Physical Sciences and Mathematics Commons^™

Ligand Discovery For The Alanine-Serine-Cysteine Transporter (Asct2, Slc1a5) From Homology Modeling And Virtual Screening, Colas Claire, Christof Grewer, Nicholas J. Otte, Armanda Gameiro, Thomas Albers, Kurnvir Singh, Helen Shere, Massimiliano Bonomi, Jeff Holst, Avner Schlessinger

Chemistry Faculty Scholarship

The Alanine-Serine-Cysteine transporter ASCT2 (SLC1A5) is a membrane protein that transports neutral amino acids into cells in exchange for outward movement of intracellular amino acids. ASCT2 is highly expressed in peripheral tissues such as the lung and intestines where it contributes to the homeostasis of intracellular concentrations of neutral amino acids. ASCT2 also plays an important role in the development of a variety of cancers such as melanoma by transporting amino acid nutrients such as glutamine into the proliferating tumors. Therefore, ASCT2 is a key drug target with potentially great pharmacological importance. Here, we identify seven ASCT2 ligands by computational …

Principles Of Information Technology Management, Jennifer Pitts, Jacqueline Radebaugh

Computer Science and Information Technology Grants Collections

This Grants Collection for Principles of Information Technology Management was created under a Round Three ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

• Linked Syllabus
• Initial Proposal
• Final Report

Examining Unmanned Aerial System Threats & Defenses: A Conceptual Analysis, Ryan J. Wallace, Jon M. Loffi

International Journal of Aviation, Aeronautics, and Aerospace

The integration of unmanned aerial systems (UAS) into the already complex global aviation system presents new and unique hazards. While many studies have addressed the potential safety concerns of UAS integration, little research has been dedicated to the potential security implications. This study sought to identify potential uses and adaptations of civil UAS systems as weapons of terrorism or crime and potential UAS defenses. Researchers examined 68 academic studies, unclassified government reports, and news articles using Conceptual Analysis to systematically capture and categorize various threats. Using the collected data, researchers developed a UAS threat model for categorically evaluating potential threats. …

Chart Adequacy: Workshop And Gebco Training, Limor Gur-Arieh, Yusoff Kamaruddin, Amon Kimeli, Anthony Klemm, Hirokazu Kurita, Shachak Pe'eri, Indra Budi Prasetyawan, Jae-Young Roh, Jaya Roperez, Nilupa Samarakoon, Jaqueline Sydenham, Maxlimer Vallee, Rochelle A. Wigley

Center for Coastal and Ocean Mapping

In July, 2015 the first NOAA Chart Adequacy Workshop was held in Silver Spring, Maryland, USA. Following a three-day workshop (14th to 16th July, 2015), four Nippon Foundation GEBCO students stayed at NOAA for an additional 10-day training at Office of Coast Survey’s Marine Chart Division. The key objective of the NOAA Chart Adequacy Workshop was to demonstrate techniques to evaluate the suitability of nautical chart products using chart quality information and publicly-available information. The attendees were cartographers, hydrographers and potential chart producers from hydrographic offices and government agencies around the world. The nations of the participants in the workshop …

บรรณาธิการ

Thai Environment

No abstract provided.

การศึกษาจุลินทรีย์ในสิ่งแวดล้อมจากแอนตาร์ติก สู่ ประเทศไทย, เสาวนีย์ วิจิตรโกสุม

Thai Environment

No abstract provided.

แผนแม่บทรองรับการเปลี่ยนแปลงสภาพภูมิอากาศ พ.ศ.2558-2593, แสงจันทร์ ลิ้มจิรกาล

Thai Environment

No abstract provided.

ประชาคมอาเซียน (Asean Community : Ac) กับความร่วมือด้านการจัดการสิ่งแวดล้อม, สิรินารี เงินเจริญ

Thai Environment

No abstract provided.

รูปแบบภูมิทัศน์เมือง เพื่อการเป็นพิพิธภัณฑ์มีชีวิตของเมืองประวัติศาสตร์เชียงแสน, เกริก กิตติคุณ

Thai Environment

No abstract provided.

