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Articles 1591 - 1620 of 3417

Full-Text Articles in Physical Sciences and Mathematics

Extra Structures On Three-Dimensional Cobordisms, Xuanye Wang Jan 2013

Extra Structures On Three-Dimensional Cobordisms, Xuanye Wang

LSU Doctoral Dissertations

A Topological Quantum Field Theory (TQFT) is a functor from a cobordism category to the category of vector spaces, satisfying certain properties. An important property is that the vector spaces should be finite dimensional. For the WRT TQFT, the relevant 2 + 1-cobordism category is built from manifolds which are equipped with an extra structure such as a p1-structure, or an extended manifold structure. In chapter 1, we perform the universal construction of [3] on a cobordism category without this extra structure and show that the resulting quantization functor assigns an infinite dimensional vector space to the torus. In chapter …


Recovery Of Understory Bird Movement In Post-Pasture Amazonia, Luke L. Powell Jan 2013

Recovery Of Understory Bird Movement In Post-Pasture Amazonia, Luke L. Powell

LSU Doctoral Dissertations

I sought to understand how forest fragmentation and secondary growth affect avian movement at the Biological Dynamics of Forest Fragments Project (BDFFP) near Manaus, Brazil. When deforested areas are abandoned, secondary forests regenerate, allowing rainforest animals to gradually recovery their ability to use formerly inhospitable habitat. My colleagues and I captured 2773 understory birds of ten foraging guilds along the edges of primary forest fragments and variable secondary forest. Age of secondary forest along edges was the most important variable driving capture rates on primary/secondary edges. Mean recovery to pre-isolation capture rates was 26 years after abandonment, but terrestrial insectivores …


Challenges And Rewards Of Single Crystal Flux Growth: Physical Properties Of Structurally Related Ln-Ru-Al Intermetallics, Gregory Morrison Jan 2013

Challenges And Rewards Of Single Crystal Flux Growth: Physical Properties Of Structurally Related Ln-Ru-Al Intermetallics, Gregory Morrison

LSU Doctoral Dissertations

The availability of single crystals is vital for understanding the intrinsic properties of crystalline materials. The flux growth method is a versatile technique which may be used to grow single crystals. However, their synthesis can often be challenging, especially when a competing phase is very robust. Herein, we study the growth competition between structurally related compounds in the Ln-Ru-Al phase space. We demonstrate the benefits of single crystals and suggest methods to grow competing phases. CeRu2Al10 has garnered interest due to its higher ordering temperate than expected from de Gennes scaling and its metal-to-insulator transition at the same temperature. Here, …


New Strategies For The Synthesis Of Porphyrinoids, Moses Inyanje Ihachi Jan 2013

New Strategies For The Synthesis Of Porphyrinoids, Moses Inyanje Ihachi

LSU Doctoral Dissertations

ABSTRACT Chapter 1 describes the most stable isomer of porphyrin called porphycene. In this chapter photodynamic therapy (PDT) is explained, and the application of porphycenes in PDT is also described. Other biological applications and its uses in catalysis are also summarized here. The general chemical reactions of porphycenes are also explained. Chapter 2 involves the synthesis of pyrroles and bipyrroles. Functionalization of pyrrollic substituents is demonstrated using organometallic coupling reactions like Stille coupling and Grubbs olefin metathesis. The synthesis of divinyl bipyrroles is intended to provide an important precursor to porphycene synthesis via ring closing metathesis using Grubbs catalyst. Chapter …


Preparation And Characterization Of Cellulose Nanoparticles And Their Application In Biopolymeric Nanocomposites, Jingquan Han Jan 2013

Preparation And Characterization Of Cellulose Nanoparticles And Their Application In Biopolymeric Nanocomposites, Jingquan Han

LSU Doctoral Dissertations

Regenerated cellulose nanoparticles (RCNs) including both elongated fiber and spherical structures were prepared from microcrystalline cellulose (MCC) and cotton using 1-butyl-3-methylimidazolium chloride followed by high-pressure homogenization. The RCN has a two-step pyrolysis, different from raw MCC and cotton that had a one-step process. The crystalline structure of RCNs was cellulose II in contrast to the cellulose I form of the starting materials. Also, the RCNs have decreased crystallinity and crystallite size. The elongated RCNs produced from cotton and MCC had average lengths of 123 ± 34 and 112 ± 42 nm, and mean widths of 12 ± 5 and 12 …


