Physical Sciences and Mathematics Commons^™

Classification And Cluster Analysis Of Complex Time-Of-Flight Secondary Ion Mass Spectrometry For Biological Samples, Stephen E. Reichenbach, Xue Tian, Qingping Tao, Alex Henderson

Steve Reichenbach

Identifying and separating subtly different biological samples is one of the most critical tasks in biological analysis. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is becoming a popular and important technique in the analysis of biological samples, because it can detect molecular information and characterize chemical composition. ToF-SIMS spectra of biological samples are enormously complex with large mass ranges and many peaks. As a result the classification and cluster analysis are challenging. This study presents a new classification algorithm, the most similar neighbor with a probability-based spectrum similarity measure (MSN- PSSM), which uses all the information in the entire ToF- SIMS …

Restoration And Reconstruction Of Avhrr Images, Stephen E. Reichenbach, Daniel Kohler, Dennis Strelow

Steve Reichenbach

This paper describes the design of small convolution kernels for the restoration and reconstruction of Advanced Very High Resolution Radiometer (AVHRR) images. The kernels are small enough to be implemented efficiently by convolution, yet effectively correct degradations and increase apparent resolution. The kernel derivation is based on a comprehensive, end-to-end system model that accounts for scene statistics, image acquisition blur, sampling effects, sensor noise, and postfilter reconstruction. The design maximizes image fidelity subject to explicit constraints on the spatial support and resolution of the kernel. The kernels can be designed with h e r resolution than the image to perform …

Geospatial Decision Support For Drought Risk Management , Steve Goddard, Sherri Harms, Stephen Reichenbach, Tsegaye Tadesse, William Waltman

Steve Reichenbach

Drought affects virtually all regions of the world and results in significant economic, social, and environmental impacts. The Federal Emergency Management Agency estimates annual drought-related losses in the U.S. at $6–$8 billion, which is more than any other natural hazard. Congress enacted the Agricultural Risk Protection Act of 2000 to encourage the U.S. Department of Agriculture (USDA) Risk Management Agency (RMA) and farmers to be more proactive in managing drought risk. Through the NSF’s Digital Government Program, the USDA RMA is working with the University of Nebraska–Lincoln Computer Science and Engineering Department, National Drought Mitigation Center (NDMC), and High Plains …

Image Interpolation By Two-Dimensional Parametric Cubic Convolution, Jiazheng Shi, Stephen E. Reichenbach

Steve Reichenbach

Cubic convolution is a popular method for image interpolation. Traditionally, the piecewise-cubic kernel has been derived in one dimension with one parameter and applied to two-dimensional (2-D) images in a separable fashion. However, images typically are statistically nonseparable, which motivates this investigation of nonseparable cubic convolution. This paper derives two new nonseparable, 2-D cubic-convolution kernels. The first kernel, with three parameters (designated 2D-3PCC), is the most general 2-D, piecewise-cubic interpolator defined on [-2, 2] x [-2, 2] with constraints for biaxial symmetry, diagonal (or 90 rotational) symmetry, continuity, and smoothness. The second kernel, with five parameters (designated 2D-5PCC), relaxes the …

Smart Templates For Peak Pattern Matching With Comprehensive Two-Dimensional Liquid Chromatography, Stephen E. Reichenbach, Peter W. Carr, Dwight R. Stoll, Qingping Tao

Steve Reichenbach

Comprehensive two-dimensional liquid chromatography (LC × LC) generates information-rich but complex peak patterns that require automated processing for rapid chemical identification and classification. This paper describes a powerful approach and specific methods for peak pattern matching to identify and classify constituent peaks in data from LC × LC and other multidimensional chemical separations. The approach records a prototypical pattern of peaks with retention times and associated metadata, such as chemical identities and classes, in a template. Then, the template pattern is matched to the detected peaks in subsequent data and the metadata are copied from the template to identify and …

New Technologies For Glycomic Analysis: Toward A Systematic Understanding Of The Glycome, John Rakus, Lara Mahal

