Physical Sciences and Mathematics Commons^™

The Role Of Hsp70 In Cancer: A Study Of The Hsp70 / Akt Relationship, John Koren

USF Tampa Graduate Theses and Dissertations

The Hsp70 family of molecular chaperones is essential for

protein folding, re-folding misfolded client proteins, clearance

of aberrant client proteins, and can also inhibit programmed

cell death. There are two major cytosolic members of this

family: the constitutive Hsc70, and the inducible Hsp72. Under

stress conditions the Hsp70 family protects the cell from

protein related damage by the induction of Hsp72. Hsc70 and

Hsp72 are highly homologous with minor differences in

substrate binding. In cancers, Hsp72 is commonly induced and

this induction is thought to aid in cancer cell survival. In these

studies we demonstrate the differential regulation of the …

Paleobiological Assessment Of Controls Underlying Long-Term Diversity Dynamics, Andrés L. Cárdenas

USF Tampa Graduate Theses and Dissertations

Deciphering the factors underlying both long-term patterns of diversity and taxonomic turnover rates (i.e., extinction, and origination) has been one of Paleobiology's major foci for the past three decades. The importance of documenting these components is that they will expand our ability to interpret and model the evolutionary processes underlying those trends, highlight the evolutionary impact of historical events, and contribute to the formulation of robust predictions about the future of global diversity in response to the current anthropologically driven environmental changes. Accordingly, the first part of this study examines the possible occurrence of global marine evolutionary environmental controls into …

Pfaffian And Wronskian Solutions To Generalized Integrable Nonlinear Partial Differential Equations, Magdy Asaad

USF Tampa Graduate Theses and Dissertations

The aim of this work is to use the Pfaffian technique, along with the Hirota bilinear method to construct different classes of exact solutions to various of generalized integrable nonlinear partial differential equations. Solitons are among the most beneficial solutions for science and technology, from ocean waves to transmission of information through optical fibers or energy transport along protein molecules. The existence of multi-solitons, especially three-soliton solutions, is essential for information technology: it makes possible undisturbed simultaneous propagation of many pulses in both directions.

The derivation and solutions of integrable nonlinear partial differential equations in two spatial dimensions have been …

Fishermen, Politics, And Participation: An Ethnographic Examination Of Commercial Fisheries Management In St. Croix, U.S. Virgin Islands, Cynthia Grace-Mccaskey

USF Tampa Graduate Theses and Dissertations

Currently, there is widespread debate regarding the overall status of the world's fisheries, with some researchers projecting their total collapse in only a few decades, and others concluding the situation is not quite as bleak. Additional debates include what strategies should be used to manage fisheries at various scales, and further research is needed to determine which strategies are most appropriate for use in particular situations and locales, as context is critical.

Recently, prominent common pool resources scholars have expressed the need for ethnographic approaches to studying resource management institutions in order to move beyond the current focus of simply …

Hydrophilic Polymers Of Poly (2-Hydroxy Ethyl Methacrylate) With Tunable Properties For Drug Release, Sequestration Of Blistering Agent, Preparation Of Ultra-Strong Hydrogels & Thermal Stability Of Various Organic Azides, Ramakanth Ananthoji

USF Tampa Graduate Theses and Dissertations

The design and synthesis of new finely tunable porous materials has spurred interest in developing novel uses in a variety of systems. Zeolites, inorganic materials with high thermal and mechanical stability, in particular, have been widely examined for use in applications such as catalysis, ion exchange and separation. A relatively new class of inorganic-organic hybrid materials known as metal-organic frameworks (MOFs) has recently surfaced, and many have exhibited their efficiency in potential applications such as ion exchange and drug delivery. A more recent development is the design and synthesis of a subclass of MOFs based on zeolite topologies (i.e. ZMOFs), …

A Spatially Explicit Agent Based Model Of Muscovy Duck Home Range Behavior, James Howard Anderson

USF Tampa Graduate Theses and Dissertations

ABSTRACT

Research in GIScience has identified agent-based simulation methodologies as effective in the study of complex adaptive spatial systems (CASS). CASS are characterized by the emergent nature of their spatial expressions and by the changing relationships between their constituent variables and how those variables act on the system's spatial expression over time. Here, emergence refers to a CASS property where small-scale, individual action results in macroscopic or system-level patterns over time. This research develops and executes a spatially-explicit agent based model of Muscovy Duck home range behavior. Muscovy duck home range behavior is regarded as a complex adaptive spatial system …