Crystal Growth And An Investigation Of Structural Stability: Synthesis, Structure, And Physical Properties Of Yb(Mn,M)Xal12-X (M = Fe, Ru; X < 2.5) And Lnmnxga3 (Ln = Ho-Tm; X < 0.15), Bradford Wesley Fulfer Jan 2013

Crystal Growth And An Investigation Of Structural Stability: Synthesis, Structure, And Physical Properties Of Yb(Mn,M)Xal12-X (M = Fe, Ru; X < 2.5) And Lnmnxga3 (Ln = Ho-Tm; X < 0.15), Bradford Wesley Fulfer

LSU Doctoral Dissertations

The contents of this dissertation describe the crystal growth, crystal structures, and physical properties of ternary intermetallic aluminides and gallides. These compounds are grown in an effort to determine how controlling reaction ratios using the flux growth method can impact chemical structure and physical properties. Three specific examples are given where slight changes in reaction ratios leads to crystalline products that adopt various structure types. LnMn2+xAl10-x (Ln = Gd, Yb) crystals adopt the CaCr2Al10 and ThMn12 structure types. We compare LnMn2+xAl10-x compounds adopting the CaCr2Al10 and ThMn12 structure types, and outline synthesis methods to obtain each polymorph. Magnetic susceptibility measurements …


Synthesis Of The Western Hemisphere Of Theonellamide C, Saroj Yadav Jan 2013

Synthesis Of The Western Hemisphere Of Theonellamide C, Saroj Yadav

LSU Doctoral Dissertations

Theonellamides A-F were isolated from Theonella swinhoei by Fusetani and co-workers. Despite considerable synthetic effort to produce theonellamide F by the Shioiri group in the early 1990’s, the total synthesis of a theonellamide has yet to be reported. We report herein our efforts toward some of the required amino acid residues and construction of the western ring of theonellamide C. We describe the synthesis of an uncoded amino acid, (2S,4R)-ɣ-hydroxy-α-amino adipic acid (Ahad), a building block for theonellamide C. We initially investigated the Corey-Lygo method for the catalytic asymmetric generation of the Cα stereocenter. Unfortunately, the alkylation of glycine benzophenone …


Gene Set Based Ensemble Methods For Cancer Classification, William Evans Duncan Jan 2013

Gene Set Based Ensemble Methods For Cancer Classification, William Evans Duncan

LSU Doctoral Dissertations

Diagnosis of cancer very often depends on conclusions drawn after both clinical and microscopic examinations of tissues to study the manifestation of the disease in order to place tumors in known categories. One factor which determines the categorization of cancer is the tissue from which the tumor originates. Information gathered from clinical exams may be partial or not completely predictive of a specific category of cancer. Further complicating the problem of categorizing various tumors is that the histological classification of the cancer tissue and description of its course of development may be atypical. Gene expression data gleaned from micro-array analysis …


Molecular-Level Investigations Combining Nanoscale Lithography And Atomic Force Microscopy, Chamarra Karmelia Saner Jan 2013

Molecular-Level Investigations Combining Nanoscale Lithography And Atomic Force Microscopy, Chamarra Karmelia Saner

LSU Doctoral Dissertations

In this dissertation, nanostructures of octadecyltrichlorosilane (OTS) and were prepared using particle lithography and evaluated using characterizations with atomic force microscopy (AFM). The nanostructures of OTS were used as a resist for patterning fibronectin, an extracellular matrix protein. Particle lithography provides a practical and reproducible approach to generate billions of nanostructures comprised of organic thin films or nanomaterials. A film of mesospheres can be applied as a surface mask to define the periodicity and size of nanopatterns using processes of self-assembly. A close-packed arrangement of mesospheres is produced spontaneously when monodisperse solutions of latex or silica are dried on a …


Cyclic Block Copolypeptoids : Synthesis, Self-Assembly And Macroscopic Properties, Chang-Uk Lee Jan 2013

Cyclic Block Copolypeptoids : Synthesis, Self-Assembly And Macroscopic Properties, Chang-Uk Lee

LSU Doctoral Dissertations

This dissertation presents the first experimental efforts for synthesizing a new class of peptidomimetic polymers, cyclic block copolypeptoids, studying their self-assembly in dilute solution, and examining their macroscopic properties. Cyclic poly(N-methyl-glycine)-b-poly(N-decyl-glycine) (PNMG-b-PNDG) diblock copolymers were synthesized via sequential, N-heterocyclic carbene (NHC)-mediated ring-opening polymerization of NCA monomers with controlled chain length and compositions. Cryo-TEM shows that PNMG105-b-PNDG10 copolymers in methanol (1 mg/mL) form spherical micelles that organize to form cylindrical micelles over time. The formation of cylindrical micelles is attributed to the crystallization of PNDG chains, as revealed by SAED and microDSC analyses. Cyclic PNMG100-b-PNDG10 copolymers form thermo-reversible, free-standing gels at …


