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Full-Text Articles in Physical Sciences and Mathematics

Analyzing Fluctuation Of Topics And Public Sentiment Through Social Media Data, Haoyue Liu Aug 2022

Analyzing Fluctuation Of Topics And Public Sentiment Through Social Media Data, Haoyue Liu

Dissertations

Over the past decade years, Internet users were expending rapidly in the world. They form various online social networks through such Internet platforms as Twitter, Facebook and Instagram. These platforms provide a fast way that helps their users receive and disseminate information and express personal opinions in virtual space. When dealing with massive and chaotic social media data, how to accurately determine what events or concepts users are discussing is an interesting and important problem.

This dissertation work mainly consists of two parts. First, this research pays attention to mining the hidden topics and user interest trend by analyzing real-world …


Computation Of Risk Measures In Finance And Parallel Real-Time Scheduling, Yajuan Li Aug 2022

Computation Of Risk Measures In Finance And Parallel Real-Time Scheduling, Yajuan Li

Dissertations

Many application areas employ various risk measures, such as a quantile, to assess risks. For example, in finance, risk managers employ a quantile to help determine appropriate levels of capital needed to be able to absorb (with high probability) large unexpected losses in credit portfolios comprising loans, bonds, and other financial instruments subject to default. This dissertation discusses the computation of risk measures in finance and parallel real-time scheduling.

Firstly, two estimation approaches are compared for one risk measure, a quantile, via randomized quasi-Monte Carlo (RQMC) in an asymptotic setting where the number of randomizations for RQMC grows large, but …


Stochastic Modeling Of Flows In Membrane Pore Networks, Binan Gu Aug 2022

Stochastic Modeling Of Flows In Membrane Pore Networks, Binan Gu

Dissertations

Membrane filters provide immediate solutions to many urgent problems such as water purification, and effective remedies to pressing environmental concerns such as waste and air treatment. The ubiquity of applications gives rise to a significant amount of research in membrane material selection and structural design to optimize filter efficiency. As physical experiments tend to be costly, numerical simulation and analysis of fluid flow, foulant transport and geometric evolution due to foulant deposition in complex geometries become particularly relevant. In this dissertation, several mathematical modeling and analytical aspects of the industrial membrane filtration process are investigated. A first-principles mathematical model for …


Performance Analysis Of The Dominant Mode Rejection Beamformer, Enlong Hu Aug 2022

Performance Analysis Of The Dominant Mode Rejection Beamformer, Enlong Hu

Dissertations

In array signal processing over challenging environments, due to the non-stationarity nature of data, it is difficult to obtain enough number of data snapshots to construct an adaptive beamformer (ABF) for detecting weak signal embedded in strong interferences. One type of adaptive method targeting for such applications is the dominant mode rejection (DMR) method, which uses a reshaped eigen-decomposition of sample covariance matrix (SCM) to define a subspace containing the dominant interferers to be rejected, thereby allowing it to detect weak signal in the presence of strong interferences. The DMR weight vector takes a form similar to the adaptive minimum …


Low-Reynolds-Number Locomotion Via Reinforcement Learning, Yuexin Liu Aug 2022

Low-Reynolds-Number Locomotion Via Reinforcement Learning, Yuexin Liu

Dissertations

This dissertation summarizes computational results from applying reinforcement learning and deep neural network to the designs of artificial microswimmers in the inertialess regime, where the viscous dissipation in the surrounding fluid environment dominates and the swimmer’s inertia is completely negligible. In particular, works in this dissertation consist of four interrelated studies of the design of microswimmers for different tasks: (1) a one-dimensional microswimmer in free-space that moves towards the target via translation, (2) a one-dimensional microswimmer in a periodic domain that rotates to reach the target, (3) a two-dimensional microswimmer that switches gaits to navigate to the designated targets in …


Diagnostics Of Energy Release In Solar Flares With Radio Dynamic Imaging Spectroscopy, Yingjie Luo Aug 2022

Diagnostics Of Energy Release In Solar Flares With Radio Dynamic Imaging Spectroscopy, Yingjie Luo

Dissertations

Studies of the magnetic energy release and conversion process lie at the core of solar flare physics. Radio observations serve as a unique diagnostic method. In this dissertation, taking advantage of broadband radio dynamic imaging spectroscopy observations made by the Karl G. Jansky Very Large Array (VLA), studies are carried out on the flare energy release processes using different types of radio emissions.