Protein Profiling Of Adenine Nucleoside And Nucleotide Analogs Binding Proteins Using N6-Biotinylated-8-Azidoadenosine Analogs As Affinity Based Protein Profiling Probes, Shikha Mahajan

USF Tampa Graduate Theses and Dissertations

Identification of differential expressions of proteins in proteomic profiles of biological samples shows great potential as a valuable technique for the early diagnosis of various diseases. An important challenge in modern protein profiling approaches is to reduce the complexity of the samples by limiting the number of proteins that need to be evaluated for distinction in the expression between normal and deceased cells. In this research, an affinity based approach for the enrichment of nucleotide and nucleoside binding proteins from a complex cell proteome has been developed. To achieve this goal, new N6-biotinylated-8-azido-adenosine probes (AdoRs) have been designed and synthesized …

Team-Teaching Experiences Of A Mathematician And A Mathematics Teacher Educator: An Interpretative Phenomenological Case Study, Sarah K. Bleiler

USF Tampa Graduate Theses and Dissertations

In recent years, experts and organizations involved in mathematics education have emphasized the importance of collaboration between mathematicians and mathematics teacher educators as a means of improving the professional preparation of mathematics teachers. While several such collaborative endeavors have been documented in the extant literature, most research reports have focused on the products, rather than the process, of collaboration. The purpose of this interpretative phenomenological case study is to gain an understanding of the lived experiences of a mathematician and a mathematics teacher educator as they engaged in a team-teaching collaboration within the context of prospective secondary mathematics teacher preparation. …

Crystal Engineering Of Multi-Component Crystal Forms: The Opportunities And Challenges In Design, Heather Dawn Marie Clarke

USF Tampa Graduate Theses and Dissertations

There is heightened interest to diversify the range of crystal forms exhibited by active pharmaceutical ingredients (APIs) in the pharmaceutical industry. The crystal form can be regarded as the Achilles' heel in the development of an API as it directly impacts the physicochemical properties, performance and safety of the API. This is of critical importance since the crystal form is the preferred method of oral drug delivery by industry and regulatory bodies. The ability to rationally design materials is a lucrative avenue towards the synthesis of functional molecular solids with customized physicochemical properties such as solubility, bioavailability and stability. Pharmaceutical …

Functional Magnetic Nanoparticles, James Gass

USF Tampa Graduate Theses and Dissertations

Nanoparticle system research and characterization is the focal point of this research and dissertation. In the research presented here, magnetite, cobalt, and ferrite nanoparticle systems have been explored in regard to their magnetocaloric effect (MCE) properties, as well as for use in polymer composites. Both areas of study have potential applications across a wide variety of interdisciplinary fields.

Magnetite nanoparticles have been successfully dispersed in a polymer. The surface chemistry of the magnetic nanoparticle proves critical to obtaining a homogenous and well separated high density dispersion in PMMA. Theoretical studies found in the literature have indicated that surface interface energy …

Temporal And Spatial Analysis Of Monogenetic Volcanic Fields, Koji Kiyosugi

USF Tampa Graduate Theses and Dissertations

Achieving an understanding of the nature of monogenetic volcanic fields depends on identification of the spatial and temporal patterns of volcanism in these fields, and their relationships to structures mapped in the shallow crust and inferred in the deep crust and mantle through interpretation of geochemical, radiometric and geophysical data.

We investigate the spatial and temporal distributions of volcanism in the Abu Monogenetic Volcano Group, Southwest Japan. E-W elongated volcano distribution, which is identified by a nonparametric kernel method, is found to be consistent with the spatial extent of P-wave velocity anomalies in the lower crust and upper mantle, supporting …

Algorithms For Visual Maritime Surveillance With Rapidly Moving Camera, Sergiy Fefilatyev

USF Tampa Graduate Theses and Dissertations

Visual surveillance in the maritime domain has been explored for more than a decade. Although it has produced a number of working systems and resulted in a mature technology, surveillance has been restricted to the port facilities or areas close to the coastline assuming a fixed-camera scenario. This dissertation presents several contributions in the domain of maritime surveillance. First, a novel algorithm for open-sea visual maritime surveillance is introduced. We explore a challenging situation with a camera mounted on a buoy or other floating platform. The developed algorithm detects, localizes, and tracks ships in the field of view of the …

