic Fluorination Of Alkylcarbastannatrane Reagents, Xinghua Ma

Dissertations, Theses, and Capstone Projects

The introduction of fluorine atoms into organic molecules significantly changes their physical, chemical, and biological properties. Fluorinated organic compounds are used as pharmaceuticals, agrochemicals, materials, and tracers for positron emission tomography (PET). For example, the site-specific fluorination of drugs can block sites of phase I metabolism by cytochrome P450 enzymes as well as improve target-binding affinities. In view of the unique features of fluorine-containing compounds, there has been increasing interest in the development of novel methods for the synthesis of fluorinated molecules, especially the site-specific monofluorination of complex molecules. Herein, we present the enantiospecific conversion of chiral secondary alkylcarbastannatranes into …

Assessment Of Hydrodynamic And Water Quality Impacts For Channel Deepening In The Thimble Shoals, Norfolk Harbor, And Elizabeth River Channels, Jian Shen, Rico Wang, Mac Sisson

Reports

To investigate the feasibility for Norfolk Harbor channel deepening in the lower James and Elizabeth Rivers, one of the key services of the project is to evaluate the impacts of deepening the Atlantic Ocean Channel to 55 feet (from 50 feet), Thimble Shoal Channel to 55 feet (from 50 feet), Elizabeth River (north of Lambert Point) to 50 feet (from 45 feet) and the Southern Branch (north of the I64 Bridge) to 50/45/45 feet. In general, the shipping channel dredging will result in enhancement of estuarine gravitational circulation, accentuate the tidal and wind wave influence upstream, and affect the ecosystem …

Evaluating Ensemble Wind Downscaling Methodologies Over A Coastal Estuary, Bryan Paul Holman

Theses and Dissertations

Current numerical weather prediction (NWP) ensemble systems are biased and under dispersive. While statistical methods have been developed to correct for these errors, the resulting post processed forecasts are typically available at observing stations only. Yet post processed forecasts are needed everywhere. Additionally, the horizontal grid spacing of current ensemble systems is too coarse to resolve the Indian River Lagoon (IRL), a coastal estuary in central Florida that impacts the local wind climatology. Thus, computationally reasonable approaches are needed that simultaneously downscale and post process ensemble wind forecasts. Currently no approach exists to do this, particularly in coastal areas such …

Nuclear Magnetic Resonance Studies Of Electrode And Electrolyte Materials For Li-Ion Batteries, Lisa Cirrincione

Dissertations, Theses, and Capstone Projects

In this thesis, Nuclear Magnetic Resonance (NMR) spectroscopic techniques are used to study lithium electrode and electrolyte materials for advanced rechargeable lithium ion batteries. Three projects are described in this thesis. The first involves ²³Na and ³⁷Al static and magic angle spinning NMR studies of NaAlH₄/C anode materials for advanced rechargeable batteries. The second project is a study of paramagnetic lithium transition-metal phosphate cathode materials for Li-ion batteries, where ⁷Li, and ³¹P single crystal NMR was used in order to obtain detailed information on the local electronic and magnetic environments. The third project investigates …

Coastal Eolian Sand-Ramp Development Related To Paleo-Sea-Level Changes During The Latest Pleistocene And Holocene (21–0 Ka) In San Miguel Island, California, U.S.A., Curt D. Peterson, Jon M. Erlandson, Errol Stock, Steve W. Hostetler, David M. Price

Geology Faculty Publications and Presentations

Coastal eolian sand ramps (5–130 m elevation) on the northern slope (windward) side of the small San Miguel Island (13 km in W-E length) range in age from late Pleistocene to modern time, though a major hiatus in sand-ramp growth occurred during the early Holocene marine transgression (16–9 ka). The Holocene sand ramps (1–5 m measured thicknesses) currently lack large dune forms, thereby representing deflated erosional remnants, locally covering thicker late Pleistocene sand-ramp deposits. The ramp sand was initially supplied from the adjacent island-shelf platform, extending about 20 km north of the present coastline. The sand-ramp deposits and interbedded loess …

