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2024

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Articles 2431 - 2460 of 8345

Full-Text Articles in Physical Sciences and Mathematics

Arterial Coordination Optimization Method Based On Vehicle Speed Guidance And Inductive Control, Mingjun Deng, Xinxia Hu, Xiang Li, Liping Xu Jun 2024

Arterial Coordination Optimization Method Based On Vehicle Speed Guidance And Inductive Control, Mingjun Deng, Xinxia Hu, Xiang Li, Liping Xu

Journal of System Simulation

Abstract: Arterial signal coordination is usually based on fixed belt speeds and time-of-day statistical flows. Actually, vehicle speeds and traffic flows are fluctuating, which causes to the mismatch between the signal scheme and the actual optimal belt speeds and traffic flow demands, and affects the intersection's traffic efficiency. Based on the vehicle infrastructure cooperation, by applying Maxband model and the maximum green wave bandwidth, the minimum number of arterial vehicle delays, arterial stops and the minor direction delays being the optimization objectives, a multi-objective optimization model for arterial signal coordination is established. Through using an improved multi-objective particle swarm algorithm …


Simulation Of Rice Disease Recognition Based On Improved Attention Mechanism Embedded In Pr-Net Model, Yang Lu, Pengfei Liu, Siyuan Xu, Qiwang Liu, Fuqian Gu, Peng Wang Jun 2024

Simulation Of Rice Disease Recognition Based On Improved Attention Mechanism Embedded In Pr-Net Model, Yang Lu, Pengfei Liu, Siyuan Xu, Qiwang Liu, Fuqian Gu, Peng Wang

Journal of System Simulation

Abstract: Aiming at the low accuracy of existing CNN models in identifying rice leaf diseases, a hybrid convolutional neural network model PRC-Net (parallel residual with coordinate attention network) combining parallel structure and residual structure is proposed. A parallel structure is introduced to improve the receptive field of convolution, and the residual structure is combined to achieve the complete and continuous transmission of feature information. An improved spatial attention mechanism is embedded into the backbone model PR-Net to enhance the degree of aggregation of lesion feature information at different scales. In order to further improve the accuracy of disease identification and …


Unsupervised Complex Condition Recognition Based On Stochastic Neighborhood Embedding, Lin Huang, Shanjun Liu, Wei Wang, Li Gong Jun 2024

Unsupervised Complex Condition Recognition Based On Stochastic Neighborhood Embedding, Lin Huang, Shanjun Liu, Wei Wang, Li Gong

Journal of System Simulation

Abstract: Modern industrial production equipment usually has a complex structure and runs alternately in different working conditions. Accurate working conditions identification based on monitoring data is the basis of health monitoring of the system, but the monitoring data of the system usually has a high dimension and a large data volume. To identify the complex equipment operating conditions, an unsupervised operating condition identification method based on stochastic neighborhood embedding is proposed. The stochastic neighborhood embedding algorithm can simultaneously preserve the local and global structural characteristics of the data, and also calculate the probability similarity of data points in high-dimensional and …


Hybrid Flow Shop Scheduling With Limited Buffers Considering Energy Consumption And Transportation, Tingxin Wen, Tingyu Guan Jun 2024

Hybrid Flow Shop Scheduling With Limited Buffers Considering Energy Consumption And Transportation, Tingxin Wen, Tingyu Guan

Journal of System Simulation

Abstract: Aiming at the untimely production scheduling and excessive energy consumption during processing, a limited buffer hybrid flow shop scheduling optimization model is constructed. To minimize the makespan and total energy consumption of the workshop, the transport time, generalized energy consumption and buffer capacity being the constraints, and the on/off energy saving strategy applied to reduce the standby energy consumption, the feasibility of the optimization model are verified. A lion swarm optimization algorithm is designed, in which a population initialization method combining random generation and greedy selection is used to improve the initial solution quality and solution efficiency, the lion …


Application Of Driving Simulation Technology In Calibration Of Traffic Simulation Parameters, Shikun Liu, Yi Tang, Yonghong Liu Jun 2024

Application Of Driving Simulation Technology In Calibration Of Traffic Simulation Parameters, Shikun Liu, Yi Tang, Yonghong Liu

