Physical Sciences and Mathematics Commons^™

Synthetic Studies On Small Molecule Modulators Of Src Homology 2 (Sh2) Domain-Containing Inositol 5’-Phosphatase (Ship), Otto Milhous Dungan

Dissertations - ALL

Small molecule modulators of SH2-containing inositol 5’-phosphatase (SHIP) have recently become a hotly pursued area in medicinal chemistry. Pharmaceutical targeting of SHIP with small molecules has been identified as a new method to directly influence the phosphoinositide 3-kinase (PI3K) cell signaling pathway. Modulation of this pathway may be utilized in the development of interesting new therapeutics. A better understanding of the role that SHIP phosphatase activity plays in a number of disease states ranging from cancer to autoimmune disease to obesity may be ascertained by use of small molecule inhibitors. These investigations involved the synthesis of aminosteroid inhibitors and a …

Towards Real-Time Monitoring Of Bacterial Cultures Without The Need For Physical Sampling: Elastic Scattering, Fluorescence And Raman Spectroscopy Of Escherichia Coli Cultures., Richard Thomas Mcdonough

Dissertations - ALL

The first part of this dissertation pertains to the fringe analysis of a hydration layer that forms spontaneously when biofilms dry. This layer at optical thickness ˂ 20 µm is approximately 1-2 orders of magnitude thinner than the biofilm thickness as measured by confocal Raman microscopy and confocal fluorescent microscopy. Drying/rehydration experiments performed on films withstood multiple cycles, returning to the same optical thickness proving their robust nature. The strength of a distinct water peak (1451 nm) in addition to others, reflects the thickness of the hydration layer. Confocal Raman microscopy showed that biofilms are chemically very similar to pure …

Studying The Impact On Urban Health Over The Greater Delta Region In Egypt Due To Aerosol Variability Using Optical Characteristics From Satellite Observations And Ground-Based Aeronet Measurements, Wenzhao Li, Elham Ali, Islam Abou Al-Magd, Moustafa Mohamed Mourad, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

This research addresses the aerosol characteristics and variability over Cairo and the Greater Delta region over the last 20 years using an integrative multi-sensor approach of remotely sensed and PM10 ground data. The accuracy of these satellite aerosol products is also evaluated and compared through cross-validation against ground observations from the AErosol RObotic NETwork (AERONET) project measured at local stations. The results show the validity of using Multi-angle Imaging Spectroradiometer (MISR) and Moderate Resolution Imaging Spectroradiometer (MODIS) sensors on the Terra and Aqua platforms for quantitative aerosol optical depth (AOD) assessment as compared to Ozone Monitoring Instrument (OMI), Sea-viewingWide Field-of-view …

The Impact Of Lng Shipping Market From China New Emission Policy, Hong Huang

World Maritime University Dissertations

No abstract provided.

A Comparative Study On Port Integration In Different Areas In China, Jiaqi Li

World Maritime University Dissertations

No abstract provided.

Comparative Analysis Of International Bulk Freight Index, Wenbo Gu

World Maritime University Dissertations

No abstract provided.

Analysis Of The Influence Of Ningbo-Zhoushan Port Development On Regional Economy, Manxi Li

World Maritime University Dissertations

No abstract provided.

Correlation Analysis Between Container Shipping Market And Sino-Us Trade Under The China-Us Trade Conflict, Changqing Lu

World Maritime University Dissertations

No abstract provided.

The Impact Of Sino-Us Trade Conflict On International Dry Bulk Shipping Market, Yuefeng Lyu

World Maritime University Dissertations

No abstract provided.

The Impact Of Imo's Global Sulphur Cap The Shipping Industry And The Latter's Countermeasure, Jorge Morales

World Maritime University Dissertations

No abstract provided.

Study On The Port Classification Of 21st Century Maritime Silk Road West Line, Jiawen Wang

World Maritime University Dissertations

No abstract provided.

Research On The Value Estimation Of Ship Optional Orders, Zhili Zhang

World Maritime University Dissertations

No abstract provided.

