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2018

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Full-Text Articles in Physical Sciences and Mathematics

Deblurring Images, Jamie Mcmullen Oct 2018

Deblurring Images, Jamie Mcmullen

WWU Honors College Senior Projects

Let the matrix B be a blurred version of a sharp image represented by the matrix X. Given B, we would like to recover X.

To accomplish this, we construct linear models of the blurring process that produced B from X. The idea is that we could then reverse the blurring to reproduce the original image.

For example, if the blurred image satisfies

B = CXRT

for some invertible matrices C and R, then we could recover X as

X = C-1B(RT)-1.

However, the blurring model …


Statistical Design Of Experiment Techniques In Manufacturing, Caroline M. Kerfonta Oct 2018

Statistical Design Of Experiment Techniques In Manufacturing, Caroline M. Kerfonta

Senior Theses

There are many statistical techniques used to design experiments. These techniques are used in many different fields. This thesis will focus on the use of the three most common techniques used to design statistical experiments in manufacturing.

The three techniques that will be investigated are completely randomized design, randomized block design, and factorial design. These techniques will be compared, contrasted, and explained. Research examples will be presented along with sample R code for each technique. These examples will be accompanied by analysis of the techniques as well as an overview of the uses and history of experiments in manufacturing


Explosive Dust Test Vessel Comparison Using Pulverized Pittsburgh Coal, Jacob Miller, Jay Schafler, Phillip R. Mulligan, Robert Eades, Kyle A. Perry, Catherine E. Johnson Oct 2018

Explosive Dust Test Vessel Comparison Using Pulverized Pittsburgh Coal, Jacob Miller, Jay Schafler, Phillip R. Mulligan, Robert Eades, Kyle A. Perry, Catherine E. Johnson

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Explosions of coal dust are a major safety concern within the coal mining industry. The explosion and subsequent fires caused by coal dust can result in significant property damage, loss of life in underground coal mines and damage to coal processing facilities. The United States Bureau of Mines conducted research on coal dust explosions until 1996 when it was dissolved. In the following years, the American Society for Testing and Materials (ASTM) developed a test standard, ASTM E1226, to provide a standard test method characterizing the “explosibility” of particulate solids of combustible materials suspended in air. The research presented herein …


La Calidad Del Agua Y El Impacto En La Salud Pública: Un Examen A Las Fuentes Del Agua En La Amazonia Cerca De Puyo, Ecuador Y La Salud De Las Comunidades Indígenas / Water Quality And The Impact On Public Health: An Examination Of Water Sources In The Amazon Near Puyo, Ecuador And The Health Of Indigenous Communities, Mary Kathryn Mcgregor Oct 2018

La Calidad Del Agua Y El Impacto En La Salud Pública: Un Examen A Las Fuentes Del Agua En La Amazonia Cerca De Puyo, Ecuador Y La Salud De Las Comunidades Indígenas / Water Quality And The Impact On Public Health: An Examination Of Water Sources In The Amazon Near Puyo, Ecuador And The Health Of Indigenous Communities, Mary Kathryn Mcgregor

Independent Study Project (ISP) Collection

Agua limpia es una de las cosas más importantes para la salud humana y el acceso a esta es un derecho humano. Sin embargo, mucha gente todavía no tiene acceso a agua limpia, especialmente en las áreas rurales. El objetivo de este proyecto fue determinar la salud de 3 de las 11 comunidades de la nacionalidad Shuar cerca de Puyo, Ecuador, en la región amazónica con análisis de macroinvertebrados, pH, temperatura y bacterias. Las comunidades de Yuu, Kunkuk y Pitirishca fueron elegidas porque Pitirishca tiene agua entubada y las otras no la tienen, así que necesitan tomar el agua de …


How Many Points Are There In A Line Segment? A New Answer From Discrete Cellular Space Viewpoint, Florentin Smarandache, Victor Christianto Oct 2018

How Many Points Are There In A Line Segment? A New Answer From Discrete Cellular Space Viewpoint, Florentin Smarandache, Victor Christianto

Branch Mathematics and Statistics Faculty and Staff Publications

While it is known that Euclid’s five axioms include a proposition that a line consists at least of two points, modern geometry avoid consistently any discussion on the precise definition of point, line, etc. It is our aim to clarify one of notorious question in Euclidean geometry: how many points are there in a line segment? – from discrete-cellular space (DCS) viewpoint. In retrospect, it may offer an alternative of quantum gravity, i.e. by exploring discrete gravitational theories. To elucidate our propositions, in the last section we will discuss some implications of discrete cellular-space model in several areas of interest: …


