Open Access. Powered by Scholars. Published by Universities.®

Social and Behavioral Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2014

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 7381 - 7410 of 25673

Full-Text Articles in Social and Behavioral Sciences

Review Of "Rethinking Asia’S Economic Miracle: The Political Economy Of War, Prosperity And Crisis", Su-Mei Ooi Jul 2014

Review Of "Rethinking Asia’S Economic Miracle: The Political Economy Of War, Prosperity And Crisis", Su-Mei Ooi

Su-Mei Ooi

The article reviews the book Rethinking Asia’s Economic Miracle: The Political Economy of War, Prosperity and Crisis by Richard Stubbs.


Review Of "Is Taiwan Chinese? The Impact Of Culture, Power, And Migration On Changing Identities", Su-Mei Ooi Jul 2014

Review Of "Is Taiwan Chinese? The Impact Of Culture, Power, And Migration On Changing Identities", Su-Mei Ooi

Su-Mei Ooi

The article reviews the book Is Taiwan Chinese? The Impact of Culture, Power, and Migration on Changing Identities by Melissa J. Brown.


Persistent Emotional Extremes And Video Relay Service Interpreters, Dawn M. Wessling, Sherry Shaw Jul 2014

Persistent Emotional Extremes And Video Relay Service Interpreters, Dawn M. Wessling, Sherry Shaw

Journal of Interpretation

This mixed methods study explored how call content emotionally affects video interpreters (VIs) who work in Video Relay Service (VRS) and how this influences perceptions of job satisfaction and general well-being. The participants included 889 self-reported VIs who completed a survey containing open and closed-ended questions regarding their work. Whereas VRS call content can be extremely emotional for the non-deaf and deaf callers, whether positive or negative, the study seeks to identify a spectrum of coping strategies to perceived stressors brought about by these emotionally charged incidents. The study examined the frequency of these types of calls processed by the …


Evidence Of A "Hearing" Dialect Of Asl While Interpreting, Campbell Mcdermid Jul 2014

Evidence Of A "Hearing" Dialect Of Asl While Interpreting, Campbell Mcdermid

Journal of Interpretation

Little is know about the characteristics of fluent hearing signers and their ultimate attainment of ASL as a second language. To address this, a study was conducted with 12 ASL-English interpreters who were native English speakers to examine their use of ASL while interpreting. Each subject was asked to simultaneously interpret a short English narrative into ASL and a panel of three Deaf native signers assessed their fluency. Though the group included both novice and expert interpreters, the results revealed many similarities in their work. These included a reduction in pronouns between the English source and ASL target text, the …


Review Of "Human Rights In Asia: A Comparative Legal Study Of Twelve Asian Jurisdictions, France And The Usa", Su-Mei Ooi Jul 2014

Review Of "Human Rights In Asia: A Comparative Legal Study Of Twelve Asian Jurisdictions, France And The Usa", Su-Mei Ooi

Su-Mei Ooi

This article reviews Human Rights in Asia: A Comparative Legal Study of Twelve Asian Jurisdictions, France and the USA by Randall Peerenboom, Carole J. Petersen, and Albert H.Y. Chen.


Winning At All Costs: A Case Study, Jacob K. Tingle, Stacy Warner Jul 2014

Winning At All Costs: A Case Study, Jacob K. Tingle, Stacy Warner

Jacob K Tingle

This case addresses the challenges of sport managers to make fair and ethical decisions while considering the many potential organizational outcomes of their decisions. The case is based on a real situation that occurred within a NCAA Division III athletics setting. It highlights the decision making process of a director of athletics who must respond to the untimely arrests of the university’s star quarterback and an assistant coach. The case provides an opportunity for students to critically examine the following: 1) how a sport organization’s policies and philosophical position impact decision making, and 2) the relationship between sport and education. …


An Administrative Mess: A Case Study From The Officiating Community, Stacy Warner, Jacob K. Tingle, Pamm Kellett Jul 2014

