Physical Sciences and Mathematics Commons^™

Bayesian Approach On Short Time-Course Data Of Protein Phosphorylation, Casual Inference For Ordinal Outcome And Causal Analysis Of Dietary And Physical Activity In T2dm Using Nhanes Data., You Wu

Electronic Theses and Dissertations

This dissertation contains three different projects in proteomics and causal inferences. In the first project, I apply a Bayesian hierarchical model to assess the stability of phosphorylated proteins under short-time cold ischemia. This study provides inference on the stability of these phosphorylated proteins, which is valuable when using these proteins as biomarkers for a disease. in the second project, I perform a comparative study of different confounding-adjusted to estimate the treatment effect when the outcome variable is ordinal using observational data. The adjusted U-statistics method is compared with other methods such as ordinal logistic regression, propensity score based stratification and …

Transient Absorption Studies Of Cdse Nanocluster Passivated With Phenyldithiocarbamate Ligands., Yizhou Xie

Electronic Theses and Dissertations

Semiconductor nanocluster (SCNC) research is a rapidly growing field driven by the promising fact that properties of such materials can be tailored by modifying their size, shape, and structure. Combination of nanocluster and organic ligands provides even wider possibilities of design and development of effective and task-specific nanostructures. Understanding of and, eventually, control of energetics, interfacial interaction, and photoinduced processes in such highly heterogeneous structures is critical to invention of novel materials including those in photovoltaic devices. In the newly established Ultrafast Laser Facility (ULF), transient absorption pump-probe spectroscopy (TAPPS) has been employed to investigate the electron transfer (ET) and …

A Cross-Sectional Exploration Of Household Financial Reactions And Homebuyer Awareness Of Registered Sex Offenders In A Rural, Suburban, And Urban County., John Charles Navarro

Electronic Theses and Dissertations

As stigmatized persons, registered sex offenders betoken instability in communities. Depressed home sale values are associated with the presence of registered sex offenders even though the public is largely unaware of the presence of registered sex offenders. Using a spatial multilevel approach, the current study examines the role registered sex offenders influence sale values of homes sold in 2015 for three U.S. counties (rural, suburban, and urban) located in Illinois and Kentucky within the social disorganization framework. Homebuyers were surveyed to examine whether awareness of local registered sex offenders and the homebuyer’s community type operate as moderators between home selling …

Fabrication And Functionalization Of Carbon Nanocages For Use In Cfx Batteries., Nathan Smith

Electronic Theses and Dissertations

A relatively inexpensive method for obtaining high quality lithium-CF_x batteries is reported. Nickel acetate and citric acid are used to synthesize a precursor which is then annealed and subsequently etched to fabricate highly uniform 3 nm radius pristine CNCs. These CNCs are then functionalized with fluorine using an RF plasma system. The resulting fluorinated CNCs are then combined with a carbon binder and pressed onto a stainless steel mesh to form a CF_x cathode. This cathode is then tested in a coin cell primary battery with a lithium anode. Results indicate that a specific capacity of 660 mAh/g …

Estimation Of The Three Key Parameters And The Lead Time Distribution In Lung Cancer Screening., Ruiqi Liu

Electronic Theses and Dissertations

This dissertation contains three research projects on cancer screening probability modeling. Cancer screening is the primary technique for early detection. The goal of screening is to catch the disease early before clinical symptoms appear. In these projects, the three key parameters and lead time distribution were estimated to provide a statistical point of view on the effectiveness of cancer screening programs. In the first project, cancer screening probability model was used to analyze the computed tomography (CT) scan group in the National Lung Screening Trial (NLST) data. Three key parameters were estimated using Bayesian approach and Markov Chain Monte Carlo …

Uses Of The Hypergeometric Distribution For Determining Survival Or Complete Representation Of Subpopulations In Sequential Sampling, Brooke Busbee

Electronic Theses and Dissertations

This thesis will explore the hypergeometric probability distribution by looking at many different aspects of the distribution. These include, and are not limited to: history and origin, derivation and elementary applications, properties, relationships to other probability models, kindred hypergeometric distributions and elements of statistical inference associated with the hypergeometric distribution. Once the above are established, an investigation into and furthering of work done by Walton (1986) and Charlambides (2005) will be done. Here, we apply the hypergeometric distribution to sequential sampling in order to determine a surviving subcategory as well as study the problem of and complete representation of the …

