Physical Sciences and Mathematics Commons^™

Interactions Of Amyloid Peptides With Lipid Membranes, Yanxing Yang

Dissertations

The aggregation of amyloid proteins into fibrils is a hallmark of several diseases including Alzheimer’s (AD), Parkinson’s, and Type II diabetes. This aggregation process involves the formation of small size oligomers preceding the formation of insoluble fibrils. Recent studies have shown that these oligomers are more likely to be responsible for cell toxicity than fibrils. A possible mechanism of toxicity involves the interaction of oligomers with the cell membrane compromising its integrity. In particular, oligomers may form pore-like structures in the cell membrane affecting its permeability or they may induce lipid loss via a detergent-like effect. This dissertation aims to …

Bioremediation Of Petroleum Hydrocarbons In Coastal Sediments, Charbel Abou Khalil

Dissertations

The biodegradation of dispersed crude oil in the ocean is relatively rapid (a half-life of a few weeks). However, it is often much slower on shorelines, usually attributed to low moisture content, nutrient limitation, and higher oil concentrations in beaches than in dispersed plumes. Another factor may be the increased salinity of the upper intertidal and supratidal zones since these parts of the beach are potentially subject to prolonged evaporation and only intermittent inundation. Therefore, two laboratory experiments are conducted to investigate whether such an increase in porewater salinity results in additional inhibitory effects on oil biodegradation in seashores.

In …

Combustion Soot Nanoparticles: Mechanism Of Restructuring And Mechanical Properties, Ali Hasani

Dissertations

Soot, a product of incomplete combustion of fossil fuels, is a global warming agent. The effect of soot particles on climate depends on their morphology. Freshly released soot particles are fractal lacey aggregates, but they often appear collapsed in atmospheric samples collected away from emission sources. A body of work has concluded that the collapse is caused by liquid shells when they form by vapor condensation around soot aggregates. However, some recent studies argue that soot remains fractal even when engulfed by the shells, collapsing only when the shells evaporate. To reconcile this disagreement, the effects of the condensation and …

Machine Learning-Based Data Analytics For Understanding Space Weather And Climate, Yasser Abduallah

Dissertations

This dissertation addresses multiple crucial problems in space weather and climate, presenting new machine learning-based data analytics algorithms and models for tackling the problems.

First, the dissertation presents two new approaches to predicting solar flares. One approach, called DeepSun, predicts solar flares by utilizing a machine-learning-as-a-service (MLaaS) platform. The DeepSun system provides a friendly interface for Web users and an application programming interface (API) for remote programming users. It adopts an ensemble learning method that employs several machine learning algorithms to perform multiclass flare prediction. The other approach, named SolarFlareNet, forecasts the occurrence of solar flares within the next 24 …

Urban Farming: Empowerment To Increase Economic, Education, And Nutritional Benefit For The Sub-Urban Community, Nasruddin Nasruddin, Yusuf Donner Dwiyantama, Banu Muhammad, Anom Bowalaksono, Dian Ayubi, Sarah Islamiati Pertiwi

ASEAN Journal of Community Engagement

This article discusses the urban farming program at Sekolah Master in Beji, Depok, Indonesia, which aims to provide the community with broader benefits, such as economy, education, and increased nutritional value. The project involves planting method that was introduced to this school community. The program itself consists of several stages, starting from the preparation—dissemination of the program and designing a plan for the greenhouse, the implementation—constructing the greenhouse and installing the automatic water system, planting the vegetation, and monitoring and evaluation of the program. Eventually, an evaluation of the successful program is required to determine whether the program can be …

How Do Cooperatives Enable Empowerment Among Rural Women? Evidence From The Municipality Of Cavinti, Laguna, Maria Theresa M. Castro-Bernardo, Liezel S. Cruz

Journal of Economics, Management and Agricultural Development

The persistent gender issues and their implications for sustainable development have led to several strategic yet collective schemes, such as the cooperatives, promising to contribute to (women) empowerment and social equality. Guided by Kabeer’s conceptual framework, this study analyzes the role of cooperative membership in promoting empowerment among its female coop-members in Cavinti, Laguna. Primary and secondary sources of data were used and analyzed using descriptive statistics and correlation analysis. The result indicates that cooperatives play a critical role in empowering women by providing new and/or improved knowledge and skills through capacity-building training necessary to make informed decisions, thus strengthening …

