Physical Sciences and Mathematics Commons^™

Design And Synthesis Of Cpg-Lytic Peptide Conjugate, Brachytherapy Beads And A Combinatorial Library Of Primary Amines Used As Potential Therapeutics In The Treatment Of Cancers, Josanne-Dee Woodroffe

USF Tampa Graduate Theses and Dissertations

Cancer remains one of the most feared diseases affecting the modern world. Second to heart disease, it is the largest cause of deaths, affecting one in three persons. Cancer cells are formed when normal, healthy cells become damage, losing their normal regulatory mechanism that control cell growth. There are many different types and progression of these cancer cells that determine the type of treatment a patient receives. The primary focus of this dissertation is to propose three studies of anticancer agents. In Chapter one, a CpG-lytic peptide conjugate was designed to target receptors on the cell membrane to concentrate the …

Generalized D-Kaup-Newell Integrable Systems And Their Integrable Couplings And Darboux Transformations, Morgan Ashley Mcanally

USF Tampa Graduate Theses and Dissertations

We present a new spectral problem, a generalization of the D-Kaup-Newell spectral problem, associated with the Lie algebra sl(2,R). Zero curvature equations furnish the soliton hierarchy. The trace identity produces the Hamiltonian structure for the hierarchy. Lastly, a reduction of the spectral problem is shown to have a different soliton hierarchy with a bi-Hamiltonian structure. The first major motivation of this dissertation is to present spectral problems that generate two soliton hierarchies with infinitely many commuting conservation laws and high-order symmetries, i.e., they are Liouville integrable.

We use the soliton hierarchies and a non-seimisimple matrix loop Lie algebra in order …

Design, Synthesis, Applications Of Polymers And Dendrimers, Alekhya Nimmagadda

USF Tampa Graduate Theses and Dissertations

WHO has reported that antibiotic resistance is the third major cause of human death all over the globe. Recent study, has focused on the development of new antibacterial resistance drugs. Herein, we tried to synthesis a series of polymers that can mimic the HDPs. HDPs can target the bacterial cell membrane and they have less chances to develop bacterial resistance. We synthesized the amphiphilic polycarbonates that are highly selective to Gram-positive bacteria, including multidrug resistant pathogens. The membrane disruption activity of these polymers was proved by fluorescence and TEM studies and the drug resistance study showed that the polymers don’t …

Manipulating Electromagnetic Waves With Enhanced Functionalities Using Nonlinear And Chiral Metamaterials, Sinhara Rishi Malinda Silva

USF Tampa Graduate Theses and Dissertations

Metamaterials are artificial structures, which periodically arranged to exhibit fascinating electromagnetic properties, not existing in nature. A great deal of research in the field of metamaterial was conducted in a linear regime, where the electromagnetic responses are independent of the external electric or magnetic fields. Unfortunately, in linear regime the desired properties of metamaterials have only been achieved within a narrow bandwidth, around a fixed frequency. Therefore, nonlinearity is introduced into metamaterials by merging meta-atoms with well-known nonlinear materials. Nonlinear metamaterials are exploited in this dissertation to introduce and develop applications in microwave frequency with broadband responses. The nonlinearity was …

Sol-Gel Niobia-Based Sorbents For The Enrichment Of Organophosphorus Compounds By Capillary Microextraction Online Coupled To High Performance Liquid Chromatography, Sheshanka Kesani

USF Tampa Graduate Theses and Dissertations

Sample preparation is a key step in chemical analysis, and includes isolation of target analytes, removal of interferences, preconcentration, and/or modification of target analytes (if needed). Sample preparation is also the most time-consuming and error-prone step in the whole analytical process. Traditional sample preparation techniques involve hazardous solvents. Considering the environmental and health safety, it is desirable to reduce or eliminate organic solvents in sample preparation. Solid phase microextraction (SPME) was introduced as a solvent free sample preparation technique. Capillary microextraction (CME) is one of the formats of SPME that can be easily coupled to high performance liquid chromatography (HPLC). …

Application Of Metamaterials To Rf Energy Harvesting And Infrared Photodetection, Clayton M. Fowler