An Administrative Mess: A Case Study From The Officiating Community, Stacy Warner, Jacob K. Tingle, Pamm Kellett

Jacob K Tingle

This case is written for instructors of classes focused on strategic management, organisational behaviour, human resource management, and/or an officiating course. The case highlights the numerous administrative processes a new employee in a sport organization would face. Although the case is fictional it is based on the authors’ personal and professional experiences in athletics administration and officiating, and further draws upon the authors’ research in the area of officiating. Consequently, this case study was constructed based on first-hand observation, interviews and conversation with numerous officials and administrators, and through the examination of documents frequently used to manage officials. As a …


Developing A Student Employee Leadership Program: The Importance Of Evaluating Effectiveness, Jacob K. Tingle, Christina Cooney, Seth E. Asbury, Sheldon Tate Jul 2014

Developing A Student Employee Leadership Program: The Importance Of Evaluating Effectiveness, Jacob K. Tingle, Christina Cooney, Seth E. Asbury, Sheldon Tate

Jacob K Tingle

Outstanding student employees are essential for campus recreation programs to achieve organizational goals. To that end, this study examined the effectiveness of a leadership development program in which three groups of campus recreation (rec sports) student employees participated at various levels in the following: oncampus training, an off-site retreat, a scavenger hunt, and biweekly meetings. Using a quasi-experimental design, data were collected in two phases from 51 students and measured the growth of each student’s leadership capabilities as reported using the Student Leadership Practices Inventory. Statistical analyses revealed that group membership did significantly affect growth in the student’s leadership capacity, …


The Experience Of Former Women Officials And The Impact On The Sporting Community, Jacob K. Tingle, Stacy Warner, Melanie L. Sartore-Baldwin Jul 2014

The Experience Of Former Women Officials And The Impact On The Sporting Community, Jacob K. Tingle, Stacy Warner, Melanie L. Sartore-Baldwin

Jacob K Tingle

In an effort to explore the shortage of female sport officials, the authors examined the experience of eight former female basketball officials from five geographically diverse states in the U.S. who voluntarily left the role. Specifically, the authors asked former female basketball officials to describe their workplace experiences. Utilizing a phenomenological approach and workplace incivility framework, the results indicated that the felt social inequity for female officials detracted from the participants experiencing a sense of community in the workplace, which ultimately led to their discontinuation in the role. Results indicate four key factors that created this uncivil work environment. An …


Officiating Attrition: The Experiences Of Former Referees Via A Sport Development Lens, Stacy Warner, Jacob K. Tingle, Pamm Kellett Jul 2014

Officiating Attrition: The Experiences Of Former Referees Via A Sport Development Lens, Stacy Warner, Jacob K. Tingle, Pamm Kellett

Jacob K Tingle

Referees are key sport personnel who have important responsibilities both on- and off- the field. Organized competition would not survive without referees, yet little is known about what cause referees to discontinue in the role. This research examines the experiences of former referees so that managers may better understand strategies that might encourage more referees to be retained. Fifteen previous basketball referees were interviewed about their refereeing experience. Ten themes emerged that were related to the sport development stages of referee recruitment, referee retention, and referee advancement. The results indicate that issues experienced during the retention phase (Problematic Social Interaction, …


Can We Talk About Race? And Other Conversations In An Era Of School Resegregation [Book Review], Jacob K. Tingle Jul 2014

Can We Talk About Race? And Other Conversations In An Era Of School Resegregation [Book Review], Jacob K. Tingle

Jacob K Tingle

Ten years after Beverly Daniel Tatum wrote, Why Are All the Black Kids Sitting Together in the Cafeteria? she again closely examines the world of American education. In her latest work, Dr. Tatum gives the reader a seat in the auditorium at 4 lectures delivered at Simmons College during 2006. These lectures, the first of the Race, Education, and Democracy series, challenge educational leaders to look for better ways to serve our student populations. Coupling the texts’ historical underpinnings and practical advice, Dr. Tatum has written a book that should be required for those who work closely with college students.


