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2016

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Articles 12151 - 12180 of 12690

Full-Text Articles in Physical Sciences and Mathematics

An Efficient Solution To The Mixed Shop Scheduling Problem Using A Modified Genetic Algorithm, V. Nguyen, H. P. Bao Jan 2016

An Efficient Solution To The Mixed Shop Scheduling Problem Using A Modified Genetic Algorithm, V. Nguyen, H. P. Bao

Mechanical & Aerospace Engineering Faculty Publications

The mixed job shop scheduling problem is one in which some jobs have fixed machine orders and other jobs may be processed in arbitrary orders. In past literature, optimal solutions have been proposed based on adaptations of classical solutions such as by Johnson, Thompson and Giffler among many others, by pseudopolynomial algorithms, by simulation, and by Genetic Algorithms (GA). GA based solutions have been proposed for flexible Job shops. This paper proposes a GA algorithm for the mixed job shop scheduling problem. The paper starts with an analysis of the characteristics of the so-called mixed shop problem. Based on those …


Margaret Chase Smith Essay: Maine And Climate Change: The View From Greenland, Angus King Jan 2016

Margaret Chase Smith Essay: Maine And Climate Change: The View From Greenland, Angus King

Maine Policy Review

Senator King discusses the issue of climate change and what it may mean for Maine and the nation in light of trip he took to Greenland in August 2016.


Heuristic And Exact Algorithms For The Two-Machine Just In Time Job Shop Scheduling Problem, Mohammed Al Salem, Leonardo Bedoya-Valencia, Ghaith Rabadi Jan 2016

Heuristic And Exact Algorithms For The Two-Machine Just In Time Job Shop Scheduling Problem, Mohammed Al Salem, Leonardo Bedoya-Valencia, Ghaith Rabadi

Engineering Management & Systems Engineering Faculty Publications

The problem addressed in this paper is the two-machine job shop scheduling problem when the objective is to minimize the total earliness and tardiness from a common due date (CDD) for a set of jobs when their weights equal 1 (unweighted problem). This objective became very significant after the introduction of the Just in Time manufacturing approach. A procedure to determine whether the CDD is restricted or unrestricted is developed and a semirestricted CDD is defined. Algorithms are introduced to find the optimal solution when the CDD is unrestricted and semirestricted. When the CDD is restricted, which is a much …


Risk And Safety Of Complex Network Systems, Xiao-Bing Hu, Adrian V. Gheorghe, Mark S. Leeson, Supeng Leng, Julien Bourgeois, Xiaobo Qu Jan 2016

Risk And Safety Of Complex Network Systems, Xiao-Bing Hu, Adrian V. Gheorghe, Mark S. Leeson, Supeng Leng, Julien Bourgeois, Xiaobo Qu

Engineering Management & Systems Engineering Faculty Publications

No abstract provided.


A Hierarchical Statistical Engineering Modeling Methodology, Teddy Steven Cotter Jan 2016

A Hierarchical Statistical Engineering Modeling Methodology, Teddy Steven Cotter

Engineering Management & Systems Engineering Faculty Publications

In the ASEM-IAC 2015, Cotter (2015) proposed a systemic joint deterministic-stochastic dynamic causal Bayesian statistical engineering model that addressed the knowledge gap needed to integrate deterministic mathematical engineering models within a stochastic framework. However, Cotter did not specify the modeling methodology through which statistical engineering models could be developed, diagnosed, and applied to predict systemic mission performance. This paper updates research into the development a hierarchical statistical engineering modeling methodology and sets forth the initial theoretical foundation for the methodology.


Energy Sustainability Of Turkey In The Case Of Lng, Omer Ilker Poyraz, Omer Keskin, Resit Unal Jan 2016

Energy Sustainability Of Turkey In The Case Of Lng, Omer Ilker Poyraz, Omer Keskin, Resit Unal

Engineering Management & Systems Engineering Faculty Publications

Energy is both vital and strategic element for a nation to sustain its fundamental activities like security, logistics, heating, etc. Countries sustain their energy demands through internal or external sources. In the case of not being able to maintain energy demands from their internal sources, they would need to import their requirements. Whenever they need to buy raw materials, they have to build terminals to process the raw material into the required form. The dependency on the imports may cause the importing country to weaken its advantage in international conflicts, unemployment, and welfare. Therefore, countries aim to mitigate dependence to …


