Physical Sciences and Mathematics Commons^™

Time-Resolved Phosphorescence Spectroscopy At Cryogenic Temperatures For The Environmental Analysis Of Polycyclic Aromatic Sulfur Heterocycles In Oil Contaminated Sites., Maha Al-Tameemi

Electronic Theses and Dissertations

The large volume of crude oil released into the Gulf of Mexico by the Deepwater Horizon (DWH) accident has raised considerable concerns over potential ecosystem impacts. The dispersion of harmful oil components into the ocean waters could pose long term risks to flora and fauna. Due to the complexity of oil contaminated sites, the unambiguous identification and quantitation of environmental pollutants often requires the sequence of high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS). A classic example is the analysis of the sixteen polycyclic aromatic hydrocarbons included in the priority pollutants list of the U.S. Environmental Protection Agency (EPA-PAHs). …

A Universal Electrochemical Biosensor For The Detection Of Nucleic Acids Based On A Four-Way Junction Structure, Dawn Mills

Electronic Theses and Dissertations

Electrochemical hybridization sensors have been explored extensively for analysis of specific nucleic acids. However, commercialization of the platform is hindered by the need for attachment of separate oligonucleotide probes complementary to a RNA or DNA target to an electrode's surface. This dissertation demonstrates that a single probe can be used to analyze several nucleic acid targets of different lengths with high selectivity, low cost and can be regenerated in 30 seconds by a simple water rinse. The universal electrochemical four-way junction (4J)-forming (UE4J) sensor consists of a universal DNA stem-loop (USL) probe attached to the electrode's surface and two adaptor …

Solving Constraint Satisfaction Problems With Matrix Product States, Sabine Pelton

Electronic Theses and Dissertations

In the past decade, Matrix Product State (MPS) algorithms have emerged as an efficient method of modeling some many-body quantum spin systems. Since spin system Hamiltonians can be considered constraint satisfaction problems (CSPs), it follows that MPS should provide a versatile framework for studying a variety of general CSPs. In this thesis, we apply MPS to two types of CSP. First, use MPS to simulate adiabatic quantum computation (AQC), where the target Hamiltonians are instances of a fully connected, random Ising spin glass. Results of the simulations help shed light on why AQC fails for some optimization problems. We then …

High Power Fiber Lasers And Fiber Devices, Zeinab Sanjabieznaveh

Electronic Theses and Dissertations

Fiber lasers and fiber amplifiers have experienced considerable improvements in recent years and demonstrated remarkable power scalability. However, due to high optical intensity in the core, the performance of high power fiber lasers is limited by detrimental nonlinear processes, such as four-wave mixing, self-phase modulation, stimulated Brillouin scattering, and stimulated Raman scattering. To mitigate nonlinear effects, very large mode area (LMA) fibers, which exhibit a mode field diameter larger than 30 ?m have been developed. However, for larger core sizes the discrimination capabilities of conventional fiber designs decrease, consequently, LMA fibers are not strictly single mode which ultimately at high …

Thermal And Waveguide Optimization Of Broad Area Quantum Cascade Laser Performance, Matthew Suttinger

Electronic Theses and Dissertations

Quantum Cascade Lasers are a novel source of coherent infrared light, unique in their tunability over the mid-infrared and terahertz range of frequencies. Advances in bandgap engineering and semiconductor processing techniques in recent years have led to the development of highly efficient quantum cascade lasers capable of room temperature operation. Recent work has demonstrated power scaling with broad area quantum cascade lasers by increasing active region width beyond the standard ~10 ?m. Taking into account thermal effects caused by driving a device with electrical power, an experimentally fitted model is developed to predict the optical power output in both pulsed …

Photothermal Lensing In Mid-Infrared Materials, Justin Cook

Electronic Theses and Dissertations

A thorough understanding of laser-materials interactions is crucial when designing and building optical systems. An ideal test method would probe both the thermal and optical properties simultaneously for materials under large optical loads where detrimental thermal effects emerge. An interesting class of materials are those used for infrared wavelengths due to their wide spectral transmission windows and large optical nonlinearities. Since coherent sources spanning the mid-wave and long-wave infrared wavelength regions have only become widely available in the past decade, data regarding their thermal and optical responses is lacking in literature. Photothermal Lensing (PTL) technique is an attractive method for …