Organizational Trust And Mindfulness In Ncaa Division Iii Athletic Departments, Jacob K. Tingle Jul 2014

Organizational Trust And Mindfulness In Ncaa Division Iii Athletic Departments, Jacob K. Tingle

Jacob K Tingle

No abstract provided.


Memory Modulation In The Classroom: Selective Enhancement Of College Examination Performance By Arousal Induced After Lecture, Kristy A. Nielson, Timothy J. Arentsen Jul 2014

Memory Modulation In The Classroom: Selective Enhancement Of College Examination Performance By Arousal Induced After Lecture, Kristy A. Nielson, Timothy J. Arentsen

Kristy Nielson

Laboratory studies examining moderate physiological or emotional arousal induced after learning indicate that it enhances memory consolidation. Yet, no studies have yet examined this effect in an applied context. As such, arousal was induced after a college lecture and its selective effects were examined on later exam performance. Participants were divided into two groups who either watched a neutral video clip (n = 66) or an arousing video clip (n = 70) after lecture in a psychology course. The final examination occurred two weeks after the experimental manipulation. Only performance on the group of final exam items that covered material …


Does Physical Activity Influence Semantic Memory Activation In Amnestic Mild Cognitive Impairment?, J. Smith, Kristy Nielson, John Woodard, Michael Seidenberg, Matthew Verber, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa Lancaster, Stephen Rao Jul 2014

Does Physical Activity Influence Semantic Memory Activation In Amnestic Mild Cognitive Impairment?, J. Smith, Kristy Nielson, John Woodard, Michael Seidenberg, Matthew Verber, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa Lancaster, Stephen Rao

Kristy Nielson

The effect of physical activity (PA) on functional brain activation for semantic memory in amnestic mild cognitive impairment (aMCI) was examined using event-related functional magnetic resonance imaging during fame discrimination. Significantly greater semantic memory activation occurred in the left caudate of High- versus Low-PA patients, (P=0.03), suggesting PA may enhance memory-related caudate activation in aMCI.


A Task To Manipulate Attentional Load, Set-Shifting, And Inhibitory Control: Convergent Validity And Test–Retest Reliability Of The Parametric Go/No-Go Test, Scott Aaron Langenecker, Jon-Kar Zubieta, Elizabeth Young, Kristy Nielson Jul 2014

A Task To Manipulate Attentional Load, Set-Shifting, And Inhibitory Control: Convergent Validity And Test–Retest Reliability Of The Parametric Go/No-Go Test, Scott Aaron Langenecker, Jon-Kar Zubieta, Elizabeth Young, Kristy Nielson

Kristy Nielson

Traditional neuropsychological measures of executive functioning are difficult to employ in functional imaging and clinical trial contexts and have tremendous practice effects. They also have poor sensitivity and specificity, while test–retest reliability is often not assessed in computer-based tests. The present study evaluates some psychometric properties of a new Parametric Go/No-Go (PGNG) Task. The PGNG consists of three levels of difficulty assessing attention, set-shifting, and processing speed, with the two more difficult levels assessing inhibitory control. A total of 63 healthy control participants were recruited at two sites to evaluate the psychometric properties of the PGNG. The PGNG was found …


Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao Jul 2014

Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao

Kristy Nielson

Leisure-time physical activity (PA) and exercise training are known to help maintain cognitive function in healthy older adults. However, relatively little is known about the effects of PA on cognitive function or brain function in those at increased risk for Alzheimer’s disease through the presence of the apolipoproteinE epsilon4 (APOE-ε4) allele, diagnosis of mild cognitive impairment (MCI), or the presence of metabolic disease. Here, we examine the question of whether PA and exercise interventions may differentially impact cognitive trajectory, clinical outcomes, and brain structure and function among individuals at the greatest risk for AD. The literature suggests that the protective …


Functional Magnetic Resonance Imaging Of Semantic Memory As A Presymptomatic Biomarker Of Alzheimer’S Disease Risk, Michael Sugarman, John L. Woodard, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Stephen M. Rao Jul 2014