Study On The Performance Of Tcp Over 10gbps High Speed Networks, Cheng Cui Jan 2013

Study On The Performance Of Tcp Over 10gbps High Speed Networks, Cheng Cui

LSU Doctoral Dissertations

Internet traffic is expected to grow phenomenally over the next five to ten years. To cope with such large traffic volumes, high-speed networks are expected to scale to capacities of terabits-per-second and beyond. Increasing the role of optics for packet forwarding and transmission inside the high-speed networks seems to be the most promising way to accomplish this capacity scaling. Unfortunately, unlike electronic memory, it remains a formidable challenge to build even a few dozen packets of integrated all-optical buffers. On the other hand, many high-speed networks depend on the TCP/IP protocol for reliability which is typically implemented in software and …


Scanning Probe Investigations Of The Surface Self-Assembly Of Organothiols And Organosilanes Using Nanoscale Lithography, Tian Tian Jan 2013

Scanning Probe Investigations Of The Surface Self-Assembly Of Organothiols And Organosilanes Using Nanoscale Lithography, Tian Tian

LSU Doctoral Dissertations

Particle lithography and scanning probe lithography were applied to study the kinetics and mechanisms of surface self-assembly processes. Organothiols on Au(111) and organosilane on Si(111) were chosen as model systems for investigations at the nanoscale using atomic force microscopy (AFM). Fundamental insight of structure/property interrelationships and understanding the properties of novel materials are critical for developments with molecular devices. Methods using an AFM probe for nanofabrication have been applied successfully to prepare sophisticated molecular architectures with high reproducibility and spatial precision. The established capabilities of AFM-based nanografting were reviewed for inscribing patterns of diverse composition, to generate complicated surface designs …


Coupling Between Spin, Lattice, And Charge At The Surface Of Complex Transition Metal Compounds, Guorong Li Jan 2013

Coupling Between Spin, Lattice, And Charge At The Surface Of Complex Transition Metal Compounds, Guorong Li

LSU Doctoral Dissertations

Understanding and controlling the complexity that develops in complex transition metal compounds such as high-Tc superconductivity, "colossal" magnetoresistance in manganites, and heavy-fermion compounds, is one of the grand challenges of the 21st century. The exotic properties displayed by these compounds are closely related to the coexistence of nearly degenerate states, coupling simultaneously several active degrees of freedom such as the charge, lattice, orbital, and spin. In this work, we have focused on two systems, one is the newly discovered Fe-based superconducting compounds ((Ba, Ca)(Fe1-xCox)2As2, FeTe1-xSex) and the other one is the doped Ruddleden-Popper (RP) ruthenates (Sr3(Ru1-xMnx)2O7). The materials community was …


Long-Term Total Suspended Sediment Yield Of Coastal Louisiana Rivers With Spatiotemporal Analysis Of The Atchafalaya River Basin And Delta Complex, Timothy Rosen Jan 2013

Long-Term Total Suspended Sediment Yield Of Coastal Louisiana Rivers With Spatiotemporal Analysis Of The Atchafalaya River Basin And Delta Complex, Timothy Rosen

LSU Master's Theses

The modern day Mississippi River Delta Plain and the Louisiana Chenier Plain have been greatly altered through anthropogenic changes to course and hydrological conditions of the Mississippi River and local rivers, most notably by levees that have excluded the Mississippi River from the delta plain. This has slowed accretion and increased land loss destroying vast quantities of marsh, endangering many coastal communities. This master’s thesis examined long-term total suspended sediment yield of four Chenier Plain rivers, total suspended sediment yield of the Mississippi River under different flow conditions, and total suspended sediment dynamics of the Atchafalaya River in relation to …


Effects Of Predator Reduction On Nest Success Of Upland Nesting Ducks In Low-Grassland Density Landscapes In Eastern North Dakota, Michael Buxton Jan 2013

Effects Of Predator Reduction On Nest Success Of Upland Nesting Ducks In Low-Grassland Density Landscapes In Eastern North Dakota, Michael Buxton

