Social and Behavioral Sciences Commons^™

Tccon Philippines: First Measurement Results, Satellite Data And Model Comparisons In Southeast Asia, Voltaire A. Velazco, Isamu Morino, Osamu Uchino, Akihiro Hori, Matthaus Kiel, Beata Bukosa, Nicholas M. Deutscher, Tetsu Sakai, Tomohiro Nagai, Gerry Bagtasa, Toshiharu Izumi, Yukio Yoshida, David W. T Griffith

Faculty of Science, Medicine and Health - Papers: part A

The Total Carbon Column Observing Network (TCCON) is a global network dedicated to the precise and accurate measurements of greenhouse gases (GHG) in the atmosphere. The TCCON station in Burgos, Ilocos Norte, Philippines was established with the primary purpose of validating the upcoming Greenhouse gases Observing SATellite-2 (GOSAT-2) mission and in general, to respond to the need for reliable ground-based validation data for satellite GHG observations in the region. Here, we present the first 4 months of data from the new TCCON site in Burgos, initial comparisons with satellite measurements of CO₂ and model simulations of CO. A nearest …

Registered Nurses Transitioning From Acute Care To Primary Healthcare Employment: A Qualitative Insight Into Nurses' Experiences, Christine Ashley, Angela M. Brown, Elizabeth J. Halcomb, Kathleen Peters

Faculty of Science, Medicine and Health - Papers: part A

Aims and objectives: To describe the experiences of acute care registered nurses transitioning to primary healthcare settings.

Background: The worldwide increasing demand for primary healthcare services has resulted in skilled acute care nurses transitioning to primary healthcare settings to meet workforce requirements. Little is known about the experiences and challenges associated with the transition. Knowledge of this will enable employers to design appropriate support processes and transitioning nurses can make informed choices.

Methods: Semistructured interviews were conducted with nurses who had transitioned into primary healthcare employment in the last 5 years. Data analysis was undertaken using Braun …

Antimalarial And Cytotoxic Activities Of Pregnene-Type Steroidal Alkaloids From Holarrhena Pubescens Roots, Sarot Cheenpracha, Pannakorn Boapun, Thunwadee Limtharakul, Surat Laphookhieo, Stephen G. Pyne

Faculty of Science, Medicine and Health - Papers: part A

The phytochemical investigation of an alkaloidal extract of Holarrhena pubescens roots led to the isolation and identification of a new pregnene-type alkaloid, mokluangin D (1), together with nine known steroidal alkaloids (2-10). The structure of the new metabolite was determined on the basis of spectroscopic analyses including 1D- and 2D-NMR spectroscopy and mass spectrometry. Compounds 3 and 4 showed potent antimalarial activity against Plasmodium falciparum K1 stain with IC₅₀ values of 1.2 and 2.0 μM, respectively, and showed weak cytotoxic activity against the NCI-H187 cell line with IC₅₀ values of 27.7 and 30.6 μM, respectively. The substituent groups …

Improved Method For Linear Carbon Monoxide Simulation And Source Attribution In Atmospheric Chemistry Models Illustrated Using Geos-Chem V9, Jenny A. Fisher, Lee Murray, Dylan B. A Jones, Nicholas M. Deutscher

Faculty of Science, Medicine and Health - Papers: part A

Carbon monoxide (CO) simulation in atmospheric chemistry models is frequently used for source-receptor analysis, emission inversion, interpretation of observations, and chemical forecasting due to its computational efficiency and ability to quantitatively link simulated CO burdens to sources. While several methods exist for modeling CO source attribution, most are inappropriate for regions where the CO budget is dominated by secondary production rather than direct emissions. Here, we introduce a major update to the linear CO-only capability in the GEOS-Chem chemical transport model that for the first time allows source-region tagging of secondary CO produced from oxidation of non-methane volatile organic compounds. …

Continental Origin Of The Gubaoquan Eclogite And Implications For Evolution Of The Beishan Orogen, Central Asian Orogenic Belt, Nw China, Wanchese Saktura, Solomon Buckman, Allen Phillip Nutman, Elena Belousova, Zhen Yan, Jonathan C. Aitchison