Insights From Combined Detrital Monazite Geochronology And Nd Isotopic Composition On Sedimentary Recycling And Provenance Reconstruction, Sarah Wade Kittross

Theses - ALL

Minerals chosen for provenance studies are typically those that are resistant to resetting during low-moderate temperature metamorphic events and thus preserve information about their source region. However, minerals that are extremely resistant to weathering (e.g. quartz, zircon) can be recycled, often multiple times, and thus can cause confusion about the amount of material derived from immediate sources versus those from the original source region. Resistant minerals, such as zircon, that generally only form under very high temperature events (i.e. magmatic events) often miss recording orogenic events that are dominated by moderate temperature, magma-poor, metamorphic events. To overcome some of these …

Defining The Problem And Exploring Non Lethal Alternatives Including Land Management, John Hadidian

John Hadidian, PhD

Symposium: The Increasing Conflicts of Deer and Human Populations in Suburban Areas

Multi-Phased Hypogene Speleogenesis In A Marginal Horst Structure Of The Malé Karpaty Mountains, Slovakia, Pavel Bella, Pavel Bosák, Petr Mikysek, Juraj Littva, Helena Hercman, Jacek Pawlak

International Journal of Speleology

The Plavecká jaskyňa Cave on the western fault edge of the Malé Karpaty Mountains (western Slovakia) is a result of multi-phased hypogene speleogenesis. It formed in fractured Triassic carbonates by waters ascending along the Vienna Basin Transform Fault between Malé Karpaty Mountains and Záhorská nížina Lowland (the north-eastern part of the Vienna Basin) and/or the N–S-trending faults that intersect it in the cave vicinity. Morphologically, the cave is featured by (1) phreatic chimneys, cupolas, ceiling pockets, enlarged fissures with spongework cavities, upward wall channels and upward oriented large scallops, (2) epiphreatic flat corrosion bedrock floors, feeding fissures and wall water-table …

A Machine Learning Model For Clustering Securities, Vanessa Torres, Travis Deason, Michael Landrum, Nibhrat Lohria

SMU Data Science Review

In this paper, we evaluate the self-declared industry classifications and industry relationships between companies listed on either the Nasdaq or the New York Stock Exchange (NYSE) markets. Large corporations typically operate in multiple industries simultaneously; however, for investment purposes they are classified as belonging to a single industry. This simple classification obscures the actual industries within which a company operates, and, therefore, the investment risks of that company.
By using Natural Language Processing (NLP) techniques on Security and Exchange Commission (SEC) filings, we obtained self-defined industry classifications per company. Using clustering techniques such as Hierarchical Agglomerative and k-means clustering we …

Predicting Wind Turbine Blade Erosion Using Machine Learning, Casey Martinez, Festus Asare Yeboah, Scott Herford, Matt Brzezinski, Viswanath Puttagunta

SMU Data Science Review

Using time-series data and turbine blade inspection assessments, we present a classification model in order to predict remaining turbine blade life in wind turbines. Capturing the kinetic energy of wind requires complex mechanical systems, which require sophisticated maintenance and planning strategies. There are many traditional approaches to monitoring the internal gearbox and generator, but the condition of turbine blades can be difficult to measure and access. Accurate and cost- effective estimates of turbine blade life cycles will drive optimal investments in repairs and improve overall performance. These measures will drive down costs as well as provide cheap and clean electricity …

Harvesting Fertilized Rye Cover Crop: Simulated Revenue, Net Energy, And Drainage Nitrogen Loss, R. W. Malone, J. F. Obrycki, Douglas L. Karlen, T. C. Kaspar, D. B. Jaynes, T. B. Parkin, S. H. Lence, G. W. Feyereisen, Q. X. Fang, T. L. Richard, K. Gillette

Douglas L Karlen

Harvesting fertilized rye (Secale cereale L.) cover crop has been suggested as a method to increase producer revenue and biofuel feedstock production, but drainage N loss impacts are currently unknown. Using the tested Root Zone Water Quality Model (RZWQM) across several N rates, spring application of 120 kg N ha^-1 prior to winter rye harvest reduced drainage N loss by 54% compared with no cover crop and by 18% compared with planted rye that was neither fertilized nor harvested. Estimates of producer revenue and net energy were also positive, with 8.3 Mg ha^-1 of harvested rye biomass. …

Impact Of Biochar Amendments On The Quality Of A Typical Midwestern Agricultural Soil, David A. Laird, Pierce Fleming, Dedrick D. Davis, Robert Horton, Baiqun Wang, Douglas L. Karlen