Market Analysis And Positioning Of Processed Halal Chevon Food Products, Jalaloden B. Marohom, Ivy Mar B. Cabornida

Journal of Economics, Management and Agricultural Development

Halal has gained popularity as a result of consumer concerns about food safety and ethical issues. Chevon is an important source of protein. However, no halal chevon products are commercially produced. Hence, the study aimed to develop positioning strategies to commercialize the products. A survey was undertaken of 400 potential consumers in the Philippines. The majority of the respondents were willing to buy halal food products. Descriptive statistics were applied, and findings revealed that products were generally acceptable. Potential consumers prefer it in wide assortment, in proper packaging, has informative labels, and easy to locate. However, their preference is significantly …

Ex-Ante Cost-Benefit Analysis Of High-End And Low-Cost Wireless Sensor Network (Wsn) Technology Packages For Efficient Irrigation Water Management In The Philippines, Marielle Q. Aringo, Victor B. Ella, Camille G. Martinez, Gamiello S. Pereira

Journal of Economics, Management and Agricultural Development

Four wireless sensor network (WSN) technology packages developed for efficient irrigation water management in the Philippines were subjected to ex-ante cost-benefit analysis (CBA) to assess their financial viability. The WSN technologies include high-end and low-cost wireless sensors for upland crop production with drip irrigation system and lowland crop production with alternate wetting and drying (AWD). Results showed that the high-end WSN technology packages are only viable for high-value crops such as red onion, bell pepper, and hot pepper. The low-cost WSN technology packages are viable for all selected crops except sweet corn. Minimum areas were also generated for each crop …

Preferences Of Coffee Farmers For Attributes Of Selected Coffee Technologies In The Philippines, Jayson S. Cabral, Dia Noelle F. Velasco, Mar B. Cruz, Nohreen Ethel P. Manipol, Hannah D. Miranda-Quibot

Journal of Economics, Management and Agricultural Development

This paper looked into the preferences of 151 coffee farmers for the attributes of selected coffee technologies. The study was done to help guide technology developers in crafting post harvest processing facilities for coffee which their target market will need which can lead to a higher probability of commercialization of new coffee technologies. The study examined the preferences for attributes for coffee dryers, moisture meters, coffee depulpers, and coffee sorters using the Analytic Hierarchy Process (AHP) framework. The results revealed that the quality of the final product is the top priority for coffee farmers when choosing a coffee dryer. Non-destructiveness …

Pollution Emissions And Economic Growth In Asia Through The Lens Of The Environmental Kuznets Curve, Brian Jason H. Ponce, Yolanda T. Garcia, Gideon P. Carnaje, Agham C. Cuevas

Journal of Economics, Management and Agricultural Development

The nonlinear relationship of pollution emissions with economic growth alongside energy consumption variables was examined to test the Environmental Kuznets Curve (EKC) hypothesis using a panel sample comprising 34 Asian economies from 2001 to 2013. Panel Autoregressive Distributed Lag models in the forms of Pooled Mean Group and Mean Group models were estimated and tested against one another using the Hausman test. For robustness checks, the same econometric techniques were applied to disaggregated panel groups based on income classifications. The study reveals that, while the EKC hypothesis holds in Asia, the findings were not robust across the disaggregated panel groups. …

Development Of Web-Based Project Tender Documents Application Using Extreme Programming Methods, Mustari Lamada, Aminuddin Bakry, Aulyah Zakilah Ifani, Khaerunnisa Khaerunnisa

Elinvo (Electronics, Informatics, and Vocational Education)

The application of technology is a need that is in demand in the industrial world today, especially in the field of contractors of goods and services that have implemented the use of applications to help the process of managing data and project documents in their companies. This study aims to optimize the web-based project tender document system using the extreme programming method. The extreme programming method consists of planning, design, coding, testing, and software increment. Research methods using extreme programming methods consisting of planning, design, coding, testing, and software increment. The planning stages obtain results in the form of functional …

Implementation Of Ahp And Black Box Testing To The Development Of An Information System For Assessing The Feasibility Of Bumdes Submissions, Hari Toha Hidayat, Husaini Husaini, Nanang Prihatin, Radhiyatammardhiyyah Radhiyatammardhiyyah