Faculty of Science, Medicine and Health - Papers: part A

The Gubaoquan eclogite occurs in the Paleozoic Beishan Orogen of NW China. Previously it has been interpreted as a fragment of subducted oceanic crust that was emplaced as a mélange within continental rocks. Contrary to this, we demonstrate that the Gubaoquan eclogite protolith was a Neoproterozoic basic dyke/sill which intruded into Proterozoic continental rocks. The SHRIMP U-Pb zircon dating of the metamorphic rims of the Gubaoquan eclogite yields an age 466 ± 27 Ma. Subdued heavy rare earth element abundances and lack of negative Eu anomalies of the metamorphic zircon domains confirm that this age represents eclogite facies metamorphism. The …

Improving Global Paleogeography Since The Late Paleozoic Using Paleobiology, Wenchao Cao, Sabin Zahirovic, Nicolas Flament, Simon E. Williams, Jan Golonka, R. Dietmar Muller

Faculty of Science, Medicine and Health - Papers: part A

Paleogeographic reconstructions are important to understand Earth's tectonic evolution, past eustatic and regional sea level change, paleoclimate and ocean circulation, deep Earth resources and to constrain and interpret the dynamic topography predicted by mantle convection models. Global paleogeographic maps have been compiled and published, but they are generally presented as static maps with varying map projections, different time intervals represented by the maps and different plate motion models that underlie the paleogeographic reconstructions. This makes it difficult to convert the maps into a digital form and link them to alternative digital plate tectonic reconstructions. To address this limitation, we develop …

Evaluation Of Pmip2 And Pmip3 Simulations Of Mid-Holocene Climate In The Indo-Pacific, Australasian And Southern Ocean Regions, Duncan Ackerley, Jessica M. Reeves, Cameron Barr, Helen C. Bostock, Kathryn Fitzsimmons, Michael-Shawn Fletcher, Chris Gouramanis, Helen V. Mcgregor, Scott D. Mooney, Steven J. Phipps, John Tibby, Jonathan Tyler

Faculty of Science, Medicine and Health - Papers: part A

This study uses the "simplified patterns of temperature and effective precipitation" approach from the Australian component of the international palaeoclimate synthesis effort (INTegration of Ice core, MArine and TErrestrial records - OZ-INTIMATE) to compare atmosphere-ocean general circulation model (AOGCM) simulations and proxy reconstructions. The approach is used in order to identify important properties (e.g. circulation and precipitation) of past climatic states from the models and proxies, which is a primary objective of the Southern Hemisphere Assessment of PalaeoEnvironment (SHAPE) initiative. The AOGCM data are taken from the Paleoclimate Modelling Intercomparison Project (PMIP) mid-Holocene (ca. 6000 years before present, 6 ka) …

A Spatio-Temporal Assessment Of Landcover And Coastal Changes At Wandandian Delta System, Southeastern Australia, Ali Kareem Mohammed Al-Nasrawi, Carl A. Hopley, Sarah Hamylton, Brian G. Jones

Faculty of Science, Medicine and Health - Papers: part A

Large numbers of people live along and depend upon the world's coastal resources. Human modifications of the coastal zone, in combination with climate induced environmental changes, have had a major effect on the natural ecological systems. GIS analysis of remote sensed data, combined with fieldwork and laboratory tests, can be used to determine the resultant eco-geomorphic changes that need to be managed sustainably on a worldwide scale. Modelling the eco-geomorphic dynamics between 1949 and 2016 on the Wandandian Creek delta (southeastern NSW, Australia) provides a case study of management options for such coastal resources. Results from theWandandian Creek delta show …

Mapping Coral Reef Environments: A Review Of Historical Methods, Recent Advances And Future Opportunities, Sarah Hamylton

Faculty of Science, Medicine and Health - Papers: part A

Coral reef environments support high levels of marine biodiversity, they are important sites for coastal habitation and they provide a range of goods and ecosystem services such as nearshore fisheries, economic revenue from tourism and breeding sites for seabirds and turtles. Mapping is a fundamental activity that underpins our understanding of coral reef environments and helps to shape policies in resource management and conservation. This is particularly the case for quantifying the area of landcover types associated with reef environments, including coral patches, seagrasses and mangroves, but also for monitoring how these change over time and modelling how spatial patterns …

