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Articles 13381 - 13410 of 302421
Full-Text Articles in Physical Sciences and Mathematics
Realizing Molecular Machine Learning Through Communications For Biological Ai: Future Directions And Challenges, Sasitharan Balasubramaniam, Samitha Somathilaka, Sehee Sun, Adrian Ratwatte, Massimiliano Pierobon
Realizing Molecular Machine Learning Through Communications For Biological Ai: Future Directions And Challenges, Sasitharan Balasubramaniam, Samitha Somathilaka, Sehee Sun, Adrian Ratwatte, Massimiliano Pierobon
School of Computing: Faculty Publications
Artificial Intelligence (AI) and Machine Learning (ML) are weaving their way into the fabric of society, where they are playing a crucial role in numerous facets of our lives. As we witness the increased deployment of AI and ML in various types of devices, we benefit from their use into energy-efficient algorithms for low powered devices. In this paper, we investigate a scale and medium that is far smaller than conventional devices as we move towards molecular systems that can be utilized to perform machine learning functions, i.e., Molecular Machine Learning (MML). Fundamental to the operation of MML is the …
Life, Death, And Ai: Exploring Digital Necromancy In Popular Culture—Ethical Considerations, Technological Limitations, And The Pet Cemetery Conundrum, James Hutson, Jay Ratican
Life, Death, And Ai: Exploring Digital Necromancy In Popular Culture—Ethical Considerations, Technological Limitations, And The Pet Cemetery Conundrum, James Hutson, Jay Ratican
Faculty Scholarship
This article explores the rise of generative AI, particularly ChatGPT, and the combination of large language models (LLM) with robotics, exemplified by Ameca the Robot. It addresses the need to study the ethical considerations and potential implications of digital necromancy, which involves using AI to reanimate deceased individuals for various purposes. Reasons for desiring to engage with a disembodied or bodied replica of a person include the preservation of memories, emotional closure, cultural heritage and historical preservation, interacting with idols or influential figures, educational and research purposes, and creative expression and artistic endeavors. As such, this article examines historical examples …
Human-Ai Collaboration For Smart Education: Reframing Applied Learning To Support Metacognition, James Hutson, Daniel Plate
Human-Ai Collaboration For Smart Education: Reframing Applied Learning To Support Metacognition, James Hutson, Daniel Plate
Faculty Scholarship
This chapter investigates the profound influence of intelligent virtual assistants (IVAs) on the educational domain, specifically in the realm of individualized learning and the instruction of writing abilities and content creation. IVAs, incorporating generative AI technologies such as ChatGPT and Stable Diffusion, hold the potential to bring about a paradigm shift in educational programs, emphasizing the enhancement of advanced metacognitive capacities rather than the fundamentals of communication. The subsequent recommendations stress the need to cultivate enduring proficiencies and ascertain tailored learning approaches for each learner, which will be indispensable for success in the evolving job market. In this context, prompt …
Avoiding Starvation Of Arms In Restless Multi-Armed Bandit, Dexun Li, Pradeep Varakantham
Avoiding Starvation Of Arms In Restless Multi-Armed Bandit, Dexun Li, Pradeep Varakantham
Research Collection School Of Computing and Information Systems
Restless multi-armed bandits (RMAB) is a popular framework for optimizing performance with limited resources under uncertainty. It is an extremely useful model for monitoring beneficiaries (arms) and executing timely interventions using health workers (limited resources) to ensure optimal benefit in public health settings. For instance, RMAB has been used to track patients' health and monitor their adherence in tuberculosis settings, ensure pregnant mothers listen to automated calls about good pregnancy practices, etc. Due to the limited resources, typically certain individuals, communities, or regions are starved of interventions, which can potentially have a significant negative impact on the individual/community in the …
Enhancing Third-Party Software Reliability Through Bug Bounty Programs, Tianlu Zhou, Dan Ma, Nan Feng
Enhancing Third-Party Software Reliability Through Bug Bounty Programs, Tianlu Zhou, Dan Ma, Nan Feng
Research Collection School Of Computing and Information Systems