High Dynamic Range Display Systems, Ruidong Zhu

Electronic Theses and Dissertations

High contrast ratio (CR) enables a display system to faithfully reproduce the real objects. However, achieving high contrast, especially high ambient contrast (ACR), is a challenging task. In this dissertation, two display systems with high CR are discussed: high ACR augmented reality (AR) display and high dynamic range (HDR) display. For an AR display, we improved its ACR by incorporating a tunable transmittance liquid crystal (LC) film. The film has high tunable transmittance range, fast response time, and is fail-safe. To reduce the weight and size of a display system, we proposed a functional reflective polarizer, which can also help …

Two-Component Covalent Inhibitors (Tcci) Of The Human Immunodeficiency Virus Reverse Transcriptase (Hiv-Rt), Carlos Ledezma

Electronic Theses and Dissertations

The traditional design of nucleoside reverse transcriptase inhibitors (NRTI's) involves the synthesis of chain-terminated nucleoside analogs. HIV-RT has relatively low fidelity which facilitates mutations that confer resistance towards NRTI's, also, drug promiscuity from NRTI's result in various side-effects that lead to poor patient adherence to treatment. We designed and tested two-component covalent inhibitors against HIV-RT. Our inhibitor design results in higher specificity due to its binary approach, which has previously been used in biosensing applications, where both components are necessary for therapeutic effect, and lower chances for mutagenesis because of its inhibitory action. The TCCI approach results in up to …

Monitoring Crystal Structure Refinements Using Solid-State Nmr Chemical Shift Tensors, Keyton Kalakewich

Electronic Theses and Dissertations

Inclusion of lattice-fields in density functional theory (DFT) methods has enabled the accurate calculation of solid-state nuclear magnetic resonance (SSNMR) chemical shift tensors. Calculated 13C and 15N tensors (i.e. 3 principle values per nucleus) can be used to monitor crystal structure refinements and to select the correct structure from a large population of computationally generated candidates. In this dissertation, chapter 2 describes a methodology to improve established crystal structures from three different diffraction techniques involving geometric refinement monitored using SSNMR tensor values. The calculated 13C tensors for three relatively simple organic compounds (i.e. acetaminophen, naphthalene, and adenosine) are shown to …

Nitrogen-Containing Materials For Mechanochemical Synthesis, Luminescence Analysis, And Heterogeneous Catalysis, David Nash

Electronic Theses and Dissertations

Various inorganic nitrogen-containing materials have been exploited for their different properties. Several nitride materials are commercially attractive due to their mechanical properties making them suitable for ceramic industries and wide bandgaps fitting for use as semiconductor and insulator materials, as well as optoelectronics. Nitride materials can exhibit versatility in applications such as the use of gallium nitride to make blue LEDs, nitrides of titanium and silicon being utilized as medical implants for their chemical inertness and hardness, and the heavy use of boron nitride as a solid lubricant in the cosmetic industry. Amines have been used as nitrogen-containing organic ligands …

Novel Photonic Resonance Arrangements Using Non-Hermitian Exceptional Points, Hossein Hodaei

Electronic Theses and Dissertations

In recent years, non-Hermitian degeneracies also known as exceptional points (EPs) have emerged as a new paradigm for engineering the response of optical systems. EPs can appear in a wide class of open non-Hermitian configurations. Among different types of non-conservative photonic systems, parity-time (PT) symmetric arrangements are of particular interest since they provide an excellent platform to explore the physics of exceptional points. In this work, the intriguing properties of exceptional points are utilized to address two of the long standing challenges in the field of integrated photonics- enforcing single mode lasing in intrinsically multimode cavities and enhancing the sensitivity …

Online, Supervised And Unsupervised Action Localization In Videos, Khurram Soomro

Electronic Theses and Dissertations

Action recognition classifies a given video among a set of action labels, whereas action localization determines the location of an action in addition to its class. The overall aim of this dissertation is action localization. Many of the existing action localization approaches exhaustively search (spatially and temporally) for an action in a video. However, as the search space increases with high resolution and longer duration videos, it becomes impractical to use such sliding window techniques. The first part of this dissertation presents an efficient approach for localizing actions by learning contextual relations between different video regions in training. In testing, …

Adversarial Attacks On Vision Algorithms Using Deep Learning Features, Andy Michel