John F. Rakus

Carbohydrates are the most difficult class of biological molecules to study by high-throughput methods owing to the chemical similarities between the constituent monosaccharide building blocks, template-less biosynthesis, and the lack of clearly identifiable consensus sequences for the glycan modification of cohorts of glycoproteins. These molecules are crucial for a wide variety of cellular processes ranging from cell-cell communication to immunity, and they are altered in disease states such as cancer and inflammation. Thus, there has been a dedicated effort to develop glycan analysis into a high-throughput analytical field termed glycomics. Herein we highlight major advances in applying separation, mass spectrometry, …

Using Lectinmicroarrays To Identify Regulatory Mechanisms For Mammalian Glycosylation, John F. Rakus

John F. Rakus

Glycosylation involves the post-translational addition of carbohydrates to protein molecules and is an intricate and indispensable biochemical process. Study of this complicated network of interactions is hindered by the lack of a coding template analogous to the genetic code, and by the vast structural complexity inherent to carbohydrate polymers. We use lectins (non-enzymatic carbohydrate-binding proteins of non-immunological origin) as microarray probes to identify carbohydrate features expressed on cellular surfaces. Specifically, we utilized lectin microarray technology to investigate the differences in carbohydrates expressed by the cell lines of the Nation Cancer Institute’s NCI-60 panel. Our investigation identified tissue-specific expression differences in …

Mir-30b/30d Regulation Of Galnac Transferases Enhances Invasion And Immunosuppression During Metastasis, Avital Gaziel-Sovran, Miguel Segura, Raffaella Di Micco, Mary Collins, Douglas Hanniford, Eleazar De Miera, John Rakus, John Dankert, Shulian Shang, Robert Kerbel, Nina Bhardwaj, Yongzhao Shao, Farbod Darvishian, Jiri Zavadil, Adrian Erlebacher, Lara Mahal, Iman Osman, Eva Hernando

John F. Rakus

To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival. Ectopic expression of miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GalNAc transferase GALNT7, resulted in increased synthesis of the immunosuppressive cytokine IL-10, and reduced immune cell activation and recruitment. …

Understanding Organic Film Behavior On Alloy And Metal Oxides, Aparna Raman, Rosalynn Quiñones, Lisa Barriger, Rachel Eastman, Arash Parsi, Ellen Gawalt

Rosalynn Quiñones-Fernández

Native oxide surfaces of stainless steel 316L and Nitinol alloys and their constituent metal oxides, namely nickel, chromium, molybdenum, manganese, iron, and titanium, were modified with long chain organic acids to better understand organic film formation. The adhesion and stability of films of octadecylphosphonic acid, octadecylhydroxamic acid, octadecylcarboxylic acid, and octadecylsulfonic acid on these substrates were examined in this study. The films formed on these surfaces were analyzed by diffuse reflectance infrared Fourier transform spectroscopy, contact angle goniometry, atomic force microscopy, and matrix-assisted laser desorption ionization mass spectrometry. The effect of the acidity of the organic moiety and substrate composition …

Quasisymmetric (K; L)-Hook Schur Functions, Sarah K. Mason, Elizabeth Niese

Elizabeth Niese

We introduce a quasisymmetric generalization of Berele and Regev's (k,l)-hook Schur functions. These quasisymmetric hook Schur functions decompose the hook Schur functions in a natural way. The quasisymmetric hook Schur functions can be defined as the generating function for a certain set of composition tableaux on two alphabets. We will look at the combinatorics of the quasisymmetric hook Schur functions, including an analogue of the RSK algorithm and a generalized Cauchy Identity.

Gait Transition Dynamics Are Modulated By Experimental Protocol, Mohammad Abdolvahab, Jason Gordon

Mohammad Abdolvahab

No abstract provided.

