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Articles 34501 - 34530 of 38777
Full-Text Articles in Social and Behavioral Sciences
Weight Loss Practices In Amateur Wrestlers And Its Relationship To Disordered Eating, Lyndsey M. Manderfield
Weight Loss Practices In Amateur Wrestlers And Its Relationship To Disordered Eating, Lyndsey M. Manderfield
Graduate Research Papers
The premise behind many athletic programs is to encourage wellness, a state of well being in both physical and emotional aspects. This research paper reviews how wrestling and other athletic programs where weight plays a significant role, may affect eating and other weight-related habits. It addresses whether weight loss practices in wrestling play a role in disordered eating patterns of its participants.
Cutting And Self-Mutilating Behaviors Among Adolescent Girls : A Counselor's Role In Understanding And Treatment, Carla C. Hughes
Cutting And Self-Mutilating Behaviors Among Adolescent Girls : A Counselor's Role In Understanding And Treatment, Carla C. Hughes
Graduate Research Papers
With the reported incidence of cutting and self-mutilating behaviors in adolescent girls on the rise, counselors need to take a look at the changing role they can play in helping these young girls understand the reasons underlying their self-destructive behaviors. The counselor can also help them find new ways to cope with the deep emotional trauma that precipitates the behavior. Understanding the causes and dynamics of this disorder will lead to better opportunities for effective treatment. This paper is intended to focus on the nature of the disorder and the role of counseling in bringing these young women back from …
Trends In The Timing Of First Marriage Among Men And Women In The Developing World, Barbara Mensch, Susheela Singh, John B. Casterline
Trends In The Timing Of First Marriage Among Men And Women In The Developing World, Barbara Mensch, Susheela Singh, John B. Casterline
Poverty, Gender, and Youth
The timing of first union merits investigation not only because of the close temporal link between marriage and the onset of childbearing, but also because the age when men and women marry has implications for the organization of family life and for gender relations within society. This paper begins by reviewing the contributions of various social science disciplines to an understanding of the timing of marriage. Using current status data from 73 countries provided by the United Nations Population Division and retrospective data from 52 Demographic and Health Surveys conducted between 1990 and 2001, we then examine recent trends in …
Chimpanzees In Research: Past, Present, And Future, Kathleen Conlee, Sarah T. Boysen
Chimpanzees In Research: Past, Present, And Future, Kathleen Conlee, Sarah T. Boysen
State of the Animals 2005
Although the welfare of chimpanzees encompasses many issues, this chapter addresses their use in research, including their historical and current use in the United States, ethical and scientific concerns, public opinion, international legislation, and future directions.
Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey
Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey
Laboratory Experiments Collection
There is much current debate surrounding the use of non-human primates (NHPs) in medical research and drug development. This review, stimulated by calls for evidence from UK-based inquiries into NHP research, takes a critical view in order to provide some important balance against papers supporting NHP research and calling for it to be expanded. We show that there is a paucity of evidence to demonstrate the positive contribution or successful translation of NHP research to human medicine, that there is a great deal of often overlooked data showing NHP research to be irrelevant, unnecessary, even hazardous to human health and …
Mainecare And Its Role In Maine’S Healthcare System, Paul Saucier
Mainecare And Its Role In Maine’S Healthcare System, Paul Saucier
Disability & Aging
No abstract provided.
Multisystemic Therapy For Social, Emotional, And Behavioral Problems In Youth Aged 10-17 (Cochrane Review), Julia H. Littell, Melania Popa, Burnee Forsythe
Multisystemic Therapy For Social, Emotional, And Behavioral Problems In Youth Aged 10-17 (Cochrane Review), Julia H. Littell, Melania Popa, Burnee Forsythe
Graduate School of Social Work and Social Research Faculty Research and Scholarship
No abstract provided.
