Physical Sciences and Mathematics Commons^™

Determination Of Dissociation Constants Of Protein Ligands By Thermal Shift Assay, Jaina A. Bhayani, Miguel Ballicora

Chemistry: Faculty Publications and Other Works

The thermal shift assay (TSA) is a powerful tool used to detect molecular interactions between proteins and ligands. Using temperature as a physical denaturant and an extrinsic fluorescent dye, the TSA tracks protein unfolding. This method precisely determines the midpoint of the unfolding transition (Tm" role="presentation">), which can shift upon the addition of a ligand. Though experimental protocols have been well developed, the thermal shift assay data traditionally yielded qualitative results. Quantitative methods for Kd" role="presentation"> determination relied either on empirical and inaccurate usage of Tm" role="presentation"> or on isothermal approaches, which do not take full advantage of the …

Assessing Feature Representations For Instance-Based Cross-Domain Anomaly Detection In Cloud Services Univariate Time Series Data, Rahul Agrahari, Matthew Nicholson, Clare Conran, Haytham Assem, John D. Kelleher

Articles

In this paper, we compare and assess the efficacy of a number of time-series instance feature representations for anomaly detection. To assess whether there are statistically significant differences between different feature representations for anomaly detection in a time series, we calculate and compare confidence intervals on the average performance of different feature sets across a number of different model types and cross-domain time-series datasets. Our results indicate that the catch22 time-series feature set augmented with features based on rolling mean and variance performs best on average, and that the difference in performance between this feature set and the next best …

Data Validating The Use Of Rubidium As A Non-Radioactive Tracer For The Localised Proliferation Of Wheat Roots In Acidic Or Limed Subsoil, Paul M. Damon, Gaus Azam, Chris Gazey, Craig Scanlan, Zed Rengel

Grain and Other Field Crops Research Articles

Existing technologies for lime (CaCO3) incorporation into acidic field soils result in the heterogeneous distribution of limed and acidic soil sections. In a study characterising the response of wheat (Triticum aestivum L.) to the amendment of an acidic soil profile with vertically limed slots[1], elucidation of the dynamics of root proliferation within the acidic and limed soil sections was a prerequisite to understanding the mechanisms driving the above-ground responses. Rubidium (Rb) has been used widely as a non-radioactive tracer for root activity[2] in soil. However, the contrasting pH in a heterogeneously limed soil profile and related aluminium toxicity effects …

Assessing Feature Representations For Instance-Based Cross-Domain Anomaly Detection In Cloud Services Univariate Time Series Data, Rahul Agrahari, Matthew Nicholson, Clare Conran, Haythem Assem, John D. Kelleher

Articles

In this paper, we compare and assess the efficacy of a number of time-series instance feature representations for anomaly detection. To assess whether there are statistically significant differences between different feature representations for anomaly detection in a time series, we calculate and compare confidence intervals on the average performance of different feature sets across a number of different model types and cross-domain time-series datasets. Our results indicate that the catch22 time-series feature set augmented with features based on rolling mean and variance performs best on average, and that the difference in performance between this feature set and the next best …

Surveillance Of Rnase P, Pmmov, And Crassphage In Wastewater As Indicators Of Human Fecal Concentration Across Urban Sewer Neighborhoods, Kentucky, Rochelle H. Holm, M. Nagarkar, R. A. Yeager, D. Talley, A. C. Chaney, J. P. Rai, A. Mukherjee, S. N. Rai, A. Bhatnagar, Ted Smith

Faculty and Staff Scholarship

Wastewater surveillance has been widely used as a supplemental method to track the community infection levels of severe acute respiratory syndrome coronavirus 2. A gap exists in standardized reporting for fecal indicator concentrations, which can be used to calibrate the primary outcome concentrations from wastewater monitoring for use in epidemiological models. To address this, measurements of fecal indicator concentration among wastewater samples collected from sewers and treatment centers in four counties of Kentucky (N = 650) were examined. Results from the untransformed wastewater data over 4 months of sampling indicated that the fecal indicator concentration of human ribonuclease P (RNase …

Pastoralism, Social, Gender, And Policy Issues, Nahid Naghizadeh

IGC Proceedings (1993-2023)

