Physical Sciences and Mathematics Commons^™

A Rapid And High Content Assay That Measures Cyto-Id-Stained Autophagic Compartments And Estimates Autophagy Flux With Potential Clinical Applications, Sujuan Guo, Yanping Liang, Susan F. Murphy, Angela Huang, Haihong Shen, Deborah F. Kelly, Pablo Sobrado, Zhi Sheng

Chemistry Faculty Research & Creative Works

The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a variety of human diseases. To address this critical issue, we developed a novel autophagy assay using the newly developed Cyto-ID fluorescence dye. We first verified that the Cyto-ID dye specifically labels autophagic compartments with minimal staining of lysosomes and endosomes. We then developed a new Cyto-ID fluorescence spectrophotometric assay that makes it possible to estimate autophagy flux based on measurements of the Cyto-ID-stained autophagic compartments. By comparing to traditional autophagy approaches, we found that this assay yielded a more …

Snails From Heavy-Metal Polluted Environments Have Reduced Sensitivity To Carbon Dioxide-Induced Acidity, Hugh Lefcort, David A. Cleary, Aaron M. Marble, Morgan V. Phillips, Timothy J. Stoddard, Lara M. Tuthill, James R. Winslow

Biology Faculty Scholarship

Anthropogenic atmospheric CO2 reacts with water to form carbonic acid (H2CO3) which increases water acidity. While marine acidification has received recent consideration, less attention has been paid to the effects of atmospheric carbon dioxide on freshwater systems—systems that often have low buffering potential. Since many aquatic systems are already impacted by pollutants such as heavy metals, we wondered about the added effect of rising atmospheric CO2 on freshwater organisms. We studied aquatic pulmonate snails (Physella columbiana) from both a heavy-metal polluted watershed and snails from a reference watershed that has not experienced mining pollution. We used gaseous CO2 …

Interpretation Of Geochemical Signatures From Modern Carbonate Springs To The Rock Record, Benjamin Maas

LSU Doctoral Dissertations

Despite the importance of carbonate aquifers as reservoirs of oil, of water, and of carbon dioxide, questions remain about the diagenetic processes that enhance porosity and permeability. Some of the questions are: 1) what are the water-rock interactions that control the geochemistry of spring waters; 2) are the geochemical signatures of saline-fresh water mixing zones preserved in the carbonate rock record; and 3) how much carbon dioxide outgases along spring runs? To address these questions, two field sites, one in Oklahoma (the site of an active saline-fresh water mixing zone) and the other in Colorado, the location of a former …

Student Fact Book, Fall 2015 - Thirty-Ninth Annual Edition, Office Of Student Information Systems, Wright State University

Wright State University Student Fact Books

The student fact book has general demographic information on all students enrolled at Wright State University for Fall Semester, 2015.

Dynamic Control Of Nanopore Wetting In Water And Saline Solutions Under An Electric Field, D. Vanzo, D. Bratko, A. Luzar

Chemistry Publications

Field-induced nanopore wetting by aqueous solutions, including electrolytes, provides opportunities for a variety of applications. Con!icting porosity requirements have so far precluded direct implementations of a two-way control: the pores have to be su"ciently wide to allow water in#ltration at experimentally relevant voltages but should not exceed the kinetic threshold for spontaneous expulsion in the absence of the #eld. Applicable widths are restricted below a few nanometers. Only a narrow window of #elds and pore geometries can simultaneously satisfy both of the above requirements. Accurate accounts of wetting equilibria and dynamics at nanoscale porosity require molecular level descriptions. Here we …

Defect-Related Luminescence In Undoped Gan Grown By Hvpe, Michael A. Reshchikov, A Usikov, H Helava, Yu. Makarov

Forensic Science Publications

Hydride vapor phase epitaxy (HVPE) is used for the growth of low-defect GaN. We have grown undoped films on sapphire and investigated them using steady-state and time-resolved photoluminescence (PL). One of the dominant PL bands in high-quality GaN grown by HVPE is the green luminescence (GL) band with a maximum at 2.4 eV. This PL band can be easily recognized in time-resolved PL measurements due to its exponential decay even at low temperatures (<50 K), with a characteristic lifetime of 1–2 μs. As the temperature increases from 70 K to 280 K, the PL lifetime for the GL band increases by an order of magnitude. This …

Science Education In Virginia, E. Rhoades

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.