Survival, Harvest, And Drumming Ecology Of Ruffed Grouse In Central Maine, Usa, Samantha Davis

Electronic Theses and Dissertations

Understanding population dynamics and how species interact with their environment are important components for conservation and management. Ruffed grouse (Bonasa umbellus) are a widely distributed and common game bird in North America and are a considered an important economic and cultural icon in Maine. Although they are a well-studied species, there has been little research focused on ruffed grouse population dynamics and habitat relationships in Maine. My thesis aims to improve this knowledge gap by focusing on research related to survival and harvest of ruffed grouse, as well as male ruffed grouse resource selection at breeding display sites. Ruffed grouse …

Constraining The Spatial Extent Of Strain Localization At The Base Of The Seismogenic Zone: A Case Study From The Sandhill Corner Shear Zone, Maine, Usa, Erik Kristian Anderson

Electronic Theses and Dissertations

Knowledge of the structure and processes of strain localization at the base of the seismogenic zone can provide constraints on the rheologic evolution of shear zones at depth and the spatial extent that seismicity influences the surrounding rock. Such knowledge is hindered by limitations of borehole measurements from such depths and a lack of structural/mineralogical preservation of original rock fabric. The Sandhill Corner Shear Zone, Maine, USA provides an opportunity to study well-preserved structures relating to strain localization along major faults exhumed from seismogenic depths. In south-central Maine, this shear zone juxtaposes two rock types: the Cape Elizabeth Formation and …

Basic Vision Research With Clinical Applications And Science Education Assessments, Andrew Wilson

Electronic Theses and Dissertations

Visual Acuity (VA) examinations are one of the most commonly conducted medical assessment throughout the world. Recent advances in computer technology allows for new forms of visual assessment to be conducted. In Part I of this thesis I demonstrate the capability of an automated computer program named VISION to assess human visual acuities. Different color combinations of an object against a background emitted from a computer screen are used to examine a variety of human color vision acuities. Results indicated a large difference in acuity scores between human subjects tested with these different color combinations. A single human subject exhibits …

A Study In Cross-Beam Polarization Fluorescence Photoactivation Localization Microscopy On Dendra2-Hemagluttinin In Fixed Nih3t3 Cells, Matthew M. Valles

Electronic Theses and Dissertations

Fluorescence microscopy is popular for its noninvasive properties and its use in imaging multiple species, simultaneously. Furthermore, superresolution fluorescence microscopy (SRFLM) utilizes photoswitchable proteins to improve the lateral resolution of conventional fluorescence microscopy by an order of magnitude. There is little work conducted on the study of excitation laser polarizations and their effect on the number of localizations as well as the brightness of molecules. This thesis attempts to study the effect of excitation wavelength polarization on the number of localizations and the brightness of molecules by comparing two orientations of circularly-polarized, excitation lasers. The first type of orientation involves …

Effects Of Ponderosa Pine Ecological Restoration On Forest Soils And Understory Vegetation In Northern Arizona, Elena M. Thomas, Kenneth W. Farrish, Brian P. Oswald, Melinda G. Shaw-Faulkner, Scott R. Abella

Electronic Theses and Dissertations

The human exclusion of wildfire and overgrazing by livestock since settlement have caused dramatic changes in ponderosa pine (Pinus ponderosa Dougl ex Laws) forest ecosystems. These changes include increased numbers of tree stems, reduced understory cover and diversity, and the introduction of invasive, non-native understory species. This study evaluated the coverage and species composition of understory vegetation present in the “cool-season” (late spring and early summer) in a ponderosa pine forest on grazed and ungrazed plots that had undergone restoration treatments on three different soil/geologic parent material types near Flagstaff, Arizona, twelve years after tree thinning and grazing exclosure …

Influence Of Common Bean (Phaseolus Vulgaris) Grown In Elevated Co2 On Apatite Dissolution, Brian Matthew Morra