The Effect Of Early Psychostimulant Treatment On Abuse Liability And Dopamine Receptors, Steven Wayne Villafranca
The Effect Of Early Psychostimulant Treatment On Abuse Liability And Dopamine Receptors, Steven Wayne Villafranca
Theses Digitization Project
Examines whether the reinforcing properties of drugs of abuse were altered in adulthood by methylphenidate, more commonly known as Ritalin. Subjects were 108 rats of Sprague-Dawley descent (Harlan). Methylphenidate, or saline was administered daily to the subjects from the postnatal period (11-20 days old). The rats preference for morphine during early adulthood was measured using conditioned place preference. The number of dopamine D₂ receptors was measured in each rat and the correlation between receptor number and morphine preference was determined. Results indicate that rats pretreated with methylphenidate showed greater preference for morphine than saline pretreated rats and suggests that exposure …
Levels Of Social Intimacy Among Women In Substance Abuse Treatment, Jean Emiko Ishihara
Levels Of Social Intimacy Among Women In Substance Abuse Treatment, Jean Emiko Ishihara
Theses Digitization Project
This study found that women in substance abuse treatment have higher levels of social intimacy than women with no history of substance abuse (treatment). Other factors examined in relation to level of intimacy were: type and number of substances used, length of use, length of treatment, participation in mental health treatment, substance abuse in the home when the subject was a child, and a history of the subject being a survivor of abuse.
The Effect Of Community Nurses And Health Volunteers On Child Mortality: The Navrongo Community Health And Family Planning Project, Brian Wells Pence, Philomena Nyarko, James F. Phillips, Cornelius Debpuur
The Effect Of Community Nurses And Health Volunteers On Child Mortality: The Navrongo Community Health And Family Planning Project, Brian Wells Pence, Philomena Nyarko, James F. Phillips, Cornelius Debpuur
Poverty, Gender, and Youth
This report presents the child mortality impact of a trial of primary health-care service-delivery strategies in rural Ghana. After adjustment for sociodemographic factors, under-five mortality in areas with village-based community-nurse services fell by 16 percent during the five years of program implementation compared with mortality before the intervention. Reductions were observed in infant (6 percent), early child (20 percent), and late child (41 percent) mortality. Community involvement and training of a local health volunteer were associated with an 11 percent increase in mortality, primarily driven by a 124 percent increase in early child mortality. Areas with both nurses and volunteers …
Overview Of Attachment Disorder And Effective Treatments For Children, Kathryn H. Hedican
Overview Of Attachment Disorder And Effective Treatments For Children, Kathryn H. Hedican
Graduate Research Papers
When children experience extreme chronic trauma as a result of the effects of the disruption of healthy attachment patterns, a disorder known as Reactive Attachment Disorder (RAD) can develop. The importance for mental health counselors to understand the etiology of RAD cannot be overemphasized. Symptoms most often associated with this disorder include the inability to trust, failure to develop intimate relationships, or show affection, lack of self-confidence, low self-esteem, and anti-social behaviors and attitudes (Levy & Orlans, 1998 as cited in Sheperis, Renfro-Michel, & Doggett, 2003). Highlighting the foundational work of Erikson, Harlow, Bowlby, and Ainsworth includes a brief overview …
Accelerating Reproductive And Child Health Program Development: The Navrongo Initiative In Ghana, James F. Phillips, Ayaga A. Bawah, Fred N. Binka
Accelerating Reproductive And Child Health Program Development: The Navrongo Initiative In Ghana, James F. Phillips, Ayaga A. Bawah, Fred N. Binka
Poverty, Gender, and Youth
Successive global health and development agendas have been embraced by African governments—Alma Ata in 1978, the Bamako Initiative in 1987, the 1994 Cairo International Conference on Population and Development, and more recently the Millennium Development Goals (MDGs)—only to be followed by widespread implementation failure. This paper presents an approach to program development in Ghana that is using research to accelerate policy implementation. Originally launched in 1994 as a participatory pilot project of the Navrongo Health Research Centre, a controlled experimental study was initiated in 1996 to assess the fertility and child-survival impact of alternative community health and family planning service …
The Effects Of Divorce On Children And Adolescents, Rachelle A. Haker
The Effects Of Divorce On Children And Adolescents, Rachelle A. Haker
Graduate Research Papers
This research paper focuses on the effects of divorce on children and adolescents. Based on a review of literature, there are many short-term and long-term effects including emotional, behavioral, and physical issues. Children and adolescents vary in adjustment to divorce depending on multiple factors such as communication, conflict, and parental adjustment. The stages that children and adolescents of divorce go through depend on one's developmental stage and gender. Counselors can greatly influence how children and adolescents adjust to divorce.