Florida Fishery-Wide Reproductive Indices Of Stone Crab, Menippe Mercenaria, And Their Application To Stock Assessment And Management, Claire Elizabeth Crowley

USF Tampa Graduate Theses and Dissertations

The stone crab, Menippe mercenaria, supported the third most valuable fishery in Florida in 2016. Declining catch per unit effort (CPUE) and overall negative trend in landings since 2000 have raised concerns among fisherman, researchers, and fishery managers about the resiliency of the fishery. The Florida Fish and Wildlife Research Institute estimated that the Florida stone crab fishery has been overexploited since 1997. Overexploited fisheries, such as the commercial stone crab fishery, risk induced changes in life history parameters, such as age at maturation and reproductive output. In turn, these population-level changes have the potential to reduce the spawning …

Low Level Exposure To Air Pollution And Risk Of Adverse Birth Outcomes In Hillsborough County, Florida, Maria B. Mainolfi

USF Tampa Graduate Theses and Dissertations

In this retrospective cohort from 2002 through 2007, 104,003 singleton live births in Hillsborough County, Florida were analyzed to elucidate the relationship between feto-infant morbidity outcomes and prenatal exposure to six criteria air pollutants. This study is based on three linked databases: The Florida Hospital Discharge database; The vital statistics records of singleton live births; Air Pollution meteorological data from the Environmental Protection Agency. There are six common air pollutants, particulate matter 2.5 (PM2.5), particulate matter 10 (PM10), ground-level ozone (O3), carbon monoxide (CO), nitrogen (NOx), and lead (Pb). These pollutants are harmful to human health and the environment. The …

Detecting Surface Oil Using Unsupervised Learning Techniques On Modis Satellite Data, Joshua Kidd

USF Tampa Graduate Theses and Dissertations

The release of crude oil or other petroleum based products into marine habitats can have a devastating impact on the environment as well as the local economies that rely on these waters for commercial fishing and tourism. The Deepwater Horizon catastrophe that started on April 20th 2010 leaked an estimated 4.4 million barrels of crude oil into the Gulf of Mexico over a 3 month period threatening thousands of species and crippling the gulf coast. The National Oceanic and Atmospheric Administration (NOAA) used several satellite remote sensing technologies to manually track and predict the extent and location of oil on …

The Impacts Of Population Density, And State & National Litter Prevention Programs On Marine Debris, Melissa Rose Brogle

USF Tampa Graduate Theses and Dissertations

Marine debris is improperly disposed of solid waste, also called litter, which is deposited in the marine environment (NOAA, 2010). Litter prevention techniques such as fines, cleanups, incentives, and others, can help to decrease litter, and ultimately decrease marine debris. This research analyzed 2000 and 2010 International Coastal Cleanup (ICC) data obtained from The Ocean Conservancy to ascertain whether certain litter prevention techniques did reduce amounts and types of marine debris found in coastal areas. The litter prevention techniques analyzed included state bottle bills, voluntary monofilament fishing line recycling programs, and the Keep America Beautiful (KAB) cigarette butt litter prevention …

Self-Assembly Of Self-Similar Structures By Active Tiles, Daria Karpenko

USF Tampa Graduate Theses and Dissertations

The natural capacity of DNA for molecular self-assembly has already been exploited to create DNA based tiles which can self-assemble into nano-scale arrays and carry out nano-scale computation. Thus far, however, all such self-assembly has been passive, in the sense that the binding capacities of a tile are never altered throughout the assembly. The idea of active tiles, tiles that can send signals to each other and activate latent binding sites, has been proposed but never incorporated into a formal model. Here, I present an extension of the existent abstract tile assembly model by defining an active tile assembly and …

Investigation And Synthesis Of Novel Graphene-Based Nanocomposites For Hydrogen Storage, Anthony Joseph D'Angelo

USF Tampa Graduate Theses and Dissertations

It is of great interest to develop and utilize a high surface area material with optimized hydrogen sorption properties. The need for a renewable energy source to replace automobile gasoline has become more critical in the past decade. Hydrogen is a viable fuel source for automobile usage; however, the question of how hydrogen will be safely and efficiently stored still remains. Critical factors for optimum hydrogen storage include ambient conditions and low activation temperature for adsorption and desorption phenomena. In order for optimum hydrogen adsorption to be achieved, the properties of (1) high surface area, (2) optimum hydrogen adsorption energy, …