Gsto1-1 Plays A Pro-Inflammatory Role In Models Of Inflammation, Colitis And Obesity, Deepthi Menon, Ashlee Innes, Aaron J. Oakley, Jane E. Dahlstrom, Lora M. Jensen, Anne Brustle, Padmaja Tummala, Melissa Rooke, Marco G. Casarotto, Jonathan Baell, Nghi Nguyen, Yiyue Xie, Matthew Cuellar, Jessica Strasser, Jayme L. Dahlin, Michael A. Walters, Gaetan Burgio, Luke O'Neill, Philip G. Board

Faculty of Science, Medicine and Health - Papers: part A

Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-infammatory role in response to LPS. Here we show that genetic knockout of Gsto1 alters the response of mice to three distinct infammatory disease models. GSTO1-1 defciency ameliorates the inflammatory response stimulated by LPS and attenuates the infammatory impact of a high fat diet on glucose tolerance and insulin resistance. In contrast, GSTO1-1 defcient mice show a more severe inflammatory response and increased escape of bacteria from the colon into the lymphatic system in a dextran sodium sulfate mediated model of infammatory bowel disease. These responses are …

Facilitation, Competition And Parasitic Facilitation Amongst Invasive And Native Liana Seedlings And A Native Tree Seedling, Kris French, Sharon A. Robinson, Liza B. Smith, Eva M. Watts

Faculty of Science, Medicine and Health - Papers: part A

Lianas are prevalent in gaps and edges of forests where they compete intensely with trees, reducing growth and recruitment. Invasive lianas have the potential to be particularly harmful as the competitive advantage of the liana life history may be coupled with the more competitive qualities of invasiveness. However, in early stages of growth of lianas and native tree seedlings, facilitatory interactions or competitive interactions associated with soil nutrients may be more prevalent. We investigated interactions at the early stages of growth between native and invasive lianas with a common rainforest tree of temperate Australian rainforests under different light conditions. Invasive …

Physical Environmental Designs In Residential Care To Improve Quality Of Life Of Older People, Stephanie L. Harrison, Suzanne M. Dyer, Kate E. Laver, Rachel K. Milte, Richard Fleming, Maria Crotty

Faculty of Science, Medicine and Health - Papers: part A

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The main objective is to assess the effects of changes to the physical environment or alternative models of residential care on the quality of life of people living in care facilities. The secondary objective is to assess whether the effects of changes to the physical environment or alternative models of residential care have a different impact on quality of life according to whether the population are living with dementia.

Designing Simulation Learning Experiences To Reduce Technological Burden On Nursing Academics: A Discussion Paper, Colleen Ryan, Sherre Roy, Barbara O'Neill, Tracey Simes, Samuel Lapkin, Elizabeth Curtis

Faculty of Science, Medicine and Health - Papers: part A

Objective: The literature reports nursing academics avoid manikin-based simulation because they feel intimidated by the technology. With that in mind we sought to design a manikin-based simulation learning experience for nursing students, with low technological burden for those nursing academics expected to work with the technology.

Setting: A multi-campus Australian regional university school of nursing.

Subjects Nursing academics with little or no experience in manikin-based simulation.

Primary argument: Nursing academics are encouraged to use manikins in their clinical teaching but little has been done to address their fears and concerns around the technology. We argue that taking …

The Total Carbon Column Observing Network Site Description For Lauder, New Zealand, David F. Pollard, Vanessa Sherlock, John Robinson, Nicholas M. Deutscher, Brian J. Connor, Hisako Shiona

Faculty of Science, Medicine and Health - Papers: part A

In this paper we describe the retrievals of atmospheric trace gases from near-infrared, high-resolution solar absorption spectroscopy measurements at the Lauder atmospheric research station in New Zealand and submitted to the Total Carbon Column Observing Network (TCCON) archive. The Lauder site (45.034^◦ S, 169.68^◦ E, 370 m a.s.l.) is located within a sparsely populated region of the South Island of New Zealand and is sheltered from the prevailing wind direction by the Southern Alps, which gives the site a high number of clear-sky days and an air mass that is largely unmodified by regional anthropogenic sources. The Lauder …

Validating The Psychiatric Nurses Methods Of Coping Questionnaire: Arabic Version, Ahmad Al-Sagarat, Marwa Barmawi, Lourance Al Hadid, Jamal A. S Qaddumi, Lorna Moxham

Faculty of Science, Medicine and Health - Papers: part A

Background: The aim of the study was to undertake a psychometric analysis of the Psychiatric Nurses Methods of Coping Questionnaire (PNMCQ) - Arabic version when used to measure coping skills in psychiatric nurses in Jordan.