การประยุกต์ใช้เทคนิค Vernadoc ในการบริการจัดการชุมชน, เจนการ เจนการกิจ

Thai Environment

No abstract provided.

Wab2e : Biocoke อีกหนึ่งทางเลือกของประเทศไทย, ธีรพล คังคะเกตุ

Thai Environment

No abstract provided.

มลพิษทางแสง, สิรินารี เงินเจริญ

Thai Environment

No abstract provided.

การเสวนาวิชาการ เรื่อง "ขยะอิเล็กทรอนิกส์ : จัดการอย่างไรให้ปลอดภัย?"

Thai Environment

No abstract provided.

Global Warming And The End-Permian Extinction Event: Proxy And Modeling Perspectives, Ying Cui, Lee R. Kump

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

The mass extinction event that occurred at the close of the Permian Period (~252million years ago) represents the most severe biodiversity loss in the ocean of the Phanerozoic. The links between the global carbon cycle, climate change and mass extinction are complex and involve a whole range of often inter-related geochemical, biological, ecologic and climatic factors. It has become widely accepted that the end-Permian mass extinction was associated with a global warming event, because the age of the Siberian Trap eruption, a potentially massive source of carbon dioxide, coincides within error with the extinction event. However, geologic data that are …

Leveraging Synergy Between Database And Programming Language Courses, Brian T. Howard

Computer Science Faculty publications

Undergraduate courses in database systems and programming languages are frequently taught without much overlap. This paper argues that there is a substantial benefit to emphasizing some areas of commonality, both old and new, between the two subjects. Examples of cross-fertilization that may be used to enhance one of both of the courses include query language design and implementation, object-relational mapping, transactional memory, and various aspects of the recent "NoSQL" movement.

Mass Spectrometry Based Proteomics And Lipidomics Studies, Huan Kang

Theses and Dissertations

Mass spectrometry has emerged as having a vital role in various applications to biochemical fields. In this thesis, we have utilized a variety of mass spectrometry techniques for both bacteriophage proteomics and colostrum and milk lipidomics studies. Our first study was the proteome characterization of Great Salt Lake bacteriophage NS01 with SDS-PAGE GEL to separate the viral proteins and high performance liquid chromatography (HPLC) coupled with an LTQ Orbitrap to identify the proteins after in-gel digestion. In this project, we have successfully identified 11 proteins with high confidence, p-values < 0.01, including coat protein gp88 with a coverage of 91% and tail protein gp86 with a coverage of 40.96%, which facilitated the classification of NS01 as a T7-like phage. Our second study was the discovery of colostrum and milk biomarkers that can be used to predict the likelihood of development of production-related metabolic diseases (PRMDs) in dairy cows through a lipidomics approach. In this study, an electrospray ionization, time-of-flight mass spectrometer was applied to lipid profiling, quantification and significant biomolecule selection. A Q-Star quadrupole, orthogonal time-of-flight mass spectrometer and an Agilent 6530 accurate-mass quadrupole/time-of flight mass spectrometer were both used for lipid biomarker fragmentation and identification. According to linear discriminative statistical modeling, three panels of biomarkers were defined. A combination of 2 milk lipid predictors, including DG18:0/18:0 and TG 18:0/18:0/18:1, provided PRMD predictions with 75.0% sensitivity at 90.0% specificity. A combination of 3 colostrum lipid predictors, including TG16:0/18:1/18:3, DG16:0/16:0 and C₄₀H₆₀NO, provided PRMD prediction with 90.0% sensitivity at …

Ozone Reaction With Interior Building Materials: Influence Of Diurnal Ozone Variation, Temperature And Humidity, Donghyun Rim, Elliott T. Gall, Randy L. Maddalena, William W. Nazaroff

