Physical Sciences and Mathematics Commons^™

Modeling Biphasic, Non-Sigmoidal Dose-Response Relationships: Comparison Of Brain- Cousens And Cedergreen Models For A Biochemical Dataset, Venkat D. Abbaraju, Tamaraty L. Robinson, Brian P. Weiser

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Biphasic, non-sigmoidal dose-response relationships are frequently observed in biochemistry and pharmacology, but they are not always analyzed with appropriate statistical methods. Here, we examine curve fitting methods for “hormetic” dose-response relationships where low and high doses of an effector produce opposite responses. We provide the full dataset used for modeling, and we provide the code for analyzing the dataset in SAS using two established mathematical models of hormesis, the Brain-Cousens model and the Cedergreen model. We show how to obtain and interpret curve parameters such as the ED50 that arise from modeling, and we discuss how curve parameters might change …

2023 August - Tennessee Monthly Climate Report, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Monthly Report

No abstract provided.

Visualizing Transaction-Level Modeling Simulations Of Deep Neural Networks, Nataniel Farzan, Emad Arasteh

Engineering Technical Reports

The growing complexity of data-intensive software demands constant innovation in computer hardware design. Performance is a critical factor in rapidly evolving applications such as artificial intelligence (AI). Transaction-level modeling (TLM) is a valuable technique used to represent hardware and software behavior in a simulated environment. However, extracting actionable insights from TLM simulations is not a trivial task. We present Netmemvisual, an interactive, cross-platform visualization tool for exposing memory bottlenecks in TLM simulations. We demonstrate how Netmemvisual helps system designers rapidly analyze complex TLM simulations to find memory contention. We describe the project’s current features, experimental results with two state-of-the-art deep …

Statistical Modeling Approaches For The Inference Of Cancer Mechanisms, Licai Huang

Dissertations & Theses (Open Access)

The aim of this study was to explore the potential of integrating multi-platform genomic datasets to improve our understanding of the biological mechanisms behind cancer. By merging clinical outcomes with the data obtained from multi-platform genomic studies, we can gain insight into the biological mechanisms behind a patient’s response to treatment. Additionally, the evaluation of the correlations between genetic variations and gene expression provides a better understanding of the functional significance of these variations. Such knowledge has the potential to revolutionize cancer diagnosis and treatment. This thesis describes methods developed to address two related aims. Aim 1: We have developed …

Depression, Anxiety, And Estimated Cardiorespiratory Fitness In College Students, Christian Ison

UNLV Theses, Dissertations, Professional Papers, and Capstones

Depression and anxiety disorders are two common mental health conditions worldwide. College students are considered a high-risk population for the development of these conditions. Improved cardiorespiratory fitness (CRF) has been shown to decrease depression and anxiety risk, symptoms, and severity but this relationship and the extent to which improved CRF can reduce these risks has yet to be examined in the college student population. Validated and reliable non-exercise estimated cardiorespiratory fitness (eCRF) algorithms could be used to identify relationships and associations with depression and anxiety severity levels among college students. The purpose of this study was to assess eCRF and …

The Future Of Cryptocurrency And Blockchain Technology In Finance, Wanyi Wong, Alan @ Ali Madjelisi Megargel

Research Collection School Of Computing and Information Systems

Cryptocurrencies have been all the rage in recent years, with many being drawn to their appeal as speculative investment assets. Its proponents also champion the secure and decentralised nature of the technology it is based on, called the blockchain. Given the secure nature of blockchain technology, the idea of adopting cryptocurrencies as legal tender currency has also been mooted and experimented with – with the most famous example being the Central American nation of El Salvador’s bold move to adopting the cryptocurrency Bitcoin as legal tender in September 2021. In theory, this would provide a solution to the high transaction …

Decoding The Underlying Meaning Of Multimodal Hateful Memes, Ming Shan Hee, Wen Haw Chong, Roy Ka-Wei Lee

Research Collection School Of Computing and Information Systems

Recent studies have proposed models that yielded promising performance for the hateful meme classification task. Nevertheless, these proposed models do not generate interpretable explanations that uncover the underlying meaning and support the classification output. A major reason for the lack of explainable hateful meme methods is the absence of a hateful meme dataset that contains ground truth explanations for benchmarking or training. Intuitively, having such explanations can educate and assist content moderators in interpreting and removing flagged hateful memes. This paper address this research gap by introducing Hateful meme with Reasons Dataset (HatReD), which is a new multimodal hateful meme …