USF Tampa Graduate Theses and Dissertations

Techniques for adapting metamaterials for the improvement of RF energy harvesting and infrared photodetection are demonstrated using experimental and computer simulation methods. Two methods for RF energy harvesting are experimentally demonstrated and supported by computer simulation. In the first method, a metamaterial perfect absorber (MPA) is made into a rectenna capable of harvesting RF energy and delivering power to a load by soldering Schottky diodes onto connected split ring resonator (SRR) structures composing the planar metasurface of the perfect absorber. The metamaterial rectenna is accompanied by a ground plane placed parallel to it, which forms a Fabry-Perot cavity between the …

Surfaces And Epitaxial Films Of Corundum-Structured Mixed Metal Oxides., Alan Richard Kramer

USF Tampa Graduate Theses and Dissertations

Throughout the last half century of materials science, significant motivations came from, and still do, the industrial applications of these materials. Whether it is electronic, thermal, tribological or chemical in nature, the study of metals, semiconductors and insulators eventually reveals that the surface plays a significant part in the properties of these materials. Understanding metal terminations reveals often that an oxide is the stable state of the metallic surface in an ambient atmosphere and the ability to predict and control these oxides has led to significant strides forward in not just the metallic bulk but the oxide as well.

Here …

Studies Of Polyacrylate Based Nanoparticle Emulsions, Faeez Mahzamani

USF Tampa Graduate Theses and Dissertations

Self-stabilizing polyacrylate nanoparticle emulsions were previously investigated in the Turos laboratory, and provided a new model for delivering antibiotics via encapsulation or covalent binding of the desired bioactive compound within the polymer nanoparticles. The method used the in water, free radical emulsion polymerization of butyl acrylate/styrene mixture to form the polymer chain stabilized with a surfactant. Current research in this dissertation further explores the versatility of related nanoparticle emulsion systems. Chapter 2 provides an overview of the loading of certain therapeutic drugs, such as 5-aminosalicylic acid and derivatives thereof, for the treatment of irritable bowel syndrome. Chapter 3 explores homo-polymer …

Experimental Study Of High-Temperature Range Latent Heat Thermal Energy Storage, Chatura Wickramaratne

USF Tampa Graduate Theses and Dissertations

Among all thermal energy storage (TES) systems, latent heat thermal energy storage (LHTES) attracts high interest due to its high energy density and high exergetic efficiency. Due to the high enthalpy of fusion and low cost, inorganic salts are becoming popular as phase change materials and are used as the storage media in LHTES systems. The main drawbacks for the inorganic salts are their low thermal conductivity and high reactivity above 500°C. Therefore, designing a cost-effective containment at these conditions with longevity is a challenge. Macro-encapsulation of the PCM is one way to solve both the PCM containment issue as …

Growth, Characterization, And Function Of Ferroelectric, Ferromagnetic Thin Films And Their Heterostructures, Mahesh Hordagoda

USF Tampa Graduate Theses and Dissertations

With recent trends in miniaturization in the electronics sector, ferroelectrics have gained popularity due to their applications in non-volatile RAM. Taking one step further researchers are now exploring multiferroic devices that overcome the drawbacks of ferroelectric (FE) and ferromagnetic (FM) RAM’s while retaining the advantages of both. The work presented in this dissertation focuses on the growth of FE and FM thin film structures. The primary goals of this work include, (1) optimization of the parameters in the pulsed laser deposition (PLD) of FE and FM films and their heterostructures, (2) development of a structure-property relation that leads to enhancements …

Improving Service Level Of Free-Floating Bike Sharing Systems, Aritra Pal

USF Tampa Graduate Theses and Dissertations

Bike Sharing is a sustainable mode of urban mobility, not only for regular commuters but also for casual users and tourists. Free-floating bike sharing (FFBS) is an innovative bike sharing model, which saves on start-up cost, prevents bike theft, and offers significant opportunities for smart management by tracking bikes in real-time with built-in GPS. Efficient management of a FFBS requires: 1) analyzing its mobility patterns and spatio-temporal imbalance of supply and demand of bikes, 2) developing strategies to mitigate such imbalances, and 3) understanding the causes of a bike getting damaged and developing strategies to minimize them. All of these …

Statistical Analysis And Modeling Of Stomach Cancer Data, Chao Gao

USF Tampa Graduate Theses and Dissertations

The objective of this study is to address some important questions associated with stomach cancer patients using the data from the Surveillance Epidemiology and End Results (SEER) program of the United States. To better understand the behavior of stomach cancer, we first perform parametric analysis for each patient group (white male, white female, African American male, African American female, other male and female) to identify the probability distribution function which can best characterize the behavior of the malignant stomach tumor sizes. We evaluate the effects of patients’ age, gender and race on the malignant stomach tumor sizes by developing quantile …

Multi-Step Tokenization Of Automated Clearing House Payment Transactions, Privin Alexander

USF Tampa Graduate Theses and Dissertations

Since its beginnings in 1974, the Automated Clearing House (ACH) network has grown into one of the largest, safest, and most efficient payment systems in the world. An ACH transaction is an electronic funds transfer between bank accounts using a batch processing system.