Automated Android Application Permission Recommendation, Lingfeng Bao, David Lo, Xin Xia, Shanping Li

Research Collection School Of Computing and Information Systems

The number of Android applications has increased rapidly as Android is becoming the dominant platform in the smartphone market. Security and privacy are key factors for an Android application to be successful. Android provides a permission mechanism to ensure security and privacy. This permission mechanism requires that developers declare the sensitive resources required by their applications. On installation or during runtime, users are required to agree with the permission request. However, in practice, there are numerous popular permission misuses, despite Android introducing official documents stating how to use these permissions properly. Some data mining techniques (e.g., association rule mining) have …

Combining Machine-Based And Econometrics Methods For Policy Analytics Insights, Robert J. Kauffman, Kwansoo Kim, Sang-Yong Tom Lee, Ai Phuong Hoang, Jing Ren

Research Collection School Of Computing and Information Systems

Computational Social Science (CSS) has become a mainstream approach in the empirical study of policy analytics issues in various domains of e-commerce research. This article is intended to represent recent advances that have been made for the discovery of new policy-related insights in business, consumer, and social settings. The approach discussed is fusion analytics, which combines machine-based methods from Computer Science (CS) and explanatory empiricism involving advanced Econometrics and Statistics. It explores several efforts to conduct research inquiry in different functional areas of Electronic Commerce and Information Systems (IS), with applications that represent different functional areas of business, as well …

Parallel Personalized Pagerank On Dynamic Graphs, Wentian Guo, Yuchen Li, Yuchen Li, Kian-Lee Tan

Research Collection School Of Computing and Information Systems

Personalized PageRank (PPR) is a well-known proximitymeasure in graphs. To meet the need for dynamic PPRmaintenance, recent works have proposed a local updatescheme to support incremental computation. Nevertheless,sequential execution of the scheme is still too slow for highspeedstream processing. Therefore, we are motivated todesign a parallel approach for dynamic PPR computation.First, as updates always come in batches, we devise a batchprocessing method to reduce synchronization cost among everysingle update and enable more parallelism for iterativeparallel execution. Our theoretical analysis shows that theparallel approach has the same asymptotic complexity asthe sequential approach. Second, we devise novel optimizationtechniques to e↵ectively reduce runtime …

S3: Syntax- And Semantic-Guided Repair Synthesis Via Programming By Examples, Xuan-Bach D. Le, Duc-Hiep Chu, David Lo, Claire Le Goues, Willem Visser

Research Collection School Of Computing and Information Systems

A notable class of techniques for automatic program repair is known as semantics-based. Such techniques, e.g., Angelix, infer semantic specifications via symbolic execution, and then use program synthesis to construct new code that satisfies those inferred specifications. However, the obtained specifications are naturally incomplete, leaving the synthesis engine with a difficult task of synthesizing a general solution from a sparse space of many possible solutions that are consistent with the provided specifications but that do not necessarily generalize. We present S3, a new repair synthesis engine that leverages programming-by-examples methodology to synthesize high-quality bug repairs. The novelty in S3 that …

Nlp2code: Code Snippet Content Assist Via Natural Language Tasks, Brock A. Campbell, Christoph Treude

Research Collection School Of Computing and Information Systems

Developers increasingly take to the Internet for code snippets to integrate into their programs. To save developers the time required to switch from their development environments to a web browser in the quest for a suitable code snippet, we introduce NLP2Code, a content assist for code snippets. Unlike related tools, NLP2Code integrates directly into the source code editor and provides developers with a content assist feature to close the vocabulary gap between developers’ needs and code snippet meta data. Our preliminary evaluation of NLP2Code shows that the majority of invocations lead to code snippets rated as helpful by users and …

On-Demand Developer Documentation, Martin P. Robillard, Andrian Marcus, Christoph Treude, Gabriele Bavota, Oscar Chaparro, Neil Ernst, Marco Aurélio Gerosa, Michael Godfrey, Michele Lanza, Mario Linares-Vasquez, Gail C. Murphy, Laura Moreno, David Shepherd, Edmund Wong

Research Collection School Of Computing and Information Systems

We advocate for a paradigm shift in supporting the information needs of developers, centered around the concept of automated on-demand developer documentation. Currently, developer information needs are fulfilled by asking experts or consulting documentation. Unfortunately, traditional documentation practices are inefficient because of, among others, the manual nature of its creation and the gap between the creators and consumers. We discuss the major challenges we face in realizing such a paradigm shift, highlight existing research that can be leveraged to this end, and promote opportunities for increased convergence in research on software documentation.