Nearly half of the Earth's land surface is classified as rangelands. Rangeland's health and productivity are directly critical to the livelihoods, cultures, and resilience of more than 500 million people worldwide, many of whom are indigenous peoples who depend on rangelands. Pastoralism is very diverse; it can be found in all continents, from the drylands of Africa and the Arabian Peninsula to the highlands of Asia and Latin America, or the tundra in the circumpolar zones, and in particular where crop cultivation is physically limited. Pastoralism supports several hundred million households worldwide and manages one billion animals, including camels, cattle, …

Ecological Science Infrastructure For Sustainability Transformations In Rangelands, Brandon T. Bestelmeyer, J. E. Herrick, J. R. Brown, D. M. Browning, B. Densambuu, E. Elias, S. E. Mccord, H. R. Peinetti, S. Spiegal, N. P. Webb, J. C. Williamson

IGC Proceedings (1993-2023)

Sustainability transformations—deliberate and radical shifts in values, governance, and management regimes to achieve sustainability—are needed in rangelands as in other components of the Earth system. We review four concepts comprising an ecological science infrastructure to support such transformations. The foundation is standard measurement of rangeland conditions in the field, especially vegetation and soil properties that underpin the environmental aspects of sustainability. Big data resources, especially gridded spatial datasets produced by models and remote sensing, can be combined with field data and computational approaches to upscale information about rangeland conditions and produce additional indicators of ecosystem functions and services. State and …

Annual Ryegrass Pasture For Dairy Cows Receiving Total Mixed Ration, M. Civiero, L. H. Schaitz, C. P. Ferris, Henrique M. N. Ribeiro-Filho

IGC Proceedings (1993-2023)

The inclusion of herbage in the diet of medium yielding dairy cows offered a total mixed ration (TMR) may be beneficial. This study, which involved mid lactation dairy cows, examined the effect of partial replacement of a TMR with annual temperate pasture. Treatments were ad libitum TMR (TMR₁₀₀), 75% ad libitum TMR + ryegrass (Lolium multiflorum ‘Maximus’) (TMR₇₅), and 50% ad libitum TMR + ryegrass (TMR₅₀). Twelve multiparous Holstein and F1 Jersey × Holstein cows were divided into six homogeneous groups, taking account of milk production (26.6 ± 4.5 kg/day), days in milk …

A Guava-Based Hortipasture System For Mitigating Climate Change And Sustaining Fodder & Fruit Supply In Semi-Arid Regions Of India, Kamini Gautam, Sunil Kumar, Amit Kumar Singh, Avijit Ghosh, Manjanagouda S. S., R. V. Kumar

IGC Proceedings (1993-2023)

Hortipasture systems have huge potential to mitigate climate change via sequestering carbon along with sustaining fodder and fruit supply especially in semi-arid regions. Therefore to evaluate climate change mitigation, fruit and fodder production potential of 10 year old rainfed based Hortipasture system (Psidium guajava (Guava) + Cenchrus ciliaris + Stylosanthes hamata) established at Central Research Farm of ICAR-Indian Grassland and Fodder Research Institute (Bundelkhand region, Jhansi, Uttar Pradesh, India), carbon stock of tree and under storey pasture components was quantified along with fruit and forage production. The experimental site is drought prone semi arid region characterized by poor …

Free-Enterprise Farming On Grasslands In Central Nsw, Australia, Des Green, Stuart Green, Ted Wolfe, Jo Richardson, Rob Eccles

IGC Proceedings (1993-2023)

A pathway is described in developing and improving the pastures on family-owned sheep and beef properties at sites near Blayney in central NSW. Initially, the twin approach of sowing perennial grasses, predominantly phalaris (Phalaris aquatica) with subterranean clover (Trifolium subterraneum) plus the recommended addition of superphosphate fertiliser, was closely followed but within a decade ill-thrift in pastures and livestock occurred. Once the core problem of soil acidity was recognised, steps were taken to overcome this constraint with applications of lime. However, an additional modification involving the application of gypsum with lime had to be sorted out …

Guano-Derived Morphologies And Associated Minerals Found In Cova De Sa Guitarreta, Llucmajor, Balearics, Antonio Merino Juncadella, Joan J. Fornós, Antoni Mulet, Joaquín Ginés