Functional Magnetic Resonance Imaging Of Semantic Memory As A Presymptomatic Biomarker Of Alzheimer’S Disease Risk, Michael Sugarman, John L. Woodard, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Stephen M. Rao

Kristy Nielson

Extensive research efforts have been directed toward strategies for predicting risk of developing Alzheimer's disease (AD) prior to the appearance of observable symptoms. Existing approaches for early detection of AD vary in terms of their efficacy, invasiveness, and ease of implementation. Several non-invasive magnetic resonance imaging strategies have been developed for predicting decline in cognitively healthy older adults. This review will survey a number of studies, beginning with the development of a famous name discrimination task used to identify neural regions that participate in semantic memory retrieval and to test predictions of several key theories of the role of the …


Memory For Emotionally Provocative Words In Alexithymia: A Role For Stimulus Relevance, Mitchell Meltzer, Kristy A. Nielson Jul 2014

Memory For Emotionally Provocative Words In Alexithymia: A Role For Stimulus Relevance, Mitchell Meltzer, Kristy A. Nielson

Kristy Nielson

Alexithymia is associated with emotion processing deficits, particularly for negative emotional information. However, also common are a high prevalence of somatic symptoms and the perception of somatic sensations as distressing. Although little research has yet been conducted on memory in alexithymia, we hypothesized a paradoxical effect of alexithymia on memory. Specifically, recall of negative emotional words was expected to be reduced in alexithymia, while memory for illness words was expected to be enhanced in alexithymia. Eighty-five high or low alexithymia participants viewed and rated arousing illness-related ("pain"), emotionally positive ("thrill"), negative ("hatred"), and neutral words ("horse"). Recall was assessed 45 …


Gender Specific Disruptions In Emotion Processing In Younger Adults With Depression, Sara L. Wright, Scott Aaron Langenecker, Patricia J. Deldin, Lisa J. Rapport, Kristy A. Nielson, Allison M. Kade, Lawrence S. Own, Huda Akil, Elizabeth A. Young, Jon-Kar Zubieta Jul 2014

Gender Specific Disruptions In Emotion Processing In Younger Adults With Depression, Sara L. Wright, Scott Aaron Langenecker, Patricia J. Deldin, Lisa J. Rapport, Kristy A. Nielson, Allison M. Kade, Lawrence S. Own, Huda Akil, Elizabeth A. Young, Jon-Kar Zubieta

Kristy Nielson

Background: One of the principal theories regarding the biological basis of major depressive disorder (MDD) implicates a dysregulation of emotion-processing circuitry. Gender differences in how emotions are processed and relative experience with emotion processing might help to explain some of the disparities in the prevalence of MDD between women and men. This study sought to explore how gender and depression status relate to emotion processing. Methods: This study employed a 2 (MDD status) × 2 (gender) factorial design to explore differences in classifications of posed facial emotional expressions (N=151). Results: For errors, there was an …


Comparison Of Semantic And Episodic Memory Bold Fmri Activation In Predicting Cognitive Decline In Older Adults, Nathan Hantke, Kristy A. Nielson, John L. Woodard, Leslie M. Guidotti Breting, Alissa Butts, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao Jul 2014

Comparison Of Semantic And Episodic Memory Bold Fmri Activation In Predicting Cognitive Decline In Older Adults, Nathan Hantke, Kristy A. Nielson, John L. Woodard, Leslie M. Guidotti Breting, Alissa Butts, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao

Kristy Nielson

Previous studies suggest that task-activated functional magnetic resonance imaging (fMRI) can predict future cognitive decline among healthy older adults. The present fMRI study examined the relative sensitivity of semantic memory (SM) versus episodic memory (EM) activation tasks for predicting cognitive decline. Seventy-eight cognitively intact elders underwent neuropsychological testing at entry and after an 18-month interval, with participants classified as cognitively “Stable” or “Declining” based on ≥1.0 SD decline in performance. Baseline fMRI scanning involved SM (famous name discrimination) and EM (name recognition) tasks. SM and EM fMRI activation, along with Apolipoprotein E (APOE) ε4 status, served as predictors of cognitive …