Bug Bounty Programs (BBPs) reward external hackers for identifying and reporting software vulnerabilities. As the number of security issues caused by third-party applications has been significantly increased recently, many digital platforms are considering launching BBPs to help enhance the reliability of third-party software. BBPs bring benefits to the platform and vendors, meanwhile impose additional costs on them as well. As a result, the overall impact of using BBP is unclear. In this paper, we present an analytical model to examine the strategic decisions of launching and participating in a BBP for the platform and the third-party vendor, respectively. We find …
Photon Propagation In Magnetized Dense Quark Matter. A Possible Solution For The Missing Pulsar Problem., Efrain J. Ferrer
Photon Propagation In Magnetized Dense Quark Matter. A Possible Solution For The Missing Pulsar Problem., Efrain J. Ferrer
Physics and Astronomy Faculty Publications and Presentations
In this paper it is reviewed the topological properties and possible astrophysical consequences of a spatially inhomogeneous phase of quark matter, known as the Magnetic Dual Chiral Density Wave (MDCDW) phase, that can exist at intermediate baryon density in the presence of a magnetic field. Going beyond mean-field approximation, it is shown how linearly polarized electromagnetic waves penetrating the MDCDW medium can mix with the phonon fluctuations to give rise to two hybridized modes of propagation called as axion polaritons because of their similarity with certain modes found in condensed matter for topological magnetic insulators. The formation of axion polaritons …
Improving Quantal Cognitive Hierarchy Model Through Iterative Population Learning, Yuhong Xu, Shih-Fen Cheng, Xinyu Chen
Improving Quantal Cognitive Hierarchy Model Through Iterative Population Learning, Yuhong Xu, Shih-Fen Cheng, Xinyu Chen
Research Collection School Of Computing and Information Systems
In this paper, we propose to enhance the state-of-the-art quantal cognitive hierarchy (QCH) model with iterative population learning (IPL) to estimate the empirical distribution of agents’ reasoning levels and fit human agents’ behavioral data. We apply our approach to a real-world dataset from the Swedish lowest unique positive integer (LUPI) game and show that our proposed approach outperforms the theoretical Poisson Nash equilibrium predictions and the QCH approach by 49.8% and 46.6% in Wasserstein distance respectively. Our approach also allows us to explicitly measure an agent’s reasoning level distribution, which is not previously possible.
The Sociolinguistics Of Code-Switching In Hong Kong’S Digital Landscape: A Mixed-Methods Exploration Of Cantonese-English Alternation Patterns On Whatsapp, Wilkinson Daniel Wong Gonzales, Yuen Man Tsang
The Sociolinguistics Of Code-Switching In Hong Kong’S Digital Landscape: A Mixed-Methods Exploration Of Cantonese-English Alternation Patterns On Whatsapp, Wilkinson Daniel Wong Gonzales, Yuen Man Tsang
Journal of English and Applied Linguistics
This paper examines the prevalence of Cantonese-English code-mixing in Hong Kong through an under-researched digital medium. Prior research on this code-alternation practice has often been limited to exploring either the social or linguistic constraints of code-switching in spoken or written communication. Our study takes a holistic approach to analyzing code-switching in a hybrid medium that exhibits features of both spoken and written discourse. We specifically analyze the code-switching patterns of 24 undergraduates from a Hong Kong university on WhatsApp and examine how both social and linguistic factors potentially constrain these patterns. Utilizing a self-compiled sociolinguistic corpus as well as survey …
Exploring The Educational Potential Of Ai Generative Art In 3d Design Fundamentals: A Case Study On Prompt Engineering And Creative Workflows, James Hutson, Bryan Robertson
Exploring The Educational Potential Of Ai Generative Art In 3d Design Fundamentals: A Case Study On Prompt Engineering And Creative Workflows, James Hutson, Bryan Robertson
Faculty Scholarship
AI will be increasingly integrated into artistic practices and creative workflows with prompt engineering assuming an increasingly important role in the process. With readilyavailable generative AI, such as Midjourney, DALL-E 2, and Craiyon (formerly DALLE-mini), anyone can seemingly create "art,” prompting questions about the future necessity of art and design education. However, whereas the ease with which content can be created has seen an outcry from the traditional artmaking community, fears over widespread adoption replacing the need for a firm foundation in art and design principles and fundamentals is unfounded. Instead, these tools should be seen and adopted as other …
Iowa Waste Reduction Center Newsletter, June 2023, University Of Northern Iowa. Iowa Waste Reduction Center.