Intro To Data Science - Data Exploration 3 (Week Four), Grant Long, Nyc Tech-In-Residence Corps Oct 2018

Intro To Data Science - Data Exploration 3 (Week Four), Grant Long, Nyc Tech-In-Residence Corps

Open Educational Resources

Lecture for the course "CSC 59970: Intro to Data Science" (Week Four) delivered at the City College of New York in Fall 2018 by Grant Long as part of the Tech-in-Residence Corps program.


Intro To Data Science - Models 2 ( Week Six), Grant Long, Nyc Tech-In-Residence Corps Oct 2018

Intro To Data Science - Models 2 ( Week Six), Grant Long, Nyc Tech-In-Residence Corps

Open Educational Resources

Lecture for the course "CSC 59970: Intro to Data Science" (Week Six) delivered at the City College of New York in Fall 2018 by Grant Long as part of the Tech-in-Residence Corps program.


Homework 6: Intro To Data Science (Week Nine), Grant Long, Nyc Tech-In-Residence Corps Oct 2018

Homework 6: Intro To Data Science (Week Nine), Grant Long, Nyc Tech-In-Residence Corps

Open Educational Resources

Homework Assignment for the course "CSC 59970: Intro to Data Science" (Week Nine) delivered at the City College of New York in Fall 2018 by Grant Long as part of the Tech-in-Residence Corps program.


Jupyter: Intro To Data Science - Assignment 5, Part 2 Linear Regression Practice, Grant Long, Nyc Tech-In-Residence Corps Oct 2018

Jupyter: Intro To Data Science - Assignment 5, Part 2 Linear Regression Practice, Grant Long, Nyc Tech-In-Residence Corps

Open Educational Resources

Jupyter Assignment for the course "CSC 59970: Intro to Data Science" delivered at the City College of New York in Fall 2018 by Grant Long as part of the Tech-in-Residence Corps program.


Jupyter: Intro To Data Science - Lecture 2 Loading And Summarizing Data, Grant Long, Nyc Tech-In-Residence Corps Oct 2018

Jupyter: Intro To Data Science - Lecture 2 Loading And Summarizing Data, Grant Long, Nyc Tech-In-Residence Corps

Open Educational Resources

Jupyter Lecture for the course "CSC 59970: Intro to Data Science" delivered at the City College of New York in Fall 2018 by Grant Long as part of the Tech-in-Residence Corps program.


First-Principles Calculation Of The Spin-Orbit Torques In A Co/Pt Bilayer, K. D. Belashchenko, Alexey A. Kovalev, M. Van Schilfgaarde Oct 2018

First-Principles Calculation Of The Spin-Orbit Torques In A Co/Pt Bilayer, K. D. Belashchenko, Alexey A. Kovalev, M. Van Schilfgaarde

Department of Physics and Astronomy: Faculty Publications

The spin-orbit torque in a disordered Co/Pt bilayer is calculated using a first-principles nonequilibrium Green's function formalism. The torque is formally split in the Fermi-sea and Fermi-surface contributions. The Fermi-sea term is important at low temperatures, but the Fermi-surface term dominates at room temperature. In addition to the usual damping-like and field-like terms, the odd torque contains a sizeable planar Hall-like term (m . E)m x (z x m) which contributes to damping. While the torques that contribute to damping are almost entirely due to spin-orbit coupling on the Pt atoms, the field-like torque does not require it.


Regulation Of Kv11.1 Potassium Channel C-Terminal Isoform Expression By The Rna-Binding Proteins Hur And Hud, Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou Oct 2018

Regulation Of Kv11.1 Potassium Channel C-Terminal Isoform Expression By The Rna-Binding Proteins Hur And Hud, Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou

Faculty Publications - Department of Biological & Molecular Science

The potassium voltage-gated channel subfamily H member 2 (KCNH2) gene encodes the Kv11.1 potassium channel, which conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative polyadenylation and forms a functional, full-length Kv11.1a isoform if exon 15 is polyadenylated or a nonfunctional, C-terminally truncated Kv11.1a-USO isoform if intron 9 is polyadenylated. The molecular mechanisms that regulate Kv11.1 isoform expression are poorly understood. In this study, using HEK293 cells and reporter gene expression, pulldown assays, and RNase protection assays, we identified the RNA-binding proteins Hu antigen R (HuR) and Hu antigen D (HuD) as regulators of Kv11.1 …