LSU Master's Theses

Nest success of upland nesting ducks is the primary driver of duck population growth in the Prairie Pothole Region. Nest success is greatly influenced by nest predation and the amount of available nesting cover on the landscape. The decline in acres enrolled in the Conservation Reserve Program (CRP) in this region has negatively impacted the amount of available nesting cover, making nesting cover sparse and confined to small patches where predation rates are potentially elevated. I evaluated the efficacy of seasonal predator reduction on increasing nest success on low-grassland density (>10% grassland cover), 93 km2 landscapes in two different …


Inductivley Coupled Plasma Optical Emission Spectroscopy Analysis Of Heavy Metal Concentrations In Gulf Menhaden (Brevoortia Patronus) Populations In The Northern Gulf Of Mexico From 2011 To 2012, Hannah Paula Rockett Jan 2013

Inductivley Coupled Plasma Optical Emission Spectroscopy Analysis Of Heavy Metal Concentrations In Gulf Menhaden (Brevoortia Patronus) Populations In The Northern Gulf Of Mexico From 2011 To 2012, Hannah Paula Rockett

LSU Master's Theses

In 2010, the Deepwater Horizon (DWH) oil spill, released 4.9 million barrels of oil into the Gulf of Mexico, creating the largest marine oil spill in the history of the U.S. petroleum industry. Trace metals, including those from crude oil, were dispersed in the water column and bound to suspended particulates. As obligate filter-feeding omnivores and a predominate fishery in the Gulf of Mexico, Gulf menhaden (Brevoortia patronus) are susceptible to trace metal accumulation. Samples of menhaden were collected at two locations in coastal Louisiana, Grand Isle (GI) and Vermillion Bay (VB), with VB serving as the non-impacted DWH oil …


Controls On The Composition Of Saline Formation Waters From Coastal And Offshore Louisiana, Marielle Elaine Ausburn Jan 2013

Controls On The Composition Of Saline Formation Waters From Coastal And Offshore Louisiana, Marielle Elaine Ausburn

LSU Master's Theses

Geothermal energy is a renewable energy source that can contribute to the U.S. energy mix. As such, new technologies are being explored for lower temperature systems which would open new areas for exploration in Louisiana. Unlike concepts proposed in the early 1980s, in which heat would have been extracted at the land surface from produced overpressured waters, methods currently being proposed would involve engineered down-hole heat exchangers with zero-mass-fluid withdrawal. A re-examination has been made of the controls on the composition of formation waters in south central and offshore Louisiana in the context of providing insight into water-rock reactions that …


Using Formative Assessment To Enhance Student Performance On Geometric Proof Writing, Benjamin Hargrave Jan 2013

Using Formative Assessment To Enhance Student Performance On Geometric Proof Writing, Benjamin Hargrave

LSU Master's Theses

The purpose of this research is to uncover best practices to create competent proof writers. Studies have shown the best setting to do this is in the high school geometry classroom. Throughout a yearlong study of geometry, students were exposed to theorems and their demonstrations. Despite constant exposure, students were still unable to produce their own proof of propositions. The questions then became how can an educator provide critical feedback that encourages student reasoning and develops logical argumentation skills? With the goal in mind, twenty-five students enrolled in a geometry course at Baton Rouge High School in Baton Rouge, Louisiana …


Mixed Categories, Formality For The Nilpotent Cone, And A Derived Springer Correspondence, Laura Joy Rider Jan 2013

Mixed Categories, Formality For The Nilpotent Cone, And A Derived Springer Correspondence, Laura Joy Rider

LSU Doctoral Dissertations

Recall that the Springer correspondence relates representations of the Weyl group to perverse sheaves on the nilpotent cone. We explain how to extend this to an equivalence between the triangulated category generated by the Springer perverse sheaf and the derived category of di_x000B_erential graded modules over a dg-ring related to the Weyl group


On-The-Fly Tracing For Data-Centric Computing : Parallelization, Workflow And Applications, Lei Jiang Jan 2013

On-The-Fly Tracing For Data-Centric Computing : Parallelization, Workflow And Applications, Lei Jiang

LSU Doctoral Dissertations

As data-centric computing becomes the trend in science and engineering, more and more hardware systems, as well as middleware frameworks, are emerging to handle the intensive computations associated with big data. At the programming level, it is crucial to have corresponding programming paradigms for dealing with big data. Although MapReduce is now a known programming model for data-centric computing where parallelization is completely replaced by partitioning the computing task through data, not all programs particularly those using statistical computing and data mining algorithms with interdependence can be re-factorized in such a fashion. On the other hand, many traditional automatic parallelization …