Mechanical and Materials Engineering Faculty Publications and Presentations

Elevated tropospheric ozone concentrations are associated with increased morbidity and mortality. Indoor ozone chemistry affects human exposure to ozone and reaction products that also may adversely affect health and comfort. Reactive uptake of ozone has been characterized for many building materials; however, scant information is available on how diurnal variation of ambient ozone influences ozone reaction with indoor surfaces. The primary objective of this study is to investigate ozone-surface reactions in response to a diurnally varying ozone exposure for three common building materials: ceiling tile, painted drywall, and carpet tile. A secondary objective is to examine the effects of air …

Congruent Visual Speech Enhances Entrainment To Continuous Auditory Speech In Noise-Free Conditions, Michael Crosse, John S. Butler, Edmumd Lalor

Articles

Congruent audiovisual speech enhances our ability to comprehend a speaker, even in noise-free conditions. When incongruent auditory and visual information is presented concurrently, it can hinder a listener’s perception and even cause him or her to perceive information that was not presented in either modality. Efforts to investigate the neural basis of these effects have often focused on the special case of discrete audiovisual syllables that are spatially and temporally congruent, with less work done on the case of natural, continuous speech. Recent electrophysiological studies have demonstrated that cortical response measures to continuous auditory speech can be easily obtained using …

Should I Follow This Fault Localization Tool's Output? Automated Prediction Of Fault Localization Effectiveness, Tien-Duy B. Le, David Lo, Ferdian Thung

Research Collection School Of Computing and Information Systems

Debugging is a crucial yet expensive activity to improve the reliability of software systems. To reduce debugging cost, various fault localization tools have been proposed. A spectrum-based fault localization tool often outputs an ordered list of program elements sorted based on their likelihood to be the root cause of a set of failures (i.e., their suspiciousness scores). Despite the many studies on fault localization, unfortunately, however, for many bugs, the root causes are often low in the ordered list. This potentially causes developers to distrust fault localization tools. Recently, Parnin and Orso highlight in their user study that many debuggers …

Validation Experiments On Finite Element Models Of An Ostrich (Struthio Camelus) Cranium, Andrew R. Cuff, Jen A. Bright, Emily J. Rayfield

School of Geosciences Faculty and Staff Publications

The first finite element (FE) validation of a complete avian cranium was performed on an extant palaeognath, the ostrich (Struthio camelus). Ex-vivo strains were collected from the cranial bone and rhamphotheca. These experimental strains were then compared to convergence tested, specimen-specific finite element (FE) models. The FE models contained segmented cortical and trabecular bone, sutures and the keratinous rhamphotheca as identified from micro-CT scan data. Each of these individual materials was assigned isotropic material properties either from the literature or from nanoindentation, and the FE models compared to the ex-vivo results. The FE models generally replicate the location …

Forest Diversity And Disturbance: Changing Influences And The Future Of Virginia’S Forests, Christine J. Small, James L. Chamberlain

Virginia Journal of Science

The Virginia landscape supports a remarkable diversity of forests, from maritime dune woodlands, swamp forests, and pine savannas of the Atlantic Coastal Plain, to post-agricultural pine-hardwood forests of the Piedmont, to mixed oak, mesophytic, northern hardwood, and high elevation spruce-fir forests across three mountain provinces in western parts of the state. Virginia’s forests also have been profoundly shaped by disturbance. Chestnut blight, hemlock woolly adelgid, emerald ash borer, and other pests have caused declines or functional extirpation of foundation species. Invasive plants like multiflora rose, Oriental bittersweet, and Japanese stiltgrass threaten both disturbed and intact forests. Oaks and other fire-dependent …

Functional Requirements Identification Using Item-To-Item Collaborative Filtering, Proceso L. Fernandez Jr, Reynald Jay F. Hidalgo

Department of Information Systems & Computer Science Faculty Publications

One of the most difficult tasks in the development of software is the identification of the functional requirements. A well-defined functional requirement will eventually map the success of a software project. A support tool that can recommend candidate functional requirements for a software project being developed will help software engineers to deliver the right software to the clients.
The purpose of this study is to determine whether a collection of previously developed software applications can serve as basis for the development of a model to identify functional requirements of a project to be developed. Completed software project documentations of Master …

