Physical Sciences and Mathematics Commons^™

In Search Of Targeted Cancer Treatment: Magnetic Fluid Hyperthermia & Ultrasound-Mediated Therapies, Ronald Kumon

Physics Presentations And Conference Materials

No abstract provided.

Manipulation Of Subsurface Carbon Nanoparticles In Bi2sr2cacu2o8+Δ Using A Scanning Tunneling Microscope, A. J. Stollenwerk, N. Hurley, B. Beck, K. Spurgeon, Tim Kidd, G. Gu

Faculty Publications

We present evidence that subsurface carbon nanoparticles in Bi₂Sr₂CaCu₂O_8+δ can be manipulated with nanometer precision using a scanning tunneling microscope. High-resolution images indicate that most of the carbon particles remain subsurface after transport observable as a local increase in height as the particle pushes up on the surface. Tunneling spectra in the vicinity of these protrusions exhibit semiconducting characteristics with a band gap of approximately 1.8 eV, indicating that the incorporation of carbon locally alters the electronic properties near the surface.

Byu Meg Report, Emily Bates

Journal of Undergraduate Research

The academic objectives were met by the proposal. Students learned to sequence DNA and to interpret the sequence to know if there was a rare genetic change occurring in the sequence that they interpreted. Students learned to write academic abstracts, introductions, results, and conclusions in the format of an academic journal. Furthermore, together the students determined that the genetic change in a family with an inherited syndrome of birth defects was not one that had previously been identified or described.

Mentoring Undergraduates Via Organic Synthesis, Steven L. Castle

Journal of Undergraduate Research

This report summarizes the results that were generated under the auspices of the mentoring environment in my laboratory from January 2013 to the present. A total of eight undergraduates participated in the mentoring environment during this period.

Computational Modeling Of Wave Propagation In Metamaterials, Shue-Sum Chow

Journal of Undergraduate Research

The project is concerned with the study of wave propagation in metamaterials. We recall the work plan described in the original proposal and provide an evaluation of the academic objectives.

Magnetic Order And Fluctuation Dynamics Of Self-Assembled Magnetite Fe3o4 Nanoparticles, Karine Chesnel

Journal of Undergraduate Research

The research plan described in the proposal (section 2.1) was well implemented during the period 2013-2014. Most of the steps listed in the plan were completed thanks to the fund: (1) nanoparticle preparation (2) structural characterization (3) magnetic characterization (4) particle deposition and self-assembling (5) net magnetization of the film measured via XMCD; we are still working on the last steps (6) magnetic order between particles measured via XRMS and (7) dynamical measurements, measured via CXRMS. The fund was especially useful to go and carry out a couple of synchrotron experiments at SSRL, SLAC at Stanford, to complete steps (5-7). …

Synthetic Approaches To Flexible Fluorescent Conjugated Polymers, Tereza Vokata

FIU Electronic Theses and Dissertations

Conjugated polymers (CPs) are intrinsically fluorescent materials that have been used for various biological applications including imaging, sensing, and delivery of biologically active substances. The synthetic control over flexibility and biodegradability of these materials aids the understanding of the structure-function relationships among the photophysical properties, the self-assembly behaviors of the corresponding conjugated polymer nanoparticles (CPNs), and the cellular behaviors of CPNs, such as toxicity, cellular uptake mechanisms, and sub-cellular localization patterns.

Synthetic approaches towards two classes of flexible CPs with well-preserved fluorescent properties are described. The synthesis of flexible poly(p-phenylenebutadiynylene)s (PPBs) uses competing Sonogashira and Glaser coupling reactions …

Unknown Threat Detection With Honeypot Ensemble Analsyis Using Big Datasecurity Architecture, Michael Eugene Sanders

Theses and Dissertations

The amount of data that is being generated continues to rapidly grow in size and complexity. Frameworks such as Apache Hadoop and Apache Spark are evolving at a rapid rate as organizations are building data driven applications to gain competitive advantages. Data analytics frameworks decomposes our problems to build applications that are more than just inference and can help make predictions as well as prescriptions to problems in real time instead of batch processes.