Approximate Sequence Alignment, Xuanting Cai Jan 2013

Approximate Sequence Alignment, Xuanting Cai

LSU Master's Theses

Given a collection of strings and a query string, the goal of the approximate string matching is to efficiently find the strings in the collection, which are similar to the query string. In this paper, we focus on edit distance as a measure to quantify the similarity between two strings. Existing q-gram based methods use inverted lists to index the q-grams of the given string collection. These methods begin with generating the q-grams of the query string, disjoint or overlapping, and then merge the inverted lists of these q-grams. Several filtering techniques have been proposed to segment inverted lists in …


Gumbos And Nanogumbos: Applications As Photosensitizers In Dye-Sensitized Solar Cells, Atiya Nicole Jordan Jan 2013

Gumbos And Nanogumbos: Applications As Photosensitizers In Dye-Sensitized Solar Cells, Atiya Nicole Jordan

LSU Doctoral Dissertations

Renewable energy is a major concern due to increased world energy consumption. In particular, solar energy is a type of renewable energy source that uses devices known as solar cells to convert sunlight to electricity. Specifically, devices referred to as dye-sensitized solar cells (DSSCs) employ dyes to absorb solar energy. Dyes derived from ruthenium complexes have been typically used in DSSCs. Unfortunately, several disadvantages are associated with current ruthenium complex photosensitizers, which can be attributed to limited supply and expense of metals, as well as reduced absorption in the near-infrared region of the electromagnetic spectrum. Accordingly, this dissertation is a …


A Semigroup/Laplace Transform Approach To Approximating Flows, Ladorian Nichele Latin Jan 2013

A Semigroup/Laplace Transform Approach To Approximating Flows, Ladorian Nichele Latin

LSU Doctoral Dissertations

It is well known that all flows in a state space O induce a semigroup of linear operators on an appropriately chosen vector space of functions (observables) from O into a vector space Z (observations). After choosing appropriate continuity assumptions on the flow, the associated semigroup will be strongly continuous and will have a linear, infinitesimal generator A. The purpose of this dissertation is to explore approximation methods for linear semigroups and/or Laplace transform inversion methods in order to reconstruct the flow starting with the linear generator A . In preparing for these investigations, we collect some of the essential …


Super-Aptamer Bio-Imprinted Hydrogels : An Investigation Into The Optimization And Characterization Of Cross-Linked Polymeric Materials Displaying Macromolecular Amplified Responses, Nicholas Alexander Gariano Jan 2013

Super-Aptamer Bio-Imprinted Hydrogels : An Investigation Into The Optimization And Characterization Of Cross-Linked Polymeric Materials Displaying Macromolecular Amplified Responses, Nicholas Alexander Gariano

LSU Doctoral Dissertations

It is becoming more important to detect ultra-low concentrations of analytes for biomedical, environmental, and national security applications. Equally important is that new methods should be easy to use, inexpensive, portable, and if possible allow detection using the naked eye. Detection of low concentrations of analytes generally cannot be achieved directly, but requires signal amplification by catalysts, macromolecules, metal surfaces or supramolecular aggregates. The rapidly progressing field of macromolecular signal amplification has been advanced using conjugated polymers, chirality in polymers, solvating polymers and polymerization/depolymerization strategies. The use of molecularly imprinted polymers is ideal for creation of novel sensors to meet …


Ecosystem Metabolism In Coastal Plain Streams Of Southeast Louisiana : Environmental And Watershed Effects, Jonathan L. West Jan 2013

Ecosystem Metabolism In Coastal Plain Streams Of Southeast Louisiana : Environmental And Watershed Effects, Jonathan L. West

LSU Doctoral Dissertations

Since its introduction in 1956, the use of open-system, diel dissolved oxygen curves for estimating the components of ecosystem metabolism in the lotic setting have been important in determining the current ecosystem theory of streams, both spatially among multiple systems and longitudinally within the same system, as well as identifying potentially impaired systems, especially when contrasted with streams considered unimpaired. Several factors have been identified as controls on both components of ecosystem metabolism and include light, nutrients, and stable substrates for gross primary production (GPP) and a source of organic matter (OM) for ecosystem respiration (ER). Stream size is important …


Application Of Helmholtz/Hodge Decomposition To Finite Element Methods For Two-Dimensional Maxwell's Equations, Zhe Nan Jan 2013

Application Of Helmholtz/Hodge Decomposition To Finite Element Methods For Two-Dimensional Maxwell's Equations, Zhe Nan

