Physical Sciences and Mathematics Commons^™

Statistical Analyses To Detect And Refine Genetic Associations With Neurodegenerative Diseases, Yuriko Katsumata

Theses and Dissertations--Epidemiology and Biostatistics

Dementia is a clinical state caused by neurodegeneration and characterized by a loss of function in cognitive domains and behavior. Alzheimer’s disease (AD) is the most common form of dementia. Although the amyloid β (Aβ) protein and hyperphosphorylated tau aggregates in the brain are considered to be the key pathological hallmarks of AD, the exact cause of AD is yet to be identified. In addition, clinical diagnoses of AD can be error prone. Many previous studies have compared the clinical diagnosis of AD against the gold standard of autopsy confirmation and shown substantial AD misdiagnosis Hippocampal sclerosis of aging (HS-Aging) …

Sedimentary Responses To Growth Fault Slip And Clay Shrink And Swell Induced Elevation Variations: East Matagorda Peninsula, Texas, Wei Ji

Theses and Dissertations--Earth and Environmental Sciences

East Matagorda Peninsula in southwestern Texas is characterized geologically by active, regional-scale and near-surface growth faulting. Decimeter scale (up to 0.42 m) vertical displacement was recorded at the study site over a period of four years, not believed to be associated with growth faulting. This research tested the hypotheses that fault slip rates were correlated with sediment accumulation rates, and that the observed vertical displacement was produced by shrink-and-swell clays in near surface sediments. To quantify sediment accumulation rates, a suite of radionuclides (⁷Be, ¹³⁷Cs, and ²¹⁰Pb) were used. To understand the effects of shrink-and-swell clays, …

Kentucky Stratigraphy With Stage Correlations, Stephen F. Greb

Map and Chart--KGS

No abstract provided.

Kentucky Water Resources Research Institute Annual Technical Report Fy 2016, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The 2016 Annual Technical Report for Kentucky consolidates reporting requirements for the Section 104(b) base grant award into a single document that includes: 1) a synopsis of each student research enhancement project that was conducted during the period, 2) citations for related publications, reports, and presentations, 3) a description of information transfer activities, 4) a summary of student support during the period, and 5) notable awards and achievements.

No funds were requested for general program administration activities. However, travel funds were provided to support the participation of the director and associate director in the annual meeting of the National Institutes …

Context-Aware Debugging For Concurrent Programs, Justin Chu

Theses and Dissertations--Computer Science

Concurrency faults are difficult to reproduce and localize because they usually occur under specific inputs and thread interleavings. Most existing fault localization techniques focus on sequential programs but fail to identify faulty memory access patterns across threads, which are usually the root causes of concurrency faults. Moreover, existing techniques for sequential programs cannot be adapted to identify faulty paths in concurrent programs. While concurrency fault localization techniques have been proposed to analyze passing and failing executions obtained from running a set of test cases to identify faulty access patterns, they primarily focus on using statistical analysis. We present a novel …

Fluvial-Lacustrine Processes Shaping The Landforms Of The Distal Paraguay Fluvial Megafan, Edward Limin Lo

Theses and Dissertations--Earth and Environmental Sciences

Tropical wetlands such as the Pantanal help regulate global biogeochemical cycles, but climate change is modifying these environments. Controls on environmental changes can potentially be assessed from ancient, well-dated lacustrine sedimentary records. An integrated field and laboratory approach was undertaken to study the limnogeology of Lake Uberaba in the northern Pantanal, and test whether the lake has preserved a reliable record of environmental change in its strata. This study was designed to understand how the basin accumulates sediment and to assess its sensitivity to hydroclimatic variability. The data showed that modern Lake Uberaba is a highly dynamic, freshwater fluvial-lacustrine basin. …

Evaluation Of Flocculation, Sedimentation, And Filtration For Dewatering Of Scenedesmus Algae, Nicholas A. Rhea, Jack Groppo, Czarena Crofcheck

Biosystems and Agricultural Engineering Faculty Publications

Algae can be used as a feedstock for agricultural fertilizers, livestock and poultry feeds, anaerobic digestion, and biofuel production. For each end product, the requirements for moisture content (or solids content) vary, such that a desirable water removal strategy needs to be adaptable to varying levels of water removal. Flocculation, sedimentation, and filtration were evaluated as possible strategies for thickening and dewatering of algae. The goal of this study was to validate that algae cells treated by such means could be processed by vacuum belt filters and to determine the conditions under which the solids content could be increased to …