Generalization Through Diversity: Improving Unsupervised Environment Design, Wenjun Li, Pradeep Varakantham, Dexun Li

Research Collection School Of Computing and Information Systems

Agent decision making using Reinforcement Learning (RL) heavily relies on either a model or simulator of the environment (e.g., moving in an 8x8 maze with three rooms, playing Chess on an 8x8 board). Due to this dependence, small changes in the environment (e.g., positions of obstacles in the maze, size of the board) can severely affect the effectiveness of the policy learned by the agent. To that end, existing work has proposed training RL agents on an adaptive curriculum of environments (generated automatically) to improve performance on out-of-distribution (OOD) test scenarios. Specifically, existing research has employed the potential for the …

Camper: An Effective Framework For Privacy-Aware Deep Entity Resolution, Yuxiang Guo, Lu Chen, Zhengjie Zhou, Baihua Zheng, Ziquan Fang, Zhikun Zhang, Yuren Mao, Yunjun Gao

Research Collection School Of Computing and Information Systems

Entity Resolution (ER) is a fundamental problem in data preparation. Standard deep ER methods have achieved state-of-the-art efectiveness, assuming that relations from diferent organizations are centrally stored. However, due to privacy concerns, it can be difcult to centralize data in practice, rendering standard deep ER solutions inapplicable. Despite eforts to develop rule-based privacy-preserving ER methods, they often neglect subtle matching mechanisms and have poor efectiveness as a result. To bridge efectiveness and privacy, in this paper, we propose CampER, an efective framework for privacy-aware deep entity resolution. Specifcally, we frst design a training pair self-generation strategy to overcome the absence …

Multi-View Graph Contrastive Learning For Solving Vehicle Routing Problems, Yuan Jiang, Zhiguang Cao, Yaoxin Wu, Jie Zhang

Research Collection School Of Computing and Information Systems

Recently, neural heuristics based on deep learning have reported encouraging results for solving vehicle routing problems (VRPs), especially on independent and identically distributed (i.i.d.) instances, e.g. uniform. However, in the presence of a distribution shift for the testing instances, their performance becomes considerably inferior. In this paper, we propose a multi-view graph contrastive learning (MVGCL) approach to enhance the generalization across different distributions, which exploits a graph pattern learner in a self-supervised fashion to facilitate a neural heuristic equipped with an active search scheme. Specifically, our MVGCL first leverages graph contrastive learning to extract transferable patterns from VRP graphs to …

Proxy Hunting: Understanding And Characterizing Proxy-Based Upgradeable Smart Contracts In Blockchains, William E Iii Bodell, Sajad Meisami, Yue Duan

Research Collection School Of Computing and Information Systems

Upgradeable smart contracts (USCs) have become a key trend in smart contract development, bringing flexibility to otherwise immutable code. However, they also introduce security concerns. On the one hand, they require extensive security knowledge to implement in a secure fashion. On the other hand, they provide new strategic weapons for malicious activities. Thus, it is crucial to fully understand them, especially their security implications in the real-world. To this end, we conduct a large-scale study to systematically reveal the status quo of USCs in the wild. To achieve our goal, we develop a complete USC taxonomy to comprehensively characterize the …

Context-Aware Event Forecasting Via Graph Disentanglement, Yunshan Ma, Chenchen Ye, Zijian Wu, Xiang Wang, Yixin Cao, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Event forecasting has been a demanding and challenging task throughout the entire human history. It plays a pivotal role in crisis alarming and disaster prevention in various aspects of the whole society. The task of event forecasting aims to model the relational and temporal patterns based on historical events and makes forecasting to what will happen in the future. Most existing studies on event forecasting formulate it as a problem of link prediction on temporal event graphs. However, such pure structured formulation suffers from two main limitations: 1) most events fall into general and high-level types in the event ontology, …

Semantically Constitutive Entities In Knowledge Graphs, Chong Cher Chia, Maksim Tkachenko, Hady Wirawan Lauw