Probing The Landscape: Toward A Systematic Taxonomy Of Online Peer Assessment Systems In Education, Dymytro Babik, Edward F. Gehringer, Jennifer Kidd, Ferry Pramudianto, David Tinapple Jan 2016

Probing The Landscape: Toward A Systematic Taxonomy Of Online Peer Assessment Systems In Education, Dymytro Babik, Edward F. Gehringer, Jennifer Kidd, Ferry Pramudianto, David Tinapple

Teaching & Learning Faculty Publications

We present the research framework for a taxonomy of online educational peer-assessment systems. This framework enables researchers in technology-supported peer assessment to understand the current landscape of technologies supporting student peer review and assessment, specifically, its affordances and constraints. The framework helps identify the major themes in existing and potential research and formulate an agenda for future studies. It also informs educators and system design practitioners about use cases and design options.


A Corpus Of Annotated Irish Traditional Dance Music Recordings: Design And Benchmark Evaluations, Pierre Beauguitte, Bryan Duggan, John D. Kelleher Jan 2016

A Corpus Of Annotated Irish Traditional Dance Music Recordings: Design And Benchmark Evaluations, Pierre Beauguitte, Bryan Duggan, John D. Kelleher

Conference papers

An emerging trend in music information retrieval (MIR) is the use of supervised machine learning to train automatic music transcription models. A prerequisite of adopting a machine learning methodology is the availability of annotated corpora. However, different genres of music have different characteristics and modelling these characteristics is an important part of creating state of the art MIR systems. Consequently, although some music corpora are available the use of these corpora is tied to the specific music genre, instrument type and recording context the corpus covers. This paper introduces the first corpus of annotations of audio recordings of Irish traditional …


Idiom Token Classification Using Sentential Distributed Semantics, Giancarlo Salton, Robert J. Ross, John D. Kelleher Jan 2016

Idiom Token Classification Using Sentential Distributed Semantics, Giancarlo Salton, Robert J. Ross, John D. Kelleher

Conference papers

Idiom token classification is the task of deciding for a set of potentially idiomatic phrases whether each occurrence of a phrase is a literal or idiomatic usage of the phrase. In this work we explore the use of Skip-Thought Vectors to create distributed representations that encode features that are predictive with respect to idiom token classification. We show that classifiers using these representations have competitive performance compared with the state of the art in idiom token classification. Importantly, however, our models use only the sentence containing the tar- get phrase as input and are thus less dependent on a potentially …


Sentiment Classification Using Negation As A Proxy For Negative Sentiment, Bruno Ohana, Brendan Tierney, Sarah Jane Delany Jan 2016

Sentiment Classification Using Negation As A Proxy For Negative Sentiment, Bruno Ohana, Brendan Tierney, Sarah Jane Delany

Conference papers

We explore the relationship between negated text and neg- ative sentiment in the task of sentiment classification. We propose a novel adjustment factor based on negation occur- rences as a proxy for negative sentiment that can be applied to lexicon-based classifiers equipped with a negation detec- tion pre-processing step. We performed an experiment on a multi-domain customer reviews dataset obtaining accuracy improvements over a baseline, and we further improved our results using out-of-domain data to calibrate the adjustment factor. We see future work possibilities in exploring nega- tion detection refinements, and expanding the experiment to a broader spectrum of opinionated …


Properties Of The Binary Black Hole Merger Gw150914, B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, A. Allocca, P. A. Altin, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun Jan 2016

Properties Of The Binary Black Hole Merger Gw150914, B. P. Abbott, R. Abbott, T. D. Abbott, M. R. Abernathy, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, A. Allocca, P. A. Altin, S. B. Anderson, W. G. Anderson, K. Arai, M. C. Araya, C. C. Arceneaux, J. S. Areeda, N. Arnaud, K. G. Arun

Physics and Astronomy Faculty Publications and Presentations

On September 14, 2015, the Laser Interferometer Gravitational-Wave Observatory (LIGO) detected a gravitational-wave transient (GW150914); we characterize the properties of the source and its parameters. The data around the time of the event were analyzed coherently across the LIGO network using a suite of accurate waveform models that describe gravitational waves from a compact binary system in general relativity. GW150914 was produced by a nearly equal mass binary black hole of masses 36-4+5M and 29-4+4M; for each parameter we report the median value and the range of the 90% credible interval. The dimensionless spin magnitude of the more massive black …