Information Security is becoming more important to organizations as the Internet and cloud technologies become more integrated with their internal processes. The number of attacks and …

Using Software Defined Networking To Solve Missed Firewall Architecture In Legacy Networks, Jared Dean Vogel

Theses and Dissertations

This study is concerned with migrating traditional networks and their inherent firewall architecture to Software Defined Networking (SDN) architecture to provide an initial attempt at preventing application downtime due to hidden firewall domain rules. In legacy organization environments the networking engineers, firewall teams, and application analysts are often silo groups, but Software Defined Networking (SDN) can blur the lines between these group silos.

This thesis first outlines the interworking of SDN, traditional firewall architecture and how it interacts with SDN, an experiment of implementation, and the resulting conclusions.

Testing with SDN shows we are approaching new environments where the edges …

Long-Term Midlatitude Mesopause Region Temperature Trend Deduced From Quarter Century (1990-2014) Na Lidar Observations, Chiao Y. She, D. A. Krueger, Tao Yuan

All Physics Faculty Publications

The long-term midlatitude temperature trend between 85 and 105 km is deduced from 25 years (March 1990-December 2014) of Na Lidar observations. With a strong warming episode in the 1990s, the time series was least-square fitted to an 11-parameter nonlinear function. This yields a cooling trend starting from an insignificant value of 0.64 ± 0.99 K decade^-1 at 85 km, increasing to a maximum of 2.8 ± 0.58K decade^-1 between 91 and 93 km, and then decreasing to a warming trend above 103 km. The geographic altitude dependence of the trend is in general agreement with model predictions. …

Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused By Vorapaxar, Omozuanvbo Aisiku, Christian G. Peters, Karen De Ceunynck, Chandra C. Ghosh, James R. Dilks, Susanna F. Fustolo-Gunnink, Mingdong Huang, Chris Dockendorff, Samir M. Parikh, Robert Flaumenhaft

Chemistry Faculty Research and Publications

Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias. Its activation by thrombin stimulates prothrombotic and proinflammatory signaling, whereas its activation by activated protein C (APC) stimulates cytoprotective and antiinflammatory signaling. A challenge in developing PAR1-targeted therapies is to inhibit detrimental signaling while sparing beneficial pathways. We now characterize a novel class of structurally unrelated small-molecule PAR1 antagonists, termed parmodulins, and compare the activity of these compounds to previously characterized compounds that act at the PAR1 ligand–binding site. We find that parmodulins target …

Can Permaculture Design Save The World?, Dante Digiacomo

Undergraduate Research at FIU (URFIU) Conference

This project will create a blueprint for an eco-settlement in the South Florida area that will house a total of ten people on a five acre plot of land. Using a combination of permaculture design principles and simple tech solutions, this settlement will be capable of supporting its inhabitants “off the grid”, or with no reliance on outside public utilities. More specifically, the settlement will be capable of supporting its inhabitants by producing a minimum of 80% of its resources on site using only all natural farming techniques, proper water management, companion planting and various other techniques. Instead of using …

Present-Day Pattern Variations In The Central And Eastern Pacific El Nino, Szandra Peter

Undergraduate Research at FIU (URFIU) Conference

El Niño and the Southern Oscillation (ENSO) is a cycle that is initiated in the equatorial Pacific Ocean and is recognized on interannual timescales by oscillating patterns in tropical Pacific sea surface temperatures (SST) and atmospheric circulations. Using correlation and regression analysis of datasets that include SST’s and other interdependent variables including precipitation, surface winds, sea level pressure, this research seeks to quantify recent changes in ENSO behavior. Specifically, the amplitude, frequency of occurrence, and spatial characteristics (i.e. events with maximum amplitude in the Central Pacific versus the Eastern Pacific) are investigated.