Douglas L Karlen

Biochar, a co-product of thermochemical conversion of lignocellulosic materials into advanced biofuels, may be used as a soil amendment to enhance the sustainability of biomass harvesting. We investigated the impact of biochar amendments (0, 5, 10, and 20 g-biochar kg− 1 soil) on the quality of a Clarion soil (Mesic Typic Hapludolls), collected (0–15 cm) in Boone County, Iowa. Repacked soil columns were incubated for 500 days at 25 °C and 80% relative humidity. On week 12, 5 g of dried and ground swine manure was incorporated into the upper 3 cm of soil for half of the columns. Once …

Regenerating Agricultural Landscapes With Perennial Groundcover For Intensive Crop Production, Kenneth J. Moore, Robert P. Anex, Amani E. Elobeid, Shuizhang Fei, Cornelia B. Flora, A. Susana Goggi, Keri L. Jacobs, Prashant Jha, Amy L. Kaleita, Douglas L. Karlen, David A. Laird, Andrew W. Lenssen, Thomas Lubberstedt, Marshall D. Mcdaniel, D. Raj Raman, Sharon L. Weyers

Douglas L Karlen

The Midwestern U.S. landscape is one of the most highly altered and intensively managed ecosystems in the country. The predominant crops grown are maize (Zea mays L.) and soybean [Glycine max (L.) Merr]. They are typically grown as monocrops in a simple yearly rotation or with multiple years of maize (2 to 3) followed by a single year of soybean. This system is highly productive because the crops and management systems have been well adapted to the regional growing conditions through substantial public and private investment. Furthermore, markets and supporting infrastructure are highly developed for both crops. As maize and …

Future Prospects For Corn As A Biofuel Crop, Kenneth J. Moore, Douglas L. Karlen, Kendall R. Lamkey

Douglas L Karlen

Ethanol production from corn grain has increased signifi cantly during the past ten years in the US. This increase was driven by government policy guided by the Renewable Fuel Standard (RFS) and embodied in the Volumetric Ethanol Excise Tax Credit and other legislation created to promote a biofuels industry. As corn grain ethanol production approaches the target set out in the RFS, the industry is looking to develop capacity for producing advanced biofuels, primarily from agricultural wastes and dedicated energy crops. The residues remaining following corn harvest have been identifi ed as a voluminous and readily available feedstock for advanced …

Reducing Agriculture's Contribution To Nitrate Contamination Of Surface Waters, Dana L. Dinnes, Cynthia A. Cambardella, Thomas S. Colvin, Daniel B. Jaynes, Douglas L. Karlen

Douglas L Karlen

One of the most prevalent environmental issues throughout the Midwest is nitrate (N03) contamination of surface waters. Non-point source pollution resulting from nitrogen (N) fertilizer use on artificially drained agricultural land has been identified as a major contributor to this problem. High levels of nitratenitrogen (N03-N) in water supplies pose risks to humans and livestock (Tyson et. al., 1992), and has cost some communities millions of dollars for N03 removal. The city of Des Moines, Iowa alone has spent in excess of 5.3 million dollars, not including labor costs, for nitrate treatment of its drinking waters from 1992-1996 (Graham, 1997). …

Biochar Impact On Nutrient Leaching From A Midwestern Agricultural Soil, David Laird, Pierce Flemming, Baiqun Wang, Robert Horton, Douglas Karlen

Douglas L Karlen

Application of biochar to highly weathered tropical soils has been shown to enhance soil quality and decrease leaching of nutrients. Little, however, is known about the effects of biochar applications on temperate region soils. Our objective was to quantify the impact of biochar on leaching of plant nutrients following application of swine manure to a typical Midwestern agricultural soil. Repacked soil columns containing 0, 5, 10, and 20 g-biochar kg− 1-soil, with and without 5 g kg− 1 of dried swine manure were leached weekly for 45 weeks. Measurements showed a significant decrease in the total amount of N, P, …

A New Approach To Sequence Local Alignment: Normalization With Concave Functions, Qiang Zhou

Electronic Thesis and Dissertation Repository

Sequence local alignment is to find two subsequences from the input two sequences respectively, which can produce the highest similarity degree among all other pairs of subsequences. The Smith-Waterman algorithm is one of the most important technique in sequence local alignment, especially in computational molecular biology. This algorithm can guarantee that the optimal local alignment can be found with respect to the distance or similarity metric. However, the optimal solution obtained by Smith-Waterman is not biologically meaningful, since it may contain small pieces of irrelevant segments, but as long as they are not strong enough, the algorithm still take them …

Algebraic Companions And Linearizations, Eunice Y. S. Chan

Electronic Thesis and Dissertation Repository

In this thesis, we look at a novel way of finding roots of a scalar polynomial using eigenvalue techniques. We extended this novel method to the polynomial eigenvalue problem (PEP). PEP have been used in many science and engineering applications such vibrations of structures, computer-aided geometric design, robotics, and machine learning. This thesis explains this idea in the order of which we discovered it.