Content Analysis Of Drug Offenders' Sketches On The Draw-An-Event Test For Risky Sexual Situations, Alan W. Stacy, Susan L. Ames, Barbara C. Leigh, Brian R. Houska, Julia Andsager
Content Analysis Of Drug Offenders' Sketches On The Draw-An-Event Test For Risky Sexual Situations, Alan W. Stacy, Susan L. Ames, Barbara C. Leigh, Brian R. Houska, Julia Andsager
CGU Faculty Publications and Research
Objectives: To evaluate the utility of the Draw-an-Event Test for risky sexual situations (DET-RS), a nonverbal memory-based assessment tool used for productions of spontaneous content associated with risky sex. Methods: Traditional holistic coding analysis of 298 drug offenders' content productions. Results: Content analyses of DET-RS sketches provided increased understanding of substance use and other context preceding risky sexual situations with different types of sex partners. None of the sketches including drugs depleted condoms, only one of the sketches with alcohol included a condom, and only 2 sketches mentioned sexually transmitted diseases. Conclusions: The DET-RS is a useful research tool for …
Implicit Cognition And Dissocative Experiences As Predictors Of Adolescent Substance Use, Susan L. Ames, Steve Sussman, Clyde W. Dent, Alan W. Stacy
Implicit Cognition And Dissocative Experiences As Predictors Of Adolescent Substance Use, Susan L. Ames, Steve Sussman, Clyde W. Dent, Alan W. Stacy
CGU Faculty Publications and Research
The present study evaluated the mediating role of implicit cognitive processes in the prediction of alcohol and marijuana use and examined the relationships between dissociative experiences, implicit processes, and sensation seeking in models of drug use and problem experiences. Participants were 467 diverse at-risk adolescents in California. Results from latent variable models revealed that implicit cognition independently predicted alcohol and marijuana use and mediated the predictive effects of sensation seeking on drug use. Dissociative experiences did not predict implicit cognition or drug use in this sample, though this factor was a significant predictor of problem experiences and was positively correlated …
Fire Retardancy And Morphology Of Nylon 6-Clay Nanocomposite Compositions, Kadhirava Shanmuganathan, Sandeep Razdan, Nicholas Dembsey, Qinguo Fan, Yong K. Kim, Paul D. Calvert, Steven B. Warner, Prabir Patra
Fire Retardancy And Morphology Of Nylon 6-Clay Nanocomposite Compositions, Kadhirava Shanmuganathan, Sandeep Razdan, Nicholas Dembsey, Qinguo Fan, Yong K. Kim, Paul D. Calvert, Steven B. Warner, Prabir Patra
Faculty of Science, Medicine and Health - Papers: part A
We investigated the effect of organically modified clay on the thermal and flammability behavior of nylon 6 nanocomposites. We also used zinc borate along with layered silicate with an aim of achieving synergistic effect in flame retardancy. It is found that addition of 10 wt% clay reduced the onset decomposition (5% wt loss) temperature of nylon 6 by 20°C, while addition of 5 wt% zinc borate and 5 wt% clay in combination reduced it by around 10°C. Differential thermogravimetric analysis indicated that the peak decomposition temperature was not affected by the addition of clay, but the rate of weight loss …
Forensic Facial Approximation: An Overview Of Current Methods Used At The Victorian Institute Of Forensic Medicine/Victoria Police Criminal Identification Squad, S Hayes, R Taylor, A Patterson
Forensic Facial Approximation: An Overview Of Current Methods Used At The Victorian Institute Of Forensic Medicine/Victoria Police Criminal Identification Squad, S Hayes, R Taylor, A Patterson
Faculty of Science, Medicine and Health - Papers: part A
Forensic facial approximation involves building a likeness of the head and face on the skull of an unidentified individual, with the aim that public broadcast of the likeness will trigger recognition in those who knew the person in life. This paper presents an overview of the collaborative practice between Ronn Taylor (Forensic Sculptor to the Victorian Institute of Forensic Medicine) and Detective Sergeant Adrian Paterson (Victoria Police Criminal Identification Squad). This collaboration involves clay modelling to determine an approximation of the person's head shape and feature location, with surface texture and more speculative elements being rendered digitally onto an image …
Development And Validation Of Instruments Measuring Body Image And Body Weight Dissatisfaction In South African Mothers And Their Daughters, Zandile Mciza, Julia Goedecke, Nelia P. Steyn, Karen E. Charlton, Thandi Puoane, Shelly Meltzer, Naomi Levitt, Estelle V. Lambert
Development And Validation Of Instruments Measuring Body Image And Body Weight Dissatisfaction In South African Mothers And Their Daughters, Zandile Mciza, Julia Goedecke, Nelia P. Steyn, Karen E. Charlton, Thandi Puoane, Shelly Meltzer, Naomi Levitt, Estelle V. Lambert