The research is based on the question; “Are …

A Rapid And Sensitive High-Throughput Screening Method To Identify Compounds Targeting Protein–Nucleic Acids Interactions, Nicole Alonso, Roboan Guillen

Undergraduate Research at FIU (URFIU) Conference

DNA-binding and RNA-binding proteins are usually considered ‘undruggable’ partly due to the lack of an efficient method to identify inhibitors from existing small molecule repositories. Here we report a rapid and sensitive high-throughput screening approach to identify compounds targeting protein–nucleic acids interactions based on protein–DNA or protein–RNA interaction enzyme-linked immunosorbent assays (PDI-ELISA or PRI-ELISA). We validated the PDI-ELISA method using the mammalian highmobility- group protein AT-hook 2 (HMGA2) as the protein of interest and netropsin as the inhibitor of HMGA2–DNA interactions. With this method we successfully identified several inhibitors and an activator for HMGA2–DNA interactions from a collection of 29 …

Screening For Ampr-Specific Inhibitors To Combat P. Aeruginosa Infections, Kevin Morales

Undergraduate Research at FIU (URFIU) Conference

Pseudomonas aeruginosa, a Gram-negative bacterium, an opportunistic pathogen that infects individuals suffering from reduced immunity or damaged tissue. The treatment of these infections has become a major problem due to its increasing antibiotic resistance. Many multi-drug resistant isolates of P. aeruginosa can thwart most antibiotic classes including ?- lactams, fluoroquinolones, and aminoglycosides. Its ability to combat ?-lactams is in part due to expression of AmpC, a major chromosomally encoded ?-lactamase. The expression of ampC is positively regulated by AmpR. Besides antibiotic resistance, AmpR is an important regulator of various factors that are required for establishing acute and chronic infections. Loss …

Using Stable Isotopes To Investigate Trophic Interactions Of Bottlenose Dolphins (Tursiops Truncatus) In The Coastal Everglades, Valerie Paz

Undergraduate Research at FIU (URFIU) Conference

Top predators are best known for their ability to affect their communities through inflicting mortality on prey and inducing behavioral modifications (e.g. risk effects). Recent scientific evidence suggests that predators may have additional roles in bottom-up processes such as transporting materials within and across habitat boundaries. The Florida Coastal Everglades (FCE) is an “upside-down” oligotrophic estuary where productivity decreases from the mouth of the estuary to freshwater marshes. Research in the FCE suggest that predators can act as mobile links between disparate habitats and can potentially affect nutrient and biogeochemical dynamics through localized behaviors (e.g. American alligators and juvenile bull …

Targeted Estimation And Inference For The Sample Average Treatment Effect, Laura B. Balzer, Maya L. Petersen, Mark J. Van Der Laan

Laura B. Balzer

While the population average treatment effect has been the subject of extensive methods and applied research, less consideration has been given to the sample average treatment effect: the mean difference in the counterfactual outcomes for the study units. The sample parameter is easily interpretable and is arguably the most relevant when the study units are not representative of a greater population or when the exposure's impact is heterogeneous. Formally, the sample effect is not identifiable from the observed data distribution. Nonetheless, targeted maximum likelihood estimation (TMLE) can provide an asymptotically unbiased and efficient estimate of both the population and sample …

User Interface Design For Electronic Learning Software: Promoting Usability And Facilitating Learning For Children, Cesar G. Villa-Garcia

Undergraduate Research at FIU (URFIU) Conference

Computing devices have become ubiquitous in our technologically-advanced world, serving as vehicles for software applications that provide users with a wide array of functions. Among these applications are electronic learning software, which are increasingly being used to educate and evaluate individuals ranging from grade school students to career professionals. This study will evaluate the design and implementation of user interfaces in these pieces of software. Specifically, it will explore how these interfaces can be developed to facilitate the use of electronic learning software by children. In order to do this, research will be performed in the area of human-computer interaction, …

Sequence-Specific, Nanomolar Peptide Binding Via Cucurbit[8]Uril-Induced Folding And Inclusion Of Neighboring Side Chains, Lauren C. Smith, David G. Leach, Brittney E. Blaylock, Omar A. Ali, Adam R. Urbach