Electronic Theses and Dissertations

Elevated concentrations of atmospheric CO₂ brought about by human activity creates changes in plant morphology, growth rate and exudate production. Our study sought to understand the effect of these changes on soil mineral weathering using plants grown under two conditions, ambient CO₂ (400ppm) and elevated CO₂ (1000ppm). Phaseolus vulgaris (common beans) were grown in flow-through microcosms consisting of a mixture of quartz and apatite sands. Plant growth was sustained by a nutrient solution devoid of calcium (Ca) and phosphorous (P). Using Atomic Adsorption Spectroscopy and colorimetry, Ca and P content of the leachate and plant tissue served …

Structural And Stratigraphic Reconstruction Of The Whiting Dome Salt Structure In Viosca Knoll-Mississippi Canyon, Gom, Using 3d Seismic Data, Matthew R. Worrell

Electronic Theses and Dissertations

Understanding the complexities of salt tectonics is one of the most important factors regarding seismic interpretation of stratigraphy, structure, and geomorphology in the Gulf of Mexico. Evaluating the processes affecting recent mobilization of salt in the shallow, well-imaged section can help provide analogues for older, similar occurrences in the deeper section, thereby providing structural models for the autochthonous salt and its effect on stratigraphy and even potential timing and migration issues of hydrocarbons.

Progradation of delta front and shelf to slope transitional sediments has expulsed and emplaced an allochthonous salt structure (Whiting Dome) in the Viosca Knoll and Mississippi Canyon …

Gravitational Study Of The Hastings Salt Dome And Associated Faults In Brazoria And Galveston Counties,Texas, Francis C. Okocha

Electronic Theses and Dissertations

Salt domes are important geological structures because they are potential major hydrocarbon traps and have a profound effect on overlying strata in the subsurface. Over five hundred salt domes have been located on the United States Gulf Coast region, including the Hastings Salt Dome. Hastings Oil Field is located about 40.2 km (25 miles) southeast of Houston, Texas. The Hasting oil field was discovered in 1934 and it was considered the largest oil reserve on the Gulf Coast. Its peak production of 75,000 BOPD (barrels of oil per day) was recorded in 1977 and it had a cumulative production of …

Revisiting Ocean Color Algorithms For Chlorophyll A And Particulate Organic Carbon In The Southern Ocean Using Biogeochemical Floats, Nils Haëntjens

Electronic Theses and Dissertations

The Southern Ocean (SO, oceans south of 30 ^oS) ecosystem plays a key role in global carbon cycles by sinking a major part (43 %) of the anthropogenic CO₂, and being an important source of nutrients for primary producers. However, undersampling of SO biogeochemical properties limits our understanding of the mechanisms taking place in this remote area. The Southern Ocean Carbon and Climate Observing and Modeling project (SOCCOM) has been deploying a large number of autonomous biogeochemical floats to study the SO (as of December 2016, 74 floats out of 200 have been deployed). SOCCOM floats measurements …

Investigating Student Learning Of Analog Electronics, Kevin L. Van De Bogart

Electronic Theses and Dissertations

Instruction in analog electronics is an integral component of many physics and engineering programs, and is typically covered in courses beyond the first year. While extensive research has been conducted on student understanding of introductory electric circuits, to date there has been relatively little research on student learning of analog electronics in either physics or engineering courses. Given the significant overlap in content of courses offered in both disciplines, this study seeks to strengthen the research base on the learning and teaching of electric circuits and analog electronics via a single, coherent investigation spanning both physics and engineering courses.

This …

Observations On Convexity, Chad A. Huckaby

Electronic Theses and Dissertations

This thesis will explore convexity as it pertains to sets of complex-valued functions. These include preliminary looks at established linear and polynomially convex hulls, along with the development of new types of convex hulls. These types will include, but are not limited to the hulls determined by inversions, shift inversions, and Mobius transformations. A convex hull must be preceded by the set of functions involved. These hulls are the smallest convex sets that contain the original set. Justifications and precise definitions are included within the body of the work.

Differentiating Between A Protein And Its Decoy Using Nested Graph Models And Weighted Graph Theoretical Invariants, Hannah E. Green

Electronic Theses and Dissertations

To determine the function of a protein, we must know its 3-dimensional structure, which can be difficult to ascertain. Currently, predictive models are used to determine the structure of a protein from its sequence, but these models do not always predict the correct structure. To this end we use a nested graph model along with weighted invariants to minimize the errors and improve the accuracy of a predictive model to determine if we have the correct structure for a protein.