Modeling Flood Risk For An Urban Cbd Using Ahp And Gis, Proceso L. Fernandez Jr, Generino P. Siddayao, Sony E. Valdez

Department of Information Systems & Computer Science Faculty Publications

The Central Business District (CBD) of a city is the activity center of the city, typically locating the main commercial and cultural establishments, as well as acting as the center point of the city’s transportation network. Flood risk assessment for a CBD is crucial for proper city planning and maintenance. In this study, we model the flood risk for the CBD of Tuguegarao City, which is located in northern Philippines. To accomplish this, we identified important flood-related factors whose data are either easily available or may be collected through some automated process that we developed. We then surveyed experts to …

The Rise Of Fire: Fossil Charcoal In Late Devonian Marine Shales As An Indicator Of Expanding Terrestrial Ecosystems, Fire, And Atmospheric Change, Susan M. Rimmer, Sarah J. Hawkins, Andrew C. Scott, Walter L. Cressler Iii

Earth & Space Sciences Faculty Publications

No abstract provided.

Towards Mhealth Solutions For Asthma Patients, Nahid Negar

Master's Theses (2009 -)

With the recent, rapid growth in mobile-computing technology, mobile health (mHealth) is becoming a popular research topic. mHealth is one of several examples of how using technology in the health sector is being more advanced every day. mHealth is being applied to the care of a broad spectrum of diseases from acute to chronic, such as the flu, asthma, and cancer. Due to the easy-to-understand and friendly user interfaces, mobility and cost effectiveness; a mobile application can be a powerful tool to collect patient information. Asthma is a common disease around the globe. Collecting the proper symptom, trigger, peak-flow and …

Mcicsl Newsletter - October 2015, Shannon R. Trimboli Education Coordinator

MCICSL Newsletter

This issue includes the following:

Mercy Academy Begins Study of Mammoth Cave’s Aquatic Habitat

National Network of Research Learning Centers Releases New Strategic Framework

as well as education and research highlights, MCICSL symposium information and FY16 Education report

Ogden College Of Science & Engineering Newsletter (Fall 2015), Cheryl Stevens, Dean

Ogden College of Science & Engineering Publications

No abstract provided.

Patagonia Con Poder: El Éxito De La Oposición Frente El Proyecto Hidroaysén, Nathaniel Korn

Independent Study Project (ISP) Collection

This investigation analyzes the movement in opposition to the HidroAysén project in Southern Chile that is often referred to as and uses the slogan “Patagonia Sin Represas” (Patagonia Without Dams). The investigation is framed through collective action theory, the study of what incentives and other factors create the conditions for mobilization and group action. In the context of social movements it is usually argued that there needs to be a better cost-benefit scenario for each actor to be involved than there is to not be involved in the movement. Immediately following return of democracy to Chile in the 1990’s social …

Pattern Formation Of Elastic Waves And Energy Localization Due To Elastic Gratings, A. Berezovski, J. Engelbrecht, Mihhail Berezovski

Publications

Elastic wave propagation through diffraction gratings is studied numerically in the plane strain setting. The interaction of the waves with periodically ordered elastic inclusions leads to a self-imaging Talbot effect for the wavelength equal or close to the grating size. The energy localization is observed at the vicinity of inclusions in the case of elastic gratings. Such a localization is absent in the case of rigid gratings.

Sea Level Rise In Virginia – Causes, Effects And Response, Tal Ezer, Larry P. Atkinson

Virginia Journal of Science

Sea level rise (SLR) along Virginia’s coasts and around the Chesapeake Bay as measured by tide gauges is analyzed and discussed. It is shown that the SLR rates vary between one location to another and in most locations the rates increase over time (i.e., SLR is accelerating). The latest science of SLR is reviewed and the causes of the high SLR rates in Virginia are discussed. The impacts of land subsidence and ocean currents (changes in the Gulf Stream in particular) on sea level are especially notable and important for predicting future SLR in Virginia. The consequences of SLR on …