Research Collection School Of Computing and Information Systems

Knowledge graphs are repositories of facts about a world. In this work, we seek to distill the set of entities or nodes in a knowledge graph into a specified number of constitutive nodes, whose embeddings would be retained. Intuitively, the remaining accessory nodes could have their original embeddings “forgotten”, and yet reconstitutable from those of the retained constitutive nodes. The constitutive nodes thus represent the semantically constitutive entities, which retain the core semantics of the knowledge graph. We propose a formulation as well as algorithmic solutions to minimize the reconstitution errors. The derived constitutive nodes are validated empirically both in …

An Adaptive Large Neighborhood Search For Heterogeneous Vehicle Routing Problem With Time Windows, Minh Pham Kien Nguyen, Aldy Gunawan, Vincent F. Yu, Mustafa Misir

Research Collection School Of Computing and Information Systems

The heterogeneous vehicle routing problem with time windows (HVRPTW) employs various vehicles with different capacities to serve upcoming pickup and delivery orders. We introduce a HVRPTW variant for reflecting the practical needs of crowd-shipping by considering the mass-rapid-transit stations, as the additional terminal points. A mixed integer linear programming model is formulated. An Adaptive Large Neighborhood Search based meta-heuristic is also developed by utilizing a basic probabilistic selection strategy, i.e. roulette wheel, and Simulated Annealing. The proposed approach is empirically evaluated on a new set of benchmark instances. The computational results revealed that ALNS shows its clear advantage on the …

The Analysis Of Extended Producer Responsibility (Epr) For E-Waste Management Policy Drivers And Challenges In Singapore, Aldy Gunawan, Tasaporn Visawameteekul, Aidan Marc Wong, Linh C. Tran

Research Collection School Of Computing and Information Systems

This work examines the role of the Extended Producer Responsibility (EPR) scheme in managing electronic waste (e-waste) logistics in Singapore. The study investigates the challenges and policy drivers of e-waste management, using an online survey to explore the attitudes and behaviors of young consumers, with a particular focus on young people. We use the Theory of Reasoned Action (TRA) and Theory of Planned Behavior (TPB) frameworks to develop a model that investigates the relationship among attitudes, perceived norms, awareness, and perceived convenience towards EPR awareness and stance. The findings highlight the needs for customized policies for different groups based on …

Sparsity Brings Vulnerabilities: Exploring New Metrics In Backdoor Attacks, Jianwen Tian, Kefan Qiu, Debin Gao, Zhi Wang, Xiaohui Kuang, Gang Zhao

Research Collection School Of Computing and Information Systems

Nowadays, using AI-based detectors to keep pace with the fast iterating of malware has attracted a great attention. However, most AI-based malware detectors use features with vast sparse subspaces to characterize applications, which brings significant vulnerabilities to the model. To exploit this sparsityrelated vulnerability, we propose a clean-label backdoor attack consisting of a dissimilarity metric-based candidate selection and a variation ratio-based trigger construction. The proposed backdoor is verified on different datasets, including a Windows PE dataset, an Android dataset with numerical and boolean feature values, and a PDF dataset. The experimental results show that the attack can slash the accuracy …

Balancing Utility And Fairness In Submodular Maximization, Yanhao Wang, Yuchen Li, Francesco Bonchi, Ying Wang

Research Collection School Of Computing and Information Systems

Submodular function maximization is a fundamental combinatorial optimization problem with plenty of applications – including data summarization, influence maximization, and recommendation. In many of these problems, the goal is to find a solution that maximizes the average utility over all users, for each of whom the utility is defined by a monotone submodular function. However, when the population of users is composed of several demographic groups, another critical problem is whether the utility is fairly distributed across different groups. Although the utility and fairness objectives are both desirable, they might contradict each other, and, to the best of our knowledge, …

Multi-Granularity Detector For Vulnerability Fixes, Truong Giang Nguyen, Cong, Thanh Le, Hong Jin Kang, Ratnadira Widyasari, Chengran Yang, Zhipeng Zhao, Bowen Xu, Jiayuan Zhou, Xin Xia, Ahmed E. Hassan, David Lo, David Lo