Faculty of Science, Medicine and Health - Papers: part A
Objective We sought to validate questionnaires concerning body image perception, body size dissatisfaction and weight-related beliefs in multi-ethnic South African mothers and their daughters. Settings and subjects: Girls attending primary school (ages 9-12 years, n = 333) and their mothers (n = 204) were interviewed regarding their demographics and body image. Weight, height and skinfold thicknesses were measured. Body image questions and body mass index (BMI) were compared with silhouettes adapted from the Pathways Study for girls and Stunkard's body image figures for mothers. A Feel-Ideal Difference (FID) index score was created by subtracting the score of the silhouette selected …
Knowledge Of Iodine Nutrition In The South African Adult Population, Pieter Jooste, Nicola Upson, Karen E. Charlton
Knowledge Of Iodine Nutrition In The South African Adult Population, Pieter Jooste, Nicola Upson, Karen E. Charlton
Faculty of Science, Medicine and Health - Papers: part A
Objectives To determine the level of knowledge regarding iodine nutrition and its relationship with socio-economic status in the South African population. Design A cross-sectional population survey collecting questionnaire information on knowledge of iodine nutrition and sociodemographic variables in a multistage, stratified, cluster study sample, representative of the adult South African population. Setting Home visits and personal interviews in the language of the respondent. Subjects Data were collected from one adult in each of the selected 2164 households, and the participation rate was 98%. Results Only 15.4% of respondents correctly identified iodised salt as the primary dietary source of iodine, 16.2% …
Bovine Feces From Animals With Gastrointestinal Infections Are A Source Of Serologically Diverse Atypical Enteropathogenic Escherichia Coli And Shiga Toxin-Producing E. Coli Strains That Commonly Possess Intimin, Michael A Hornitzky, Kim Mercieca, Karl A Bettelheim, Steven P. Djordjevic
Bovine Feces From Animals With Gastrointestinal Infections Are A Source Of Serologically Diverse Atypical Enteropathogenic Escherichia Coli And Shiga Toxin-Producing E. Coli Strains That Commonly Possess Intimin, Michael A Hornitzky, Kim Mercieca, Karl A Bettelheim, Steven P. Djordjevic
Faculty of Science, Medicine and Health - Papers: part A
Shiga toxin-producing Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) cells were isolated from 191 fecal samples from cattle with gastrointestinal infections (diagnostic samples) collected in New South Wales, Australia. By using a multiplex PCR, E. coli cells possessing combinations of stx1, stx2, eae, and ehxA were detected by a combination of direct culture and enrichment in E. coli (EC) (modified) broth followed by plating on vancomycin-cefixime-cefsulodin blood (BVCC) agar for the presence of enterohemolytic colonies and on sorbitol MacConkey agar for the presence of non-sorbitol-fermenting colonies. The high prevalence of the intimin gene eae …
Enzyme Activity And Flexibility At Very Low Hydration, V Kurkal, R M. Daniel, John L. Finney, Moeava Tehei, R V. Dunn, Jeremy C. Smith
Enzyme Activity And Flexibility At Very Low Hydration, V Kurkal, R M. Daniel, John L. Finney, Moeava Tehei, R V. Dunn, Jeremy C. Smith
Faculty of Science, Medicine and Health - Papers: part A
Recent measurements have demonstrated enzyme activity at hydrations as low as 3%. This raises the question of whether hydration-induced enzyme flexibility is important for activity. Here, to address this, picosecond dynamic neutron scattering experiments are performed on pig liver esterase powders at 0%, 3%, 12%, and 50% hydration by weight and at temperatures ranging from 120 to 300 K. At all temperatures and hydrations, significant quasielastic scattering intensity is found in the protein, indicating the presence of anharmonic, diffusive motion. As the hydration increases, a temperature-dependent dynamical transition appears and strengthens involving additional diffusive motion. The implication of these results …
A Practical Guide To Assessing Clinical Decision-Making Skills Using The Key Features Approach, Elizabeth Farmer, Gordon Page
A Practical Guide To Assessing Clinical Decision-Making Skills Using The Key Features Approach, Elizabeth Farmer, Gordon Page
Faculty of Science, Medicine and Health - Papers: part A
Aim This paper in the series on professional assessment provides a practical guide to writing key features problems (KFPs). Key features problems test clinical decision-making skills in written or computer-based formats. They are based on the concept of critical steps or ‘key features’ in decision making and represent an advance on the older, less reliable patient management problem (PMP) formats.