Method: A descriptive, cross-sectional design was adopted in this study. A demographic questionnaire and the 35-item PNMCQ -Arabic were the measures used to collect data.

Result: The PNMCQ demonstrated valid and reliable values when administered to psychiatric nurses in Jordan after it had been submitted to factor analysis.

Conclusion: The development of PNMCQ: Arabic Version adequately measures coping skills in psychiatric nurses …

Cereal Fibre Intake In Australia: A Cross Sectional Analysis Of The 2011-12 National Nutrition And Physical Activity Survey, Eden Barrett, Yasmine Probst, Eleanor J. Beck

Faculty of Science, Medicine and Health - Papers: part A

Extensive evidence supports health benefits of cereal fibre, however globally no national intake data exists. This study aimed to determine estimates of intake and food sources of cereal fibre, and relationships to dietary fibre intake in an Australian sample population. A cereal fibre database was applied to dietary intake data from the 2011-12 National Nutrition and Physical Activity Survey (n ¼ 12,153). Usual intake based on 2-day intake data was weighted to infer population results. Median daily cereal fibre intake was 6.4 g/d (9.7 g/10 MJ/d) for adults (19-85 years) and 6.2 g/d (10.2 g/10 MJ/d) for children/adolescents (2-18 years). …

The Three-Dimensional Shapes Of Underground Coal Miners' Feet Do Not Match The Internal Dimensions Of Their Work Boots, Jessica Dobson, Diane L. Riddiford-Harland, Alison F. Bell, Julie R. Steele

Faculty of Science, Medicine and Health - Papers: part A

Mining work boots provide an interface between the foot and the ground, protecting and supporting miners' feet during lengthy coal mining shifts. Although underground coal miners report the fit of their work boots as reasonable to good, they frequently rate their boots as uncomfortable, suggesting that there is a mismatch between the shape of their feet and their boots. This study aimed to identify whether dimensions derived from the three-dimensional scans of 208 underground coal miners' feet (age 38.3 ± 9.8 years) differed from the internal dimensions of their work boots. The results revealed underground coal miners wore boots that …

A Contribution To Understanding The Impact Of Variations In Body Mass On Fractionating The Metabolic Burden Of Military Load Carriage, Heather Bowes, Catriona A. Burdon, Nigel A.S. Taylor

Faculty of Science, Medicine and Health - Papers: part A

Purpose: The oxygen cost associated with load carriage is dependent upon both its mass and its placement about the body. For occupations in which load carriage is routinely performed, and involves identical loads for all individuals, the relative metabolic cost varies inversely with body mass. However, whilst we understand the average impact of varying load placement, our appreciation of its impact on a morphologically diverse, contemporary workforce is very limited. Methods:The relationship between load placement and body mass was evaluated in 65 men (23.0 y [SD 3.0]; 80.5 kg [SD 1.7]: range 56.0-109.8 kg), matched for height-adjusted adiposity (59.3 mm …

Molecular Mechanisms Of Antipsychotic Drug-Induced Diabetes, Jiezhong Chen, Xu-Feng Huang, Renfu Shao, Chen Chen, Chao Deng

Faculty of Science, Medicine and Health - Papers: part A

Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As mental disorders are chronic diseases, these drugs are often used over a life-time. However, APDs can cause serious glucometabolic side-effects including type 2 diabetes and hyperglycaemic emergency, leading to medication non-compliance. At present, there is no effective approach to overcome these side-effects. Understanding the mechanisms for APD-induced diabetes should be helpful in prevention and treatment of these side-effects of APDs and thus improve the clinical outcomes of APDs. In this review, the potential mechanisms for APD-induced diabetes are summarized so that novel approaches can be considered to relieve …

Evaluation Of A Mass-Media Campaign To Increase The Awareness Of The Need To Reduce Discretionary Salt Use In The South African Population, Edelweiss Wentzel-Viljoen, Krisela Steyn, Carl J. Lombard, Anniza De Villiers, Karen E. Charlton, Sabine Frielinghaus, Christelle Crickmore, Vash Mungal-Singh