Journal of System Simulation

Abstract: To address the insufficient accuracy in traffic simulation modeling due to the lack of in-depth consideration of complex driving behaviors, a calibration method for traffic simulation parameters based on driving simulation technology is proposed. The reconstruction and expansion project of Shenzhen Bao'an International Airport Expressway is selected as the case. Using VISSIM simulation software, a comprehensive traffic simulation model of the entire route is constructed, and UC-winRoad software is employed to create the highly realistic driving simulation scenarios. Driving simulation experiments are conducted to extract the typical driving behavior characteristics in complex scenarios. Calibration functions for simulation parameters are …


Optimal Trajectory Of Full-Duplex Uav Relaying Over Hybrid Probability Channels, Tao Wang, Ji Xiaodong Jun 2024

Optimal Trajectory Of Full-Duplex Uav Relaying Over Hybrid Probability Channels, Tao Wang, Ji Xiaodong

Journal of System Simulation

Abstract: A fixed-wing UAV being the full-duplex moving relay, and a hybrid probability channel being the source to send data to the destination, through the flight optimal trajectory design. On the basis of ensuring the total data amount of source-destination communication, the energy consumption of the system is minimized. Two optimization problems of runway shape and mixed trajectory are established, which are non-convex and are difficult to get the closed-form solution. The hybrid probability channels gains are replaced by the average channel gains, and the lower bounds of the received data at the UAV and the destination are calculated by …


Classification Cooperative Scheduling Of U-Automated Container Terminal Based On Container Markers, Fei Wang, Daofang Chang, Furong Wen Jun 2024

Classification Cooperative Scheduling Of U-Automated Container Terminal Based On Container Markers, Fei Wang, Daofang Chang, Furong Wen

Journal of System Simulation

Abstract: To improve the confusing scheduling of U-shaped yard operations due to improper classification of containers, the classification cooperative scheduling process is proposed, in which the classification cooperative scheduling model is established with the constraints of coordinated operation and efficient independent operation. The container classification principle and the container multiple stacking principle are proposed, the stacking point is selected by the weighted calculation based on the container operation mark to design the penalty mechanism, and the classification cooperative heuristic algorithm solution model is designed. Comparative experiments show that the strategy used in the algorithm is superior,which can reduce the equipment …


Simulation Of Robotic Peg-In-Hole Assembly Strategy Based On Drl, Zilu Zhu, Yongkui Liu, Lin Zhang, Lihui Wang, Tingyu Lin Jun 2024

Simulation Of Robotic Peg-In-Hole Assembly Strategy Based On Drl, Zilu Zhu, Yongkui Liu, Lin Zhang, Lihui Wang, Tingyu Lin

Journal of System Simulation

Abstract: Aiming at the existing peg-in-hole assembly method problems of dependence on accurate contact state models, difficulties in data acquisition, low sampling efficiency, and poor security, a simulation research method for robot peg-in-hole assembly strategy based on DRL is proposed. A simulation environment of robot peg-in-hole assembly based on ROS-Gazebo is built, and a method of gravity compensation for force/torque sensor based on a least square method is proposed. The reinforcement learning paradigm is employed to model the robot peg-in-hole assembly, and a method based on soft actor-critic(SAC) algorithm is proposed. The communication mechanism between the simulation environment and the …


Adaptive Pid Control Algorithm Based On Ppo, Zhiyong Zhou, Fei Mo, Kai Zhao, Yunbo Hao, Yufeng Qian Jun 2024

Adaptive Pid Control Algorithm Based On Ppo, Zhiyong Zhou, Fei Mo, Kai Zhao, Yunbo Hao, Yufeng Qian

Journal of System Simulation

Abstract: A six-axis robotic arm is built and simulated in a complex control environment with disturbances by using MATLAB physics engine and Python, which provides a trial-and-error environment for the robotic arm training that could not be provided in reality. Proximal policy optimization(PPO) algorithm in reinforcement learning is proposed to improve the traditional PID control algorithm. By introducing the multi-agent idea and on the basis of the different effects of the three parameters of PID on control system and the characteristics of the six-axis robotic arm, the three parameters are separately trained as different intelligent individuals to achieve a new …


Fusing Rotation Angle Coding In Spherical Space For Human Action Recognition, Benyue Su, Bangguo Zhu, Mengjuan Guo, Min Sheng Jun 2024

Fusing Rotation Angle Coding In Spherical Space For Human Action Recognition, Benyue Su, Bangguo Zhu, Mengjuan Guo, Min Sheng