Poster: Privacy-Preserving Boosting With Random Linear Classifiers, Sagar Sharma, Keke Chen Oct 2018

Poster: Privacy-Preserving Boosting With Random Linear Classifiers, Sagar Sharma, Keke Chen

Kno.e.sis Publications

We propose SecureBoost, a privacy-preserving predictive modeling framework, that allows service providers (SPs) to build powerful boosting models over encrypted or randomly masked user submit- ted data. SecureBoost uses random linear classifiers (RLCs) as the base classifiers. A Cryptographic Service Provider (CSP) manages keys and assists the SP’s processing to reduce the complexity of the protocol constructions. The SP learns only the base models (i.e., RLCs) and the CSP learns only the weights of the base models and a limited leakage function. This separated parameter holding avoids any party from abusing the final model or conducting model-based attacks. We evaluate …


The Rotational Spectrum And Potential Energy Surface Of The Ar-Sio Complex, Michael C. Mccarthy, Steve Alexandre Ndengue, Richard Dawes Oct 2018

The Rotational Spectrum And Potential Energy Surface Of The Ar-Sio Complex, Michael C. Mccarthy, Steve Alexandre Ndengue, Richard Dawes

Chemistry Faculty Research & Creative Works

The rotational spectra of five isotopic species of the Ar-SiO complex have been observed at high-spectral resolution between 8 and 18 GHz using chirped Fourier transform microwave spectroscopy and a discharge nozzle source; follow-up cavity measurements have extended these measurements to as high as 35 GHz. The spectrum of the normal species is dominated by an intense progression of a-type rotational transitions arising from increasing quanta in the Si-O stretch, in which lines up to v = 12 (~14 500 cm-1) were identified. A structural determination by isotopic substitution and a hyperfine analysis of the Ar-Si17O …


Polymer Coated Gold-Ferric Oxide Superparamagnetic Nanoparticles For Theranostic Applications, Muhammad Raisul Abedin, Siddesh Umapathi, Harika Mahendrakar, Tunyaboon Laemthong, Holly Coleman, Denise Muchangi, Santimukul Santra, Manashi Nath, Sutapa Barua Oct 2018

Polymer Coated Gold-Ferric Oxide Superparamagnetic Nanoparticles For Theranostic Applications, Muhammad Raisul Abedin, Siddesh Umapathi, Harika Mahendrakar, Tunyaboon Laemthong, Holly Coleman, Denise Muchangi, Santimukul Santra, Manashi Nath, Sutapa Barua

Chemistry Faculty Research & Creative Works

Background: Engineered inorganic nanoparticles (NPs) are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids. In many cases however, functionalization is not sufficient: the particles become either coated by a corona of serum proteins or precipitate out of the solvent. We show that by changing the coating of magnetic iron oxide NPs using poly-l-lysine (PLL) polymer the colloidal stability of the dispersion is improved in aqueous solutions including water, phosphate buffered saline (PBS), PBS with 10% fetal bovine serum (FBS) and cell culture medium, and …


Algal Blooms In Arkansas Streams, Ponds, And Lakes, Bradley J. Austin, Brie Olsen, Tate Wentz, Brian E. Haggard Oct 2018

Algal Blooms In Arkansas Streams, Ponds, And Lakes, Bradley J. Austin, Brie Olsen, Tate Wentz, Brian E. Haggard

Fact Sheets

Did you know that algae are a natural part of ponds, lakes, streams, and rivers? These organisms grow in the water (plankton) and on rocks, plants, and other surfaces (periphyton) and sometimes periphyton slough off into the water (seston). Most of the time these algae are hardly noticeable in waterbodies; however, sometimes they can form very noticeable algal blooms.