Chemistry Faculty Research

This paper describes the molecular recognition of the tripeptide Tyr-Leu-Ala by the synthetic receptor cucurbit[8]uril (Q8) in aqueous buffer with nanomolar affinity and exceptional specificity. This combination of characteristics, which also applies to antibodies, is desirable for applications in biochemistry and biotechnology but has eluded supramolecular chemists for decades. Building on prior knowledge that Q8 binds to peptides with N-terminal aromatic residues, a library screen of 105 peptides was designed to test the effects of residues adjacent to N-terminal Trp, Phe, or Tyr. The screen used tetramethylbenzobis(imidazolium) (MBBI) as a fluorescent indicator and resulted in the unexpected discovery that MBBI …

Excitonic And Logic Gates On Dna Brick Nanobreadboards, Brittany L. Cannon, Donald L. Kellis, Paul H. Davis, Jeunghoon Lee, Wan Kuang, William L. Hughes, Elton Graugnard, Bernard Yurke, William Knowlton

Chemistry and Biochemistry Faculty Publications and Presentations

A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems.

Weak Values As Interference Phenomena, Justin Dressel

Mathematics, Physics, and Computer Science Faculty Articles and Research

Weak values arise experimentally as conditioned averages of weak (noisy) observable measurements that minimally disturb an initial quantum state, and also as dynamical variables for reduced quantum state evolution even in the absence of measurement. These averages can exceed the eigenvalue range of the observable ostensibly being estimated, which has prompted considerable debate regarding their interpretation. Classical conditioned averages of noisy signals only show such anomalies if the quantity being measured is also disturbed prior to conditioning. This fact has recently been rediscovered, along with the question whether anomalous weak values are merely classical disturbance effects. Here we carefully review …

Isomorphism And Similarity For 2-Generation Pedigrees, Haitao Jiang, Guohui Lin, Weitian Tong, Daming Zhu, Binhai Zhu

Department of Computer Science Faculty Publications

We consider the emerging problem of comparing the similarity between (unlabeled) pedigrees. More specifically, we focus on the simplest pedigrees, namely, the 2-generation pedigrees. We show that the isomorphism testing for two 2-generation pedigrees is GI-hard. If the 2-generation pedigrees are monogamous (i.e., each individual at level-1 can mate with exactly one partner) then the isomorphism testing problem can be solved in polynomial time. We then consider the problem by relaxing it into an NP-complete decomposition problem which can be formulated as the Minimum Common Integer Pair Partition (MCIPP) problem, which we show to be FPT by exploiting a property …

Conjugated Polymer Nanoparticles For Biological Labeling And Delivery, Eladio A. Mendez

FIU Electronic Theses and Dissertations

Cancer remains one of the world’s most devastating diseases, with more than 10 million new cases every year. However, traditional treatments have proven insufficient for successful medical management of cancer due to the chemotherapeutics’ difficulty in achieving therapeutic concentrations at the target site, non-specific cytotoxicity to normal tissues, and limited systemic circulation lifetime. Although, a concerted effort has been placed in developing and successfully employing nanoparticle(NP)-based drug delivery vehicles successfully mitigate the physiochemical and pharmacological limitations of chemotherapeutics, work towards controlling the subcellular fate of the carrier, and ultimately its payload, has been limited. Because efficient therapeutic action requires drug …

Changes In Spatial Patterns Of Caragana Stenophylla Along A Climatic Drought Gradient On The Inner Mongolian Plateau, Li-Na Xie, Hong-Yu Guo, Christopher A. Gabler, Qing-Fang Li, Cheng-Cang Ma

School of Earth, Environmental, and Marine Sciences Faculty Publications and Presentations

Few studies have investigated the influence of water availability on plant population spatial patterns. We studied changes in the spatial patterns of Caragana stenophylla along a climatic drought gradient within the Inner Mongolian Plateau, China. We examined spatial patterns, seed density, “nurse effects” of shrubs on seedlings, transpiration rates and water use efficiency (WUE) of C. stenophylla across semi-arid, arid, and intensively arid zones. Our results showed that patches of C. stenophylla populations shifted from a random to a clumped spatial pattern towards drier environments. Seed density and seedling survival rate of C. stenophylla decreased from the semi-arid zone to …