Currently, the ACH Network moves almost $43 trillion and 25 billion electronic financial transactions each year. With the increasing movement toward an electronic, interconnected and mobile infrastructure, it is critical that electronic payments work safely and efficiently for all users. ACH transactions carry sensitive data, such as a consumer's name, account number, tax identification number, account holder …

On Extending Hansel's Theorem To Hypergraphs, Gregory Sutton Churchill

USF Tampa Graduate Theses and Dissertations

For integers $n \geq k \geq 2$, let $V$ be an $n$-element set, and let $\binom{V}{k}$ denote the family of all $k$-element subsets of $V$. For disjoint subsets $A, B \subseteq V$, we say that $\{A, B\}$ {\it covers} an element $K \in \binom{V}{k}$ if $K \subseteq A \dot\cup B$ and $K \cap A \neq \emptyset \neq K \cap B$. We say that a collection $\cC$ of such pairs {\it covers} $\binom{V}{k}$ if every $K \in \binom{V}{k}$ is covered by at least one $\{A, B\} \in \cC$. When $k=2$, covers $\cC$ of $\binom{V}{2}$ were introduced in~1961 by R\'enyi~\cite{Renyi}, where they …

Geothermal Flux And Phreatic Speleogenesis In Gypsum, Halite, And Quartzite Rocks, Giovanni Badino

International Journal of Speleology

The first layers of rock underground are in thermal contact with the external atmosphere mainly through infiltrating meteoric water. This relatively cool zone absorbs rising geothermal energy, which heats the water. If the aquifer consists of gypsum, halite or quartzite, the water at those depths is usually salt-saturated, so the increase in temperature renders the water aggressive again. This in turn leads to rock dissolution and formation of phreatic conduits. This way, the geothermal flow creates caves that do not necessarily reach the surface. This paper analyzes the speed of the excavation, which, in different types of rocks, depends only …

The Ecology Of Antibiotic Resistance: Sources And Persistence Of Vancomycin-Resistant Enterococci And Antibiotic Resistant Genes In Aquatic Environments, Suzanne M. Young

USF Tampa Graduate Theses and Dissertations

The growing crisis of antibiotic resistance is a major threat to ecosystems and human health. Infections caused by known and emerging antibiotic resistant pathogens are on the rise globally, with approximately 700,000 deaths per year caused by antibiotic resistant bacteria (1). In the United States, infections from antibiotic resistant bacteria cause more than 2 million illnesses and 23,000 deaths (2). Antibiotic resistant bacteria and antibiotic resistance genes are released into aquatic ecosystems through hospital waste, residential sewer lines and animal agricultural waste streams. Animal agriculture accounts for approximately 70% of antibiotic use in the United States (3). In agricultural ecosystems, …

Evaluating Satellite And Supercomputing Technologies For Improved Coastal Ecosystem Assessments, Matthew James Mccarthy

USF Tampa Graduate Theses and Dissertations

Water quality and wetlands represent two vital elements of a healthy coastal ecosystem. Both experienced substantial declines in the U.S. during the 20^th century. Overall coastal wetland cover decreased over 50% in the 20^th century due to coastal development and water pollution. Management and legislative efforts have successfully addressed some of the problems and threats, but recent research indicates that the diffuse impacts of climate change and non-point source pollution may be the primary drivers of current and future water-quality and wetland stress. In order to respond to these pervasive threats, traditional management approaches need to adopt modern …

Constructing A Clinical Research Data Management System, Michael C. Quintero

USF Tampa Graduate Theses and Dissertations

Clinical study data is usually collected without knowing what kind of data is going to be collected in advance. In addition, all of the possible data points that can apply to a patient in any given clinical study is almost always a superset of the data points that are actually recorded for a given patient. As a result of this, clinical data resembles a set of sparse data with an evolving data schema. To help researchers at the Moffitt Cancer Center better manage clinical data, a tool was developed called GURU that uses the Entity Attribute Value model to handle …

The Ability Of The U.S. Army Heat Strain Decision Aid (Hsda) To Predict A Limiting Heat Stress Exposure, Katelynn E. Glisson

USF Tampa Graduate Theses and Dissertations

Working below the threshold limit value (TLV) for heat stress is not always feasible. When work above the TLV is required, an exposure method is needed that can help protect workers from time limiting heat stress by calculating a safe time for work at certain heat exposures. The purpose of this paper is to determine whether the USARIEM Heat Strain Decision Aid (HSDA) can be used to predict time limiting heat stress exposure in an occupational setting.