Recognition Of Famous Names Predicts Cognitive Decline In Healthy Elders, Michael Seidenberg, Christina D. Kay, John L. Woodard, Kristy A. Nielson, J. Carson Smith, Cassandra Kandah, Leslie Guidotti, Julia Novitski, Melissa A. Lancaster, Monica Matthews, Nathan Hantke, Alissa Butts, Stephen M. Rao Jul 2014

Recognition Of Famous Names Predicts Cognitive Decline In Healthy Elders, Michael Seidenberg, Christina D. Kay, John L. Woodard, Kristy A. Nielson, J. Carson Smith, Cassandra Kandah, Leslie Guidotti, Julia Novitski, Melissa A. Lancaster, Monica Matthews, Nathan Hantke, Alissa Butts, Stephen M. Rao

Kristy Nielson

Objective: The ability to recognize familiar people is impaired in both Mild Cognitive Impairment (MCI) and Alzheimer’s Dementia (AD). In addition, both groups often demonstrate a time-limited temporal gradient (TG) in which well known people from decades earlier are better recalled than those learned recently. In this study, we examined the TG in cognitively intact elders for remote famous names (1950–1965) compared to more recent famous names (1995–2005). We hypothesized that the TG pattern on a famous name recognition task (FNRT) would predict future cognitive decline, and also show a significant correlation with hippocampal volume. Method: Seventy-eight healthy elders (ages …


Individual Differences Associated With The Repeated Endorsement Of Post-Event Misinformation, Timothy Arentsen, Benjamin Bock, Kristy Nielson Jul 2014

Individual Differences Associated With The Repeated Endorsement Of Post-Event Misinformation, Timothy Arentsen, Benjamin Bock, Kristy Nielson

Kristy Nielson

No abstract provided.


Semantic Memory Activation In Amnestic Mild Cognitive Impairment, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, Piero Antuono, Leslie Guidotti, Sally Durgerian, Qi Zhang, Melissa A. Lancaster, Nathan Hantke, Alissa Butts, Stephen M. Rao Jul 2014

Semantic Memory Activation In Amnestic Mild Cognitive Impairment, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, Piero Antuono, Leslie Guidotti, Sally Durgerian, Qi Zhang, Melissa A. Lancaster, Nathan Hantke, Alissa Butts, Stephen M. Rao

Kristy Nielson

Cognitively intact older individuals at risk for developing Alzheimer’s disease frequently show increased functional magnetic resonance imaging (fMRI) brain activation presumably associated with compensatory recruitment, whereas mild cognitive impairment (MCI) patients tend not to show increased activation presumably due to reduced neural reserve. Previous studies, however, have typically used episodic memory activation tasks, placing MCI participants at a performance disadvantage relative to healthy elders. In this event-related fMRI study, we employed a low effort, high accuracy semantic memory task to determine if increased activation of memory circuits is preserved in amnestic MCI when task performance is controlled. Fifty-seven participants, aged …


Reduction Of The Misinformation Effect By Arousal Induced After Learning, Shaun English, Kristy Nielson Jul 2014

Reduction Of The Misinformation Effect By Arousal Induced After Learning, Shaun English, Kristy Nielson

Kristy Nielson

Misinformation introduced after events have already occurred causes errors in later retrieval. Based on literature showing that arousal induced after learning enhances delayed retrieval, we investigated whether post-learning arousal can reduce the misinformation effect. 251 participants viewed four short film clips, each followed by a retention test, which for some participants included misinformation. Afterward, participants viewed another film clip that was either arousing or neutral. One week later, the arousal group recognized significantly more veridical details and endorsed significantly fewer misinformation items than the neutral group. The findings suggest that arousal induced after learning reduced source confusion, allowing participants to …