North Dakota Carbonsafe – A Feasibility Study, University Of North Dakota. Energy And Environmental Research Center

EERC Brochures and Fact Sheets

Fact sheet about the Carbon Storage Assurance Facility Enterprise (CarbonSAFE) project, which offers clean, safe, and affordable energy throughout North Dakota. Includes information on carbon capture, including geological storage, and the U.S. Department of Energy’s involvement.

Catchment-Scale Alder Cover Controls Nitrogen Fixation In Boreal Headwater Streams, Daniel L. Hiatt, Caleb J. Robbins, Jeffrey A. Back, Pamela K. Kostka, Robert D. Doyle, Coowe M. Walker, Mark C. Rains, Dennis F. Whigham, Ryan S. King

School of Geosciences Faculty and Staff Publications

Alder (Alnus spp.) is a woody plant with bacterial symbionts that fix atmospheric N2into bioavailable N. We studied 12 North American boreal headwater streams spanning a steep gradient of catchment alder cover (0–27%) to test the hypothesis that increasing inputs of inorganic N associated with increasing alder cover would reduce or eliminate in-stream benthic N2 fixation. We measured N2 fixation rates, chlorophyll a, and ash-free dry mass (AFDM) of periphyton in early (May) and late (August) summer 2011. Dissolved inorganic N (DIN) concentrations, composed almost entirely of NO3/NO2-N, ranged from below detection limits to nearly 2 mg/L and …

Antarctic Ice Sheet Slope And Aspect Based On Icesat's Repeat Orbit Measurement, L. Yuan, F. Li, S. Zhang, Surui Xie, F. Xiao, T. Zhu, Y. Zhang

School of Geosciences Student Publications

Accurate information of ice sheet surface slope is essential for estimating elevation change by satellite altimetry measurement. A study is carried out to recover surface slope of Antarctic ice sheet from Ice, Cloud and land Elevation Satellite (ICESat) elevation measurements based on repeat orbits. ICESat provides repeat ground tracks within 200 meters in cross-track direction and 170 meters in along-track direction for most areas of Antarctic ice sheet. Both cross-track and along-track surface slopes could be obtained by adjacent repeat ground tracks. Combining those measurements yields a surface slope model with resolution of approximately 200 meters. An algorithm considering elevation …

Nuisance Flooding And Relative Sea-Level Rise: The Importance Of Present-Day Land Motion, Makan A. Karegar, Timothy H. Dixon, Rocco Malservisi, Jurgen Kusche, Simon E. Engelhart

School of Geosciences Faculty and Staff Publications

Sea-level rise is beginning to cause increased inundation of many low-lying coastal areas. While most of Earth’s coastal areas are at risk, areas that will be affected first are characterized by several additional factors. These include regional oceanographic and meteorological effects and/or land subsidence that cause relative sea level to rise faster than the global average. For catastrophic coastal flooding, when wind-driven storm surge inundates large areas, the relative contribution of sea-level rise to the frequency of these events is difficult to evaluate. For small scale “nuisance flooding,” often associated with high tides, recent increases in frequency are more clearly …

A Synergistic Approach For Evaluating Climate Model Output For Ecological Applications, Rachel D. Cavanagh, Eugene J. Murphy, Thomas J. Bracegirdle, John Turner, Cheryl A. Knowland, Stuart P. Corney, Walker O. Smith Jr., Claire M. Waluda, Nadine M. Johnston, Richard G. J. Bellerby, Eileen E. Hofmann