Roman Domination In Complementary Prisms, Alawi I. Alhashim

Electronic Theses and Dissertations

The complementary prism GG of a graph G is formed from the disjoint union of G and its complement G by adding the edges of a perfect match- ing between the corresponding vertices of G and G. A Roman dominating function on a graph G = (V,E) is a labeling f : V(G) → {0,1,2} such that every vertex with label 0 is adjacent to a vertex with label 2. The Roman domination number γR(G) of G is the minimum f(V ) = Σv∈V f(v) over all such functions of G. We study the Roman domination number of complementary prisms. …

Ab Initio And Semi-Empirical Calculations Of Cyanoligated Rhodium Dimer Complexs, Yazeed Asiri

Electronic Theses and Dissertations

Molecular modeling, using both ab initio and semi-empirical methods has been undertaken for a series of dirhodium complexes in order to improve the understanding of the nature of the chemical bonding in this class of homogeneous catalysts. These complexes, with carboxylamidate and carboxylate ligands, are extremely functional metal catalysts used in the synthesis of pharmaceuticals and agrochemicals. The X-ray crystallography shows anomalies in the bond angles that have potential impact on understanding the catalysis. To resolve these issues, minimum energy structures of several examples (e.g. Rh₂(NHCOCH₃)₄, Rh₂(NHCOCH₃)₄NC, Rh …

Peptide Identification: Refining A Bayesian Stochastic Model, Theophilus Barnabas Kobina Acquah

Electronic Theses and Dissertations

Notwithstanding the challenges associated with different methods of peptide identification, other methods have been explored over the years. The complexity, size and computational challenges of peptide-based data sets calls for more intrusion into this sphere. By relying on the prior information about the average relative abundances of bond cleavages and the prior probability of any specific amino acid sequence, we refine an already developed Bayesian approach in identifying peptides. The likelihood function is improved by adding additional ions to the model and its size is driven by two overall goodness of fit measures. In the face of the complexities associated …

Late Quaternary Dragon Lizards (Agamidae: Squamata) From Western Australia, Julie Rej

Electronic Theses and Dissertations

Fossil Agamidae from Western Australia have been the subject of limited study. To aid in fossil agamid identification, Hocknull (2002) examined the maxilla and dentary of several extant species from Australia and determined diagnostic characters for various species groups. In the study here, fossil agamids from two localities in Western Australia, Hastings Cave and Horseshoe Cave, were examined, grouped, and identified to the lowest unambiguous taxonomic level. Morphometric analyses were conducted to compare morphotypes, and find additional diagnostic characters. From Hastings Cave there were two maxilla morphotypes and three dentary morphotypes. Based on identifications, taxa present at this locality were …

An Investigation Into The Performance Evaluation Of Connected Vehicle Applications: From Real-World Experiment To Parallel Simulation Paradigm, Md Salman Ahmed

Electronic Theses and Dissertations

A novel system was developed that provides drivers lane merge advisories, using vehicle trajectories obtained through Dedicated Short Range Communication (DSRC). It was successfully tested on a freeway using three vehicles, then targeted for further testing, via simulation. The failure of contemporary simulators to effectively model large, complex urban transportation networks then motivated further research into distributed and parallel traffic simulation. An architecture for a closed-loop, parallel simulator was devised, using a new algorithm that accounts for boundary nodes, traffic signals, intersections, road lengths, traffic density, and counts of lanes; it partitions a sample, Tennessee road network more efficiently than …

Performance Of Imputation Algorithms On Artificially Produced Missing At Random Data, Tobias O. Oketch

Electronic Theses and Dissertations

Missing data is one of the challenges we are facing today in modeling valid statistical models. It reduces the representativeness of the data samples. Hence, population estimates, and model parameters estimated from such data are likely to be biased.