Novel Two-Dimensional Devices For Future Applications, Pratik Agnihotri Jan 2016

Novel Two-Dimensional Devices For Future Applications, Pratik Agnihotri

Legacy Theses & Dissertations (2009 - 2024)

The scalability of field effect transistor has led to the monumental success of complementary metal-oxide-semiconductor (CMOS) technology. In the past, device scaling was not the major issue to a greater extent. Recently with current technology nodes, transistor characteristics show signs of reduced performance due to short channel effects and other issues related to device scaling. Device designers look for innovative ways to enhance the transistor performance while keeping up with device miniaturization. Successful inventions include the development of tri-gate technology, gate all around (GAA) field effect transistors, silicon-on-insulator substrate, and high-k dielectrics. These developments have enabled the device scaling that …


Convergence Of A Smooth Random Average And Its Variation Inequality, Jaeyong Choi Jan 2016

Convergence Of A Smooth Random Average And Its Variation Inequality, Jaeyong Choi

Legacy Theses & Dissertations (2009 - 2024)

The Ergodic Theorem talks about the convergence of time averages of systems. The pointwise Ergodic Theorem states that the time averages converge to the space averages almost everywhere, for any integrable function $f$. When we consider in continuous time, because of instrumental limitations, time measurements cannot be taken exactly at any instant of time. Therefore, instead of dealing with averages along arithmetic sequences, in applications one has a smooth average around the time of observation. In this dissertation we investigate the pointwise behavior of smoothed out average with a measure preserving continuous flow on a probability space, $\displaystyle K_{n} f(x) …


On Topological Indices And Domination Numbers Of Graphs, Shaohui Wang Jan 2016

On Topological Indices And Domination Numbers Of Graphs, Shaohui Wang

Electronic Theses and Dissertations

Topological indices and dominating problems are popular topics in Graph Theory. There are various topological indices such as degree-based topological indices, distance-based topological indices and counting related topological indices et al. These topological indices correlate certain physicochemical properties such as boiling point, stability of chemical compounds. The concepts of domination number and independent domination number, introduced from the mid-1860s, are very fundamental in Graph Theory. In this dissertation, we provide new theoretical results on these two topics. We study k-trees and cactus graphs with the sharp upper and lower bounds of the degree-based topological indices(Multiplicative Zagreb indices). The extremal cacti …


Gas Exchange Of Hg Over Wetlands, Effect Of Biochar And Activated Carbon On Hg Emissions From Soil, And Seasonal Concentrations Of Hg In Rain, Divya Nallamothu Jan 2016

Gas Exchange Of Hg Over Wetlands, Effect Of Biochar And Activated Carbon On Hg Emissions From Soil, And Seasonal Concentrations Of Hg In Rain, Divya Nallamothu

Electronic Theses and Dissertations

Mercury (Hg) is a global pollutant with human-health and ecological impacts. Gaseous Hg exchange between the atmosphere and aquatic or terrestrial surfaces serves as an important, but not well understood, route for Hg to enter and exit ecosystems. To better understand the role of gaseous Hg exchange in the biogeochemical cycling of Hg, we investigated Hg0 fluxes over natural wetlands (Sky Lake) and artificial wetlands (UM Field Station) using a dynamic flux chamber and an Hg vapor analyzer based on atomic fluorescence (Chapter 1). We also examined the effect of activated carbon and biochar on Hg emissions from soils for …


Anodic Metal Dissolution In Haloaluminate Molten Salts/Ionic Liquids, Chen Wang Jan 2016

Anodic Metal Dissolution In Haloaluminate Molten Salts/Ionic Liquids, Chen Wang

Electronic Theses and Dissertations

The anodization of Aluminium was investigated in the low-melting, mixed halide molten salt system, lialbr4-naalcl4-kalcl4 (30-50-20 m/o), and in the Lewis acidic Chloroaluminate ionic liquid, aluminum chloride-1-ethyl-3-methylimidazolium chloride (alcl3-etmeimcl) using rotating disk electrode voltammetry. In both cases, at modest overpotentials, the anodization reaction proceeds under mixed kinetic/mass-transport control. However, at larger positive overpotentials and correspondingly higher anodization rates, the reaction transitions to a mass transport-limited process governed by the dissolution of a passive layer of alcl3(s) and/or albr3(s) on the electrode surface. In alcl3-etmeimcl, the passive current density scales linearly with the concentration of alcl4- in the ionic liquid. The …