Elinvo (Electronics, Informatics, and Vocational Education)

The existence of institutional village enterprises (BUMDES) has never been adequately monitored in terms of the growth of village-owned businesses in each village. According to the data, there are 17 BUMDES in the Muara District that have been inactive for the most part. Due to the difficulty of monitoring the progress of BUMDES, a significant number of them have become stalled or even inactive. In addition, many BUMDES managers are frequently unprepared to operate the newly opened business. Readiness in terms of the quality of human resources also affects the formation of BUMDES. Consequently, the objective of this study is …

Comparison Of Web 2.0 Use On State University Websites In Indonesia And Top World Universities Related To Webometric Ranking, Handaru Jati

Elinvo (Electronics, Informatics, and Vocational Education)

The present work determines the presence in the web 2.0 that twenty universities had through their educational portals. The universities are selected according to the Webometrics ranking (the ten best located in Indonesia and the best located worldwide) to identify what Web 2.0 tools they use. This study explores the educational portals of the twenty selected universities to determine which Web 2.0 tools they use and variables of the tools found will be assessed. The study only considers those Web 2.0 tools which are linked to the websites of universities. Of the two most used tools, the relevant indicators are …

Aljabar Semiprima Mendasar Dan Aplikasinya Pada Protokol Autentikasi, Khurul Wardati, Muhammad Zaki Riyanto

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Library research dengan pendekatan deduksi-induksi ini bertujuan untuk mengkaji kesemiprimaan mendasar aljabar tak bebas yang dibangun secara hingga atas ring komutatif unital. Tujuan secara praktis penelitian ini adalah mengaplikasikan suatu contoh aljabar semiprima mendasar yang non-komutatif pada protokol autentikasi berdasarkan masalah dekomposisi. Di samping itu, aljabar semiprima mendasar lebih umum dari aljabar semiprima, hal ini ditunjukkan dengan suatu contoh penyangkal. Hasil utama dari penelitian ini adalah suatu aljabar yang dibangun secara hingga bersifat semiprima mendasar jika dan hanya jika ideal dasar nol merupakan irisan dari semua ideal dasar prima. Lebih lanjut ideal dasar nol merupakan satu-satunya ideal dasar nilpoten. Syarat …

Design Framework Of Uav-Based Environment Sensing, Localization, And Imaging System, Yue Sun

Graduate Doctoral Dissertations

In this dissertation research, we develop a framework for designing an Unmanned Aerial Vehicle or UAV-based environment sensing, localization, and imaging system for challenging environments with no GPS signals and low visibility. The UAV system relies on the various sensors that it carries to conduct accurate sensing and localization of the objects in an environment, and further to reconstruct the 3D shapes of those objects. The system can be very useful when exploring an unknown or dangerous environment, e.g., a disaster site, which is not convenient or not accessible for humans. In addition, the system can be used for monitoring …

Seleksi Nilai Fuzziness Exponent Optimal Pada Algoritma Fuzzy C-Means Untuk Mengelompokkan Provinsi Di Indonesia Berdasarkan Indikator Pembangunan Ekonomi, Umu Sa'adah, Endang Wahyu Handamari, Kwardiniya Andawaningtyas, Nur Fitriana Setyowati

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Pada tahun 2015, PBB merancang 17 Tujuan Pembangunan Berkelanjutan (SDGs) untuk mencapai kesejahteraan manusia pada tahun 2030 dengan mengintegrasikan tiga dimensi pembangunan berkelanjutan: ekonomi, sosial, dan lingkungan. Salah satu faktor yang digunakan untuk menilai keberhasilan sebuah wilayah atau pemerintahan dalam mengelola kesejahteraan dan kemakmuran masyarakat adalah tingkat perekonomian. Untuk mewujudkan kondisi tersebut diperlukan strategi dalam pembangunan pada sektor ekonomi. Penelitian ini bertujuan untuk mengelompokkan Provinsi di Indonesia menjadi 3 klaster berdasarkan indikator pembangunan ekonomi menggunakan algoritma fuzzy c-means. Penentuan 3 klaster dimaksudkan untuk klaster provinsi dengan tingkat pembangunan ekonomi rendah, sedang dan tinggi. Data yang digunakan dalam penelitian ini …