Twelve adults participated in time limited heat stress exposures. A range of heat stress conditions were designed using three different ensembles and five …

Strong-Dism: A First Attempt To A Dynamically Typed Assembly Language (D-Tal), Ivory Hernandez

USF Tampa Graduate Theses and Dissertations

Dynamically Typed Assembly Language (D-TAL) is not only a lightweight and effective solution to the gap generated by the drop in security produced by the translation of high-level language instructions to low-level language instructions, but it considerably eases up the burden generated by the level of complexity required to implement typed assembly languages statically. Although there are tradeoffs between the static and dynamic approaches, focusing on a dynamic approach leads to simpler, easier to reason about, and more feasible ways to understand deployment of types over monomorphically-typed or untyped intermediate languages. On this occasion, DISM, a simple but powerful and …

Predicting Hand Surface Area From A Two-Dimensional Hand Tracing, Myles O'Mara

USF Tampa Graduate Theses and Dissertations

Recent occupational health studies have focused on dermal exposure at the hands, but have been unable to accurately express dose without knowing the HSA. There is no standard method to calculate HSA, though some researchers have derived HSA formulas based on dimensions from a Taiwanese population. This research paper describes a shortcut method to estimate the hand surface area (HSA) of a human hand from a two-dimensional hand tracing, and repeated a Taiwanese HSA study in order to explore the viability of its HSA formula in an American university population. A sample of nine adult men and nine adult women, …

Perceptions Affecting Tree Valuation: An Analysis Of Recently Sold And Leased Properties In Tampa, Florida, Cody R. Winter

USF Tampa Graduate Theses and Dissertations

The urban forest is a structure that is fluid in both species composition and how it is integrated in our cities and suburban areas. Much like the fluidity in its structure, the urban forest provides ecosystem services and disservices in many forms. These services and disservices can often come in the form of temperature regulation, lower crime rates, and even higher property values. The latter, which is associated with the economic value of trees, is a part of the hedonic pricing literature which suggests that there is a disparity in the value associated with trees to house prices. With the …

Packaging Of Genetic Material By Gene Transfer Agents (Gtas) Produced By Marine Roseobacter Species And Their Effect On Stimulating Bacterial Growth, Shahd Bader Aljandal

USF Tampa Graduate Theses and Dissertations

Horizontal gene transfer is one of the most important mechanisms for prokaryotic genome innovation and evolution. Gene Transfer Agents (GTAs) are phage-like particles that package small fragments of the genome of a GTA-producing bacterial cell. GTA chromosomal gene clusters usually contain 15-conserved open reading frames (ORFs) and are present in most of the sequenced marine alpha-proteobacteria genomes. Some marine strains have been shown to produce GTA particles that were biologically active in marine environment.

GTA particles range in size, morphology and the amount of host DNA they package. To date, the characteristics of GTAs are largely based on observations of …

The Role Of High-Elevation Headwater Runoff In Streamflow Generation And Water Supply In The Northern Andes, Colombia, Laura Lotero Lozano

USF Tampa Graduate Theses and Dissertations

Water security requires that sufficient quantities of water be available at critical times. This is particularly challenging for high-intensity urban and agricultural settings. In underdeveloped nations, streamflow is commonly the preferred water source, as it is readily available and delivered cost-free to users. Yet, the sources of these critical streamflows are often unknown. This issue is salient in the Northern Andes, where basic knowledge of controlling factors for the quantity, quality, and timing of runoff is lacking. High-elevation headwaters are the primary catchment areas in the Northern Andes, but the extent of water providing to municipalities in the Northern Andes …

Reef Fish Biodiversity In The Florida Keys National Marine Sanctuary, Megan E. Hepner