Investigation Of Neural And Epithelial Cadherin Monomer Properties Using A Molecular Dynamics Approach, Lianyi Fan Jan 2016

Investigation Of Neural And Epithelial Cadherin Monomer Properties Using A Molecular Dynamics Approach, Lianyi Fan

Electronic Theses and Dissertations

Neural and epithelial cadherin are adhesion proteins intensely studied by our lab. Although the sequence, structure, and conformation are similar for the two cadherins, there are several physical properties that differ: dimerization affinity, dimerization kinetics, intermediate structure, and critical residues for dimerization. In the presence of calcium, cadherins are in equilibrium between monomeric and dimeric states, and the scope of this thesis focuses on monomeric cadherin. These molecular dynamics evaluations are based on the testing of specific hypotheses regarding the intramolecular interactions of neural and epithelial cadherin. We particularly focus on interactions involving critical residues at the N-terminus of the …


Independent Domination Of Subcubic Graphs, Bruce Allan Priddy Jan 2016

Independent Domination Of Subcubic Graphs, Bruce Allan Priddy

Electronic Theses and Dissertations

Let G be a simple graph. The independent domination number i(G) is the minimum cardinality among all maximal independent sets of G. A graph is subcubic whenever the maximum degree is at most three. In this paper, we will show that the independent domination number of a connected subcubic graph of order n having minimum degree at least two is at most 3(n+1)/7, providing a sharp upper bound for subcubic connected graphs with minimum degree at least two.


Calculating Liquefaction Potential Of Northern Mississippi Using Shear Wave Data, Peshani Herath Jan 2016

Calculating Liquefaction Potential Of Northern Mississippi Using Shear Wave Data, Peshani Herath

Honors Theses

The potential for liquefaction can be determined using the Liquefaction Potential Index (LPI). The LPI takes into account the thickness of the liquefiable layers and the factors of safety with respect to depth. This study creates a hybrid method for determining the LPI for different locations in Northern Mississippi. It calculates an average CSR for the region using existing borehole information. The CRR is then calculated using shear wave velocity profile data from a MASW survey. The LPI obtained from this process is compared to LPI values calculated using CPT data and borehole shear wave data. Surface shear wave velocity …


Rhenium-Pyridyl-Nhcs For Photocatalytic Co2 Reduction, Emily Anne Sharpe Jan 2016

Rhenium-Pyridyl-Nhcs For Photocatalytic Co2 Reduction, Emily Anne Sharpe

Honors Theses

The ability to transform CO2 into a useable fuel source would have a remarkably positive impact on the environment by taking the vast amounts of previous unusable CO2 from the atmosphere and reducing it to CO, which can then be turned into fuel. This project involves the synthesis and testing of air and water stable Re (I) pyridyl N- heterocyclic carbene (NHC) compounds for photocatalytic reduction of CO2 into CO using a simulated solar spectrum. Previous research in this area focused on the use of Re(bpy)CO3X, which quickly became the benchmark of homogeneous CO2 reduction photocatalysts. The Re (I) pyridyl …


Gold And Silver Alloy Nanoparticles: Synthesis, Characterization And Atomic Structure, Chanaka Kapila Kumara Jan 2016

Gold And Silver Alloy Nanoparticles: Synthesis, Characterization And Atomic Structure, Chanaka Kapila Kumara

Electronic Theses and Dissertations

Nanotechnology is an emerging field of science with applications in digital electronics, medicine, catalysis and energy. Gold nanoparticles are nanomaterials that have less than 100 nm at least in one dimension. The composition and the structure/geometry of the nanoparticles determine the chemical properties and reactivity. Modern research focus on method development in atomically monodisperse nanoparticle synthesis. This dissertation describes the method development for synthesis and isolation of atomically precise gold and gold-silver alloy nanoparticles and their comprehensive characterization and atomic structure investigation. Chapter one offers an introduction to the synthesis and isolation methods. These nanoparticles can be represented in the …