Mathematics Model Of Inheritance Three Different Traits In Genetics With Matrix Approach, Jufra Jufra, Asrul Sani, Sardin Sardin

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Mathematical models can solve problems to find out which individuals are superior from crosses in the field of genetics. The matrix form of the mathematical model using the concept of matrix diagonalization can solve these problems. The general definition of matrix diagonalization is with the diagonalized matrix elements obtained from the probability of crossing the average parent and the recessive parent. The mathematical model of a cross between the average parent and recessive parent can be formulated as . The behavior of the solution from the cross is in the form of an explicit equation which can be formulated as …

Generalisasi Pertidaksamaan Euler Untuk Membuktikan Planaritas Graf K_5 Dan K_(3,3), Emut Emut

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Kajian literatur tentang teori graf, khususnya planaritas suatu graf, yaitu menentukan apakah suatu graf itu termasuk graf planar atau bukan sudah banyak dibahas. Pada artikel ini pembahasan sedikit berbeda yaitu melakukan generalisasi atau perumuman teorema planaritas untuk dan teorema planaritas untuk Eksistensi perumuman ini penting karena dapat membuktikan planaritas dan sekaligus serta planaritas beberapa graf yang terkait. Pembuktian ketidakplanaran graf lengkap dan memberikan manfaat besar terhadap pengembangan teori planaritas graf dan memantapkan jaminan kebenaran pada terapannya. Urgensi pembuktiannya memiliki peran yang besar dalam menentukan planaritas graf-graf yang terkait, baik isomorfik atau subdivisi. Salah satu produk yang dihasilkan adalah teorema Kuratovski …

Algoritme Migrating Birds Optimization Dan Algoritme Particle Swarm Optimization: Penyelesaian Masalah Knapsack 0-1, Bib Paruhum Silalahi, Mohamad Novanto, Prapto Tri Supriyo

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Permasalahan knapsack merupakan salah satu masalah optimisasi. Masalah knapsack merupakan suatu permasalahan bagaimana memilih objek dari beberapa objek yang akan dimasukkan ke media penyimpanan dengan masing-masing objek memiliki bobot dan total bobot dari objek yang dipilih tidak boleh melebihi kapasitas media penyimpanannya, sehingga diperoleh nilai yang maksimal. Ketika objek yang dimasukkan ke dalam media penyimpanan bersifat harus dimasukkan semua atau tidak sama sekali, permasalahan ini dikenal dengan nama knapsack 0-1. Salah satu metode penyelesaian masalah knapsack 0-1 adalah dengan menggunakan metode meta-heuristic. Terdapat beberapa metode meta-heuristic seperti algoritma migrating birds optimization dan particle swarm optimization. Paper ini membahas …

Tinjauan Matematis Waktu Tundaan Pada Model Covid-19 Dengan Vaksinansi, Fitriana Yuli Saptaningtyas, Ahmadi Ahmadi

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Article ini membahas pemodelan matematika penyebaran Covid-19 dengan vaksinasi yang melibatkan waktu tundaan. Waktu tundaan merepresentasikan waktu individu mengalami penurunan kekebalan tubuh sehingga kembali rentan terhadap Covid-19 setelah sembuh. Kita tahu bahwa individu yang dinyatakan sembuh dari Covid-19 dapat terinfeksi kembali. Penelitian ini menganalisa titik ekuilibirum beserta kestabilannya, menentukan bilangan reproduksi dasar untuk melihat penyebaran penyakit, menentukan jenis bifurkasi yang muncul yang diakibatkan oleh waktu tundaan, dan melakukan simulasi numerik untuk melihat perilaku penyebaran penyakit. Di samping itu juga dilakukan kajian analitik untuk menentukan bilangan reproduksi dasar dan analisa perbandingan kestabilan lokal untuk model tanpa waktu tundaan dan dengan waktu …

Gw Monitoring, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

A Neural Analysis-Synthesis Approach To Learning Procedural Audio Models, Danzel Serrano

Theses

The effective sound design of environmental sounds is crucial to demonstrating an immersive experience. Classical Procedural Audio (PA) models have been developed to give the sound designer a fast way to synthesize a specific class of environmental sounds in a physically accurate and computationally efficient manner. These models are controllable due to the choice of parameters from analyzing a class of sound. However, the resulting synthesis lacks the fidelity for the preferred immersive experience; thus, the sound designer would rather search through an extensive database for real recordings of a target sound class. This thesis proposes the Procedural audio Variational …