Iowa Waste Reduction Center Newsletter, June 2023, University Of Northern Iowa. Iowa Waste Reduction Center.
Iowa Waste Reduction Center Newsletter
In this issue:
--- Save-the-date: Iowa Recycling and Solid Waste Management Conference
--- Save-the-Date: EPA Region 7, Iowa State University
--- EPA Region 7, Iowa State University
--- IWRC and ISU Collaborate to promote sustainable brewing practices
--- From UNI Intern Turned IWRC Professional
--- IWRC Welcomes New Summer Interns
--- Industry News
Statistical And Biological Analyses Of Acoustic Signals In Estrildid Finches, Moises Rivera
Statistical And Biological Analyses Of Acoustic Signals In Estrildid Finches, Moises Rivera
Dissertations, Theses, and Capstone Projects
Acoustic communication is a process that involves auditory perception and signal processing. Discrimination and recognition further require cognitive processes and supporting mechanisms in order to successfully identify and appropriately respond to signal senders. Although acoustic communication is common across birds, classical research has largely disregarded the perceptual abilities of perinatal altricial taxa. Chapter 1 reviews the literature of perinatal acoustic stimulation in birds, highlighting the disproportionate focus on precocial birds (e.g., chickens, ducks, quails). The long-held belief that altricial birds were incapable of acoustic perception in ovo was only recently overturned, as researchers began to find behavioral and physiological evidence …
Characterization Of Boreal-Arctic Vegetation Growth Phases And Active Soil Layer Dynamics In The High-Latitudes Of North America: A Study Combining Multi-Year In Situ And Satellite-Based Observations, Michael G. Brown
Dissertations, Theses, and Capstone Projects
This dissertation examined the seasonal freeze/thaw activity in boreal-Arctic soils and vegetation physiology in Alaska, USA and Alberta, Canada, using in situ environmental measurements and passive microwave satellite observations. The boreal-Arctic high-latitudes have been experiencing ecosystem changes more rapidly in comparison to the rest of Earth due to the presently warming climatic conditions having a magnified effect over Polar Regions. Currently, the boreal-Arctic is a carbon sink; however, recent studies indicate a shift over the next century to become a carbon source. High-latitude vegetation and cold soil dynamics are influenced by climatic shifts and are largely responsible for the regions …
Hydrodynamic And Physicochemical Interactions Between An Active Janus Particle And An Inactive Particle, Jessica S. Rosenberg
Hydrodynamic And Physicochemical Interactions Between An Active Janus Particle And An Inactive Particle, Jessica S. Rosenberg
Dissertations, Theses, and Capstone Projects
Active matter is an area of soft matter science in which units consume energy and turn it into autonomous motion. Groups of these units – whether flocks of birds, bacterial colonies, or even collections of synthetically-made active particles – may exhibit complex behavior on large scales. While the large-scale picture is of great importance, so is the microscopic scale. Studying the individual particles that make up active matter will allow us to understand how they move, and whether and under what circumstances their activity can be controlled.