Faculty of Science, Medicine and Health - Papers: part A

The South African strategic plan to reduce cardiovascular disease (CVD) includes reducing population salt intake to less than 5 g/day. A mass media campaign was undertaken to increase public awareness of the association between high salt intake, blood pressure and CVD, and focused on the reduction of discretionary salt intake. Community based surveys, before and after the campaign, were conducted in a cohort of black women aged 18-55 years. Questions on knowledge, attitudes and beliefs regarding salt use were asked. Current interest in engaging with salt reduction behaviors was assessed using the "stage of change" model. Five hundred fifty women …

A Mixed-Methods Feasibility Study Of Routinely Weighing Patients In General Practice To Aid Weight Management, Andrew D. Bonney, Duncan Mackinnon, Stephen Barnett, Darren J. Mayne, Bridget R. Dijkmans-Hadley, Karen E. Charlton

Faculty of Science, Medicine and Health - Papers: part A

Background and objectives The optimal role of general practice in population weight management remains unclear. The aim of this mixed-methods study was to test the feasibility of routinely weighing all adult patients attending their general practice as an intervention to aid weight management in clinical practice. Methods Consenting patients in six general practices were weighed at each presentation over a 12-month period. Data were analysed using linear mixed growth models. Participants' interviews at the completion of the study were thematically analysed. Results The overall weight loss in patients who completed the study (n = 217) was 0.51 kg (P = …

Testing A Model Of Functional Impairment In Telephone Crisis Support Workers, Taneile Kitchingman, Coralie J. Wilson, Peter Caputi, Ian G. Wilson, Alan Woodward

Faculty of Science, Medicine and Health - Papers: part A

Background: It is well known that helping professionals experience functional impairment related to elevated symptoms of psychological distress as a result of frequent empathic engagement with distressed others. Whether telephone crisis support workers are impacted in a similar way is not currently reported in the literature. Aims: The purpose of this study was to test a hypothesized model of factors contributing to functional impairment in telephone crisis support workers. Method: A national sample of 210 telephone crisis support workers completed an online survey including measures of emotion regulation, symptoms of general psychological distress and suicidal ideation, intentions to seek help …

The Use Of Phenomenology In Mental Health Nursing Research, Caroline Picton, Lorna Moxham, Christopher F. Patterson

Faculty of Science, Medicine and Health - Papers: part A

Background: Historically, mental health research has been strongly influenced by the underlying positivism of the quantitative paradigm. Quantitative research dominates scientific enquiry and contributes significantly to understanding our natural world. It has also greatly benefitted the medical model of healthcare. However, the more literary, silent, qualitative approach is gaining prominence in human sciences research, particularly mental healthcare research.

Aim: To examine the qualitative methodological assumptions of phenomenology to illustrate the benefits to mental health research of studying the experiences of people with mental illness. Discussion: Phenomenology is well positioned to ask how people with mental illness reflect …

Why Phenomenology Is Increasingly Relevant To Nurse Researchers, Lorna Moxham, Christopher F. Patterson

Faculty of Science, Medicine and Health - Papers: part A

When nurse researchers contemplate designing a study they spend time, or at least they should, considering the ways in which epistemological assumptions inform their choice of methodology (Polit and Beck 2012). Pratt (2012) suggests that to understand the philosophical and methodological underpinnings of a research approach takes time, effort, commitment and total immersion on the part of the researcher. Once chosen, the right methodology for framing inquiry in nursing will guide the approaches used to collect data and conduct rigorous analysis.

Effect Of The Ginger Derivative, 6-Shogaol, On Ferritin Levels In Patients With Low To Intermediate-1-Risk Myelodysplastic Syndrome-A Small, Investigative Study, Terry Golombick, Terrence H. Diamond, Arumugam Manoharan, Raj Ramakrishna, Vladimir Badmaev

Faculty of Science, Medicine and Health - Papers: part A

Background: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal stem cell disorders characterized by dysplastic and ineffective hematopoiesis and peripheral cytopenias. Elevated serum ferritin (SF) is often observed in nontransfused, lower risk MDS. It has been reported that ineffective erythropoiesis enhances iron absorption in MDS through downregulation of hepcidin and its prohormones such that SF rises. Aim: To determine the effect of 6-shogaol, a dehydration derivative of ginger, known to have hepatoprotective and chemotherapeutic activity, on 6 early-stage, transfusion-independent patients with MDS, 3 of whom had raised levels of SF. Method: Six patients with MDS with low or intermediate-1 …