International Journal of Speleology

Cova de sa Guitarreta is located in the southern part of Mallorca Island (western Mediterranean). It was formed presumably by hypogenic processes in Upper Miocene reefal calcarenites. The cave hosts an important breeding colony of bats during the end of spring and early summer. Its microclimate is influenced by the presence of a thermal phreatic water table (27.7ºC) as well as by bat populations remaining in the cave along the reproductive season. The morphological bat-related features include bat claws and thumb marks scratches, together with several morphologies linked to bat excreta and aggressive leachates from guano. From the mineralogical point …

Water Insecurity, Water Borrowing, And Psychosocial Stress Among Daasanach Pastoralists In Northern Kenya, Leslie Ford, Hilary J. Bethancourt, Zane Swanson, Rosemary Nzunza, Amber Wutich, Alexandra Brewis, Sera Young, David Almeida, Matthew J. Douglass, Emmanuel K. Ndiema, David R. Braun, Herman Pontzer, Asher Y. Rosinger

School of Natural Resources: Faculty Publications

This article quantifies Daasanach water insecurity experiences in Northern Kenya, examines how water insecurity is associated with water borrowing and psychosocial stress, and evaluates if water borrowing mitigates the stress from water insecurity. Of 133 households interviewed in 7 communities, 95% were water insecure and 74.4% borrowed water three or more times in the prior month. Regression analyses demonstrate water borrowing frequency moderates the relationship between water insecurity and psychosocial stress. Only those who rarely or never borrowed water reported greater stress with higher water insecurity. The coping mechanism of water borrowing may help blunt water insecurity-related stress.

A New Matroid Lift Construction And An Application To Group-Labeled Graphs, Zach Walsh

Faculty Publications

A well-known result of Brylawski constructs an elementary lift of a matroid M from a linear class of circuits of M. We generalize this result by constructing a rank-k lift of M from a rank-k matroid on the set of circuits of M. We conjecture that every lift of M arises via this construction. We then apply this result to group-labeled graphs, generalizing a construction of Zaslavsky. Given a graph G with edges labeled by a group, Zaslavsky's lift matroid K is an elementary lift of the graphic matroid M(G) that respects the group-labeling; specifically, the cycles of G that …

Interplay Between Education And Identity: Inter Caste Marriages, Gendered Stream Choice And Caste Peer Effects., Komal Sahai Dr.

Doctoral Theses

No abstract provided.

Blood Flow Restriction Training After Patellar Instability (Brains Trial), Benjamin D. Brightwell, Austin V. Stone, Xiaojuan Li, Peter A. Hardy, Katherine L. Thompson, Brian W. Noehren, Cale A. Jacobs

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background

Patellar instability is a common and understudied condition that disproportionally affects athletes and military personnel. The rate of post-traumatic osteoarthritis that develops following a patellar dislocation can be up to 50% of individuals 5–15 years after injury. Conservative treatment is the standard of care for patellar instability however, there are no evidence-informed rehabilitation guidelines in the scientific literature. The purpose of this study is to assess the effectiveness of blood-flow restriction training (BFRT) for patellar instability. Our hypotheses are that this strategy will improve patient-reported outcomes and accelerate restoration of symmetric strength and knee biomechanics necessary to safely return …

The Molecular Structure And Curious Motions In 1,1-Difluorosilacyclopent-3-Ene And Silacyclopent-3-Ene As Determined By Microwave Spectroscopy And Quantum Chemical Calculations, Thomas M.C. Mcfadden, Nicole Moon, Frank E. Marshall, Amanda J. Duerden, Esther J. Ocola, Jaan Laane, Gamil A. Guirgis, Garry S. Grubbs

Chemistry Faculty Research & Creative Works

The molecules 1,1-difluorosilacyclopent-3-ene (3SiCPF2) and silacyclopent-3-ene (3SiCP) have been synthesized and studied using chirped pulse, Fourier transform microwave (CP-FTMW) spectroscopy. For 3SiCP this is the first ever microwave study of the molecule and, for 3SiCPF2, the spectra reported in this work have been combined with that of previous work in a global fit. The spectra of each contain splitting which has been fit using a Hamiltonian consisting of semirigid and Coriolis coupling parameters. A refit of the original 3SiCPF2 work was also carried out. All fits and approaches are reported. Analyses of the spectra provide evidence that the molecule is …

Security, Trust And Privacy For Cloud, Fog And Internet Of Things, Chien-Ming Chen, Shehzad Ashraf Chaudhry, Kuo-Hui Yeh, Muhammad Naveed Aman

School of Computing: Faculty Publications

No abstract provided.