CCPO Publications

Increasing concern about the impacts of climate change on ecosystems is prompting ecologists and ecosystem managers to seek reliable projections of physical drivers of change. The use of global climate models in ecology is growing, although drawing ecologically meaningful conclusions can be problematic. The expertise required to access and interpret output from climate and earth system models is hampering progress in utilizing them most effectively to determine the wider implications of climate change. To address this issue, we present a joint approach between climate scientists and ecologists that explores key challenges and opportunities for progress. As an exemplar, our focus …

Bleached! The Catastrophe Management Of Corals, Irus Braverman

Journal Articles

Corals have recently emerged as both a sign and a measure of the imminent catastrophic future of life on earth and, as such, have become the focus of intense conservation management. Bleached! draws on in-depth interviews and participatory observations with coral scientists and managers to explore the management of the corals’ ecological catastrophe to come. The article starts by describing the unique life of corals, the importance of calculability in catastrophe management, and the coral scientists’ preoccupation with classifying, counting, and seeing in their attempt to comprehensibly monitor corals and anticipate their decline. Algorithmic models and elaborate temporal analyses are …

A Stochastic Mesoscale Model Of Transiently Networked Fluids., Lin Zhou, L. Pamela Cook

Publications and Research

Macroscale models of physically networked fluids suffer from the inability to connect directly to mesoscale processes due to nonlinearity and thus the need for closure approximations. In this paper physically networked complex fluids are modeled stochastically at the mesoscale, thus avoiding the need for closure assumptions. In the modeling and simulations the network consists of linear chains of Hookean bead-spring dumbbells. The linear chains break and reform stochastically subject to prescribed local attractive potentials. In the simulations the topology of the network is tracked allowing for quantification of the distribution of chain lengths and of individual dumbbell stretch. This formulation …

Comparing And Improving Facial Recognition Method, Brandon Luis Sierra

Electronic Theses, Projects, and Dissertations

Facial recognition is the process in which a sample face can be correctly identified by a machine amongst a group of different faces. With the never-ending need for improvement in the fields of security, surveillance, and identification, facial recognition is becoming increasingly important. Considering this importance, it is imperative that the correct faces are recognized and the error rate is as minimal as possible. Despite the wide variety of current methods for facial recognition, there is no clear cut best method. This project reviews and examines three different methods for facial recognition: Eigenfaces, Fisherfaces, and Local Binary Patterns to determine …

Synthesis And Evaluation Of Tetrahydroprotoberberines As Dopamine Receptor Ligands, Satishkumar V. Gadhiya

Dissertations, Theses, and Capstone Projects

Dopamine (DA) receptors belong to the G-protein coupled receptors (GPCRs) family, divided in to two groups based on their high homology transmembrane domains; D1-like DA receptors (D1, D5) and D2-like DA receptors (D2-D4). DA receptor specific ligands have been exploited as a means for studying the prognosis and curing several CNS disorders. Though several efforts have been devoted to discover selective and potent DA receptor ligands, complete selectivity within the DA receptor subtypes remains a challenge.

Tetrahydroprotoberberines (THPBs) are a group of naturally occurring tetracyclic alkaloids that belong to the tetrahydroisoquinoline family. A wide range of biological activities are associated …

Some Metric Properties Of The Teichmüller Space Of A Closed Set In The Riemann Sphere, Nishan Chatterjee

Dissertations, Theses, and Capstone Projects

Let E be an infinite closed set in the Riemann sphere, and let T(E) denote its Teichmüller space. In this dissertation we study some metric properties of T(E). We prove Earle's form of Teichmüller contraction for T(E), holomorphic isometries from the open unit disk into T(E), extend Earle's form of Schwarz's lemma for classical Teichmüller spaces to T(E), and finally study complex geodesics and unique extremality for T(E).