Isotopic Signature Of Massive, Buried Ice In Eastern Taylor Valley, Antarctica: Implications For Its Origin, Christopher B. Gardner, Melisa A. Diaz, Devin F. Smith, Andrew G. Fountain, Joseph S. Levy, W. Berry Lyons

Geography Faculty Publications and Presentations

The coastal regions of the McMurdo Dry Valleys, Antarctica, contain deposits of the Ross Sea Drift, sedimentary material left from the Ross Sea ice sheet from the advance of the West Antarctic ice sheet during the Last Glacial Maximum. Much of this deposit is ice-cored, but data on the stable isotopic composition of water from this ice, which may contain a valuable climate archive, are sparse or incomplete. Widespread thermokarstic ground subsidence in this “coastal thaw zone” of the McMurdo Dry Valleys suggests that these potential records are rapidly being lost due to the melting of ground ice and permafrost. …

Model Identifikasi Singkong Berdasarkan Warna Untuk Tepung Mocaf Berbasis Citra Digital, Sri Andayani, Ega Noviastuti

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Penelitian ini bertujuan menghasilkan model untuk mengidentifikasi mutu singkong berdasarkan warna sebagai bahan pembuatan tepung mocaf dengan berbasis citra digital. Metode yang digunakan meliputi beberapa tahap pengolahan citra digital antara lain preprocessing dan ekstraksi ciri. Preprocessing meliputi cropping, resizing, dan grayscaling, sedangkan ekstraksi ciri meliputi segmentasi threshold dan binerisasi. Data penelitian menggunakan 118 citra singkong yang dibagi menjadi 72 citra data latih dan 46 data uji. Hasil penelitian berupa model identifikasi yang mendasarkan pada dua hal berikut: a) menggunakan ekstraksi ciri yang meliputi segmentasi threshold dengan nilai ambang 170 dan binerisasi dengan nilai ambang 75; dan b) penentuan mutu singkong …

Struktur Aljabar Koszul Pada Aljabar Lie M_(3,1) (R)‹Šã"–Glã"—_3 (R), Nur Hafizhah, Edi Kurniadi, Ema Carnia

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Dalam penelitian ini dipelajari aljabar Lie affine aff(3) berdimensi 12 yang merupakan jumlah semi langsung dari ruang vektor matriks berukuran 3x1 dan aljabar Lie matriks berukuran 3x3 . Tujuan penelitian ini adalah untuk membuktikan eksistensi dan struktur aljabar koszul pada aljabar Lie aff(3). Aljabar Lie tersebut adalah aljabar Lie Frobenius. Oleh karena itu, terdapat suatu fungsional linear yang mengakibatkan nilai fungsional linear pada matriks strukturnya tidak sama dengan nol. Fungsional linear yang demikian ini disebut fungsional Frobenius. Dalam penelitian ini diberikan juga bagaimana mendapatkan matriks struktur, menghitung determinannya serta memilih fungsional Frobenius yang tepat. Hasil yang diperoleh dalam penelitian ini …

Klasifikasi Kematangan Manggis Berdasarkan Fitur Warna Dan Tekstur Menggunakan Algoritma Naive Bayes, Raihan Abimanyu Suharman, Hartono Hartono

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Manggis merupakan salah satu komoditas buah asli Indonesia yang memiliki prospek pasar yang menjanjikan, terlebih dalam pasar ekspor. Namun masih ada permasalahan dalam hal penyortiran buah hasil panen. Buah manggis hasil panen disortir berdasarkan kematangan buahnya untuk tujuan pasar yaitu pasar ekspor dan pasar domestik. Faktor penentu kematangan buah manggis adalah warna dan tekstur dari kulit buahnya. Penelitian ini bertujuan untuk mengklasifikasi kematangan buah manggis berdasarkan warna dan tekstur menggunakan algoritma Naive Bayes. Fitur warna dan tekstur yang diekstraksi adalah kontras, korelasi, energi, homogenitas, entropi, standar deviasi, mean, varians, skewness, dan kurtosis. Fitur diekstraksi dari citra RGB, citra grayscale, citra …