Journal of System Simulation

Abstract: The existing human action recognition methods focus more on the translation information such as the coordinates and displacements of skeleton structure, and pay less attention to the motion trend of skeleton structure and the rotation information representing the motion direction of joints and bones. A spatio-temporal convolutional neural network method combining the rotation angle coding in spherical space is introduced. The angle information with scale invariance is obtained by mapping the human action in three-dimensional spherical space, and the dynamic angular velocity information is extracted as the angle code to represent the rotation information of joints and bones in …


Development And Application Of Simulation Platform For Aquatic Movement Of An Amphibious Armored Vehicle, Mingzhe Chen, Yunzheng Song, Pei Wang, Lei Zhang Jun 2024

Development And Application Of Simulation Platform For Aquatic Movement Of An Amphibious Armored Vehicle, Mingzhe Chen, Yunzheng Song, Pei Wang, Lei Zhang

Journal of System Simulation

Abstract: In order to design and verify the fire control system(FCS) algorithm of amphibious assault vehicle under heavy wind and wave conditions, a real-time simulation platform is developed. The traditional single rigid body dynamic model can't describe the body-turret-barrel dynamic coupling relationship and it is not suitable for FCS simulation with high dynamic characteristics. Twist-wrench method is used to establish the multiple rigid body dynamic model of vehicle, the buoyancy and the hydrodynamic calculation is carried out according to the body and the moving relationship between visual generated waves, and the hydrodynamic coefficient is obtained by the computational fluid dynamic …


Curriculum Learning-Based Simulation Of Uav Air Combat Under Sparse Rewards, Jingyu Zhu, Hongli Zhang, Minchi Kuang, Heng Shi, Jihong Zhu, Zhi Qiao, Wenqing Zhou Jun 2024

Curriculum Learning-Based Simulation Of Uav Air Combat Under Sparse Rewards, Jingyu Zhu, Hongli Zhang, Minchi Kuang, Heng Shi, Jihong Zhu, Zhi Qiao, Wenqing Zhou

Journal of System Simulation

Abstract: To address the limited exploration capabilities and sparse rewards of conventional reinforcement learning methods in air combat environment, a curriculum learning distributed proximal policy optimization (CLDPPO) reinforcement learning algorithm is proposed. A reward function informed by professional empirical knowledge is integrated, a discrete action space is developed, and a global observation and local value and decision network featuring separated global and local observations is established. A methodology for unmanned aerial vehicles UAVs is presented to acquire combat expertise through a sequence of fundamental courses that progressively intensify in their offensive, defensive, and comprehensive content. The experimental results show that …


Design Of Real-Time Simulation & Test Software Based On Windows/Rtx, Yongbo Li, Runmei Tian, Hui Zhang, Shanpeng Guo, Qi Li Jun 2024

Design Of Real-Time Simulation & Test Software Based On Windows/Rtx, Yongbo Li, Runmei Tian, Hui Zhang, Shanpeng Guo, Qi Li

Journal of System Simulation

Abstract: Aiming at the limited real-time performance of traditional test software and the low generality of traditional simulation interface software, a real-time simulation software based on Windows/RTX is designed to meet the requirements of unit testing and control system simulation verification of semiphysical simulation software. Through modular design, GUI layer human-computer interface and RTX layer real-time operation program are developed. To ensure the real-time, the lock-free cyclic buffer plus dual-threading technology is used to solve the timeout problem of serial data transmission and reception when the simulation step size is 1 ms under RTX environment. A timeout detection algorithm is …


Cooperative Ant Colony Algorithm Combining Evaluation Reward And Punishment Mechanism And Neighborhood Dynamic Degradation, Yujie Wang, Xiaoming You, Sheng Liu Jun 2024

Cooperative Ant Colony Algorithm Combining Evaluation Reward And Punishment Mechanism And Neighborhood Dynamic Degradation, Yujie Wang, Xiaoming You, Sheng Liu

Journal of System Simulation

Abstract: To address the slow convergence and the tendency to fall into local optimality in solving TSP, a cooperative ant colony algorithm combining evaluation reward and punishment mechanism and neighborhood dynamic degradation (ENCACO) is proposed. The paths are classified into active and abandon paths according to the path evaluation value, and with the path evaluation value as the weight, the different pheromone reward and punishment strategies are adopted for the two types of paths to accelerate the convergence speed of the algorithm. Through the neighborhood dynamic degradation strategy, and the neighborhood radius is used to divide the set of cities …