The Major Types Of Added Sugars And Non-Nutritive Sweeteners In A Sample Of Australian Packaged Foods, Yasmine Probst, Alexis Dengate, Jennifer Jacobs, Jimmy Chun Yu Louie, Elizabeth K. Dunford

Faculty of Science, Medicine and Health - Papers: part A

Limiting the intake of added sugars in the diet remains a key focus of global dietary recommendations. To date there has been no systematic monitoring of the major types of added sugars used in the Australian food supply. The present study aimed to identify the most common added sugars and non-nutritive sweeteners in the Australian packaged food supply. Secondary analysis of data from the Australian FoodSwitch database was undertaken. Forty-six added sugars and eight non-nutritive sweetener types were extracted from the ingredient lists of 5744 foods across seventeen food categories. Australia. Not applicable. Added sugar ingredients were found in 61 …

Diet Quality In Patients With End-Stage Kidney Disease Undergoing Dialysis, Lauren Roach, Kelly Lambert, Jane Holt, Barbara J. Meyer

Faculty of Science, Medicine and Health - Papers: part A

ACKGROUND: People on haemodialysis (HD) are at risk of consuming a poor quality diet. This includes inadequate intake of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). OBJECTIVE: This study aims to investigate diet quality, with a particular focus on n-3 LCPUFA intake, in a population of incentre HD patients. DESIGN: Dietary intake was measured using three 24 hour recalls; the Polyunsaturated food frequency questionnaire (PUFA FFQ) and the Total Diet Score (TDS). Dietary intake was also compared to evidence based practice guidelines (EBPG). Nutritional status was assessed using the Patient Generated Subjective Global Assessment (PG SGA). SUBJECTS: A total …

Teaching And Supporting Nursing Students On Clinical Placements: Doing The Right Thing, Carina Anderson, Lorna Moxham, Marc Broadbent

Faculty of Science, Medicine and Health - Papers: part A

Problem: Pre registration nursing students do not always feel supported by Registered Nurses during their clinical placements. To help develop and refine clinical skills, in order to deliver safe, competent nursing care, nursing students rely on Registered Nurses to teach and support them in their clinical learning.

Background: Pre-registration nursing students in Australia must undertake a minimum of 800 clinical placement hours as part of their undergraduate nursing education. Registered Nurses are required to provide professional development and to teach and support students during these clinical placements. Little is known about Registered Nurses' understanding of this nursing standard …

The Experiences Of Australian Undergraduate Nursing Students Of A Clinical Placement In Cambodia, Elizabeth J. Halcomb, Carolyn J. Antoniou, Rebekkah Middleton, Maria T. Mackay

Faculty of Science, Medicine and Health - Papers: part A

Background: International clinical placements are being increasingly offered to expose students to different health settings internationally. Both nationally and internationally there is a need to build the primary health care nursing workforce to meet changing community needs. Exposure to specialty areas during clinical placement can impact career choices.

Aim: This paper explores the experiences of Australian undergraduate nursing students undertaking a primary health care clinical placement in Cambodia.

Method: This exploratory qualitative study used semi-structured interviews to gather experiential narratives. Eight Australian undergraduate nursing students from a single University in New South Wales, Australia participated in the …

Perioperative Changes In Serum Ca125 Levels: A Prognostic Factor For Disease-Specific Survival In Patients With Ovarian Cancer, Nienke Zwakman, Rafli Van De Laar, Toon Van Gorp, Petra Zusterzeel, Marc Snijders, Isabel Ferreira, Leon Massuger, Roy Kruitwagen

Faculty of Science, Medicine and Health - Papers: part A

Objective: In patients with advanced stage epithelial ovarian cancer (EOC) the volume of residual tumor after debulking is known as prognostic factor for survival. We wanted to examine the relationship between postoperative decline in serum CA125 and residual disease after cytoreductive surgery and evaluate perioperative changes in serum CA125 levels as predictor for disease-specific survival. Methods: A retrospective study was conducted of patients with FIGO stage IIb-IV EOC treated with cytoreductive surgery, followed by chemotherapy between 1996 and 2010 in three hospitals in the Southeastern region of the Netherlands. Data were analyzed with the use of multilevel linear regression and …