Multidimensional Spectroscopy Of Semiconductor Quantum Dots, Jason Michael Bylsma

USF Tampa Graduate Theses and Dissertations

The coherent properties of semiconductor nanostructures are inherently difficult to measure and one-dimensional spectroscopies are often unable to separate inhomogeneous and homogeneous linewidths. We have refined and improved a method of performing multidimensional Fourier transform spectroscopy based on four-wave

mixing (FWM) experiments in the box geometry. We have modified our system with broadband beamsplitters in all interferometer arms, high-resolution translation stages and the ability to work in reflection geometry. By improving the phase-stability of our setup and scanning pulse delays with sub-optical cycle precision, we are able to

reproduce 2DFT spectra of GaAs multiple quantum wells. With the FWM signal …

Design And Construction Of Functional Metal-Metalloporphyrin Frameworks, Le Meng

USF Tampa Graduate Theses and Dissertations

Porous metal-organic frameworks are a new type of functional materials with potential applications for gas storage, gas separation, catalysis, biomedical and chemical sensors. This thesis describes several porous metal-metalloporphyrin frameworks (MMPFs), which were synthesized with a series of transition metals and 5,15-bis(3,5-dicarboxyphenyl)-10,20-bis(2,6-dibromophenyl)porphine. Among these MMPFs, the cobalt MMPF (CoBrPTC) has a fcu structure, which represents the first porphyrin-based MOF with this topology. CoBrPTC was evaluated as heterogeneous catalyst and demonstrated interesting catalytic performances.

Willingness-To-Pay For Maintenance And Improvements To Existing Sanitation Infrastructure: Assessing Community-Led Total Sanitation In Mopti, Mali, Justin Vern Meeks

USF Tampa Graduate Theses and Dissertations

In recent years, much focus has been put on the sustainability of water and sanitation development projects. Experts in this field have found that many of the projects of the past have failed to achieve sustainability because of a lack of demand for water and sanitation interventions at a grassroots level. For years projects looked to create this demand through various subsidy schemes, with the "software" of behavior change and education taking a backseat to the "hardware" of infrastructure provision. Community-Led Total Sanitation (CLTS) is a fairly new way of looking at the issues of increasing basic sanitation coverage, promoting …

Examining The Economic Costs And Sources Of Potable And Nonpotable Water In Northern Mexico, Kathryn Marie Marlor

USF Tampa Graduate Theses and Dissertations

Water availability and the cost of different water sources have been studied at great length. However, information is still needed to determine the policy directions to be undertaken by nations that have not yet achieved universal coverage of an improved water source. To further examine differences in water availability and pricing in the context of the developing world, three communities in Northern Mexico were surveyed to determine the differences in water distribution schemes and associated costs between rural and urban centers. It was observed that rural communities without a piped water supply paid 13 percent more for potable water supplies …

A Principled Approach To Policy Composition For Runtime Enforcement Mechanisms, Zachary Negual Carter

USF Tampa Graduate Theses and Dissertations

Runtime enforcement mechanisms are an important and well-employed method for ensuring an execution only exhibits acceptable behavior, as dictated by a security policy. Wherever interaction occurs between two or more parties that do not completely trust each other, it is most often the case that a runtime enforcement mechanism is between them in some form, monitoring the exchange. Considering the ubiquity of such scenarios in the computing world, there has been an increased effort to build formal models of runtime monitors that closely capture their capabilities so that their effectiveness can be analysed more precisely. While models have grown more …

Evidence For Viral Infection In The Copepods Labidocera Aestiva And Acartia Tonsa In Tampa Bay, Florida, Darren Stephenson Dunlap

USF Tampa Graduate Theses and Dissertations

Mesozooplankton are of critical importance to marine food webs by transferring energy from the microbial food web to higher trophic levels and depositing energy to the deeper ocean layers through fecal deposition. While decades of research have shown that viruses have significant impacts in the oceans, and infect a wide range of organisms from bacteria to whales, there is still little known about the impacts of viruses on the mesozooplankton community. As copepods are the most abundant mesozooplankton group, this study sought to characterize the viruses present in natural populations of the calanoid copepods Acartia tonsa and Labidocera aestiva in …