A Partial Nonlinear Extension Of Lax-Richtmyer Approximation Theory, Aradhana Kumari

Dissertations, Theses, and Capstone Projects

Lax and Richtmyer developed a theory of algorithms for linear initial value problems that guarantees, under certain circumstances, the convergence to numerical solution of initial value problem. The assumptions are first that the difference equations (algorithms) approx- imate the differential equations under study (this is called consistency) and, secondly, that the initial value problem be well-posed (which means that the solutions exist, are unique and depend continuously on initial data). Under these assumptions the stability condition (which requires that errors in the algorithm do not accumulate nor increase as one iter- ates the algorithm) is necessary and sufficient for convergence …

Walking As Ontological Shifter: Thoughts In The Key Of Life, Bibi (Silvina) Calderaro

Dissertations, Theses, and Capstone Projects

With walking as ontological shifter I pursue an alternative to the dominant modernist episteme that offers either/or onto-epistemologies of opposition and their reifying engagements. I propose this type of walking is an intentional turning towards a set of radical positions that, as integrative aesthetic and therapeutic practice, brings multiplicity and synchronicity to experience and being in an expanded sociality. This practice facilitates the conditions of possibility for recurring points of contact between the interiority perceived as ‘body’ and the exteriority perceived as ‘world.’ While making evident the self’s at once incoherence with it-self, it opens to a space beyond the …

Computational Investigation Of The Pore Formation Mechanism Of Beta-Hairpin Antimicrobial Peptides, Richard Lipkin

Dissertations, Theses, and Capstone Projects

β-hairpin antimicrobial peptides (AMPs) are small, usually cationic peptides that provide innate biological defenses against multiple agents. They have been proposed as the basis for novel antibiotics, but their pore formation has not been directly observed on a molecular level. We review previous computational studies of peptide-induced membrane pore formation and report several new molecular dynamics simulations of β-hairpin AMPs to elucidate their pore formation mechanism. We simulated β-barrels of various AMPs in anionic implicit membranes, finding that most of the AMPs’ β-barrels were not as stable as those of protegrin. We also performed an optimization study of protegrin β-barrels …

Morphogenesis And Growth Driven By Selection Of Dynamical Properties, Yuri Cantor

Dissertations, Theses, and Capstone Projects

Organisms are understood to be complex adaptive systems that evolved to thrive in hostile environments. Though widely studied, the phenomena of organism development and growth, and their relationship to organism dynamics is not well understood. Indeed, the large number of components, their interconnectivity, and complex system interactions all obscure our ability to see, describe, and understand the functioning of biological organisms.

Here we take a synthetic and computational approach to the problem, abstracting the organism as a cellular automaton. Such systems are discrete digital models of real-world environments, making them more accessible and easier to study then their physical world …

The Formation Of Fine-Grained Chondrule Rims In Unequilibrated Ordinary Chondrites, John Bigolski

Dissertations, Theses, and Capstone Projects

Fine-grained rims are ubiquitous, non-igneous, features that completely or partially envelope the majority of chondrules within the least equilibrated of the unequilibrated ordinary chondrites (UOCs). A detailed examination of such rims in 4 UOC samples less than petrologic type 3.2 was conducted in order to 1) characterize the relative distribution of rims within chondrite samples, 2) inspect differences between fine-grained rims and adjacent matrix material, 3) petrologically analyze the rims and their relationships with chondrule cores, 4) characterize an ungrouped UOC, Northwest Africa 5717, 5) conduct a microanalytical investigation of rim / matrix boundaries to discern relative chronologies of fine-grained …

Secure And Efficient Delegation Of A Single And Multiple Exponentiations To A Single Malicious Server, Matluba Khodjaeva

Dissertations, Theses, and Capstone Projects

Group exponentiation is an important operation used in many cryptographic protocols, specifically public-key cryptosystems such as RSA, Diffie Hellman, ElGamal, etc. To expand the applicability of group exponentiation to computationally weaker devices, procedures were established by which to delegate this operation from a computationally weaker client to a computationally stronger server. However, solving this problem with a single, possibly malicious, server, has remained open since a formal cryptographic model was introduced by Hohenberger and Lysyanskaya in 2005. Several later attempts either failed to achieve privacy or only achieved constant security probability.

In this dissertation, we study and solve this problem …