Aims & Scope

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.

Knowledge Enabled Approach To Predict The Location Of Twitter Users, Revathy Krishnamurthy, Pavan Kapanipathi, Amit P. Sheth, Krishnaprasad Thirunarayan

Kno.e.sis Publications

Knowledge bases have been used to improve performance in applications ranging from web search and event detection to entity recognition and disambiguation. More recently, knowledge bases have been used to analyze social data. A key challenge in social data analysis has been the identification of the geographic location of online users in a social network such as Twitter. Existing approaches to predict the location of users, based on their tweets, rely solely on social media features or probabilistic language models. These approaches are supervised and require large training dataset of geo-tagged tweets to build their models. As most Twitter users …

Knowledge-Driven Personalized Contextual Mhealth Service For Asthma Management In Children, Pramod Anantharam, Tanvi Banerjee, Amit P. Sheth, Krishnaprasad Thirunarayan, Surendra Marupudi, Vaikunth Sridharan

Kno.e.sis Publications

Wide adoption of smartphones and availability of low-cost sensors has resulted in seamless and continuous monitoring of physiology, environment, and public health notifications. However, personalized digital health and patient empowerment can become a reality only if the complex multisensory and multimodal data is processed within the patient context. Contextual processing of patient data along with personalized medical knowledge can lead to actionable information for better and timely decisions. We present a system called kHealth capable of aggregating multisensory and multimodal data from sensors (passive sensing) and answers to questionnaire (active sensing) from patients with asthma. We present our preliminary data …

Gender-Based Violence In 140 Characters Or Fewer: A #Bigdata Case Study Of Twitter, Hemant Purohit, Tanvi Banerjee, Andrew Hampton, Valerie L. Shalin, Nayanesh Bhandutia, Amit P. Sheth

Kno.e.sis Publications

Public institutions are increasingly reliant on data from social media sites to measure public attitude and provide timely public engagement. Such reliance includes the exploration of public views on important social issues such as gender-based violence (GBV). In this study, we examine big (social) data consisting of nearly fourteen million tweets collected from Twitter over a period of ten months to analyze public opinion regarding GBV, highlighting the nature of tweeting practices by geographical location and gender. We demonstrate the utility of Computational Social Science to mine insight from the corpus while accounting for the influence of both transient events …

Evaluation Of Tcp Header Fields For Data Overhead Efficiency, Justin K. Yirka

Undergraduate Research Posters

Bandwidth across the internet is constricted by monetary factors and hardware development, so researchers are left to improve the efficiency of data transmitted in order to improve internet speeds. The transmission control protocol (TCP) is the primary transport protocol on the modern internet, ensuring reliable delivery of the majority of data transmitted. I evaluated the TCP header fields for efficient use of data overhead so as to determine current waste and to suggest possible areas for revision. I examined original specifications for TCP mechanisms, comparing them to modern implementations as determined by updated standards and modern practices in the networking …

Realistic Spiking Neuron Statistics In A Population Are Described By A Single Parametric Distribution, Lauren Crow 9370373

Undergraduate Research Posters

The spiking of activity of neurons throughout the cortex is random and complicated. This complicated activity requires theoretical formulations in order to understand the underlying principles of neural processing. A key aspect of theoretical investigations is characterizing the probability distribution of spiking activity. This study aims to better understand the statistics of the time between spikes, or interspike interval, in both real data and a spiking model with many time scales. Exploration of the interspike intervals of neural network activity can provide a better understanding of neural responses to different stimuli. We consider different parametric distribution fitting techniques to characterize …

Expression Of The Nkcc2a Cotransporter In Mouse Central Nervous System, Katherine E. Fahy, James B. Lucot, Hayo Castrop, Mauricio Di Fulvio