Here we delve into the world of active matter by studying colloidal-sized (100 …
Gradient-Based Trade-Off Design For Engineering Applications, Lena A. Royster, Gene Hou
Gradient-Based Trade-Off Design For Engineering Applications, Lena A. Royster, Gene Hou
Mechanical & Aerospace Engineering Faculty Publications
The goal of the trade-off design method presented in this study is to achieve newly targeted performance requirements by modifying the current values of the design variables. The trade-off design problem is formulated in the framework of Sequential Quadratic Programming. The method is computationally efficient as it is gradient-based, which, however, requires the performance functions to be differentiable. A new equation to calculate the scale factor to control the size of the design variables is introduced in this study, which can ensure the new design achieves the targeted performance objective. Three formal approaches are developed in this study for trade-off …
Catching The Fast Payments Trend: Optimal Designs And Leadership Strategies Of Retail Payment And Settlement Systems, Zhiling Guo, Dan Ma
Catching The Fast Payments Trend: Optimal Designs And Leadership Strategies Of Retail Payment And Settlement Systems, Zhiling Guo, Dan Ma
Research Collection School Of Computing and Information Systems
Recent financial technologies have enabled fast payments and are reshaping retail payment and settlement systems globally. We developed an analytical model to study the optimal design of a new retail payment system in terms of settlement speed and system capability under both bank and fintech firm heterogeneous participation incentives. We found that three types of payment systems emerge as equilibrium outcomes: batch retail (BR), expedited retail (ER), and real-time retail (RR) payment systems. Although the base value of the payment service positively affects both settlement speed and system capability, the expected liquidity cost negatively impacts settlement speed, and total transaction …
Towards Explaining Sequences Of Actions In Multi-Agent Deep Reinforcement Learning Models, Phyo Wai Khaing, Minghong Geng, Budhitama Subagdja, Shubham Pateria, Ah-Hwee Tan
Towards Explaining Sequences Of Actions In Multi-Agent Deep Reinforcement Learning Models, Phyo Wai Khaing, Minghong Geng, Budhitama Subagdja, Shubham Pateria, Ah-Hwee Tan
Research Collection School Of Computing and Information Systems
Although Multi-agent Deep Reinforcement Learning (MADRL) has shown promising results in solving complex real-world problems, the applicability and reliability of MADRL models are often limited by a lack of understanding of their inner workings for explaining the decisions made. To address this issue, this paper proposes a novel method for explaining MADRL by generalizing the sequences of action events performed by agents into high-level abstract strategies using a spatio-temporal neural network model. Specifically, an interval-based memory retrieval procedure is developed to generalize the encoded sequences of action events over time into short sequential patterns. In addition, two abstraction algorithms are …
A Mixed-Integer Linear Programming Reduction Of Disjoint Bilinear Programs Via Symbolic Variable Elimination, Jihwan Jeong, Scott Sanner, Akshat Kumar
A Mixed-Integer Linear Programming Reduction Of Disjoint Bilinear Programs Via Symbolic Variable Elimination, Jihwan Jeong, Scott Sanner, Akshat Kumar
Research Collection School Of Computing and Information Systems
A disjointly constrained bilinear program (DBLP) has various practical and industrial applications, e.g., in game theory, facility location, supply chain management, and multi-agent planning problems. Although earlier work has noted the equivalence of DBLP and mixed-integer linear programming (MILP) from an abstract theoretical perspective, a practical and exact closed-form reduction of a DBLP to a MILP has remained elusive. Such explicit reduction would allow us to leverage modern MILP solvers and techniques along with their solution optimality and anytime approximation guarantees. To this end, we provide the first constructive closed-form MILP reduction of a DBLP by extending the technique of …
Evading Deepfake Detectors Via Adversarial Statistical Consistency, Yang Hou, Qing Guo, Yihao Huang, Xiaofei Xie, Lei Ma, Jianjun Zhao
Evading Deepfake Detectors Via Adversarial Statistical Consistency, Yang Hou, Qing Guo, Yihao Huang, Xiaofei Xie, Lei Ma, Jianjun Zhao