Trust Based Privacy Policy Enforcement In Cloud Computing, Karthick Ramachandran

Electronic Thesis and Dissertation Repository

Cloud computing offers opportunities for organizations to reduce IT costs by using the computation and storage of a remote provider. Despite the benefits offered by cloud computing paradigm, organizations are still wary of delegating their computation and storage to a cloud service provider due to trust concerns. The trust issues with the cloud can be addressed by a combination of regulatory frameworks and supporting technologies. Privacy Enhancing Technologies (PET) and remote attestation provide the technologies for addressing the trust concerns. PET provides proactive measures through cryptography and selective dissemination of data to the client. Remote attestation mechanisms provides reactive measures …

Heisenberg Scaling With Weak Measurement: A Quantum State Discrimination Point Of View, Andrew N. Jordan, Jeff Tollaksen, James E. Troupe, Justin Dressel, Yakir Aharonov

Mathematics, Physics, and Computer Science Faculty Articles and Research

We examine the results of the paper “Precision metrology using weak measurements” (Zhang et al. arXiv:1310.5302, 2013) from a quantum state discrimination point of view. The Heisenberg scaling of the photon number for the precision of the interaction parameter between coherent light and a spin one-half particle (or pseudo-spin) has a simple interpretation in terms of the interaction rotating the quantum state to an orthogonal one. To achieve this scaling, the information must be extracted from the spin rather than from the coherent state of light, limiting the applications of the method to phenomena such as cross-phase modulation. …

Validation Of An Analytical Method For The Identification Of Smartwater Csi Forensic Marking Technology, Demi Moreda, Claudia Martinez

Undergraduate Research at FIU (URFIU) Conference

SmartWater is a chemical taggant used as a crime deterrent. The chemical taggant is a colorless liquid that fluoresces yellow under ultra-violet (UV) light and contains distinctive, identifiable and traceable elemental composition. For instance, upon a break and entry scenario, the burglar is sprayed with a solution that has an elemental signature custom-made to a specific location. The residues of this taggant persist on skin and other objects and can be easily recovered for further analysis. The product has been effectively used in Europe as a crime deterrent and has been recently introduced in South Florida. In 2014, Fourt Lauderdale …

Tamed And Compatible Symplectic Forms On Four-Dimensional Almost Complex Lie Algebras, Andres Cubas

Undergraduate Research at FIU (URFIU) Conference

We are able to give a complete description of four-dimensional Lie algebras g which satisfy the tame-compatible question of Donaldson for all almost complex structures J on g are completely described. As a consequence, examples are given of (non-unimodular) four-dimensional Lie algebras with almost complex structures which are tamed but not compatible with symplectic forms.? Note that Donaldson asked his question for compact four-manifolds. In that context, the problem is still open, but it is believed that any tamed almost complex structure is in fact compatible with a symplectic form. In this presentation, I will define the basic objects involved …

Conformational Kinetics Study Of Mp-11 Using Tims-Ms And Molecular Dynamics, Christopher Harrilal, Jaroslava Miksovska, Emily R. Schenk

Undergraduate Research at FIU (URFIU) Conference

In the present work, we studied the conformational kinetics of microperoxidase 11 (MP-11), a digest fragment of cytochrome C that contains 11 amino acids with a covalently attached heme group. In particular, a novel technique recently developed at FIU in collaboration with Bruker Daltonics Inc. combined with theoretical calculation was used for the characterization of MP- 11 conformational space [1-3]. Accurate ion-neutral collision cross sections were measured for all MP-11 generated charge states. Since MP-11 (like cytochrome C) undergoes conformational changes as a function of the solvent state, MP-11 ions were produced by electrospray ionization (ESI) in order to preserve …

Insight Into The Calmodulin And Dream Protein Complex Interaction, Mechanism And Function, Walter Gonzalez

Undergraduate Research at FIU (URFIU) Conference

DREAM (Downstream regulatory element antagonistic modulator) is a neuronal calcium sensor which has been shown to modulate gene expression as well as being involved in numerous neuronal processes. In this report, we show that association of calcium bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM N-termini The association of CaM with a peptide analogous to DREAM(29-44) or to full length DREAM protein is calcium dependent with the dissociation constant of 136 nM and 3.4 ?M, respectively. Thermodynamic and kinetic studies show that the observed decrease in …