USF Tampa Graduate Theses and Dissertations

The biological diversity of reef-fish in the Florida Keys National Marine Sanctuary (FKNMS) from 1999 – 2016 was evaluated in terms of abundance, biomass, species richness, evenness, Shannon diversity, Simpson diversity, and functional diversity, using observations collected by multiple agencies and institutions under the Reef Visual Census (RVC) program. To compare the different diversity indices species richness, Shannon diversity, Simpson diversity, and functional diversity were converted into effective number of species. I examined the seven indices by no-take marine zones, in seven benthic habitat strata, and across the three-distinct geographic subregions in the Florida Keys domain (Upper, Middle, and Lower …

A Geochemical And Petrological Analysis Of The San Rafael Volcanic Field, Utah, Danielle Koebli

USF Tampa Graduate Theses and Dissertations

The San Rafael Volcanic Field, Utah, is a 4.6 Ma extinct monogenetic field that is found in the Northern Transition Zone of the Colorado Plateau. The field has been eroded, leaving the dikes, conduits, and sills visible. Within the sills we see evidences of immiscibility in the form of an intermediate syenite (~50 wt% SiO₂) enclosed in a mafic shonkinite (~48 wt % SiO₂). Field relations indicate that sills were formed due to single events (Richardson et al., 2015), which makes in-situ differentiation the process at the origin of both rock types. Geochemical data supports differentiation …

Climatic Control On Icelandic Volcanic Activity During The Mid-Holocene, Graeme T. Swindles, Elizabeth J. Watson, Ivan P. Savov, Ian T. Lawson, Anja Schmidt, Andrew Hooper, Claire L. Cooper, Charles B. Connor, Manuel Gloor, Jonathan L. Carrivick

School of Geosciences Faculty and Staff Publications

Human-induced climate change is causing rapid melting of ice in many volcanically active regions. Over glacial-interglacial time scales changes in surface loading exerted by large variations in glacier size affect the rates of volcanic activity. Numerical models suggest that smaller changes in ice volume over shorter time scales may also influence rates of mantle melt generation. However, this effect has not been verified in the geological record. Furthermore, the time lag between climatic forcing and a resultant change in the frequency of volcanic eruptions is unknown. We present empirical evidence that the frequency of volcanic eruptions in Iceland was affected …

Thermodynamic And Kinetic Aspects Of Hen Egg White Lysozyme Amyloid Assembly, Tatiana Miti

USF Tampa Graduate Theses and Dissertations

Deposition of protein fibers with a characteristic cross-β sheet structure is the molecular marker associated with human disorders ranging from Alzheimer's disease to type II diabetes and spongiform encephalopathy. Given the large number of non-disease related proteins and peptides that have been shown to form amyloid fibrils in vitro, it has been suggested that amyloid fibril formation represents a generic protein phase transition. In the last two decades it has become clear that the same protein/peptide can assemble into distinct morphologically and structurally amyloid aggregates depending on the solution conditions. Moreover, recent studies have shown that the early stage, oligomeric …

Genetic Identification And Population Characteristics Of Deep-Sea Cephalopod Species In The Gulf Of Mexico And Northwestern Atlantic Ocean, Amanda Sosnowski

USF Tampa Graduate Theses and Dissertations

Nearly all deep-sea cephalopod life history studies have been completed by examination of specimens collected in the wild. Much of this work is like piecing together a puzzle; knowledge of the life history of many species remains fragmented and hence, taxonomically and phylogenetically confused. Molecular approaches and sequencing technologies are powerful tools for deciphering wild-type cephalopod life history and population dynamics. Use of molecular markers offers additional certainty for identifying specimens damaged during deep-sea collections and can elucidate often cryptic, intra- and interspecific diversity. The research presented in this study assessed broad genetic patterns of biodiversity in deep-sea cephalopods from …

Darwin Day In Deep Time: Promoting Evolutionary Science Through Paleontology, Sarah L. Sheffield, Jennifer E. Bauer

School of Geosciences Faculty and Staff Publications

Charles Darwin’s birthday, February 12th, is an international celebration coined Darwin Day. During the week of his birthday, universities, museums, and science-oriented organizations worldwide host events that celebrate Darwin’s scientific achievements in evolutionary biology. The University of Tennessee, Knoxville (UT) has one of the longest running celebrations in the nation, with 2016 marking the 19th year. For 2016, the theme for our weeklong series of events was paleontology, chosen to celebrate new research in the field and to highlight the specific misconceptions of evolution within the context of geologic time. We provide insight into the workings of one of our …