A Method For Reflectance Index Wavelength Selection From Moisture-Controlled Soil And Crop Residue Samples, Ali Hamidisepehr, Michael P. Sama, Aaron P. Turner, Ole O. Wendroth

Biosystems and Agricultural Engineering Faculty Publications

Reflectance indices are a method for reducing the dimensionality of spectral measurements used to quantify material properties. Choosing the optimal wavelengths for developing an index based on a given material and property of interest is made difficult by the large number of wavelengths typically available to choose from and the lack of homogeneity when remotely sensing agricultural materials. This study aimed to determine the feasibility of using a low-cost method for sensing the moisture content of background materials in traditional crop remote sensing. Moisture-controlled soil and wheat stalk residue samples were measured at varying heights using a reflectance probe connected …

Initial Microseismic Recordings At The Onset Of Unconventional Hydrocarbon Development In The Rome Trough, Eastern Kentucky, Andrew Holcomb

Theses and Dissertations--Earth and Environmental Sciences

The Cambrian Rogersville Shale is a part of a hydrocarbon system in the Rome Trough of eastern Kentucky and West Virginia that can only be produced unconventionally. In Kentucky, the Rogersville Shale ranges in depth from ~1,800 to ~3,700 m below the surface with the crystalline basement ~1,000 m lower than the formation’s base. Baseline Rome Trough microseismicity data were collected, focusing on wastewater injection wells and recently completed and planned unconventional hydrocarbon test wells in the Rogersville Shale, using thirteen broadband seismic stations installed between June, 2015 and June, 2016 and existing University of Kentucky and central and eastern …

Mixture Modeling With Applications In Alzheimer's Disease, Frank Appiah

Theses and Dissertations--Epidemiology and Biostatistics

This dissertation involves an application of mixture of regression models to 114 individuals who are cognitively intact (from the Alzheimer's Disease and Neuroimaging Initiative-ADNI, data). The correct number of components in the model were estimated with the Singular BIC (SBIC), marking the first time it has been applied to such a problem. The smallest true model in conjunction with the approximation of SBIC was fixed at 1. The resulting posterior probabilities from the model were used to estimate the probability of a person transitioning and risk plots were obtained that could in principle be used by clinicians to identify patients …

Establishment Of Serological Reference Ranges For Elk In Kentucky And Effects Of Quarantine And Translocation On Elk, Aaron M. Hildreth

Theses and Dissertations--Forestry and Natural Resources

Establishing blood serum profiles is important for understanding animal disease ecology and nutrition, the effects of capture and immobilization, and general physiological variation among individuals and populations. Elk (Cervus elaphus nelsoni) have been successfully translocated to several states for reintroduction or population augmentation, including most recently in Kentucky, where over the course of three years (2011-13) wild elk were captured, temporarily quarantined, and subsequently moved to Missouri and Virginia to establish populations in those states. I used this opportunity to collect a variety of biological samples, including blood from which I present and compare serological profiles for a …

Improving The Computational Efficiency In Bayesian Fitting Of Cormack-Jolly-Seber Models With Individual, Continuous, Time-Varying Covariates, Woodrow Burchett

Theses and Dissertations--Statistics

The extension of the CJS model to include individual, continuous, time-varying covariates relies on the estimation of covariate values on occasions on which individuals were not captured. Fitting this model in a Bayesian framework typically involves the implementation of a Markov chain Monte Carlo (MCMC) algorithm, such as a Gibbs sampler, to sample from the posterior distribution. For large data sets with many missing covariate values that must be estimated, this creates a computational issue, as each iteration of the MCMC algorithm requires sampling from the full conditional distributions of each missing covariate value. This dissertation examines two solutions to …

Development Of Diverse Size And Shape Rna Nanoparticles And Investigation Of Their Physicochemical Properties For Optimized Drug Delivery, Daniel L. Jasinski

Theses and Dissertations--Pharmacy

RNA nanotechnology is an emerging field that holds great promise for advancing drug delivery and materials science. Recently, RNA nanoparticles have seen increased use as an in vivo delivery system. RNA was once thought to have little potential for in vivo use due to biological and thermodynamic stability issues. However, these issues have been solved by: (1) Finding of a thermodynamically stable three-way junction (3WJ) motif; (2) Chemical modifications to RNA confer enzymatic stability in vivo; and (3) the finding that RNA nanoparticles exhibit low immunogenicity in vivo.