Using Electronic Health Records To Characterize Prescription Patterns: Focus On Antidepressants In Nonpsychiatric Outpatient Settings, Joseph J. Deferio, Tomer T. Levin, Judith Cukor, Samprit Banerjee, Rozan Abdulrahman, Amit P. Sheth, Neel Mehta, Jyotishman Pathak Oct 2018

Using Electronic Health Records To Characterize Prescription Patterns: Focus On Antidepressants In Nonpsychiatric Outpatient Settings, Joseph J. Deferio, Tomer T. Levin, Judith Cukor, Samprit Banerjee, Rozan Abdulrahman, Amit P. Sheth, Neel Mehta, Jyotishman Pathak

Kno.e.sis Publications

Objective

To characterize nonpsychiatric prescription patterns of antidepressants according to drug labels and evidence assessments (on-label, evidence-based, and off-label) using structured outpatient electronic health record (EHR) data. Methods

A retrospective analysis was conducted using deidentified EHR data from an outpatient practice at a New York City-based academic medical center. Structured “medication–diagnosis” pairs for antidepressants from 35 325 patients between January 2010 and December 2015 were compared to the latest drug product labels and evidence assessments. Results

Of 140 929 antidepressant prescriptions prescribed by primary care providers (PCPs) and nonpsychiatry specialists, 69% were characterized as “on-label/evidence-based uses.” Depression diagnoses were associated …


Restoring The Eastern Oyster: How Much Progress Has Been Made In 53 Years?, Ab Hernandez, Rochelle Brumbaugh, P Fredrick, R Grizzle, Mark Luckenbach, Ch Peterson, C Angelini Oct 2018

Restoring The Eastern Oyster: How Much Progress Has Been Made In 53 Years?, Ab Hernandez, Rochelle Brumbaugh, P Fredrick, R Grizzle, Mark Luckenbach, Ch Peterson, C Angelini

VIMS Articles

Coastal ecosystem restoration is accelerating globally as a means of enhancing shoreline protection, carbon storage, water quality, fisheries, and biodiversity. Among the most substantial of these efforts have been those focused on re-establishing oyster reefs across the US Atlantic and Gulf coasts. Despite considerable investment, it is unclear how the scale of and approaches toward oyster restoration have evolved. A synthesis of 1768 projects undertaken since 1964 reveals that oyster substrate restoration efforts have primarily been concentrated in the Chesapeake Bay and the Gulf Coast, have been heavily reliant on oyster shell, and have re-established 4.5% of the reef area …


An Evaluation Of Geotagged Twitter Data During Hurricane Irma Using Sentiment Analysis And Topic Modeling For Disaster Resilience, Ike Robert Vayansky Oct 2018

An Evaluation Of Geotagged Twitter Data During Hurricane Irma Using Sentiment Analysis And Topic Modeling For Disaster Resilience, Ike Robert Vayansky

Electronic Theses and Dissertations

Disasters require quick response times, thought-out preparations, overall community, and government support. These efforts will ensure prevention of loss of life and reduce possible damages. The United States has been battered by multiple major hurricanes in the recent years and multiple avenues of disaster response efforts were being tested. Hurricane Irma can be recognized as the most popular hurricane in terms of social media attention. Irma made landfall in Florida as a Category 4 storm and preparation measures taken were intensive thus providing a good measure to evaluate in terms of efficacy. The effectiveness of the response methods utilized are …


Wireless Security (Ksu), Meng Han, Lei Li, Zhigang Li, Svetana Peltsverger, Ming Yang, Guangzhi Zheng Oct 2018

Wireless Security (Ksu), Meng Han, Lei Li, Zhigang Li, Svetana Peltsverger, Ming Yang, Guangzhi Zheng

Computer Science and Information Technology Grants Collections

This Grants Collection for Wireless Security was created under a Round Ten ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

  • Linked Syllabus
  • Initial Proposal
  • Final Report


Discrete Structures (Ksu), Rebecca H. Rutherfoord, Dawn Tatum, Susan Vandeven, Richard Halstead-Nussloch, James Rutherfoord, Zhigang Li Oct 2018

Discrete Structures (Ksu), Rebecca H. Rutherfoord, Dawn Tatum, Susan Vandeven, Richard Halstead-Nussloch, James Rutherfoord, Zhigang Li

Computer Science and Information Technology Grants Collections

This Grants Collection for Discrete Structures was created under a Round Eleven ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

  • Linked Syllabus
  • Initial Proposal
  • Final Report


Folding Of Gα Subunits: Implications For Disease States, Matthew Najor, Brian D. Leverson, Jesse L. Goossens, Saad Kothawala, Kenneth W. Olsen, Duarte Mota De Freitas Oct 2018