Research Collection School Of Computing and Information Systems

With the increasing reliance on Open Source Software, users are exposed to third-party library vulnerabilities. Software Composition Analysis (SCA) tools have been created to alert users of such vulnerabilities. SCA requires the identification of vulnerability-fixing commits. Prior works have proposed methods that can automatically identify such vulnerability-fixing commits. However, identifying such commits is highly challenging, as only a very small minority of commits are vulnerability fixing. Moreover, code changes can be noisy and difficult to analyze. We observe that noise can occur at different levels of detail, making it challenging to detect vulnerability fixes accurately. To address these challenges and …

Numgpt: Improving Numeracy Ability Of Generative Pre-Trained Models, Zhihua Jin, Xin Jiang, Xiangbo Wang, Qun Liu, Yong Wang, Xiaozhe Ren, Huamin Qu

Research Collection School Of Computing and Information Systems

Existing generative pre-trained language models (e.g., GPT) focus on modeling the language structure and semantics of general texts. However, those models do not consider the numerical properties of numbers and cannot perform robustly on numerical reasoning tasks (e.g., math word problems and measurement estimation). In this paper, we propose NumGPT, a generative pre-trained model that explicitly models the numerical properties of numbers in texts. Specifically, it leverages a prototype-based numeral embedding to encode the mantissa of the number and an individual embedding to encode the exponent of the number. A numeral-aware loss function is designed to integrate numerals into the …

A Certificateless Designated Verifier Sanitizable Signature, Yonghua Zhan, Bixia Yi, Yang Yang, Renjie He, Rui Shi

Research Collection School Of Computing and Information Systems

Sanitizable Signature is a digital signature variant that enables modification operations, allowing sanitizers to alter the signed data in a regulated manner without requiring any interaction with the original signer. It is widely used in scenarios such as healthcare data privacy protection, social networks, secure routing, etc. In existing sanitizable signature schemes, anyone can verify the validity and authenticity of the sanitized message, which results in costly certificate management overhead or complicated key escrow problems. To address these challenges, a designated verifier certificateless sanitizable signature scheme is proposed. This scheme introduces the concept of a designated verifier into sanitizable signatures, …

Evolve Path Tracer: Early Detection Of Malicious Addresses In Cryptocurrency, Ling Cheng, Feida Zhu, Yong Wang, Ruicheng Liang, Huiwen Liu

Research Collection School Of Computing and Information Systems

With the boom of cryptocurrency and its concomitant financial risk concerns, detecting fraudulent behaviors and associated malicious addresses has been drawing significant research effort. Most existing studies, however, rely on the full history features or full-fledged address transaction networks, both of which are unavailable in the problem of early malicious address detection and therefore failing them for the task. To detect fraudulent behaviors of malicious addresses in the early stage, we present Evolve Path Tracer, which consists of Evolve Path Encoder LSTM, Evolve Path Graph GCN, and Hierarchical Survival Predictor. Specifically, in addition to the general address features, we propose …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Revised 2023 Residential Metals Abatement Program (Rmap) Field Sampling Plan (Fsp) – Indoor Dust – Group 8 – Gold Hill Lutheran Church (Creativity Factory Preschool) And United Congregational (Crayon Academy Preschool) (Dated July 26, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Experimental Study Of Linux Flightsize Estimation, Mingrui Zhang

Department of Computer Science and Engineering: Dissertations, Theses, and Student Research

Transmission Control Protocol (TCP) is a fundamental Internet protocol responsible for controlling and coordinating the Internet traffic. As a result, TCP significantly influences the overall performance and stability of the Internet. One critical information required by a TCP connection to make decisions is FlightSize, which is the total amount of outstanding data contributed by the connection to the Internet. The FlightSize information is used by a TCP connection to determine its future sending rate and also avoid traffic congestion and collapse in the Internet. Consequently, an inaccurate estimation of FlightSize can result in degraded performance and instability of the Internet. …

High-Power Laser Cooling And Temperature-Dependent Fluorescence Studies Of Ytterbium Doped Silica, Brian Topper

Optical Science and Engineering ETDs

Experimental observation of optical refrigeration using ytterbium doped silica glass in recent years has created a new solution for heat mitigation in high-power laser systems, nonlinear fiber experiments, integrated photonics, and precision metrology. Current efforts of different groups focus on compositional optimization, fiber fabrication, and investigating how much silica can be cooled with a laser. At the start of this work, the best effort in laser cooling ytterbium doped silica saw cooling by 6 K from room temperature. This dissertation follows the experimental efforts that culminated in the increase of this initial record by one order of magnitude. Comprehensive spectroscopic …

Iowa Waste Reduction Center Newsletter, August 2023, University Of Northern Iowa. Iowa Waste Reduction Center.