Symposium of Student Research, Scholarship, and Creative Activities Materials

Na-K-2Cl cotransporter 2A (NKCC2A), also known as the bumetanide-sensitive cotransporter 1 (BSC1), transports Na+, K+ and Cl- with a stoichiometry of 1:1:2. NKCC2A is considered a kidney specific cotransporter. It is abundantly expressed in apical membrane of the tubular cells in the thick ascending limb of the loop of Henle (TALH) and in the macula densa. However, NKCC2 has also been found at low levels in different cells, including insulin-secreting ones. This secondary active transporter uses the energy stored in the electrochemical gradients of Na and K maintained by the Na/K-ATPase located on the basolateral membrane of the TALH. The …

High Power Pulsed Terahertz Light Generation From Superconducting Antenna Arrays, Nicholas C. Padgett, Stephanie R. Lake, Jason A. Deibel, T. Bullard, D. Latypov, J. Patel, J. Murphy, J. Bulmer, W. Tang, M. Sebastian, Timothy J. Haugan

Symposium of Student Research, Scholarship, and Creative Activities Materials

Terahertz radiation is invaluable in spectroscopy and imaging due to its nondestructive nature. It has become a key focus for those wishing to develop sensors capable of detecting weapons and narcotics unobtrusively and at a distance. An ultrafast pulsed (femtoseconds) laser incident on a superconducting ring causes the emission of terahertz (THz) radiation. It is theorized that the radiation is a result of the supercurrent being modulated by the breaking and recombining of Cooper pairs on the order of picoseconds, where the time scale determines the frequency of the emitted radiation. We propose to investigate the terahertz emission from Yttrium …

Highly Transparent Conductive Electrode With Ultra-Low Haze By Grain Boundary Modification Of Aqueous Solution Fabricated Alumina-Doped Zinc Oxide Nanocrystals, Qiong Nian, Michael J. Callahan, David C. Look, Harry Efstathiadis, John Bailey, Gary J. Cheng

Physics Faculty Publications

Commercial production of transparent conducting oxide (TCO) polycrystalline films requires high electrical conductivity with minimal degradation in optical transparency. Aqueous solution deposited TCO films would reduce production costs of TCO films but suffer from low electrical mobility, which severely degrades both electrical conductivity and optical transparency in the visible spectrum. Here, we demonstrated that grain boundary modification by ultra-violet laser crystallization (UVLC) of solution deposited aluminium-doped zinc oxide (AZO) nanocrystals results in high Hall mobility, with a corresponding dramatic improvement in AZO electrical conductance. The AZO films after laser irradiation exhibit electrical mobility up to 18.1 cm² V^{−1 …}

The Green Chemistry And Filipino Approach To High School Experiments In Saint Paul College Pasig, Ronald G. Santos, Armando M. Guidote Jr

Chemistry Faculty Publications

This paper is a call for teachers to initiate measures in improving the quality of high school chemistry education in the Philippines and that is by going back to practical laboratory work. The experiment presented in this paper is a proof to the possibility of tailor-made experiments that integrate principles of green chemistry. Integrating green chemistry concepts in the design of high school chemistry experiments makes students aware of the responsibility that goes with the use and production of chemicals. Moreover, the experiment was designed to consciously integrate aspects of Filipino culture, values, and traditions. Such enculturation of chemistry by …

A Mathematical Framework Of Human Thought Process: Rectifying Software Construction Inefficiency And Identifying Characteristic Efficiencies Of Networked Systems Via Problem-Solution Cycle, Jonathan Sarbah-Yalley

Master's Theses

Problem

The lack of a theory to explain human thought process latently affects the general perception of problem solving activities. This present study was to theorize human thought process (HTP) to ascertain in general the effect of problem solving inadequacy on efficiency.