Interactive Effects Of Physical Activity And Apoe-Ε4 On Bold Semantic Memory Activation In Healthy Elders, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao Jul 2014

Interactive Effects Of Physical Activity And Apoe-Ε4 On Bold Semantic Memory Activation In Healthy Elders, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao

Kristy Nielson

Evidence suggests that physical activity (PA) is associated with the maintenance of cognitive function across the lifespan. In contrast, the apolipoproteinE-ε4 (APOE-ε4) allele, a genetic risk factor for Alzheimer's disease (AD), is associated with impaired cognitive function. The objective of this study was to examine the interactive effects of PA and APOE-ε4 on brain activation during memory processing in older (ages 65–85) cognitively intact adults. A cross-sectional design was used with four groups (n = 17 each): (1) Low Risk/Low PA; (2) Low Risk/High PA; (3) High Risk/Low PA; and (4) High Risk/High PA. PA level was based on …


Stressor-Induced Increase In Muscle Fatigability Of Young Men And Women Is Predicted By Strength But Not Voluntary Activation, Manda Keller-Ross, Hugo Pereia, Jaclyn Pruse, Tejin Yoon, Bonnie Schlinder-Delap, Kristy Nielson, Sandra Hunter Jul 2014

Stressor-Induced Increase In Muscle Fatigability Of Young Men And Women Is Predicted By Strength But Not Voluntary Activation, Manda Keller-Ross, Hugo Pereia, Jaclyn Pruse, Tejin Yoon, Bonnie Schlinder-Delap, Kristy Nielson, Sandra Hunter

Kristy Nielson

This study investigated mechanisms for the stressor-induced changes in muscle fatigability in men and women. Participants performed an isometric-fatiguing contraction at 20% maximal voluntary contraction (MVC) until failure with the elbow flexor muscles. Study one (n = 55; 29 women) involved two experimental sessions: 1) a high-stressor session that required a difficult mental-math task before and during a fatiguing contraction and 2) a control session with no mental math. For some participants (n = 28; 14 women), cortical stimulation was used to examine mechanisms that contributed to muscle fatigability during the high-stressor and control sessions. Study two (n = 23; …


Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber Jul 2014

Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber

Kristy Nielson

Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants …


Risk Factors For Alzheimer’S Disease And Longitudinal Memory Performance, M. K. Foster, M. Seidenberg, J. Woodard, Kristy A. Nielson, J. Smith, M. Lancaster, M. Matthews, N. Hantke, A. Butts, S. Rao Jul 2014

Risk Factors For Alzheimer’S Disease And Longitudinal Memory Performance, M. K. Foster, M. Seidenberg, J. Woodard, Kristy A. Nielson, J. Smith, M. Lancaster, M. Matthews, N. Hantke, A. Butts, S. Rao

Kristy Nielson

No abstract provided.


Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao Jul 2014

Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao

Kristy Nielson

Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ?4 allele could moderate the effect of PA or CA on hippocampal structure or …


Prediction Of Cognitive Decline In Healthy Older Adults Using Fmri, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, J Carson Smith, Piero Antuono, Sally Durgerian, Leslie Guidotti, Qi Zhang, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao Jul 2014

Prediction Of Cognitive Decline In Healthy Older Adults Using Fmri, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, J Carson Smith, Piero Antuono, Sally Durgerian, Leslie Guidotti, Qi Zhang, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao

Kristy Nielson

Few studies have examined the extent to which structural and functional MRI, alone and in combination with genetic biomarkers, can predict future cognitive decline in asymptomatic elders. This prospective study evaluated individual and combined contributions of demographic information, genetic risk, hippocampal volume, and fMRI activation for predicting cognitive decline after an 18-month retest interval. Standardized neuropsychological testing, an fMRI semantic memory task (famous name discrimination), and structural MRI (sMRI) were performed on 78 healthy elders (73% female; mean age = 73 years, range = 65 to 88 years). Positive family history of dementia and presence of one or both apolipoprotein …