Iowa Waste Reduction Center Newsletter

In This Issue:

--- STAR4D at the Iowa State Fair
--- Farewell to Our Interns
--- Reminder: Iowa Recycling and Solid Waste Management Conference
--- Free Energy Assessments
--- Industry News

Per- And Polyfluoroalkyl Substances (Pfas) In Treated Sewage Sludge From Michigan Wastewater Treatment Plants, Garrett Wesley Link

Masters Theses

Concentrations, compositions, and variability of Per- and Polyfluoroalkyl Substances (PFAS) in sewage sludge are characterized using an extensive dataset of 350 samples from 190 wastewater treatment plants (WWTPs) across Michigan. All samples are comprised of final treated sewage sludge generated at the end of the wastewater treatment process. Concentrations of Σ₂₄ PFAS are log normally distributed with a range of 1 to 3200 ng/g dry wt. and of average 108 ± 277 ng/g dry wt. Compounds with carboxyl and sulfonic functional groups comprised 29% and 71% of Σ₂₄ PFAS concentrations, respectively, on average. Primary sample variability is associated …

Per- And Polyfluoroalkyl Substances (Pfas) In Treated Sewage Sludge From Michigan Wastewater Treatment Plants, Garrett Wesley Link

Masters Theses

Concentrations, compositions, and variability of Per- and Polyfluoroalkyl Substances (PFAS) in sewage sludge are characterized using an extensive dataset of 350 samples from 190 wastewater treatment plants (WWTPs) across Michigan. All samples are comprised of final treated sewage sludge generated at the end of the wastewater treatment process. Concentrations of Σ₂₄ PFAS are log normally distributed with a range of 1 to 3200 ng/g dry wt. and of average 108 ± 277 ng/g dry wt. Compounds with carboxyl and sulfonic functional groups comprised 29% and 71% of Σ24 PFAS concentrations, respectively, on average. Primary sample variability is associated with …

Application Of Business Analytics Approaches To Address Climate-Change-Related Challenges, Donald J. Jenkins

Graduate Doctoral Dissertations

Climate change is an existential threat facing humanity, civilization, and the natural world. It poses many multi-layered challenges that call for enhanced data-driven decision support methods to help inform society of ways to address the deep uncertainty and incomplete knowledge on climate change issues. This research primarily aims to apply management, decision, information, and data science theories and techniques to propose, build, and evaluate novel data-driven methodologies to improve understanding of climate-change-related challenges. Given that we pursue this work in the College of Management, each essay applies one or more of the three distinct business analytics approaches (i.e., descriptive, prescriptive, …

Addressing Health Crises Through Courts? Climate Litigation In Latin America, The Right To Health And Vulnerable Populations, Thalia Viveros Uehara

Graduate Doctoral Dissertations

As Latin America faces increasing climate-related health crises that disproportionately affect populations experiencing poverty and social exclusion, it becomes increasingly urgent to realize the most vulnerable's right to health. While the region's new constitutionalism (NLAC) has made progress in protecting this right, it has only recently begun to intersect with climate change law through rights-based climate litigation. This dissertation takes a transdisciplinary multi-methods research approach to answer the following question: How do health crises emerge within, and how are they addressed by courts through, domestic climate litigation in Latin America? Specifically, it examines how health concerns for vulnerable populations are …

Fem Simulations Of Plasmon Field Enhancement In Gold Nanoparticle Dimers And Gold Nanoparticle-Nanorod Dimers, Edward J. Lipchus

Graduate Masters Theses

Plasmon resonance refers to the collective oscillation of free electrons in a nanomaterial in response to an incident electromagnetic field. When two plasmonic nanoparticles are placed close together, their localized surface plasmon resonances can couple and interact. The resulting plasmonic coupling leads to the formation of new plasmonic modes in the dimer system, significantly enhancing the electromagnetic fields in the vicinity of the nanoparticles, with various interesting and potentially useful applications. This thesis investigates the optical field enhancement arising from gold nanoparticle dimers in an aqueous dielectric medium, using the Finite Element Method simulation software COMSOL Multiphysics. The simulations provide …