In Chapter 2, a new kind of companion matrix is introduced for scalar polynomials of the form $c(\lambda) = \lambda a(\lambda)b(\lambda)+c_0$, where upper Hessenberg companions are known for the polynomials $a(\lambda)$ and $b(\lambda)$. This construction can …

Is Ai Intelligent, Really?, Bruce D. Baker

SPU Works

The question of intelligence opens up a bouquet of interrelated questions:

Suppose that some future AGI systems (on-screen or robots) equaled human performance. Would they have real intelligence, real understanding, real creativity? Would they have selves, moral standing, free choice? Would they be conscious? And without consciousness, could they have any of those other properties?[1]

The only way out of the morass is to recognize that truth claims do not stand on their own, aloof and cut off from the sea of meaning which grants epistemic access. In other words, truth presumes access to: (1) a way of knowing, …

Synthesis And Characterization Of Heteronuclear Inorganic Complexes For The Photodegradation Of Persistant Organic Pollutants, Matthew A. Moyet

Electronic Theses and Dissertations

The focus of this thesis is to investigate the structural modification and characterization potential of common photocatalysts that have various uses for environmental remediation purposes. Pollution involving organic chemicals is one of the most common scenarios found in communities throughout the country. Efforts to rid contaminated drinking water supplies of these chemicals include physical and chemical filters, which have limited ability and efficacy. This lack of efficient filtration services has led to an increased demand for more effective treatment methods. Chemical species that react in the presence of light are known as photocatalysts and have been used in previous studies …

Mechanisms Of Ice Core Stable Isotope Variability In The Upper Kaskawulsh-Donjek Region, St. Elias Mountains, Yukon, Canada, Erin A. Mcconnell

Electronic Theses and Dissertations

I use instrumental and ice core records to examine drivers of observed isotope variability in the Upper Kaskawulsh-Donjek (UKD) region of the St. Elias Mountains, Yukon, Canada over the time frame of instrument-proxy overlap (mid-1900s to present). One of the drivers of post-depositional isotope signal alteration is the vertical percolation of meltwater from the glacier surface through shallow layers of snow, which causes a reduction in the amplitude of the isotope signal recorded in ice cores. I examine isotope signal preservation in two sites in the St. Elias Mountains: Eclipse Icefield and Icefield Divide. These sites are relatively close (~30 …

Multi-Level Governance Of Climate Change Adaptation: United Nations Negotiations And Adaptation Project Implementation In Nicaragua And Samoa, Anna E. Mcginn

Electronic Theses and Dissertations

The rapid entry into force of the Paris Agreement reaffirmed, with certainty, that the international community would continue its efforts to mitigate greenhouse gas emissions and adapt to climate change impacts opening a new era of international cooperation on climate change. This thesis explores how both negotiations around climate change adaptation and adaptation project implementation have evolved in this post-Paris Agreement era (from adoption in December 2015 to present). Using the United Nations Framework Convention on Climate Change’s (UNFCCC) Adaptation Fund as the central lens, the chapters explore international negotiations around the Fund as well as two Adaptation Fund funded …

Spectroscopic Description Of The E1 State Of Mo Nitrogenase Based On Mo And Fe X‑Ray Absorption And MöSsbauer Studies, Casey Van Stappen, Roman Davydov, Zhi-Yong Yang, Ruixi Fan, Yisong Guo, Eckhard Bill, Lance C. Seefeldt, Brian M. Hoffman, Serena Debeer

Chemistry and Biochemistry Faculty Publications

Mo nitrogenase (N2ase) utilizes a two-component protein system, the catalytic MoFe and its electron-transfer partner FeP, to reduce atmospheric dinitrogen (N₂) to ammonia (NH₃). The FeMo cofactor contained in the MoFe protein serves as the catalytic center for this reaction and has long inspired model chemistry oriented toward activating N₂. This field of chemistry has relied heavily on the detailed characterization of how Mo N2ase accomplishes this feat. Understanding the reaction mechanism of Mo N2ase itself has presented one of the most challenging problems in bioinorganic chemistry because of the ephemeral nature of its …