Electronic Theses and Dissertations

Computer vision algorithms, such as those implementing object detection, are known to be susceptible to adversarial attacks. Small barely perceptible perturbations to the input can cause vision algorithms to incorrectly classify inputs that they would have otherwise classified correctly. A number of approaches have been recently investigated to generate such adversarial examples for deep neural networks. Many of these approaches either require grey-box access to the deep neural net being attacked or rely on adversarial transfer and grey-box access to a surrogate neural network. In this thesis, we present an approach to the synthesis of adversarial examples for computer vision …

Laser-Induced Crystallization Mechanisms In Chalcogenide Glass Materials For Advanced Optical Functionality, Laura Sisken

Electronic Theses and Dissertations

Glass-ceramics (GC) are promising candidates for gradient refractive index (GRIN) optics. These multi-phase, composite materials also exhibit improved physical properties as compared to the parent base glass resulting from the formation of a secondary crystalline phase(s). Nanocrystal phase formation in a multi-component chalcogenide glass (ChG), (GeSe2-3As2Se3)(1-x)-(PbSe)x glass where x = 0-40 has been investigated, and the role of the starting material morphology has been correlated to the resulting composite's optical properties including refractive index, transmission, dispersion, and thermo-optic coefficient. Optical property evolution was related to the type and amount of the crystal phases formed, since through control of the local …

Assessing Interactions Between Estuary Water Quality And Terrestrial Land Cover In Hurricane Events With Multi-Sensor Remote Sensing, Chandan Mostafiz

Electronic Theses and Dissertations

Estuaries are environmentally, ecologically and environmentally important places as they act as a meeting place for land, freshwater and marine ecosystems. They are also called nurseries of the sea as they often provide nesting and feeding habitats for many aquatic plants and animals. These estuaries also withstand the worst of some natural disasters, especially hurricanes. The estuaries as well as the harbored ecosystems undergo significant changes in terms of water quality, vegetation cover etc. and these components are interrelated. When hurricane makes landfall it is necessary to assess the damages as quickly as possible as restoration and recovery processes are …

Super Resolution Of Wavelet-Encoded Images And Videos, Vildan Atalay

Electronic Theses and Dissertations

In this dissertation, we address the multiframe super resolution reconstruction problem for wavelet-encoded images and videos. The goal of multiframe super resolution is to obtain one or more high resolution images by fusing a sequence of degraded or aliased low resolution images of the same scene. Since the low resolution images may be unaligned, a registration step is required before super resolution reconstruction. Therefore, we first explore in-band (i.e. in the wavelet-domain) image registration; then, investigate super resolution. Our motivation for analyzing the image registration and super resolution problems in the wavelet domain is the growing trend in wavelet-encoded imaging, …

Advanced Liquid Crystal Displays With Supreme Image Qualities, Haiwei Chen

Electronic Theses and Dissertations

Several metrics are commonly used to evaluate the performance of display devices. In this dissertation, we analyze three key parameters: fast response time, wide color gamut, and high contrast ratio, which affect the final perceived image quality. Firstly, we investigate how response time affects the motion blur, and then discover the 2-ms rule. With advanced low-viscosity materials, new operation modes, and backlight modulation technique, liquid crystal displays (LCDs) with an unnoticeable image blur can be realized. Its performance is comparable to an impulse-type display, like cathode ray tube (CRT). Next, we propose two novel backlight configurations to improve an LCD's …

Spherical Self-Assembly Of Rous Sarcoma Virus Ca, Probed By Ssnmr And The Structure Of Pap And Reflectin Protein, Xin Qiao

Electronic Theses and Dissertations

In this dissertation, we investigate the morphology of three different protein assemblies, which are formed by prostate acidic phosphatase, residues 248-286 (PAP39), reflectin and rous sarcoma virus capsid (RSV CA). First of all, the main aim of this research is to study the structure of PAP39 which is derived from protease cleavage of Prostate Acidic Phosphatase. The PAP39 can form fibrils of different morphologies in phosphate-buffered saline (PBS) and NaBiCarb (25 mM sodium bicarbonate and 40 mM sodium phosphate, pH=8.83) buffer conditions, each exhibiting different potentials to enhance the infection of HIV in vitro due to different assemble pathways. In …

Generation Of High-Flux Attosecond Pulses And Towards Attosecond-Attosecond Pump-Probe Experiments, Yang Wang