Construction Of A Virtual Interactive System For Orchards Based On Digital Twin, Hongjun Wang, Junqiang Lin, Xiangjun Zou, Po Zhang, Mingxuan Zhou, Weirui Zou, Yunchao Tang, Lufeng Luo Jun 2024

Construction Of A Virtual Interactive System For Orchards Based On Digital Twin, Hongjun Wang, Junqiang Lin, Xiangjun Zou, Po Zhang, Mingxuan Zhou, Weirui Zou, Yunchao Tang, Lufeng Luo

Journal of System Simulation

Abstract: Aiming at the low visibility, poor real-time, weak adaptability and single interaction mode in orchard planting management system, a six-dimensional model of orchard digital twin system for planting management process is proposed. The system model construction theory and technology system is discussed from four aspects, entity modeling of management elements, dynamic modeling of management process, simulation modeling of management system and optimization modeling of management strategy. Based on the six-dimensional model, supported by the theory and technology system, the virtual interactive system architecture of the orchard based on the digital twin is designed, and the key technologies of the …


Just-In-Time Learning Energy Consumption Predictive Modeling Method In Multi-Condition Production Process, Sheng Wei, Yan Wang, Zhicheng Ji Jun 2024

Just-In-Time Learning Energy Consumption Predictive Modeling Method In Multi-Condition Production Process, Sheng Wei, Yan Wang, Zhicheng Ji

Journal of System Simulation

Abstract: Aiming at the problem that the global energy consumption prediction model is only suitable for part of the prediction sample and the model is computationally intensive, the idea of just-in-time learning is introduced, and the local weighted partial least squares method combined with the energy consumption model is used to establish a temporary local energy consumption prediction model. The inertia weights of the particle swarm algorithm are improved, considering the effects of particle fitness, number of iterations and population size on the convergence speed and convergence accuracy of the particle swarm algorithm, a nonlinear change adaptive inertia weight strategy …


Completion Time Simulation Prediction Method For Aircraft Assembly Process With Batch And Sortie, Changjian Jiang, Hu Fan, Tao Luo, Wen Yuan, Zehao He Jun 2024

Completion Time Simulation Prediction Method For Aircraft Assembly Process With Batch And Sortie, Changjian Jiang, Hu Fan, Tao Luo, Wen Yuan, Zehao He

Journal of System Simulation

Abstract: Aiming at the product differentiation analysis limitation of traditional discrete event simulation method, a simulation prediction method for aircraft assembly process with batch and sortie is proposed. Around the aircraft sortie number, the formal definition of various basic elements and interactions in the assembly process with batch and sortie is studied, and the construction of station and whole line simulation model is carried out. The simulation promotion framework and execution mechanism supporting the product differentiation analysis are studied. Based on the simulation results, a method for predicting the completion time of sorties based on interval estimation method is proposed. …


Discovering Potential In Non-Cancer Medications: A Promising Breakthrough For Multiple Myeloma Patients., Omar S Al-Odat, Emily Nelson, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Dhimant Desai, Manoj K Pandey Jun 2024

Discovering Potential In Non-Cancer Medications: A Promising Breakthrough For Multiple Myeloma Patients., Omar S Al-Odat, Emily Nelson, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Dhimant Desai, Manoj K Pandey

College of Science & Mathematics Departmental Research

Multiple myeloma (MM) is a common type of cancer that unfortunately leads to a significant number of deaths each year. The majority of the reported MM cases are detected in the advanced stages, posing significant challenges for treatment. Additionally, all MM patients eventually develop resistance or experience relapse; therefore, advances in treatment are needed. However, developing new anti-cancer drugs, especially for MM, requires significant financial investment and a lengthy development process. The study of drug repurposing involves exploring the potential of existing drugs for new therapeutic uses. This can significantly reduce both time and costs, which are typically a major …


Dynamic Air Defense Resource Allocation Optimization Based On Improved Differential Evolution Algorithm, Tianyu Luo, Lining Xing, Rui Wang, Ling Wang, Jianmai Shi, Xin Sun Jun 2024