Unprecedented Ractivity Of 1-Aza-2-Azoniaallene Salts: New Methodologies And Mechanistic Studies For The Formation Of Diazenium Salts And Tetrahydropyridazines, Nezar Al-Bataineh Jan 2016

Unprecedented Ractivity Of 1-Aza-2-Azoniaallene Salts: New Methodologies And Mechanistic Studies For The Formation Of Diazenium Salts And Tetrahydropyridazines, Nezar Al-Bataineh

Graduate College Dissertations and Theses

This thesis describes the research conducted towards the overall goal of developing new synthetic organic methods to facilitate the synthesis of structurally complex nitrogen-containing polycyclic compounds. More specifically, I will describe the diverse reactivity of 1-aza-2-azoniaallene systems to make polycyclic diazenium salts and tetrahydropyridazine rings. I will also describe mechanistic studies undertaken to better understand this reactivity.

The Brewer research group has discovered that hydrazones undergo an oxidation reaction with chlorodimethylsulfonium chloride to afford -chloroazo compounds, which react intramolecularly with pendent alkene units to give bicyclic ring fused and bridged diazenium salts. My work includes a mechanistic study to understand …


Placing Natural Resource Decisions In Social And Historical Contexts: Sociological Inquiries Into Agency Communications, Management Rationalities, And Community Change, Emilian Geczi Jan 2016

Placing Natural Resource Decisions In Social And Historical Contexts: Sociological Inquiries Into Agency Communications, Management Rationalities, And Community Change, Emilian Geczi

Graduate College Dissertations and Theses

A sociological understanding of natural resource management decisions traces the links between historical change (How does this historical period differ from other periods?), society (What social relations exist at this time and how do they persist or change?), and individuals (What types of conduct and discourse prevail in this society and in this period?). The papers submitted for this dissertation examine the connections between identity, social milieu, and historical change relative to three resource management issues:

(1) The promotion of nature play areas as a novel landscape form. Analysis of agency materials suggests that these spaces are advertised as bucolic …


Investigations Into Carbon Nanotube And Natural Product Synthesis., Geoffrey Giampa Jan 2016

Investigations Into Carbon Nanotube And Natural Product Synthesis., Geoffrey Giampa

Graduate College Dissertations and Theses

This dissertation describes research into the synthesis of carbon nanotubes using traditional organic synthetic methods, as well as work on the fragmentation of β-hydroxy-α-diazoesters with a γ-hetero group and applications of their reactivity towards natural product synthesis.

Carbon nanotubes are unique structures that can exhibit different electronic properties based on their chiral vector, and are a potential future source of semiconductors. Current methods of synthesis are unable to be adapted to commercial synthesis, providing the opportunity for the application of organic synthetic methods to generate them more uniformly and on a larger scale.

The generation of tethered aldehyde ynoates and …


The Relationship Between Magmatism And Deformation During The Acadian Orogeny: A Case Study From Eastern-Central Vermont, Samuel William Lagor Jan 2016

The Relationship Between Magmatism And Deformation During The Acadian Orogeny: A Case Study From Eastern-Central Vermont, Samuel William Lagor

Graduate College Dissertations and Theses

The Silurian-Devonian metasedimentary rocks of the Connecticut Valley-Gaspé trough (CVGT) were subjected to multiple deformational and metamorphic events during the Acadian orogeny in the Middle-Late Devonian. Plutons intruding the Devonian Waits River and Gile Mountain Formations have been considered post-tectonic, but microstructural studies of the intrusions and their metamorphic aureoles indicate some of these plutons intruded syntectonically. This study investigates the relationship between Acadian deformation and intrusion of the Knox Mountain pluton (KMP) of central Vermont. Structural and geochronological data were collected along a c. 15 km transect from the western limit of the CVGT, where the unconformable Richardson Memorial …


Earthworms In Vermont Forest Soils: A Study Of Nutrient, Carbon, Nitrogen And Native Plant Responses, Ryan Melnichuk Jan 2016

Earthworms In Vermont Forest Soils: A Study Of Nutrient, Carbon, Nitrogen And Native Plant Responses, Ryan Melnichuk

Graduate College Dissertations and Theses

Anthropogenic activities surrounding horticulture, agriculture and recreation have increased dispersal of invasive earthworms. The introduction of earthworms initiates many physical and chemical alterations in forest soils previously unoccupied by earthworms. Three trials were performed to assess the effects of earthworms on soil-water dynamics, C and N and defensive/storage compound production by a native plant.