Electronic Theses and Dissertations

At present, the energy of a single isolated attosecond pulse is limited to nanojoule levels. As a result, an intense femtosecond pulse has always been used in combination with a weak attosecond pulse in time-resolved experiments. To reach the goal of conducting true attosecond pump-attosecond probe experiments, a high flux laser source has been developed that can potentially deliver microjoule level isolated attosecond pulses in the 50 eV range, and a unique experimental end station has been fabricated and implemented that can provide precision control of the attosecond-attosecond pump-probe pulses. In order to scale up the attosecond flux, a unique …

The Consequences Of A Reduced Superlattice Thickness On Quantum Cascade Laser Performance, Pedro Figueiredo

Electronic Theses and Dissertations

Coherent infrared radiation sources are essential for the operability of a wide range of scientific, industrial, military and commercial systems. The importance of the mid-infrared spectral region cannot be understated. Numerous molecules have some vibrational band in this range, allowing for identification of species by means of absorption, emission or some other form of spectroscopy. As such, spectroscopy alone has numerous applications ranging from industrial process control to disease diagnosis utilizing breath analysis. However, despite the discovery of the LASER in the 60s, to this day the amount of coherent sources in this range is limited. It is for this …

Design Of A Hydrogen-Filled Hollow-Core Fiber Raman Laser, Yangyang Qin

Electronic Theses and Dissertations

The purpose of this study is to investigate the design of a Raman fiber laser based on a molecule hydrogen-filled hollow-core fiber with non-touching single ring of capillaries structure. O-hydrogen vibrational frequency shift of 4155 cm-1 and rotational frequency shift of 587 cm-1 were employed to generate Raman scattering from a 1064nm pump source. A thorough exploration was made to show how all Raman fiber laser components made up: gas chamber, hollow-core fibers, windows. The whole process of chamber design, modification and fabrication were demonstrated. Besides, two kinds of anti-resonant hollow-core fibers were studied and tested. The transmission and loss …

Plasma Dynamics Of Laser Filaments, Danielle Reyes

Electronic Theses and Dissertations

Laser filamentation is a complex phenomenon occurring for pulses with peak power above a critical value. A filament is a dynamic self-guided structure characterized by several unique qualities, which include a beam with a high-intensity core surrounded by an energy reservoir, a weakly ionized plasma channel, and supercontinuum generation. Several of the proposed applications for filamentation utilize the plasma channel, such as for assisted electric discharge and microwave guiding. However, filament properties are highly influenced by the physical conditions under which they are formed. A host of studies have been conducted to further characterize filaments, but much work still remains …

System For Metal Coated Fiber Fabrication, Da Zhang

Electronic Theses and Dissertations

For many specific applications, such as sensors, aerospace, chemical industry, deep-well oil-field industry, metal-coated fiber shows strong abilities to satisfy people's requirement. With in-line coating technology, we are able to coat Aluminum on the fibers. Using electromagnetic induction, we can easily heat an electrically conducting thing such as a metal with the eddy current. This process is defined as Induction heating. And we will melt the Aluminum by this induction heating during drawing the fibers on the tower. Introduce the fiber tower system. The drawing process of in-line technology is formed of the following steps: Position, Melting, Forming into fibers, …

Target Based Design And Synthesis Of Heterocycles In The Potential Treatment Of Cancer And Opportunistic Infection, Shruti Choudhary

Electronic Theses and Dissertations

Dose limiting toxicity and development of multidrug resistance by the tumors are the major limitations of current cancer chemotherapy. Microtubule targeting agents (MTAs) are a structurally diverse set of compounds that disrupt microtubule dynamics and exert their anticancer effect. Among the various classes of such agents, the colchicine site binding agents are particularly important as they circumvent the Pgp and β-III tubulin mediated clinical resistance. These resistance mechanisms, when manifested, are a major reason for the failure of clinically used agents such as taxanes and vinca alkaloids. A series of monocyclic pyrimidine analogs were designed and synthesized as colchicine site …

Sources And Long-Term Trends In Fecal Bacteria Contamination In The Fresh And Marine Waters Of The Grand Strand, Cara E. Schildtknecht