Folding Of Gα Subunits: Implications For Disease States, Matthew Najor, Brian D. Leverson, Jesse L. Goossens, Saad Kothawala, Kenneth W. Olsen, Duarte Mota De Freitas

Chemistry: Faculty Publications and Other Works

G-proteins play a central role in signal transduction by fluctuating between “on” and “off” phases that are determined by a conformational change. cAMP is a secondary messenger whose formation is inhibited or stimulated by activated Giα1 or Gsα subunit. We used tryptophan fluorescence, UV/vis spectrophotometry, and circular dichroism to probe distinct structural features within active and inactive conformations from wild-type and tryptophan mutants of Giα1 and Gsα. For all proteins studied, we found that the active conformations were more stable than the inactive conformations, and upon refolding from higher temperatures, activated wild-type subunits recovered significantly more native structure. We also …


Overcoming Early Career Barriers To Interdisciplinary Climate Change Research, Christopher J. Hein, John E. Ten Hoeve, Sathya Gopalakrishnan, Et Al Oct 2018

Overcoming Early Career Barriers To Interdisciplinary Climate Change Research, Christopher J. Hein, John E. Ten Hoeve, Sathya Gopalakrishnan, Et Al

VIMS Articles

Climate-change impacts are among the most serious and complex challenges facing society, affecting both natural and social systems. Addressing these requires a new paradigm of interdisciplinary collaboration which incorporates tools, techniques, and insights from across the social, natural, and engineering sciences. Yet, a wide range of intrinsic and extrinsic hurdles need to be overcome to conduct successful, integrated interdisciplinary research. The results of a bibliometric analysis and survey of early to mid-career scientists from 56 countries who were involved with the interdisciplinary DISsertations initiative for the advancement of Climate Change ReSearch (DISCCRS) emphasize the particular challenges faced by early career …


Family Physician Remuneration Schemes And Specialist Referrals: Quasi-Experimental Evidence From Ontario, Canada., Sisira Sarma, Nirav Mehta, Rose Anne Devlin, Koffi Ahoto Kpelitse, Lihua Li Oct 2018

Family Physician Remuneration Schemes And Specialist Referrals: Quasi-Experimental Evidence From Ontario, Canada., Sisira Sarma, Nirav Mehta, Rose Anne Devlin, Koffi Ahoto Kpelitse, Lihua Li

Epidemiology and Biostatistics Publications

Understanding how family physicians respond to incentives from remuneration schemes is a central theme in the literature. One understudied aspect is referrals to specialists. Although the theoretical literature has suggested that capitation increases referrals to specialists, the empirical evidence is mixed. We push forward the empirical research on this question by studying family physicians who switched from blended fee-for-service to blended capitation in Ontario, Canada. Using several health administrative databases from 2005 to 2013, we rely on inverse probability weighting with fixed-effects regression models to account for observed and unobserved differences between the switchers and nonswitchers. Switching from blended fee-for-service …


Identification Of Hostile Hemodynamics And Geometries Of Cerebral Aneurysms: A Case-Control Study, Bong Jae Chung, F. Mut, C. M. Putman, F. Hamzei-Sichani, W. Brinjikji, D. Kallmes, C. M. Jimenez, Juan R. Cebral Oct 2018

Identification Of Hostile Hemodynamics And Geometries Of Cerebral Aneurysms: A Case-Control Study, Bong Jae Chung, F. Mut, C. M. Putman, F. Hamzei-Sichani, W. Brinjikji, D. Kallmes, C. M. Jimenez, Juan R. Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

BACKGROUND AND PURPOSE: Hostile hemodynamic conditions and geometries are thought to predispose aneurysms for instability and rupture. This study compares stable, unstable, and ruptured aneurysms while controlling for location and patient characteristics. MATERIALS AND METHODS: The hemodynamics and geometries of 165 stable, 65 unstable, and 554 ruptured aneurysms were compared. Hemodynamics was modeled using image-based computational fluid dynamics. Case-control pairs were selected matching aneurysm location, patient age, and sex. Paired Wilcoxon tests were used to compare hemodynamic and geometric variables among different aneurysm groups. The pairing was repeated 100 times, and the combined P values were calculated and adjusted for …


Comparison Of Methodologies Of Using Colorimetry To Detect Low Concentrations Of Bromide As A Hydrologic Tracer, Emily Wolf Oct 2018