Research Collection School Of Computing and Information Systems
In recent years, as various realistic face forgery techniques known as DeepFake improves by leaps and bounds, more and more DeepFake detection techniques have been proposed. These methods typically rely on detecting statistical differences between natural (i.e., real) and DeepFake-generated images in both spatial and frequency domains. In this work, we propose to explicitly minimize the statistical differences to evade state-of-the-art DeepFake detectors. To this end, we propose a statistical consistency attack (StatAttack) against DeepFake detectors, which contains two main parts. First, we select several statistical-sensitive natural degradations (i.e., exposure, blur, and noise) and add them to the fake images …
Dynamic Police Patrol Scheduling With Multi-Agent Reinforcement Learning, Songhan Wong, Waldy Joe, Hoong Chuin Lau
Dynamic Police Patrol Scheduling With Multi-Agent Reinforcement Learning, Songhan Wong, Waldy Joe, Hoong Chuin Lau
Research Collection School Of Computing and Information Systems
Effective police patrol scheduling is essential in projecting police presence and ensuring readiness in responding to unexpected events in urban environments. However, scheduling patrols can be a challenging task as it requires balancing between two conflicting objectives namely projecting presence (proactive patrol) and incident response (reactive patrol). This task is made even more challenging with the fact that patrol schedules do not remain static as occurrences of dynamic incidents can disrupt the existing schedules. In this paper, we propose a solution to this problem using Multi-Agent Reinforcement Learning (MARL) to address the Dynamic Bi-objective Police Patrol Dispatching and Rescheduling Problem …
Distpreserv: Maintaining User Distribution For Privacy-Preserving Location-Based Services, Yanbing Ren, Xinghua Li, Yinbin Miao, Robert H. Deng, Jian Weng, Siqi Ma, Jianfeng Ma
Distpreserv: Maintaining User Distribution For Privacy-Preserving Location-Based Services, Yanbing Ren, Xinghua Li, Yinbin Miao, Robert H. Deng, Jian Weng, Siqi Ma, Jianfeng Ma
Research Collection School Of Computing and Information Systems
Location-Based Services (LBSs) are one of the most frequently used mobile applications in the modern society. Geo-Indistinguishability (Geo-Ind) is a promising privacy protection model for LBSs since it can provide formal security guarantees for location privacy. However, Geo-Ind undermines the statistical location distribution of users on the LBS server because of perturbed locations, thereby disabling the server to provide distribution-based services (e.g., traffic congestion maps). To overcome this issue, we give a privacy definition, called DistPreserv, to enable the LBS server to acquire valid location distributions while providing users with strict location protection. Then we propose a privacy-preserving LBS scheme …
Knowledge Compilation For Constrained Combinatorial Action Spaces In Reinforcement Learning, Jiajing Ling, Moritz Lukas Schuler, Akshat Kumar, Pradeep Varakantham
Knowledge Compilation For Constrained Combinatorial Action Spaces In Reinforcement Learning, Jiajing Ling, Moritz Lukas Schuler, Akshat Kumar, Pradeep Varakantham
Research Collection School Of Computing and Information Systems
Action-constrained reinforcement learning (ACRL), where any action taken in a state must satisfy given constraints, has several practical applications such as resource allocation in supply-demand matching, and path planning among others. A key challenge is to enforce constraints when the action space is discrete and combinatorial. To address this, first, we assume an action is represented using propositional variables, and action constraints are represented using Boolean functions. Second, we compactly encode the set of all valid actions that satisfy action constraints using a probabilistic sentential decision diagram (PSDD), a recently proposed knowledge compilation framework. Parameters of the PSDD compactly encode …
Ifundit: Visual Profiling Of Fund Investment Styles, Rong Zhang, Bon Kyung Ku, Yong Wang, Xuanwu Yue, Siyuan Liu, Ke Li, Huamin Qu
Ifundit: Visual Profiling Of Fund Investment Styles, Rong Zhang, Bon Kyung Ku, Yong Wang, Xuanwu Yue, Siyuan Liu, Ke Li, Huamin Qu
Research Collection School Of Computing and Information Systems