In vivo biodistribution and pharmacokinetics are affected by the physicochemical …

Hybrid Parallelization Of The Nasa Gemini Electromagnetic Modeling Tool, Buxton L. Johnson Sr.

Theses and Dissertations--Electrical and Computer Engineering

Understanding, predicting, and controlling electromagnetic field interactions on and between complex RF platforms requires high fidelity computational electromagnetic (CEM) simulation. The primary CEM tool within NASA is GEMINI, an integral equation based method-of-moments (MoM) code for frequency domain electromagnetic modeling. However, GEMINI is currently limited in the size and complexity of problems that can be effectively handled. To extend GEMINI’S CEM capabilities beyond those currently available, primary research is devoted to integrating the MFDlib library developed at the University of Kentucky with GEMINI for efficient filling, factorization, and solution of large electromagnetic problems formulated using integral equation methods. A secondary …

Novel Computational Methods For Censored Data And Regression, Yifan Yang

Theses and Dissertations--Statistics

This dissertation can be divided into three topics. In the first topic, we derived a recursive algorithm for the constrained Kaplan-Meier estimator, which promotes the computation speed up to fifty times compared to the current method that uses EM algorithm. We also showed how this leads to the vast improvement of empirical likelihood analysis with right censored data. After a brief review of regularized regressions, we investigated the computational problems in the parametric/non-parametric hybrid accelerated failure time models and its regularization in a high dimensional setting. We also illustrated that, when the number of pieces increases, the discussed models are …

Informational Index And Its Applications In High Dimensional Data, Qingcong Yuan

Theses and Dissertations--Statistics

We introduce a new class of measures for testing independence between two random vectors, which uses expected difference of conditional and marginal characteristic functions. By choosing a particular weight function in the class, we propose a new index for measuring independence and study its property. Two empirical versions are developed, their properties, asymptotics, connection with existing measures and applications are discussed. Implementation and Monte Carlo results are also presented.

We propose a two-stage sufficient variable selections method based on the new index to deal with large p small n data. The method does not require model specification and especially focuses …

Inference Using Bhattacharyya Distance To Model Interaction Effects When The Number Of Predictors Far Exceeds The Sample Size, Sarah A. Janse

Theses and Dissertations--Statistics

In recent years, statistical analyses, algorithms, and modeling of big data have been constrained due to computational complexity. Further, the added complexity of relationships among response and explanatory variables, such as higher-order interaction effects, make identifying predictors using standard statistical techniques difficult. These difficulties are only exacerbated in the case of small sample sizes in some studies. Recent analyses have targeted the identification of interaction effects in big data, but the development of methods to identify higher-order interaction effects has been limited by computational concerns. One recently studied method is the Feasible Solutions Algorithm (FSA), a fast, flexible method that …

Acenes, Heteroacenes And Analogous Molecules For Organic Photovoltaic And Field Effect Transistor Applications, Devin B. Granger

Theses and Dissertations--Chemistry

Polycyclic aromatic hydrocarbons composed of benzenoid rings fused in a linear fashion comprise the class of compounds known as acenes. The structures containing three to six ring fusions are brightly colored and possess band gaps and charge transport efficiencies sufficient for semiconductor applications. These molecules have been investigated throughout the past several decades to assess their optoelectronic properties. The absorption, emission and charge transport properties of this series of molecules has been studied extensively to elucidate structure-property relationships. A wide variety of analogous molecules, incorporating heterocycles in place of benzenoid rings, demonstrate similar properties to the parent compounds and have …

Stratigraphic, Geochemical, And Geochronological Analysis Of The Wolfcamp-D Interval, Midland Basin, Texas, Zachary S. Perlman

Theses and Dissertations--Earth and Environmental Sciences

Subsurface data derived from ~388 ft of drill core from Martin County (TX) were used to understand the depositional setting of the Wolfcamp-D, a petroleum producing interval in the Midland Basin. Elemental geochemistry collected via x-ray fluorescence revealed a highly variable depositional history marked by the deposition of diverse siliciclastic and carbonate lithofacies. Integration of multiple datasets resulted in the interpretation of nine lithofacies, whose deposition appears cyclical. Correlations between molybdenum and total organic carbon indicate slow recharge of bottom waters and anoxic/euxinicconditions within the basin. The presence of phosphatic nodules coinciding with siliceous black mudrocks suggested high levels of …