Method

To theorize human thought process (HTP), basic human problem solving activities were investigated through the vein of problem-solution cycle (PSC). The scope of PSC investigation was focused on the inefficiency problem in software construction and latent characteristic efficiencies of a similar networked system. In order to analyze said PSC activities, three mathematical quotients and a messaging wavefunction …

Advanced Math Curriculum - Act Prep And Pre-College Algebra, Lauren Louise Morris

LSU Master's Theses

The purpose of this thesis was to create a non-traditional Advanced Mathematics course paired with Math XL® for School (MXL) for senior-level students with low ACT Math scores. The Advanced Math course was created with the purpose of helping students increase their ACT Math scores and preparing them for first-year college math, College Algebra. The course was taught at a private high school in Louisiana for the 2014-2015 school year and is attached to this thesis as an appendix. Upon completion of this course, the participating students achieved an average increase of 3.1 points in their ACT Math scores. After …

Calibration Of Option Pricing In Reproducing Kernel Hilbert Space, Lei Ge

Electronic Theses and Dissertations

A parameter used in the Black-Scholes equation, volatility, is a measure for variation of the price of a financial instrument over time. Determining volatility is a fundamental issue in the valuation of financial instruments. This gives rise to an inverse problem known as the calibration problem for option pricing. This problem is shown to be ill-posed. We propose a regularization method and reformulate our calibration problem as a problem of finding the local volatility in a reproducing kernel Hilbert space. We defined a new volatility function which allows us to embrace both the financial and time factors of the options. …

Crosscap Number: Handcuff Graphs And Unknotting Number, Anne Kerian

Department of Mathematics: Dissertations, Theses, and Student Research

Many types of invariants are used in the study of knots. Some are based on polynomials, some are purely algebraic, and some have their origins in geometry. One of the best known geometric knot invariants is the genus of a knot. A closely related but lesser-known invariant, crosscap number, was first introduced by Bradd Evans Clark in 1978. This thesis primarily concerns crosscap number two knots. Starting with a list of knots found to have crosscap number two by Burton and Ozlen using a linear programing approach, we verify, though are unable to expand, this list using a computer search. …

Analysis And Simulation For Homogeneous And Heterogeneous Sir Models, Joseph Wilda

Electronic Theses and Dissertations

In mathematical epidemiology, disease transmission is commonly assumed to behave in accordance with the law of mass action; however, other disease incidence terms also exist in the literature. A homogeneous Susceptible-Infectious-Removed (SIR) model with a generalized incidence term is presented along with analytic and numerical results concerning effects of the generalization on the global disease dynamics. The spatial heterogeneity of the metapopulation with nonrandom directed movement between populations is incorporated into a heterogeneous SIR model with nonlinear incidence. The analysis of the combined effects of the spatial heterogeneity and nonlinear incidence on the disease dynamics of our model is presented …

On The Theory Of Zeta-Functions And L-Functions, Almuatazbellah Awan

Electronic Theses and Dissertations

In this thesis we provide a body of knowledge that concerns Riemann zeta-function and its generalizations in a cohesive manner. In particular, we have studied and mentioned some recent results regarding Hurwitz and Lerch functions, as well as Dirichlet's L-function. We have also investigated some fundamental concepts related to these functions and their universality properties. In addition, we also discuss different formulations and approaches to the proof of the Prime Number Theorem and the Riemann Hypothesis. These two topics constitute the main theme of this thesis. For the Prime Number Theorem, we provide a thorough discussion that compares and contrasts …

Toxic Landscapes, Environmental Justice, And The Community: An Assessment Of Citizen Participation In Superfund Site Remediation Across Vulnerable Populations, Simone Justine Domingue

LSU Master's Theses

The environmental justice movement has made progress toward unveiling environmental inequalities and addressing these inequalities through the empowerment of low-income and minority communities. Federal agencies like the EPA have incorporated environmental justice principles into their operating frameworks, with the goals of ensuring every community is treated similarly when it comes to the implementation of environmental statutes, and ensuring community members are active participants in environmental activities that affect community well-being. Community involvement at federal Superfund sites is rarely conceptualized as an event related to environmental justice despite the role it has in shaping decisions at hazardous waste sites. This study …

Theoretical Study Of Laser Beam Quality And Pulse Shaping By Volume Bragg Gratings, Sergiy Kaim