Developing Predictive Models For Lung Tumor Analysis, Satrajit Basu

USF Tampa Graduate Theses and Dissertations

A CT-scan of lungs has become ubiquitous as a thoracic diagnostic tool. Thus, using CT-scan images in developing predictive models for tumor types and survival time of patients afflicted with Non-Small Cell Lung Cancer (NSCLC) would provide a novel approach to non-invasive tumor analysis. It can provide an alternative to histopathological techniques such as needle biopsy. Two major tumor analysis problems were addressed in course of this study, tumor type classification and survival time prediction. CT-scan images of 109 patients with NSCLC were used in this study. The first involved classifying tumor types into two major classes of non-small cell …

An Ecological Assessment Of A Juvenile Estuarine Sportfish, Common Snook (Centropomus Undecimalis), In A Tidal Tributary Of Tampa Bay, Florida, Adam Benjamin Brame

USF Tampa Graduate Theses and Dissertations

The common snook, Centropomus undecimalis, is an estuarine dependent sport fish that relies upon subtidal wetlands as nursery habitat. Despite the economic and recreational significance of this species, there are portions of its life history and biology that are poorly understood, particularly its early life history. Understanding juvenile snook use of wetland habitats is crucial given the rapid loss and degradation of these areas to anthropogenic impacts. Young-of-the-year snook were collected in pond and creek habitats of a single wetland system to assess early life ecology and habitat use. Proxies of habitat quality were used to determine which habitats …

Overcoming Limitations Of Serial Audio Search, Isabela Cordeiro Ribeiro Moura Hidalgo

USF Tampa Graduate Theses and Dissertations

The typical approach for finding audio recordings, such as music and sound effects, in a database is to enter some textual information into a search field. The results appear summarized in a list of textual descriptions of the audio files along with a function for playing back the recordings. Exploring such a list sequentially is a time-consuming and tedious way to search for sounds. This research evaluates whether searching for audio information can become more effective with a user interface capable of presenting multiple audio streams simultaneously.

A prototype audio player was developed with a user interface suitable for both …

Removal Of Bisphenol A Model Compounds And Related Substances Using Octolig®, Rachael Josephine Alessio

USF Tampa Graduate Theses and Dissertations

Bisphenol A used in the production of polycarbonate plastics and epoxy resins is ubiquitous in the environment. The raw material is released to the environment during the manufacturing process and by leaching from consumer products. Recent studies are suggesting that low-dose amounts of Bisphenol A may have adverse health effects on humans. The possibility of removing Bisphenol A from natural water sources or from solvents used to extract the material from consumer products before they enter the market has been studied. The use of model compounds and related substances (4-isopropylphenol, 4-(t-butyl) phenol, and nitrophenols) have been used to study their …

Compound-Specific Stable Isotopic Analysis Of Protein Amino Acids: Ecological Applications In Modern And Ancient Systems, Greg Ellis

USF Tampa Graduate Theses and Dissertations

Stable isotopic analysis of the major biochemically important elements is an increasingly utilized tool in the study of ecology. Patterns of isotopic fractionation in carbon and nitrogen are used to determine trophic linkages, nutrient pathways, and sources of primary production in numerous contexts. Traditional techniques rely on measurements made of bulk samples such as tissue, but emerging methods using individual chemical compounds provide a means of achieving deeper understanding in a variety of inquiries.

Amino acids, as the building blocks of proteins, are the dominant nitrogen-bearing biomolecules and are a major constituent of all life. Patterns of isotopic fractionation during …

Synthesis And Characterization Of Nanocomposites For Electrochemical Capacitors, Farah Alvi

USF Tampa Graduate Theses and Dissertations

Presently there are deep concerns over the environmental consequences and the consumption of non-renewable energy sources, with the accelerated greenhouse effect, triggered enormous interest in the use of renewable energy sources e.g., solar, hydropower, wind and geothermal. However the intermittent nature of harvesting renewable energy sources has recently gained considerable attention in the alternative reliable, cost effective, and environmentally friendly energy storage devices. The supercapacitor and lithium ion batteries are considered more efficient electrical energy storage devices than conventional energy storage systems.

Both devices have many useful and important applications; they could be an excellent source for high power and …