Infrared Spectroscopy Of Symbiotic Stars. X. Orbits For Three S-Type Systems: V1044 Centauri, Hen 3-1213, And Ss 73-96, Francis C. Fekel, Kenneth H. Hinkle, Richard R. Joyce, Peter R. Wood

Information Systems and Engineering Management Research Publications

Employing new infrared radial velocities, we have computed orbits of the cool giants in three southern S-type symbiotic systems. The orbit for V1044 Cen, an M5.5 giant, has a period of 985 days and a modest eccentricity of 0.16. Hen 3-1213 is a K4 giant, yellow symbiotic with an orbital period of 533 days and a similar eccentricity of 0.18. For the M2 giant SS 73-96 the orbital period is 828 days, and this system has a somewhat larger eccentricity of 0.26. Measurement of the H i Paschen δ emission lines, which may at least partially reflect the motion of …

Extreme Geomagnetic Disturbances Due To Shocks Within Cmes, Noe E. Lugaz, Charles J. Farrugia, Chia-Lin L. Huang, Harlan E. Spence

Physics & Astronomy

We report on features of solar wind-magnetosphere coupling elicited by shocks propagating through coronal mass ejections (CMEs) by analyzing the intense geomagnetic storm of 6 August 1998. During this event, the dynamic pressure enhancement at the shock combined with a simultaneous increase in the southward component of the magnetic field resulted in a large earthward retreat of Earth's magnetopause, which remained close to geosynchronous orbit for more than 4 h. This occurred despite the fact that both shock and CME were weak and relatively slow. Another similar example of a weak shock inside a slow CME resulting in an intense …

Thz-Pulse-Induced Selective Catalytic Co Oxidation On Ru, Jerry L. Larue, Tetsuo Katayama, Aaron Lindenberg, Alan S. Fisher, Henrik Öström, Anders Nilsson, Hirohito Ogasawara

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We demonstrate the use of intense, quasi-half-cycle THz pulses, with an associated electric field component comparable to intramolecular electric fields, to direct the reaction coordinate of a chemical reaction by stimulating the nuclear motions of the reactants. Using a strong electric field from a THz pulse generated via coherent transition radiation from an ultrashort electron bunch, we present evidence that CO oxidation on Ru(0001) is selectively induced, while not promoting the thermally induced CO desorption process. The reaction is initiated by the motion of the O atoms on the surface driven by the electric field component of the THz pulse, …

Prevalence And Prediction Of Obstructive Coronary Artery Disease In Patients Referred For Valvular Heart Surgery, Jason M. Lappe, Justin L. Grodin, Yuping Wu, Corinne Bott Silverman, Leslie Cho

Mathematics and Statistics Faculty Publications

Current guidelines recommend a coronary evaluation before valvular heart surgery (VHS). Diagnostic coronary angiography is recommended in patients with known coronary artery disease (CAD) and those with high pretest probability of CAD. In patients with low or intermediate pretest probability of CAD, the guidelines recommend coronary computed tomographic angiography. However, there are no tools available to objectively assess a patient’s risk for obstructive CAD before VHS. To address this deficit, 5,360 patients without histories of CAD who underwent diagnostic coronary angiography as part of preoperative evaluation for VHS were identified. Obstructive CAD was defined as ≥50% stenosis in ≥1 artery. …

Engineering Room-Temperature Superconductors Via Ab-Initio Calculations, Mamikon Gulian, Gurgen Melkonyan, Armen Gulian

Mathematics, Physics, and Computer Science Faculty Articles and Research

The BCS, or bosonic model of superconductivity, as Little and Ginzburg have first argued, can bring in superconductivity at room temperatures in the case of high-enough frequency of bosonic mode. It was further elucidated by Kirzhnits et al., that the condition for existence of high-temperature superconductivity is closely related to negative values of the real part of the dielectric function at finite values of the reciprocal lattice vectors. In view of these findings, the task is to calculate the dielectric function for real materials. Then the poles of this function will indicate the existence of bosonic excitations which can …

Undiagnosed Diabetes And Pre-Diabetes In Health Disparities, Susan P. Fisher-Hoch, Kristina Vatcheva, Mohammad H. Rahbar, Joseph B. Mccormick

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Globally half of all diabetes mellitus is undiagnosed. We sought to determine the extent and characteristics of undiagnosed type 2 diabetes mellitus and pre-diabetes in Mexican Americans residing in the United States. This disadvantaged population with 50% lifetime risk of diabetes is a microcosm of the current pandemic. We accessed baseline data between 2004 and 2014 from 2,838 adults recruited to our Cameron County Hispanic Cohort (CCHC); a two-stage randomly selected 'Framingham-like' cohort of Mexican Americans on the US Mexico border with severe health disparities. We examined prevalence, risk factors and metabolic health in diagnosed and undiagnosed diabetes and pre-diabetes. …