Dynamic Air Defense Resource Allocation Optimization Based On Improved Differential Evolution Algorithm, Tianyu Luo, Lining Xing, Rui Wang, Ling Wang, Jianmai Shi, Xin Sun

Journal of System Simulation

Abstract: Based on the integrated performance of weapon equipments such as radars, launchers and missiles, a mixed-integer decision model that minimizes the total target intercept value and the probability of survival based on Target-Set, Resource-Set is developed. A new improved differential evolutionary algorithm has been introduced to solve the problem, and the initial solutions is generated by using the reverse learning strategies to ensure the quality of the initial populations. An inspiration rule for the fast repair and reconstruction is designed to work at multi-stage to improve the search capability of the algorithm. The simulation experiment results show the algorithm's …


Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program Mandan Park Soil Rawp (Dated May 10, 2024), Molly Roby Jun 2024

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program Mandan Park Soil Rawp (Dated May 10, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Surface Structures And Properties Of High-Voltage Licoo2: Reviews And Prospects, Jian-Jun Fang, Yu-Hao Du, Zi-Jian Li, Wen-Guang Fan, Heng-Yu Ren, Hao-Cong Yi, Qing-He Zhao, Feng Pan Jun 2024

Surface Structures And Properties Of High-Voltage Licoo2: Reviews And Prospects, Jian-Jun Fang, Yu-Hao Du, Zi-Jian Li, Wen-Guang Fan, Heng-Yu Ren, Hao-Cong Yi, Qing-He Zhao, Feng Pan

Journal of Electrochemistry

Nowadays, the development of high-voltage LiCoO2 (lithium cobalt oxide, LCO) cathodes has attracted the widespread attention from both the academic and industry fields. Among the multiple concerns, researches on the surface issues would provide the most effective performance optimization pathway for the synthesis of high-voltage LCO. In this work, the issues of high-voltage LCO, including the phase transitions and crack formation, the oxygen redox related issues and side reactions, as well as the surface structure degradation, have been systematically reviewed. Then, we further clarify the surface modulations, and the interplay between the surface modulation and electrolyte tuning. Finally, we …


In Situ Diffuse Reflectance Spectroelectrochemistry Of Cathode Materials In Lithium-Ion Batteries, Lu-Lu Chen, Hao-Ran Li, Wei-Yi Liu, Wei Wang Jun 2024

In Situ Diffuse Reflectance Spectroelectrochemistry Of Cathode Materials In Lithium-Ion Batteries, Lu-Lu Chen, Hao-Ran Li, Wei-Yi Liu, Wei Wang

Journal of Electrochemistry

Developing in situ spectroelectrochemistry methods, which can provide detailed information about species transformation during electrochemical reactions, is very important for studying electrode reaction mechanisms and improving battery performance. Studying real-time changes in the surface of electrode materials during normal operation can be an effective way to assess and optimize the practical performance of electrode materials, thus, in situ and in operando characterization techniques are particularly important. However, batteries are hard to be studied by in situ characterization measurements due to their hermetically sealed shells, and there is still much room for battery characterizations. In this work, a specially designed battery …


Molybdenum Disulfide And Carbon Nanotubes Composite Electrode For Electrochemical Conversion Of Salinity Gradient Energy, Jia-Jun Li, Wei-Bin Zhang, Xin-Yu Liu, Jing-Lei Yang, Yi Yin, Ze-Qin Yang, Xue-Jing Ma Jun 2024

Molybdenum Disulfide And Carbon Nanotubes Composite Electrode For Electrochemical Conversion Of Salinity Gradient Energy, Jia-Jun Li, Wei-Bin Zhang, Xin-Yu Liu, Jing-Lei Yang, Yi Yin, Ze-Qin Yang, Xue-Jing Ma

Journal of Electrochemistry

The ocean accounts for 97% of the total water resources on earth, covering over 70% of the map's surface area. With the continuous consumption of non-renewable energy sources such as fossil fuels and the rapid development of renewable energy, humans are increasingly paying attention to the utilization of ocean resources. Ocean energy includes tidal energy, wave energy, temperature difference energy, and salinity gradient energy. Salinity gradient energy is the energy generated by the interaction of seawater and fresh water, which is the ocean energy existing in the form of chemical energy. This energy is mostly generated in estuaries. The osmotic …