LSU Doctoral Dissertations

In this work we apply the two-dimensional Helmholtz/Hodge decomposition to develop new finite element schemes for two-dimensional Maxwell's equations. We begin with the introduction of Maxwell's equations and a brief survey of finite element methods for Maxwell's equations. Then we review the related fundamentals in Chapter 2. In Chapter 3, we discuss the related vector function spaces and the Helmholtz/Hodge decomposition which are used in Chapter 4 and 5. The new results in this dissertation are presented in Chapter 4 and Chapter 5. In Chapter 4, we propose a new numerical approach for two-dimensional Maxwell's equations that is based on …


Higher Algebraic K-Theory And Tangent Spaces To Chow Groups, Sen Yang Jan 2013

Higher Algebraic K-Theory And Tangent Spaces To Chow Groups, Sen Yang

LSU Doctoral Dissertations

In this work, using higher algebraic K-theory, we provide an answer to the following question asked by Green-Griffiths in [13]: Can one define the Bloch-Gersten-Quillen sequence Gj on infinitesimal neighborhoods Xj so that Ker(G1 &rarr G0)= TG0, Here TG0 should be the Cousin resolution of TKm(OX) and X is any n-dimensional smooth projective variety over a field k, chark=0. Our main results are as follows. The existence of Gj is discussed in chapter 3, following [8] and [18]. The main theorems are theorem5.2.5, theorem 5.2.6 and theorem …


A Multi-Scale Investigation Of Nutrient Dynamics In The Lake Pontchartrain Estuary And Basin, Eric Daniel Roy Jan 2013

A Multi-Scale Investigation Of Nutrient Dynamics In The Lake Pontchartrain Estuary And Basin, Eric Daniel Roy

LSU Doctoral Dissertations

Humans are responsible for global-scale alteration of nitrogen (N) and phosphorus (P) biogeochemical cycles to support food production. Increases in N and P inputs into soils and waste-streams has resulted in excessive nutrient loading to surface waters, including the Mississippi River, leading to eutrophication. Here I investigated N and P dynamics occurring in the Lake Pontchartrain Estuary and Basin. I measured two biogeochemical processes using intact sediment core incubations and quantified their importance in the context of nutrient-rich Mississippi River flood diversions through the Bonnet Carré Spillway. I show that diffusion of nitrate-N into sediments accounts for a substantial magnitude …


Toward The Advancement Of Tetraphosphine Ligand Synthesis For Homogeneous Bimetallic Catalysis, Marc Anthony Peterson Jan 2013

Toward The Advancement Of Tetraphosphine Ligand Synthesis For Homogeneous Bimetallic Catalysis, Marc Anthony Peterson

LSU Doctoral Dissertations

A tetraphosphine ligand rac-et,ph-P4 (Et2PCH2CH2(Ph)PCH2P(Ph)CH2CH2PEt2) is used for the formation of a highly active and regioselective bimetallic hydroformylation catalyst. The proposed active catalytic species in acetone, [Rh2H2(µ-CO)2(rac-et,ph- P4)]2+, is formed in situ under H2/CO pressure. This is one of the most impressive examples of cooperativity in homogeneous catalysis. The fragmentation of this catalyst by CO has been investigated and confirmed by in situ NMR spectroscopic studies. A new tetraphosphine ligand rac-et,ph-P4-Ph (et,ph-P4-Ph = Et2P(o-C6H4)P(Ph)CH2(Ph)P(o-C6H4)PEt2) has been synthesized to combat this fragmentation problem. However, the inability to successfully separate the meso and racemic diastereomers led to the attempted alteration of the …


Polymer Microsystems For The Enrichment Of Circulating Tumor Cells And Their Clinical Demonstration, Joyce W. Kamande Jan 2013

Polymer Microsystems For The Enrichment Of Circulating Tumor Cells And Their Clinical Demonstration, Joyce W. Kamande

LSU Doctoral Dissertations

Cancer research is centered on the discovery of new biomarkers that could unlock the obscurities behind the mechanisms that cause cancer or those associated with its spread (i.e., metastatic disease). Circulating tumor cells (CTCs) have emerged as attractive biomarkers for the management of many cancer-related diseases due primarily to the ease of securing them from a simple blood draw. However, their rarity (~1 CTC per mL of whole blood) makes enrichment analytically challenging. Microfluidic systems are viewed as exquisite platforms for the clinical analysis of CTCs due to their ability to be used in an automated fashion, minimizing sample loss …