The VLA is a general-purpose radio observatory located in New Mexico, which provides high-quality radio dynamic imaging spectroscopic observations with an ultra-fast time cadence. In the first study, stochastic decimetric radio spike bursts are observed by the …


Understanding The Role Of Magnetic Field Evolution In The Initiation And Development Of Solar Eruptions, Nian Liu Aug 2022

Understanding The Role Of Magnetic Field Evolution In The Initiation And Development Of Solar Eruptions, Nian Liu

Dissertations

This dissertation aims to understand the initiation and evolution of solar eruptions. The essential science questions to answer include: What is the role of magnetohydro dynamic (MHD) instabilities and magnetic reconnection in triggering and driving eruptions? What are the role of Kink Instability (KI) and Torus Instability (TI) in determining the successful and failed eruptions? What is the thermal behavior of flare precursors in the initiation stage of solar eruptions? Finally, how does the corona magnetic field respond to the flare eruptions? The dissertation mainly includes the following studies.

First, this dissertation presents a multi-instrument study of the two precursor …


Mgrre_Thinsections_05_A_6, Mgrre Aug 2022

Mgrre_Thinsections_05_A_6, Mgrre

Thin Sections

No abstract provided.


Spatial Analysis For Enhancing The Use Of Health Data Availability From Different Sources To Help The Decision-Making Process, Tris Eryando Aug 2022

Spatial Analysis For Enhancing The Use Of Health Data Availability From Different Sources To Help The Decision-Making Process, Tris Eryando

Kesmas

Spatial analysis in public health has become a common method used by researchers to understand the distribution of public health aspects related to the surrounding environment. It can also be used to analyze individual information in the form of a dot and the location or line of aggregated information in a specific area of study. Another benefit is the possibility of using different data sources to be analyzed in one statistical model analysis, as long as the identification area is sufficiently clear as a key variable. Spatial analysis can show an object's distribution on a locational map and explain the …


A Stunting Prevention Risk Factors Pathway Model For Indonesian Districts/Cities With A Stunting Prevalence Of ≥30%, Nina Fentiana, Endang L. Achadi, Besral Besral, Abram Kamiza, Trini Sudiarti Aug 2022

A Stunting Prevention Risk Factors Pathway Model For Indonesian Districts/Cities With A Stunting Prevalence Of ≥30%, Nina Fentiana, Endang L. Achadi, Besral Besral, Abram Kamiza, Trini Sudiarti

Kesmas

The prevalence of stunting in Indonesian children aged 0-23 months is a public health problem caused by direct and indirect factors. This study aimed to discover the path of the relationship between various risk factors and the stunting prevalence of ≥30% in 165 districts/cities in Indonesia. Data were obtained from the 2018 National Basic Health Research, National Socioeconomic Survey, and the Statistics Indonesia with a cross-sectional approach. The secondary data on stunting and risk factors were aggregated at the district/city level from individual data; children aged 0-23 months. The path analysis used to determine a stunting prevention model showed that …


Determinants Of Type 2 Diabetes Mellitus Among Passive Smokers, Adinda Rahma Triyaniarta, Santi Martini, Kurnia Dwi Artanti, Sri Widati, Rizma Dwi Nastiti Aug 2022

Determinants Of Type 2 Diabetes Mellitus Among Passive Smokers, Adinda Rahma Triyaniarta, Santi Martini, Kurnia Dwi Artanti, Sri Widati, Rizma Dwi Nastiti