Comment/Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling Plans (Fsps) For Bres No. 121 – Travona Dump, Bres No. 125 – Child Harold-2 Dump, Bres No. 34e – Eveline Dump East, Bres No. 45 – Garfield, Bres No. 49 – Old Glory, Bres No. 52 – Moscow, Bres No. 74 – West Gagnon Dump, And Bres No. 78 Original Mine (Dated May 7, 2024), Molly Roby Jun 2024

Comment/Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling Plans (Fsps) For Bres No. 121 – Travona Dump, Bres No. 125 – Child Harold-2 Dump, Bres No. 34e – Eveline Dump East, Bres No. 45 – Garfield, Bres No. 49 – Old Glory, Bres No. 52 – Moscow, Bres No. 74 – West Gagnon Dump, And Bres No. 78 Original Mine (Dated May 7, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program Park Soil Sampling Field Sampling Plan Submittal #14 [Silver Bow Homes Park, Butte Koa, Fairmont Rv Park, And Cccs Gymnasium] (Dated May 10, 2024), Molly Roby Jun 2024

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program Park Soil Sampling Field Sampling Plan Submittal #14 [Silver Bow Homes Park, Butte Koa, Fairmont Rv Park, And Cccs Gymnasium] (Dated May 10, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Comments For The 2024 Butte Priority Soils (Bpsou) Residential Metals Abatement Program (Rmap) – Quality Assurance Project Plan (Qapp) For Non-Residential Parcels And Residential Daycares (Dated May 23, 2024), Molly Roby Jun 2024

Comments For The 2024 Butte Priority Soils (Bpsou) Residential Metals Abatement Program (Rmap) – Quality Assurance Project Plan (Qapp) For Non-Residential Parcels And Residential Daycares (Dated May 23, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program Park Soil Sampling Field Sampling Plan Submittal #13 [Copper Mountain Park] (Dated May 10, 2024), Molly Roby Jun 2024

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Residential Metals Abatement Program Park Soil Sampling Field Sampling Plan Submittal #13 [Copper Mountain Park] (Dated May 10, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – Fourth Quarter 2023 (Dated March 28, 2024), Emma Rott Jun 2024

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – Fourth Quarter 2023 (Dated March 28, 2024), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Study Of Modified Salinomycin Analogs On Inhibition Of Triple Negative Breast Cancer Metastasis And Invasion, Farnaz Malekmarzban Jun 2024

Study Of Modified Salinomycin Analogs On Inhibition Of Triple Negative Breast Cancer Metastasis And Invasion, Farnaz Malekmarzban

Theses and Dissertations

Triple negative breast cancer (TNBC) is a more aggressive type of breast cancer which contains faster growth, higher metastasis rate and worse prognosis. The main challenge toward treatment of this type of cancer is being heterogeneous. Recently, Salinomycin (SAL) has been considered as a potential agent for triple negative breast cancer treatment. However, chemical modification of SAL is needed to improve SAL selectivity to cations and decrease its cytotoxicity. The purpose of this study was to evaluate the effect of chemically modified analogs of SAL on the viability, metastasis, Wnt pathway as well as angiogenesis of Triple negative breast cancer …


Harnessing Redox Polymer Dynamics For Enhanced Glucose-Oxygen Coupling In Dual Biosensing And Therapeutic Applications, Wassim El Housseini, Egor Baiarashov, Rokas Gerulskis, Adam Milam, Shelley D. Minteer Jun 2024

Harnessing Redox Polymer Dynamics For Enhanced Glucose-Oxygen Coupling In Dual Biosensing And Therapeutic Applications, Wassim El Housseini, Egor Baiarashov, Rokas Gerulskis, Adam Milam, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

The burgeoning field of continuous glucose monitoring (CGM) for diabetes management faces significant challenges, particularly in achieving precise and stable biosensor performance under changing environmental conditions such as varying glucose concentrations and O2 levels. To address this, we present a novel biosensor based on the electroless coupling of glucose oxidation catalyzed by flavin-dependent glucose dehydrogenase (FAD-GDH) and O2 reduction catalyzed by bilirubin oxidase (BOD) via a redox polymer, dimethylferrocene-modified linear poly(ethylenimine), FcMe2-LPEI. Initial cyclic voltammetry tests confirm the colocalization of both enzymatic reactions within the potential range of the polymer, indicating an effective electron shuttle mechanism. …