Mutual funds are becoming increasingly popular with the emergence of Internet finance. Clear profiling of a fund's investment style is crucial for fund managers to evaluate their investment strategies, and for investors to understand their investment. However, it is challenging to profile a fund's investment style as it requires a comprehensive analysis of complex multi-dimensional temporal data. In addition, different fund managers and investors have different focuses when analysing a fund's investment style. To address the issue, we propose iFUNDit, an interactive visual analytic system for fund investment style analysis. The system decomposes a fund's critical features into performance attributes …
Position-Guided Text Prompt For Vision-Language Pre-Training, Alex Jinpeng Wang, Pan Zhou, Mike Zheng Shou, Yan Shuicheng
Position-Guided Text Prompt For Vision-Language Pre-Training, Alex Jinpeng Wang, Pan Zhou, Mike Zheng Shou, Yan Shuicheng
Research Collection School Of Computing and Information Systems
Vision-Language Pre-Training (VLP) has shown promising capabilities to align image and text pairs, facilitating a broad variety of cross-modal learning tasks. However, we observe that VLP models often lack the visual grounding/localization capability which is critical for many downstream tasks such as visual reasoning. In this work, we propose a novel Position-guided Text Prompt (PTP) paradigm to enhance the visual grounding ability of cross-modal models trained with VLP. Specifically, in the VLP phase, PTP divides the image into N x N blocks, and identifies the objects in each block through the widely used object detector in VLP. It then reformulates …
Avoiding Starvation Of Arms In Restless Multi-Armed Bandit, Dexun Li, Pradeep Varakantham
Avoiding Starvation Of Arms In Restless Multi-Armed Bandit, Dexun Li, Pradeep Varakantham
Research Collection School Of Computing and Information Systems
Restless multi-armed bandits (RMAB) is a popular framework for optimizing performance with limited resources under uncertainty. It is an extremely useful model for monitoring beneficiaries (arms) and executing timely interventions using health workers (limited resources) to ensure optimal benefit in public health settings. For instance, RMAB has been used to track patients’ health and monitor their adherence in tuberculosis settings, ensure pregnant mothers listen to automated calls about good pregnancy practices, etc. Due to the limited resources, typically certain individuals, communities, or regions are starved of interventions, which can potentially have a significant negative impact on the individual/community in the …
Gis Data: Harford County, Maryland – Shoreline Inventory Data 2023, Karinna Nunez, Tamia Rudnicky, Sharon Killeen, Jessica Hendricks, Catherine R. Duning, Evan Hill
Gis Data: Harford County, Maryland – Shoreline Inventory Data 2023, Karinna Nunez, Tamia Rudnicky, Sharon Killeen, Jessica Hendricks, Catherine R. Duning, Evan Hill
Data
The shoreline inventory files have been generated to support the application of the Maryland Shoreline Stabilization Model (SSM), developed by the Center for Coastal Resources Management (CCRM), Virginia Institute of Marine Science (VIMS), to enhance and streamline regulatory decision making in Maryland. This shoreline inventory includes the features needed as inputs to run the SSM.
The data developed for the Shoreline Inventory is based on a three-tiered shoreline assessment approach. This assessment characterizes conditions by using observations made remotely at the desktop using high resolution imagery. The three-tiered shoreline assessment approach divides the shore zone into three regions:
1) the …
Gis Data: Cecil County, Maryland – Shoreline Inventory Data 2023, Karinna Nunez, Tamia Rudnicky, Sharon Killeen, Jessica Hendricks, Catherine R. Duning, Evan Hill
Gis Data: Cecil County, Maryland – Shoreline Inventory Data 2023, Karinna Nunez, Tamia Rudnicky, Sharon Killeen, Jessica Hendricks, Catherine R. Duning, Evan Hill
Data
The shoreline inventory files have been generated to support the application of the Maryland Shoreline Stabilization Model (SSM), developed by the Center for Coastal Resources Management (CCRM), Virginia Institute of Marine Science (VIMS), to enhance and streamline regulatory decision making in Maryland. This shoreline inventory includes the features needed as inputs to run the SSM.