Method The practical steps in writing these problems are discussed and illustrated by examples. Steps include assembling problem-writing groups, selecting a suitable clinical scenario or problem and defining its key features, writing the questions, selecting question response formats, preparing scoring …
Fatality After Deliberate Ingestion Of The Pesticide Rotenone: A Case Report., David Wood, Hadi Alsahaf, Peter Streete, Paul Dargan, Alison L. Jones
Fatality After Deliberate Ingestion Of The Pesticide Rotenone: A Case Report., David Wood, Hadi Alsahaf, Peter Streete, Paul Dargan, Alison L. Jones
Faculty of Science, Medicine and Health - Papers: part A
Rotenone is a pesticide derived from the roots of plants from the Leguminosae family. Poisoning following deliberate ingestion of these plant roots has commonly been reported in Papua New Guinea. However, poisoning with commercially available rotenone in humans has been reported only once previously following accidental ingestion in a 3.5-year-old child. Therefore, the optimal management of rotenone poisoning is not known. After deliberate ingestion of up to 200 ml of a commercially available 0.8% rotenone solution, a 47-year-old female on regular metformin presented with a reduced level of consciousness, metabolic acidosis and respiratory compromise. Metformin was not detected in premortem …
Time-Dependent Mobility And Recombination Of The Photoinducted Charge Carriers In Conjugated Polymer/Fullerene Bulk Heterojunction Solar Cells, Attila J. Mozer, D Dennler, N S. Sariciftci, M Westerling, A Pivrikas, R Österbacka, J Juška
Time-Dependent Mobility And Recombination Of The Photoinducted Charge Carriers In Conjugated Polymer/Fullerene Bulk Heterojunction Solar Cells, Attila J. Mozer, D Dennler, N S. Sariciftci, M Westerling, A Pivrikas, R Österbacka, J Juška
Faculty of Science, Medicine and Health - Papers: part A
Time-dependent mobility and recombination in the blend of poly[2-methoxy-5-(3,7-dimethyloctyloxy)-phenylene vinylene] (MDMO-PPV) and 1-(3-methoxycarbonyl)propyl-1-phenyl-(6,6)-C61(PCBM) is studied simultaneously using the photoinduced charge carrier extraction by linearly increasing voltage technique. The charge carriers are photogenerated by a strongly absorbed, 3 ns laser flash, and extracted by the application of a reverse bias voltage pulse after an adjustable delay time (tdel). It is found that the mobility of the extracted charge carriers decreases with increasing delay time, especially shortly after photoexcitation. The time-dependent mobility μ(t) is attributed to the energy relaxation of the charge carriers towards the tail states of the density of states …
A New Early Silurian Species Of Trimerella (Brachiopoda: Craniata) From The Orange District, New South Wales, Ian G. Percival, Anthony J. Wright
A New Early Silurian Species Of Trimerella (Brachiopoda: Craniata) From The Orange District, New South Wales, Ian G. Percival, Anthony J. Wright
Faculty of Science, Medicine and Health - Papers: part A
Trimerella australis, a new species of craniate brachiopod, is described from silicified material extracted from Early Silurian limestone in the Bowan Park district, 22 km west of Orange in central New South Wales. Accompanying conodonts of the Distomodus staurognathoides Zone indicate this unnamed unit is mid Llandovery (latest Aeronian to earliest Telychian) in age, and support correlation with the Cobblers Creek Limestone at the base of the Waugoola Group. As with most other occurrences of trimerellide brachiopods in the Late Ordovician and Early Silurian of the Lachlan Orogen, T. australis completely dominates its depauperate faunal associates of corals including Aphyllum? …
Silurian Graptolites From The Barnby Hills Shale And The Hanover Formation, New South Wales, R B. Rickards, J R. Farrell, Anthony J. Wright, E J. Morgan
Silurian Graptolites From The Barnby Hills Shale And The Hanover Formation, New South Wales, R B. Rickards, J R. Farrell, Anthony J. Wright, E J. Morgan
Faculty of Science, Medicine and Health - Papers: part A
Additional collections of graptolites from the Barnby Hills Shale and new collections of graptolites from the Hanover Formation in the Lachlan Fold Belt of central western NSW are documented. The Late Silurian Hanover Formation is shown to range from the spineus Biozone (late Ludlow) to the parultimus Biozone (Pridol ). A fauna containing Monograptus ludensis is recorded from the Barnby Hills Shale, which is now known to range from the ludensis Biozone (late Wenlock) to the inexspectatus or kozlowskii Biozone (late Ludlow). New dendroid graptolite taxa described here include Dendrograptus typhlops sp. nov. from the Barnby Hills Shale and Dictyonema …