Characterizing The Properties Of Specific Binomial Coefficients In Congruence Relations, Tyler Robert Russ

Master's Theses and Doctoral Dissertations

The number theoretic conjecture we examine in this paper originates when trying to construct a characterizable generating set for the complex cobordism polynomial ring. To date there is no efficient, universal method for characterizing such a generating set. Wilfong conjectures that smooth projective toric varieties can act as these generators [7]. Toric varieties are related to polytopes by a bijective correspondence. Studying the combinatorial structure of these polytopes is much more manageable than studying properties of toric varieties directly. This gives rise to the number theoretic conjecture considered here. A proof of this number theoretic conjecture would in turn prove …

Superconducting Antenna Concept For Gravitational Waves, Armen Gulian, J Foreman, Vahan Nikoghosyan, Shmuel Nussinov, Louis Sica, Jeff Tollaksen

Mathematics, Physics, and Computer Science Faculty Articles and Research

The most advanced contemporary efforts and concepts for registering gravitational waves are focused on measuring tiny deviations in large arm (kilometers in case of LIGO and thousands of kilometers in case of LISA) interferometers via photons. In this report we discuss a concept for the detection of gravitational waves using an antenna comprised of superconducting electrons (Cooper pairs) moving in an ionic lattice. The major challenge in this approach is that the tidal action of the gravitational waves is extremely weak compared with electromagnetic forces. Any motion caused by gravitational waves, which violates charge neutrality, will be impeded by Coulomb …

Current-Biased Transition-Edge Sensors Based On Re-Entrant Superconductors, Armen Gulian, Vahan Nikoghosyan, Jeff Tollaksen, V. Vardanyan, A. Kuzanyan

Mathematics, Physics, and Computer Science Faculty Articles and Research

Transition-edge sensors are widely recognized as one of the most sensitive tools for the photon and particles detection in many areas, from astrophysics to quantum computing. Their application became practical after understanding that rather than being biased in a constant current mode, they should be biased in a constant voltage mode. Despite the methods of voltage biasing of these sensors are well developed since then, generally the current biasing is more convenient for superconducting circuits. Thus transition-edge sensors designed inherently to operate in the current-biased mode are desirable. We developed a design for such detectors based on re-entrant superconductivity. In …

On The Relationship Between The North Atlantic Oscillation And Early Warm Season Temperatures In The Southwestern United States, Boksoon Myoung, Seung Hee Kim, Jinwon Kim, Menas Kafatos

Mathematics, Physics, and Computer Science Faculty Articles and Research

It is reported herein that the North Atlantic Oscillation (NAO), which has been known to directly affect winter weather conditions in western Europe and the eastern United States, is also linked to surface air temperature over the broad southwestern U.S. (SWUS) region, encompassing California, Nevada, Arizona, New Mexico, Utah, and Colorado, in the early warm season. The authors have performed monthly time-scale correlations and composite analyses using three different multidecadal temperature datasets. Results from these analyses reveal that NAO-related upstream circulation positively affects not only the means, but also the extremes, of the daily maximum and minimum temperatures in the …

Prospective Solid-State Photonic Cryocooler Based On The “Phonon-Deficit Effect”, Gurgen Melkonyan, Armen Gulian

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this design microwave photons are propagating in a sapphire rod, and are being absorbed by a superconductor deposited on the surface of the rod. The frequency of the radiation is tuned to be less than the energy gap in the superconductor, so that the pair breaking is not taking place. This photon pumping redistributes the electron-hole quasiparticles: their distribution function is non-equilibrium, and the “phonon-deficit effect” takes place. There is a dielectric material deposited on top of superconductor, which serves asthe “cold finger” of the cooler. Its “acoustical density” is supposed to be smaller than that of the superconducting …

Application Of Resurgence Theory To Approximate Inverse Square Potential In Quantum Mechanics, Jian Zhang Ms.

Macalester Journal of Physics and Astronomy

Previous work concluded that the leading term of the energy spectrum of a quantum particle moving in an inverse-square law potential with regulated singularity is non-perturvative in nature. Trans-series and resurgence theory predicts the emergence of perturbative, and potentially logarithmic, corrections to the leading behavior. This talk relates an attempt to systematically calculate such corrections for the first time.