Comparison Of Methodologies Of Using Colorimetry To Detect Low Concentrations Of Bromide As A Hydrologic Tracer, Emily Wolf

Water Resources Professional Project Reports

The objective of this research was to compare colorimetric methods for measuring low concentrations of bromide in natural waters. The bromide ion has long been used as a tracer to study hydrodynamic processes and properties. Its conservative nature makes it ideal as a tracer. Bromide is almost entirely immune to loss from a solution via adsorption on rocks and sediments, or reaction with other solutes present in the water. Using three methodologies to use colorimetry in the detection of bromide, I analyzed samples taken from the Gila River, Jemez Creek, and the Rio Grande after injections of sodium bromide were …


To Rebate Or Not To Rebate: The Influences And Deterrents For Residential Customers To Participate In Water Authority Rebates, Meagan Virginia Oldham Oct 2018

To Rebate Or Not To Rebate: The Influences And Deterrents For Residential Customers To Participate In Water Authority Rebates, Meagan Virginia Oldham

Water Resources Professional Project Reports

The depletion of aquifers and reduced surface water flows are a growing concern for water managers. Educational outreach and incentives to promote conservation have been a growing trend over the past couple of decades in the arid Southwestern United States, including Albuquerque, New Mexico. Rebates for the installation of water efficient appliances and xeric landscape conversions are a couple of ways that water authorities incentivize their residential consumers to do their part at home to conserve water. This study involves a survey sent to a random sample of 2,215 Albuquerque Bernalillo County Water Utility Authority residential customers, with a 31% …


Malware Analysis On Android Using Supervised Machine Learning Techniques, Md Shohel Rana, Andrew H. Sung Oct 2018

Malware Analysis On Android Using Supervised Machine Learning Techniques, Md Shohel Rana, Andrew H. Sung

Faculty Publications

In recent years, a widespread research is conducted with the growth of malware resulted in the domain of malware analysis and detection in Android devices. Android, a mobile-based operating system currently having more than one billion active users with a high market impact that have inspired the expansion of malware by cyber criminals. Android implements a different architecture and security controls to solve the problems caused by malware, such as unique user ID (UID) for each application, system permissions, and its distribution platform Google Play. There are numerous ways to violate that fortification, and how the complexity of creating a …


Geologic Mapping Of Nebraska: Old Rocks, New Maps, Fresh Insights, R. Matthew Joeckel, Robert F. Diffendal Jr., P. R. Hanson, Jesse T. Korus Oct 2018

Geologic Mapping Of Nebraska: Old Rocks, New Maps, Fresh Insights, R. Matthew Joeckel, Robert F. Diffendal Jr., P. R. Hanson, Jesse T. Korus

Robert F. Diffendal, Jr., Publications

Geologic mapping in Nebraska and environs is an ongoing endeavor that has spanned more than 170 years, involved dozens of scientists, and evolved through many changes. Digital mapping has risen to dominance in the state only since 1996. Geologic mapping in Nebraska today concentrates on surficial mapping, which emphasizes materials exposed at the land surface and their relationships with landforms, and which is particularly relevant because non- bedrock geologic materials (regolith) lie at the surface across at least 87% of the state. Moreover, surfi cial geologic maps assist the understanding of groundwater and sand and gravel resources, to name a …


Synthesis And Evaluation Of Protein-Phenylboronic Acid Conjugates As Lectin Mimetics, Joshua Whited, Czharena Kay Rama, Xue-Long Sun Oct 2018

Synthesis And Evaluation Of Protein-Phenylboronic Acid Conjugates As Lectin Mimetics, Joshua Whited, Czharena Kay Rama, Xue-Long Sun

Chemistry Faculty Publications

Glycan-binding molecules, such as lectins, are very important tools for characterizing, imaging, or targeting glycans and are often involved in either physiological or pathological processes. However, their availability is far less compared to the diversity of native glycans. Therefore, development of lectin mimetics with desired specificity and affinity is in high demand. Boronic acid reacts with 1,2- and 1,3-diols of saccharides in aqueous media through reversible boronate ester formation and are regarded as synthetic lectin mimetics. In this study, bovine serum albumin (BSA)-phenylboronic acid (PBA) conjugates were synthesized in a density-controlled manner by targeting both aspartic and glutamic acids to …