The first trial was a greenhouse experiment, performed to assess the impact of two ecologically contrasting invasive earthworm species on percolate and evaporative soil water loss. Mesocosms were constructed to simulate a typical forest Entisol commonly penetrated by the species of interest, Lumbricus terrestris and Amynthas …


Polarization Charge Density In Strained Graphene, Noah Wilson Jan 2016

Polarization Charge Density In Strained Graphene, Noah Wilson

Graduate College Dissertations and Theses

Graphene, the world's first truly two-dimensional material, is unique for having an electronic structure described by an effective Lorentz invariant theory. One important consequence is that the ratio or Coulomb energy to kinetic energy is a constant, depending only on conditions within the lattice rather than on the average charge density as in a typical Galilean invariant material. Given this unusual property, a natural question would be how do phenomena, such as screening of a Coulomb impurity, happen in graphene? Moreover, how does the addition of uniaxial strain enhance or diminish this behavior? Here I discuss our work to calculate …


Comparing Meteoric 10be, In Situ 10be, And Native 9be Across A Diverse Set Of Watersheds, Emily Sophie Greene Jan 2016

Comparing Meteoric 10be, In Situ 10be, And Native 9be Across A Diverse Set Of Watersheds, Emily Sophie Greene

Graduate College Dissertations and Theses

The cosmogenic nuclide 10Be is a tool for quantifying earth surface processes that occur on millennial timescales. 10Be is produced in the atmosphere (meteoric 10Be) or in mineral grains (in situ 10Be). Well-understood nuclear physics, physical mixing processes, and the denudation of regolith control concentrations of in situ 10Be; in contrast, a combination of geomorphic, pedogenic, geochemical, and biological processes influence meteoric 10Be concentrations. Some have hypothesized that meteoric 10Be can be used as a tracer of sediment movement if meteoric 10Be is normalized against the concentration of native 9Be in grain coatings. This study aims to better understand Be …


Establishing Chemical Mechanisms And Estimating Phase State Of Secondary Organic Aerosol From Atmospherically Relevant Organic Precursors, Shashank Jain Jan 2016

Establishing Chemical Mechanisms And Estimating Phase State Of Secondary Organic Aerosol From Atmospherically Relevant Organic Precursors, Shashank Jain

Graduate College Dissertations and Theses

Organic aerosol (OA) is a ubiquitous component of atmospheric particulate that influences both human health and global climate. A large fraction of OA is secondary in nature (SOA), being produced by oxidation of volatile organic compounds (VOCs) emitted by biogenic and anthropogenic sources. Despite the integral role of SOA in atmospheric processes, there remains a limited scientific understanding of the chemical and physical changes induced in SOA as it ages in the atmosphere. This thesis describes work done to increase the knowledge of processes and properties of atmospherically relevant SOA.

In the work presented in this thesis, I have worked …


Homology Modeling And Molecular Docking Of Antagonists To Class B G-Protein Coupled Receptor Pituitary Adenylate Cyclase Type 1 (Pac1r), Suzanne Louise Stanton Jan 2016

Homology Modeling And Molecular Docking Of Antagonists To Class B G-Protein Coupled Receptor Pituitary Adenylate Cyclase Type 1 (Pac1r), Suzanne Louise Stanton

Graduate College Dissertations and Theses

Recent studies have identified the Class B g-protein coupled receptor (GPCR) pituitary adenylate cyclase activating polypeptide type 1 (PAC1R) as a key component in physiological stress management. Over-activity of neurological stress response systems due to prolonged or extreme exposure to traumatic events has led researchers to investigate PAC1R inhibition as a possible treatment for anxiety disorders such as post-traumatic stress disorder (PTSD). In 2008, Beebe and coworkers identified two such small molecule hydrazide antagonists and a general pharmacaphore for PAC1R inhibition. However, a relative dearth of information about Class B GPCRs in general, and PAC1R in specific, has significantly hindered …