Simulating Correlated Disorder In Spin Glass, Jared D. Willard

Macalester Journal of Physics and Astronomy

Almost all materials undergo spontaneous symmetry breaking at sufficiently low

temperatures. For most magnetic materials, the spin rotational symmetry is broken

to form magnetic ordering. The discovery of metallic alloys which fail to form

conventional magnetic order has remained a puzzle for the last few decades.

Unfortunately, analytical calculations cannot provide an unbiased answer for the

problem. Furthermore, on the numerical side, Monte Carlo simulations require

extremely long equilibration times. The parallel tempering method has proven a

powerful tool to alleviate the long equilibration time. With the extensive efforts of

numerical simulation research, some of the idealized models have been …

Football Betting And The Efficient Market Hypothesis, Ravija Badarinathi, Ladd Kochman

Ladd Kochman

Three betting rules which had been nonrandomly profitable in both their initial application to the 1969-74 National Football League seasons and their replication during the years of 1975-81 were applied to all NFL games played between September 1984 and January 1994. One rule proved to be nonrandom and profitable for a third consecutive trial--a feat suggesting that bettors may be able to "beat the bookie" and, more broadly, that prices in competitive markets may not discount all available information in swift fashion.

The Gambler's Fallacy: A Test Of Football-Betting Market Efficiency, Ladd Kochman, Ravija Badarinathi

Ladd Kochman

Imaginary wagers placed on college football teams during the 2006-2010 seasons that were expected to beat the point spread following two games in which they lost both on the field and against the spread produced a wins-to-bets ratio that was statistically nonrandom but not profitable. However, when that rule was limited to the major conference schools, a significantly profitable W/B ratio emerged that challenges the efficiency of a competitive market.

Dogs No Longer Man's Best Friend: A Test Of Football Market Efficiency, Ladd Kochman

Ladd Kochman

The outcomes of wagers on underdogs in the National Football League for the 2003-2007 seasons indicated that what had been anomalous behavior no longer existed. The failure of underdogs to beat the spread in profitable or nonrandom fashion supports the argument that competitive markets are efficient and undermines the proposition that behavioral finance can illuminate exploitable betting patterns.

Revisiting The Streaking Teams Phenomenom: A Note, Ladd Kochman, Randy Goodwin

Ladd Kochman

In an effort to learn if systematic misperceptions by market participants can undermine efficient prices and create regular profit opportunities, Camerer (1989) and Brown and Sauer (1993) investigated whether participants in the basketball-betting market overbet streaking (or "hot") teams. The purpose of this note is determine whether streaking teams - both hot and cold-in college football alter point spreads to an exploitable degree. The pointwise outcomes of college football teams following 2-, 3-, 4-, 5-, 6-, 7-, 8-, and 9-game streaks during the 1996-2000 seasons. Streaks in the aggregate produced only breakeven results when used to predict the outcomes of …

The Efficiency Of The College Football Betting Market For Southeastern Conference Teams, Ravija Badarinathi, Ladd Kochman

Ladd Kochman

To illustrate economic testing and at the same time to conduct an inquiry into the efficiency of the college football betting market, an analysis applies all the betting rules reported by Stark (1992) to the 10 teams comprising the Southeastern Conference before the recent addition of the universities of Arkansas and South Carolina. The combination of 10 teams and 7 conditions produces a total of 70 betting strategies. Since each rule to bet for a team is shadowed by the alternative of betting against that team, the actual number of rules tested is 140. Among those 140 rules, only 7 …

Baseball Attendance And Outcome Uncertainty: A Note, Ladd Kochman, Ravija Badarinathi

Ladd Kochman

Recent claims that spiraling players' salaries doom the demand for Major League Baseball (MLB) make studies like Knowles et al. (1992) especially timely and useful. By following the lead of past writers--most notably Quirk and El Hodiri (1974)--Knowles et al. proxied the demand for MLB with game attendance and (like Quirk and El Hodiri) reported that attendance is maximized when the home team is slightly favored.