Promoting The Students Practicum: A Cd Rom For Nursing Preceptors, Kerry Reid-Searl, Lorna Moxham
Promoting The Students Practicum: A Cd Rom For Nursing Preceptors, Kerry Reid-Searl, Lorna Moxham
Faculty of Science, Medicine and Health - Papers: part A
Students who undertake a degree that leads to a professional qualification, such as nursing, are often required to undertake a practical component in their course of study. This frequently involves the use of industry to support, mentor and assess student progress. Such a role is vitally important if the student is to achieve successful learning outcomes. In order to facilitate learning opportunities and evaluate student progress, the industry educators require knowledge to undertake the role with confidence and effectiveness. Using nursing as a case study, but acknowledging that this process is applicable to a variety of disciplines, this paper showcases …
'The Psychiatric Consumer': The Use Of Student Stories To Inform Course Development, Julie Bradshaw, Lorna Moxham
'The Psychiatric Consumer': The Use Of Student Stories To Inform Course Development, Julie Bradshaw, Lorna Moxham
Faculty of Science, Medicine and Health - Papers: part A
With one in five Australians likely to experience the burden of a major mental illness (Commonwealth Department of Health and Aged Care Services, 1997), undergraduate nursing programs must prepare graduates to be able to work in the area of mental health. A change to the undergraduate nursing curriculum at Central Queensland University provided the impetus to review the traditional way in which we develop and teach our subjects. The authors saw it as essential to develop a psychiatric nursing subject that not only teaches the student the necessary skills and knowledge to safely and effectively care for the mentally ill …
The Burden Of The Rheumatic Diseases In The General Adult Population Of Greece: The Esordig Study, A A. Andrianakos, Spyridon Miyakis, P Trontzas, G Kaziolas, F Christoyannis, D Karamitsos, G Karanikolas, P Dantis
The Burden Of The Rheumatic Diseases In The General Adult Population Of Greece: The Esordig Study, A A. Andrianakos, Spyridon Miyakis, P Trontzas, G Kaziolas, F Christoyannis, D Karamitsos, G Karanikolas, P Dantis
Faculty of Science, Medicine and Health - Papers: part A
OBJECTIVE: To estimate the burden of rheumatic diseases in terms of disability and health-care utilization in the Greek general adult population. METHODS: The study was conducted on the total adult population of seven communities (8547 subjects), as well as on 2100 out of 5686 randomly selected subjects in an additional two communities. Rheumatologists visited the participants at their homes to assess the prevalence of six morbidity indicators concerning disability and health-care utilization associated with rheumatic diseases or other major disease groups. RESULTS: The participation rate in the study was 82.1%. The prevalence of chronic health problems, long-term disability, short-term disability, …
Systemic Levels Of Interleukin-6 And Matrix Metalloproteinase-9 In Patients With Multiple Myeloma May Be Useful As Prognostic Indexes Of Bone Disease, Aikaterini Sfiridaki, Spyridon Miyakis, George Tsirakis, Athanasios Alegakis, Andreas M. Passam, Ermioni Kandidaki, Andrerw N. Margioris, Michael Alexandrakis
Systemic Levels Of Interleukin-6 And Matrix Metalloproteinase-9 In Patients With Multiple Myeloma May Be Useful As Prognostic Indexes Of Bone Disease, Aikaterini Sfiridaki, Spyridon Miyakis, George Tsirakis, Athanasios Alegakis, Andreas M. Passam, Ermioni Kandidaki, Andrerw N. Margioris, Michael Alexandrakis
Faculty of Science, Medicine and Health - Papers: part A
Multiple myeloma is characterized by accelerated production of the proteolytic enzyme matrix metalloproteinase (MMP)-9. We hypothesized that myeloma- produced MMP-9 may influence the rate of bone turnover in a paracrine manner. Thus, we examined the correlations of MMP-9 levels, disease severity, and bone turnover rate as evaluated by markers of bone formation and resorption. Thirty-seven newly diagnosed multiple myeloma patients (nine of Durie-Salmon stage I, 12 of stage II and 16 of stage III) and 12 age-matched controls were studied. Serum MMP-9 levels were significantly higher at stage II compared to stage I (188.78"91.27 vs. 59.25"33.09 ng/mL, p-0.004). Additionally, free …