The Oligocene West Elk Breccia: Evidence For Massive Volcanic Debris Avalanches In The Eastern Gunnison River Valley, West-Central Colorado, U.S.A., Patrick J. Whalen

Theses and Dissertations--Earth and Environmental Sciences

The West Elk Breccia has been studied since the late 1800’s with many interpretations regarding its origin. One unrecognized possibility is that parts of it are debris-avalanche deposits. This study has recognized evidence for this interpretation at three scales: volcano scale, outcrop scale, and intra-outcrop scale. At the volcano scale, a scarp in the old volcano reveals underlying Mesozoic bedrock, suggesting sector collapse. At the outcrop scale, megablocks of the original edifice, up to hundreds of meters in length, have atypical orientations and are surrounded by a gravel matrix. At the intra-outcrop scale, jigsaw-fit fracturing and rip-up clasts are common …

Potential Field Modeling Across The Neodymium Line Defining The Paleoproterozoic-Mesoproterozoic Boundary Of The Southeastern Margin Of Laurentia, Rachel Lauren Durham

Theses and Dissertations--Earth and Environmental Sciences

A zone of high magnetization along the SE margin of Paleoproterozoic Laurentia in the United States is indicated by magnetic anomaly data. The SE edge corresponds to the geochemical Neodymium mantle derivation model age (T_DM) boundary and the entire anomaly overlies the Paleoproterozoic Mazatzal Province. Two-dimensional gravity and magnetic models across the Nd boundary are created with Moho constrained from receiver functions with gravity, sedimentary thickness and the base of the crustal magnetization. Upper crustal magnetization does not show strong variation across this boundary and much of the strong magnetization appears to lie in the middle crust. Using …

Tuning The Effective Electron Correlation In Iridate Systems Featuring Strong Spin-Orbit Interaction, John H. Gruenewald

Theses and Dissertations--Physics and Astronomy

The 5d transition metal oxides have drawn substantial interest for predictions of being suitable candidates for hosting exotic electronic and magnetic states, including unconventional superconductors, magnetic skyrmions, topological insulators, and Weyl semimetals. In addition to the electron-electron correlation notable in high-temperature 3d transition metal superconductors, the 5d oxides contain a large spin-orbit interaction term in their ground state, which is largely responsible for the intricate phase diagram of these materials. Iridates, or compounds containing 5d iridium bonded with oxygen, are of particular interest for their spin-orbit split J_eff = 1/2 state, which is partially filled without the presence …

Interpretation Of The Depositional Environments And Soft-Sediment Deformation In The Upper Tanglewood Member (Upper Ordovician) Of The Lexington Limestone, Central Kentucky, U.S.A., Dibya R. Koirala

Theses and Dissertations--Earth and Environmental Sciences

The upper Tanglewood Member is the final member of the Lexington Limestone and is well-known for its soft-sediment deformation. This study has confirmed the carbonate-shoal-complex origin of the unit, and detailed study shows that its development took place during five small-scale, sequence-like, fining-upward cycles related to eustasy and tectonics. Four lithofacies are represented in the unit. Facies analysis of each cycle shows that the thickest and coarsest part of each cycle corresponds to previously uplifted basement-fault blocks; the occurrence of thick, coarse facies on the same fault blocks suggests that the blocks continued to experience uplift due to Taconian far-field …

Examining The Activities, Effectiveness, And Contribution Of Local Health Departments Using A National Longitudinal Survey Of Public Health Systems, Lava R. Timsina

Theses and Dissertations--Epidemiology and Biostatistics

Health services research and public health services and systems research in the past have contributed to a strong foundation of evidence-based progress in organizing, financing, and delivering medical care and public health strategies across the United States. The purpose of this dissertation was to examine disparities in public health systems and in the delivery of population health services in communities served by these systems using nationally representative data from the National Longitudinal Survey of Local Public Health Systems (1998, 2006, 2012, and 2014).