However, the missing data problem is an area under study, and alternative better statistical procedures have been presented to mitigate its shortcomings. In this paper, we review causes of missing data, and various methods of handling missing data. Our main focus is evaluating various multiple imputation (MI) methods from the multiple imputation of chained equation (MICE) package in the statistical software …

Denoising Tandem Mass Spectrometry Data, Felix Offei

Electronic Theses and Dissertations

Protein identification using tandem mass spectrometry (MS/MS) has proven to be an effective way to identify proteins in a biological sample. An observed spectrum is constructed from the data produced by the tandem mass spectrometer. A protein can be identified if the observed spectrum aligns with the theoretical spectrum. However, data generated by the tandem mass spectrometer are affected by errors thus making protein identification challenging in the field of proteomics. Some of these errors include wrong calibration of the instrument, instrument distortion and noise. In this thesis, we present a pre-processing method, which focuses on the removal of noisy …

Spatiotemporal Analyses Of Recycled Water Production, Jana E. Archer

Electronic Theses and Dissertations

Increased demands on water supplies caused by population expansion, saltwater intrusion, and drought have led to water shortages which may be addressed by use of recycled water as recycled water products. Study I investigated recycled water production in Florida and California during 2009 to detect gaps in distribution and identify areas for expansion. Gaps were detected along the panhandle and Miami, Florida, as well as the northern and southwestern regions in California. Study II examined gaps in distribution, identified temporal change, and located areas for expansion for Florida in 2009 and 2015. Production increased in the northern and southern regions …

Role Of Nanoparticles In Voltammetric Signal Enhancement Exhibited By Layer-By-Layer (Lbl) Gold Nanoparticle-Modified Screen-Printed Carbon Electrodes (Spces), Ben K. Ahiadu

Electronic Theses and Dissertations

Screen-printed electrodes (SPEs) have found wide use as sensing platforms due to their simple fabrication, customizability in terms of geometry and composition, and relatively low cost of production. Nanoparticles have been incorporated in or interfaced with SPEs in order to improve sensor response or provide electrocatalytic capabilities. Though nanomaterial-modified SPEs are becoming increasingly common sensing platforms, the benefits provided by nanomaterials are often determined through voltammetric studies with common redox probes, such as ferricyanide. However, recent reports have documented the ferri-/ferrocyanide redox couple to be an unreliable system for characterizing some carbon-based electrodes due to the dependence of its electrochemical …

Quantifying The Structure Of Misfolded Proteins Using Graph Theory, Walter G. Witt

Electronic Theses and Dissertations

The structure of a protein molecule is highly correlated to its function. Some diseases such as cystic fibrosis are the result of a change in the structure of a protein so that this change interferes or inhibits its function. Often these changes in structure are caused by a misfolding of the protein molecule. To assist computational biologists, there is a database of proteins together with their misfolded versions, called decoys, that can be used to test the accuracy of protein structure prediction algorithms. In our work we use a nested graph model to quantify a selected set of proteins that …

On T-Restricted Optimal Rubbling Of Graphs, Kyle Murphy

Electronic Theses and Dissertations

For a graph G = (V;E), a pebble distribution is defined as a mapping of the vertex set in to the integers, where each vertex begins with f(v) pebbles. A pebbling move takes two pebbles from some vertex adjacent to v and places one pebble on v. A rubbling move takes one pebble from each of two vertices that are adjacent to v and places one pebble on v. A vertex x is reachable under a pebbling distribution f if there exists some sequence of rubbling and pebbling moves that places a pebble on x. A pebbling distribution where every …

Range-Wide Prevalence And Impacts Of Pseudocercosporella Inconspicua On Lilium Grayi And An Assessment Of L. Superbum And L. Michauxii As Reservoirs, Cindy L. Barrett

Electronic Theses and Dissertations

Lilium grayi (Gray’s Lily), a southern Appalachian endemic species, is threatened by a Lilium-specific fungal pathogen, Pseudocercosporella inconspicua. The disease is characterized by tan lesions that can cause early senescence, while also lowering seed production and viability. This project tested for P. inconspicua conidia and accessed health at nine locations. The disease was present and ubiquitous across the range of L. grayi. Through identification of P. inconspicua conidia in the field, L. superbum (Turk’s Cap Lily) was identified as an additional host, while L. michauxii (Michaux’s Lily) was disease-free. However, infection was inducible in both species. With …