Electronic Theses and Dissertations

The theory of stretching and compressing of short light pulses by the chirped volume Bragg gratings (CBG) is reviewed based on spectral decomposition of short pulses and on the wavelength-dependent coupled wave equations. The analytic theory of diffraction efficiency of a CBG with constant chirp and approximate theory of time delay dispersion are presented. Based on those, we performed comparison of the approximate analytic results with the exact numeric coupled-wave modeling. We also study theoretically various definitions of laser beam width in a given cross-section. Quality of the beam is characterized by the dimensionless beam propagation products (?x???_x)?? , which …

Bifurcation Analysis Of Mutually Coupled Laser Systems, Vincent Brennan

Theses

Coupled laser systems have application in everyday modern life, including for example, telecommunications and cryptography. Therefore it is important to gain insight into the dynamic processes at work and theoretical modeling can elucidate such processes. The work presented in this thesis is primarily concerned with aspects such as excitability and phase locking in mutually coupled oscillators. Phase-only delay-coupled oscillator models are introduced to demonstrate excitability and it is subsequently shown that similar processes can occur in a low-dimensional variation of these models. Further, delay differential rate equation models also exhibit excitability and these are explored and contrasted with another, similar, …

Vacuum Polarization On The Brane, Cormac Breen, Matthew Hewitt,, Elizabeth Winstanley, Adrian Ottewill

Articles

We compute the renormalized expectation value of the square of a massless, conformally coupled, quantum scalar field on the brane of a higher-dimensional black hole. Working in the AADD braneworld scenario, the extra dimensions are flat and we assume that the compactification radius is large compared with the size of the black hole. The four-dimensional on-brane metric corresponds to a slice through a higher-dimensional Schwarzschild-Tangherlini black hole geometry and depends on the number of bulk space-time dimensions. The quantum scalar field is in a thermal state at the Hawking temperature. An exact, closed-form expression is derived for the renormalized expectation …

Hamiltonian Approach To Internal Wave-Current Interactions In A Two-Media Fluid With A Rigid Lid, Alan Compelli, Rossen Ivanov

Articles

We examine a two-media 2-dimensional fluid system consisting of a lower medium bounded underneath by a flatbed and an upper medium with a free surface with wind generated surface waves but considered bounded above by a lid by an assumption that surface waves have negligible amplitude. An internal wave driven by gravity which propagates in the positive x-direction acts as a free common interface between the media. The current is such that it is zero at the flatbed but a negative constant, due to an assumption that surface winds blow in the negative x-direction, at the lid. We are concerned …

Primary Spaces, Mackey's Obstruction, And The Generalized Barycentric Decomposition, Patrick Iglesias-Zemmour, Francois Ziegler

Department of Mathematical Sciences Faculty Publications

We call a hamiltonian N-space primary if its moment map is onto a single coadjoint orbit. The question has long been open whether such spaces always split as (homogeneous) x (trivial), as an analogy with representation theory might suggest. For instance, Souriau's barycentric decomposition theorem asserts just this when N is a Heisenberg group. For general N, we give explicit examples which do not split, and show instead that primary spaces are always flat bundles over the coadjoint orbit. This provides the missing piece for a full "Mackey theory" of hamiltonian G-spaces, where G is an overgroup in which N …

Learning Love From A Tiger: Approaches To Nature In An American Buddhist Monastery, Daniel S. Capper

Faculty Publications

In current debates about Buddhist approaches to the non-human natural world, studies describe Buddhism variously as anthropocentric, biocentric or ecocentric. These perspectives derive for the most part from examinations of philosophical and normative aspects of the tradition without much attention to moments when embodied practice diverges from religious ideals. Responding to the need for narrative thick descriptions of lived Buddhist attitudes toward nature, I ethnographically explore a Vietnamese monastery in the United States. There I find multifaceted Buddhist approaches to nature which sometimes disclose disunity between theory and practice. Philosophically and normatively, this monastery embraces ecocentrism through notions of interconnectedness, …