A High-Performance Continuous-Flow Mea Reactor For Electroreduction Co2 To Formate, Pei-Xuan Liu, Lu-Wei Peng, Rui-Nan He, Lu-Lu Li, Jin-Li Qiao

Journal of Electrochemistry

The electrochemical carbon dioxide reduction reaction (CO₂RR) is a promising approach to produce liquid fuels and industrial chemicals by utilizing intermittent renewable electricity for mitigating environmental problems. However, the traditional H-type reactor seriously limits the electrochemical performance of CO₂RR due to the low CO₂ solubility in electrolyte, and high ohmic resistance caused by the large distance between two electrodes, which is unbeneficial for industrial application. Herein, we demonstrated a high-performance continuous flow membranes electrode assembly (MEA) reactor based on a self-growing Cu/Sn bimetallic electrocatalyst in 0.5 mol·L^-1 KHCO₃ for converting CO₂ to …

Acetate Solutions With 3.9 V Electrochemical Stability Window As An Electrolyte For Low-Cost And High-Performance Aqueous Sodium-Ion Batteries, Dao-Yun Lan, Xiao-Feng Qu, Yu-Ting Tang, Li-Ying Liu, Jun Liu

Journal of Electrochemistry

Low-cost and high-safety aqueous sodium-ion batteries have received widespread attention in the field of large-scale energy storage, but the narrow electrochemical stability window (1.23 V) of water limits the energy density of aqueous sodium-ion batteries. The “water-in-salt” strategy which uses the interaction between cations and water molecules in the solution can inhibit water decomposition and broaden the electrochemical stability window of water. In this work, two types of low-cost salts, namely, ammonium acetate (NH₄CH₃COOH) and sodium acetate (NaCH₃COOH), were used to configure a mixed aqueous electrolyte for aqueous sodium-ion batteries. The solution consisted of …

The Power Of First-Order Smooth Optimization For Black-Box Non-Smooth Problems, Alexander V. Gasnikov., Anton Novitskii, Vasilii Novitskii, Farshed Abdukhakimov, Dmitry Kamzolov, Aleksandr Beznosikov, Martin Takáč, Pavel Dvurechensky, Bin Gu

Machine Learning Faculty Publications

Gradient-free/zeroth-order methods for black-box convex optimization have been extensively studied in the last decade with the main focus on oracle calls complexity. In this paper, besides the oracle complexity, we focus also on iteration complexity, and propose a generic approach that, based on optimal first-order methods, allows to obtain in a black-box fashion new zeroth-order algorithms for non-smooth convex optimization problems. Our approach not only leads to optimal oracle complexity, but also allows to obtain iteration complexity similar to first-order methods, which, in turn, allows to exploit parallel computations to accelerate the convergence of our algorithms. We also elaborate on …

On Class Imbalanced Learning:Design Of Non-Parametricclassifiers, Performance Indices, And Deep Oversampling Strategies., Sankha Mullick Dr.

Doctoral Theses

The relevance of classification is almost endless in the everyday application of machine learning. However, the performance of a classifier is only limited to the fulfillment of the inherent assumptions it makes about the training examples. For example, to facilitate unbiased learning a classifier is expected to be trained with an equal number of labeled data instances from all of the classes. However, in a large number of practical applications such as anomaly detection, semantic segmentation, disease prediction, etc. it may not be possible to gather an equal number of diverse training points for all the classes. This results in …

Mathematical Formulations For Complex Resource Scheduling Problems., T. R. Lalita Dr.

Doctoral Theses

This thesis deals with development of effective models for large scale real-world resource scheduling problems. Efficient utilization of resources is crucial for any organization or industry as resources are often scarce. Scheduling them in an optimal way can not only take care of the scarcity but has potential economic benefits. Optimal utilization of resources reduces costs and thereby provides a competitive edge in the business world. Resources can be of different types such as human (personnel-skilled and unskilled), financial(budgets), materials, infrastructures(airports and seaports with designed facilities, windmills, warehouses’ area, hotel rooms etc) and equipment (microprocessors, cranes, machinery, aircraft simulators for …

Many-Objective Evolutionary Algorithms: Objective Reduction, Decomposition And Multi-Modality., Monalisa Pal Dr.