Data from the 1998 cohort of 497 local health jurisdictions serving at least 100,000 residents, and from …

Towards The Total Synthesis Of 7-Epi-Clusianone, Shubhankar Dutta

Theses and Dissertations--Chemistry

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are plant- (Guttiferae) derived natural products. They have fascinating bicyclo[3.3.1]nonane-2,4,9-trione or [3.2.1]nonane-2,4,8-trione cores decorated with prenyl or geranyl groups. More than 200 PPAPs have been isolated, but only a few of them have been synthesized, although most of the synthesized PPAPs are of type A and have an exo substituent at C (7). Here, we are trying to make a type B 7-endo PPAP, 7-epi-clusianone. The synthetic plan involves an alkynylation–aldol strategy to construct the bicyclic core. Having established the bicyclic core, the synthesis presents a new challenge: the oxidation of a very hindered …

Some Take-Away Games On Discrete Structures, Kristen M. Barnard

Theses and Dissertations--Mathematics

The game of Subset Take-Away is an impartial combinatorial game posed by David Gale in 1974. The game can be played on various discrete structures, including but not limited to graphs, hypergraphs, polygonal complexes, and partially ordered sets. While a universal winning strategy has yet to be found, results have been found in certain cases. In 2003 R. Riehemann focused on Subset Take-Away on bipartite graphs and produced a complete game analysis by studying nim-values. In this work, we extend the notion of Take-Away on a bipartite graph to Take-Away on particular hypergraphs, namely oddly-uniform hypergraphs and evenly-uniform hypergraphs whose …

Synthesis And Development Of Zwitterionic Pei (Zpei) For Optimized Delivery Of Nucleic Acids, Joseph Raleigh Duke Iii

Theses and Dissertations--Chemistry

Gene therapy holds promise for the treatment a wide range of diseases ranging from cystic fibrosis to cardiovascular disease to cancer. The need for safe and efficient gene delivery methods remains the primary barrier to human gene therapy. Non-viral vector materials, including polymers, can be designed to be biocompatible and non-immunogenic, but lack the efficiency to be clinically relevant. Gene therapy awaits the development of new materials that are both safe and efficient. Here, we have synthesized a series of modified zwitterionic polymers based on the common transfecting agent polyethylenimine (PEI). Using a variety of biochemical and biophysical methods we …

Characterization And Application Of Hybrid Nanostructures For Enhanced Biological Imaging Using Fluorescence Microscopy Techniques, William E. Martin

Theses and Dissertations--Chemistry

Fluorescence microscopy is a powerful tool for interpreting the structure and function of biomolecules, and their interactions with one another. Understanding fundamental biological mechanisms is important to the development of improved treatments for a variety of diseases. Fluorescent tags are used to track the motion and longevity of such events, with the ability to monitor several biomolecules at once. Currently, many of these studies are conducted using bulk measurements, or several biological events at the same time, because the added light from several emitters can more easily overcome the high fluorescence background inherent to biological systems. Although important in their …

Charge Transport In Electronic-Ionic Composites, Long Zhang

Theses and Dissertations--Chemical and Materials Engineering

The goal of this thesis is to generate fundamental understandings of charge transport behaviors of composites consisting of garnet structured Al substituted Li₇La₃Zr₂O₁₂ (LLZO) electrolyte and LiCoO₂ electrode. In order to take full advantage of all-solid-state batteries, bulk type composite electrodes should be introduced to increase energy and power density. However, the charge utilization of bulk type composite electrodes is quite low. Understanding ionic conduction behavior is, therefore, important for improving the performance of all-solid-state batteries, because ion conduction within solids depends on effective pathways. Electronic conductivity can be easily compensated by …

Energetic Effects Of Hole Transporting Materials On The Performance Of Organometal Halide Perovskite Photovoltaic Cells, So Min Park

Theses and Dissertations--Chemistry

Efficient, inexpensive, lightweight and flexible solar cells are desired to help meet the world’s growing energy needs. Organometal halide perovskite (OMHP) photovoltaic (PV) cells have shown dramatic increases in solar cell efficiencies increase over the last 5 years. OMHP PV cells have attracted significant attention due to their broad absorption spectra, high electron and hole mobility, and low production cost. The interface between hole transporting layer (HTL) and perovskite thin films have a significant influence on charge transfer and overall solar cell performance. 2,2’,7,7’-tetrakis(N,N-di-p-methoxyphenylamine)9,9’-spirobifluorene (Spiro-OMeTAD) is a small molecule largely used as HTL in perovskite solar cells. However, this material …