Teori Titik Tetap Untuk Pemetaan (ψ,φ)_Ω-Kontraksi Pada Ruang P-Metrik Modular Berorder, Afifah Hayati, Lusi Harini, Ambar Winarni, Nur'aini Muhassanah

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Penelitian ini bertujuan untuk memberikan definisi pemetaan (psi,varphi)_omega-kontraksi dalam ruang p-metrik modular, memberikan teorema titik tetap untuk pemetaan -kontraksi pada ruang p-metrik modular, dan memberikan aplikasi dari teorema titik tetap tersebut. Penelitian ini dilakukan dengan memperumum definisi pemetaan (psi,varphi)_omega-kontraksi dalam ruang p-metrik dan teorema titik tetapnya ke dalam ruang p-metrik modular. Hasil penelitian menunjukkan bahwa pemetaan (psi,varphi)_omega-kontraksi dapat didefinisikan dalam ruang p-metrik modular dan teorema titik tetap untuk pemetaan tersebut pada ruang p-metrik modular dapat diberikan dengan penambahan beberapa sifat yang diasumsikan. Selain itu, hasil penelitian lainnya adalah aplikasi teorema titik tetap tersebut yang menjamin eksistensi solusi suatu persamaan integral …

Perbandingan Metode Fuzzy Times Series Cheng Dan Fuzzy Times Series Markov Chain Dalam Memprediksi Tingkat Pengangguran Terbuka Di Bali, Kadek Tresna Dwipayana, I Gusti Nyoman Yudi Hartawan, I Made Candiasa

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Penelitian ini bertujuan menemukan model untuk tingkat pengangguran terbuka di Bali dengan Fuzzy Times series Cheng (FTS Cheng) dan Fuzzy Times series Markov Chain (FTS Markov Chain) serta membandingkan tingkat akurasi kedua model tersebut. Jenis penelitian ini adalah jenis penelitian kuantitatif. Data tingkat pengangguran terbuka di Bali yang digunakan sebanyak 34 dari periode Februari 2006 sampai dengan Agustus 2021. Dari 34 data kemudian dibagi menjadi dua dengan proporsi 30% data latih dan 70% data uji. Tahapan penelitian yang dilakukan dengan menghitung FTS Cheng dan FTS Markov Chain pada data latih kemudian dilanjutkan pada data uji. Selanjutnya model FTS Cheng dan …

Kendali Model Prediktif Kokoh Pada Model Suhu Rumah Kaca, Ratna Widayati, Sholikhatun Sholikhatun, Noorma Yulia Megawati

PYTHAGORAS : Jurnal Matematika dan Pendidikan Matematika

Dalam paper ini dibahas mengenai masalah sistem kendali suhu rumah kaca dengan mempertimbangkan variabel gangguan. Masalah kendali suhu rumah kaca ini dimodelkan dengan RMPC (Robust Model Predictive Control). Algoritma Particle Swarm Optimization (PSO) dan Genetic Algortihm (GA) digunakan untuk mencari penyelesaian masalah RMPC pada sistem suhu rumah kaca yang berupa masalah optimisasi berkendala. Berdasarkan hasil simulasi, teknik kendali RMPC mampu mengatur suhu rumah kaca sesuai suhu yang diinginkan dengan gangguan relatif kecil yaitu sebesar 0.09^oC. Selain itu, waktu iterasi Algoritma PSO lebih cepat dalam menyelesaikan masalah RMPC pada sistem suhu rumah kaca dibandingkan dengan Algoritma Genetika.

Host-Pathogen Interactions In A Changing World: Microbes, Mucosal Defenses, And Multiple Hosts, Brandon C. Labumbard

Graduate Doctoral Dissertations

As fungal diseases continue to emerge, research increasingly focuses on host-microbiome interactions and links to disease. Certain skin-associated microbes may benefit hosts by protecting them from invading pathogens. Seasonal changes in the host environment can also result in shifts in the microbial community and pathogen virulence – potentially influencing disease dynamics. I investigated how cutaneous microbial communities differ across hosts, seasons, and Batrachochytrium dendrobatidis (Bd) infection status by sequencing the microbial communities of 1,100 leopard frogs at five locations across the US. Percent anti-Bd function varied seasonally and with Bd infection status. Bacterial communities also varied across locations and time. …