Electronic Theses and Dissertations

Microbial water quality is of significant concern in the two watersheds of the Grand Stand. Polluted runoff, malfunctioning septic tanks, and centralized sanitary sewer failures are common sources of fecal bacteria contamination in coastal areas and pose a threat to human health through recreational use of waterbodies and shellfish consumption. Volunteer water quality monitoring programs are crucial in expanding upon assessments of fecal bacteria contamination by regulatory monitoring. Bacteria monitoring data collected by volunteers and Coastal Carolina University’s Environmental Quality Laboratory has been used to identify sites to be investigated by microbial source tracking. Microbial source tracking has been used …

Response Of Soil Properties To 23-25 Years Of Diverse Crop Rotations And Tillage Systems In South Dakota, Usa, Abdullah H. Alhameid

Electronic Theses and Dissertations

Diverse cropping systems and no-till (NT) are beneficial in improving soil organic carbon (SOC) and other soils properties. The present study was conducted to evaluate the interactions and impacts of long-term tillage and diverse crop rotation systems on soil quality indicators that include a range of soil chemical, physical, hydrological, and microbial properties. The study was established in 1991 at Beresford, South Dakota and included three crop rotation systems [2-yr; maize (Zea mays L.)-soybean (Glycine max L.), 3-yr; maize-soybean-oat (Avena sativa L.), and 4-yr; maize-soybean-oat-wheat (Triticum aestivum L.)] managed under two tillage systems (NT and CT; conventional- tillage). Soil sampling …

The Decline And Recovery Of Thermal Oxidative Stability Of Ultra-Low Sulfur Diesel Blends, Abigail Schoor Cohen

Electronic Theses and Dissertations

Dissertation supervised by Professor Bruce D. Beaver

The oxidative stability of ultra-low sulfur diesel (ULSD) has generally been expected to continuously decline over time. However, recent studies have suggested that it may fluctuate.^1-2 In this study, the oxidative stability of stored commercially purchased ULSD was monitored with a methanol extraction method.³ In this methodology, proposed by Hardy and Wechter, fuel blends are extracted with methanol before and after thermal stressing.⁴ The methanol-soluble layer contains the oxygenated and oxidizable components of the fuel (SMORS) and the change in this mass upon stressing thus represents the oxidative stability of …

Nitric Oxide Release From Poly(Lactic-Co-Glycolic Acid) Nanoparticles And Titanium Alloy, Nina A. Reger

Electronic Theses and Dissertations

Current methods for the treatment of bacterial infection involve the use of systemic antibiotics, which are high concentrations of antibiotics delivered over a long period time. Unfortunately, the use of systemic antibiotics can cause harmful side effects to the patient and increases the possibility for antibiotic resistance. The delivery of antibiotics or alternative antimicrobial compounds, such as nitric oxide, directly to the site of infection would decrease the amount of antibiotic necessary to treat a bacterial infection.

Poly (lactic-co-glycolic acid)/polyvinyl alcohol nanoparticles and a titanium- aluminum-vanadium metal oxide alloy implant were surface functionalized to deliver nitric oxide. Polymer nanoparticles can …

Rationalizing The Band Gap Tunability Of Semiconductors Via Electronic Structure Calculations, Matthew N. Srnec

Electronic Theses and Dissertations

The polymorphs of titanium dioxide and various diamond-like semiconductor materials are promising candidates in photovoltaic solar cell applications. Several of these polymorphs have been studied with experimental and computational methods, which often aim at tuning the electronic structure, particularly the band gap value of the crystalline solid. Prior studies report that the addition of a substituent into the structure of titanium dioxide decreases its band gap value, but the reasons for this are unknown. Possible explanations for the change in band gap involve the substituent atom's crystal radius, electronegativity, and ionization energy. Understanding the cause of these changes will provide …

Design, Synthesis And Biological Evaluation Of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors In Colorectal Cancer, Faez Alotaibi

Electronic Theses and Dissertations

Colorectal cancer is a life threatening and second cause of death from cancer in the United States. Several proteins (molecular targets) are highly expressed in Colorectal cancer (CRC). Among these molecular targets is Epidermal Growth Factor Receptors (EGFRs) which are overexpressed in cancer cells. Targeting and blocking the downstream signaling could lead to cease cell proliferation and division and hence control the spread of the disease. Molecular modeling is a powerful tool in drug discovery, which has been utilized to design many drug candidates that exhibit biological effect in many disease including cancer. Additionally, pharmacophores such as 1,2,3-triazole showed potency …