The data developed for the Shoreline Inventory is based on a three-tiered shoreline assessment approach. This assessment characterizes conditions by using observations made remotely at the desktop using high resolution imagery. The three-tiered shoreline assessment approach divides the shore zone into three regions:
1) the …
Planning For A Gnarly Future: Reimagining Planning To Empower Your Community, Elizabeth Sodja
Planning For A Gnarly Future: Reimagining Planning To Empower Your Community, Elizabeth Sodja
All Current Publications
The purpose of this document is to summarize key takeaways and resources from our 5-part online learning series featuring planning solutions to challenges facing Gateway and Natural Amenity Region (GNAR) communities in the west.
Cpsrp43 Is Both Highly Flexible And Stable: Structural Insights Using A Combined Experimental And Computational Approach, Mitchell Benton, Mercede Furr, Vivek Govind Kumar, Adithya Polasa, Feng Gao, Colin David Heyes, Thallapuranam Krishnaswamy Suresh Kumar, Mahmoud Moradi
Cpsrp43 Is Both Highly Flexible And Stable: Structural Insights Using A Combined Experimental And Computational Approach, Mitchell Benton, Mercede Furr, Vivek Govind Kumar, Adithya Polasa, Feng Gao, Colin David Heyes, Thallapuranam Krishnaswamy Suresh Kumar, Mahmoud Moradi
Chemistry & Biochemistry Faculty Publications and Presentations
The novel multidomain protein, cpSRP43, is a unique subunit of the post-translational chloroplast signal recognition particle (cpSRP) targeting pathway in higher plants. The cpSRP pathway is responsible for targeting and insertion of light-harvesting chlorophyll a/b binding proteins (LHCPs) to the thylakoid membrane. Upon emergence into the stroma, LHCPs form a soluble transit complex with the cpSRP heterodimer, which is composed of cpSRP43 and cpSRP54. cpSRP43 is irreplaceable as a chaperone to LHCPs in their translocation to the thylakoid membrane and remarkable in its ability to dissolve aggregates of LHCPs without the need for external energy input. In previous studies, cpSRP43 …
The Alternating Access Mechanism In Mammalian Multidrug Resistance Transporters And Their Bacterial Homologs, Shadi A. Badiee, Ugochi H. Isu, Ehsaneh Khodadadi, Mahmoud Moradi
The Alternating Access Mechanism In Mammalian Multidrug Resistance Transporters And Their Bacterial Homologs, Shadi A. Badiee, Ugochi H. Isu, Ehsaneh Khodadadi, Mahmoud Moradi
Chemistry & Biochemistry Faculty Publications and Presentations
Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC) transporter group play a crucial role in the export of cytotoxic drugs across cell membranes. These proteins are particularly fascinating due to their ability to confer drug resistance, which subsequently leads to the failure of therapeutic interventions and hinders successful treatments. One key mechanism by which multidrug resistance (MDR) proteins carry out their transport function is through alternating access. This mechanism involves intricate conformational changes that enable the binding and transport of substrates across cellular membranes. In this extensive review, we provide an overview of ABC transporters, including their classifications …
Motif Graph Neural Network, Xuexin Chen, Ruicui Cai, Yuan Fang, Min Wu, Zijian Li, Zhifeng Hao
Motif Graph Neural Network, Xuexin Chen, Ruicui Cai, Yuan Fang, Min Wu, Zijian Li, Zhifeng Hao
Research Collection School Of Computing and Information Systems
Graphs can model complicated interactions between entities, which naturally emerge in many important applications. These applications can often be cast into standard graph learning tasks, in which a crucial step is to learn low-dimensional graph representations. Graph neural networks (GNNs) are currently the most popular model in graph embedding approaches. However, standard GNNs in the neighborhood aggregation paradigm suffer from limited discriminative power in distinguishing high-order graph structures as opposed to low-order structures. To capture high-order structures, researchers have resorted to motifs and developed motif-based GNNs. However, the existing motif-based GNNs still often suffer from less discriminative power on high-order …