Doctoral Theses

Evolutionary Algorithms (EAs) for Many-Objective Optimization (MaOO) problems are challenging in nature due to the requirement of large population size, difficulty in maintaining the selection pressure towards global optima and inability of accurate visualization of high-dimensional Pareto-optimal Set (in decision space) and Pareto-Front (in objective space). The quality of the estimated set of Pareto-optimal solutions, resulting from the EAs for MaOO problems, is assessed in terms of proximity to the true surface (convergence) and uniformity and coverage of the estimated set over the true surface (diversity). With more number of objectives, the challenges become more profound. Thus, better strategies have …

Silver Bow Creek/Butte Area Npl Site, Trec Inc., A Woodard And Curran Company

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Advances Of Phosphide Promoter Assisted Pt Based Catalyst For Electrooxidation Of Methanol, Meng Li, Li-Gang Feng

Journal of Electrochemistry

Transition metal phosphide (TMP), as an ideal catalytic promoter in methanol fuel oxidation, has received increased attention because of its multifunctional active sites, tunable structure and composition, as well as unique physical and chemical properties and efficient multi-composition synergistic effect. Some advances have been made for this catalyst system recently. In the current review, the research progresses of transition metal phosphides (TMPs) in the assisted electrooxidation of methanol including the catalysts fabrication and their performance evaluation for methanol oxidation are reviewed. The promotion effect of TMPs has been firstly presented and the catalyst systems based on the different metal centers …

Silver Bow Creek/Butte Area Npl Site Butte Priority Soils Operable Unit 2022 Final Interim Site-Wide Surface Water Monitoring Qapp, Trec Inc., A Woodard And Curran Company

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Silver Bow Creek Butte Area Npl Site 2022 Final Butte Priority Soils Operable Unit Interim Site-Wide Surface Water Monitoring Quality Assurance Project Plan. Consent Decree- Civil Action No. Cv 89-039-Bu-She, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Copy Of Revision Summary - Sbc/Butte Area Npl Site Final Bpsou Interim Site-Wide Surface Water Monitoring Qapp 2020 And 2021 Monitoring Period, 10/14/20, Atlantic Richfield Company, Trec Inc., A Woodard And Curran Company

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Synthesis Of Lithium-Rich Manganese-Based Layered Cathode Materials And Study On Its Structural Evolution Of First Cycle Overcharge, Chen-Xu Luo, Chen-Guang Shi, Zhi-Yuan Yu, Ling Huang, Shi-Gang Sun

Journal of Electrochemistry

Lithium-rich manganese-based cathode materials have become one of promising cathode materials due to their low cost and large discharge specific capacity exceeding 250 mAh·g^-1. However, their problems such as low coulombic efficiency of first cycle and apparent voltage decay influence commercialization process. The high charging voltage will cause instability of structure and increase the hidden danger of the battery. Therefore, structural evolution of first cycle at higher voltage needs to be further studied. In this work, the precursor was synthesized by the co-precipitation method, and the lithium-rich manganese-based layered cathode materials were prepared by lithium-mixed and high-temperature sintering, …

Progress Of Pt-Based Catalysts In Proton-Exchange Membrane Fuel Cells: A Review, Long Huang, Hai-Chao Xu, Bi Jing, Qiu-Xia Li, Wei Yi, Shi-Gang Sun

Journal of Electrochemistry

Fuel cells are energy conversion devices that convert chemical energy directly into electricity. It has the advantages of high energy density, high utilization efficiency of fuel, clean and noiseless during working. Among all kinds of fuel cells, proton exchange membrane fuel cells (PEMFCs) are most popular since PEMFCs function at near ambient temperature, while their power densities are higher than those of other fuel cells. Currently, Pt-based nanomaterials are still the unreplaceable catalysts in commercialized PEMFCs. The lack of low-cost and high-performance cathode catalysts is still one of key factors that hampers the commercialization of PEMFCs. In this review, the …