Kesmas

Type 2 diabetes mellitus (T2DM) leads to complications of other diseases. The modifiable risk factors for T2DM are overweight, physical activity, hypertension, unhealthy diet, and smoking. This study aimed to analyze determinants of T2DM incidence in passive smokers among various factors. This study was conducted at Hospital X in Surabaya City, East Java Province, Indonesia, from September 2019 to April 2020. The variables were univariate, bivariate, and multivariate. Case samples were T2DM patients and passive smokers, while control samples were non-T2DM patients and passive smokers, with 52 respondents per group, of 104 total respondents. Variables statistically significant related to the …


The Effect Of Health Promotion Program On Perceived Self-Efficacy And Self-Care Practices Among Elderly With Multimorbidity In Chiang Mai, Thailand, Jukkrit Wungrath, Nuttida Khumai, Phinphot Phrommasen Aug 2022

The Effect Of Health Promotion Program On Perceived Self-Efficacy And Self-Care Practices Among Elderly With Multimorbidity In Chiang Mai, Thailand, Jukkrit Wungrath, Nuttida Khumai, Phinphot Phrommasen

Kesmas

Multimorbidity in the elderly is a major public health issue with serious consequences. This study investigated the effects of health promotion programs on perceived self-efficacy and self-care practices among the elderly with multimorbidity using a quasi-experimental study design from February to July 2021. The study samples were the elderly from Doi Saket District, Chiang Mai Province, Thailand, selected by a multistage random sampling technique. The experimental and control groups each comprised 40 elderlies with multimorbidity. All elderly participants took part in a 12-week health promotion program. The perceived self-efficacy and self-care practices of the study samples were assessed using interviews, …


Perspectives On Reproductive Health Education Among Javanese Parents, Bagoes Widjanarko, Ratih Indraswari, Aditya Kusumawati, Novia Handayani Aug 2022

Perspectives On Reproductive Health Education Among Javanese Parents, Bagoes Widjanarko, Ratih Indraswari, Aditya Kusumawati, Novia Handayani

Kesmas

This study aimed to investigate the perspectives of reproductive health education among Javanese parents of children aged 9-11 years. This cross-sectional study was conducted with 12,306 parents in Semarang City, Central Java Province, Indonesia, using a purposive sampling technique. Some parents agreed that reproductive health education at home was unnecessary (29.5%), taboo (45%), difficult (73.1%), and awkward (41.5%). Most parents (72.7%) were not transparent in providing reproductive health information to their children by using other terms to name the genitals, considering the politeness aspect. Good practices of providing reproductive health information are slightly more common in mothers (54.2%), unemployed parents …


Excitation-Dependent Photoluminescence Of Bazro3:Eu3+ Crystals, Santosh K. Gupta, Hisham Abdou, Carlo U. Segre, Yuanbing Mao Aug 2022

Excitation-Dependent Photoluminescence Of Bazro3:Eu3+ Crystals, Santosh K. Gupta, Hisham Abdou, Carlo U. Segre, Yuanbing Mao

Chemistry Faculty Publications and Presentations

The elucidation of local structure, excitation-dependent spectroscopy, and defect engineering in lanthanide ion-doped phosphors was a focal point of research. In this work, we have studied Eu3+-doped BaZrO3 (BZOE) submicron crystals that were synthesized by a molten salt method. The BZOE crystals show orange–red emission tunability under the host and dopant excitations at 279 nm and 395 nm, respectively, and the difference is determined in terms of the asymmetry ratio, Stark splitting, and intensity of the uncommon 5D07F0 transition. These distinct spectral features remain unaltered under different excitations for the BZOE …


Using Electrochemical Oxidation To Remove Pfas In Simulated Investigation-Derivedwaste (Idw): Laboratory And Pilot-Scale Experiments, Amy Yanagida, Elise Webb, Clifford E. Harris, Mark Christenson, Steven Comfort Aug 2022

Using Electrochemical Oxidation To Remove Pfas In Simulated Investigation-Derivedwaste (Idw): Laboratory And Pilot-Scale Experiments, Amy Yanagida, Elise Webb, Clifford E. Harris, Mark Christenson, Steven Comfort

School of Natural Resources: Faculty Publications

Repeated use of aqueous firefighting foams at military aircraft training centers has contaminated groundwater with per and polyfluorinated alkyl substances (PFAS). To delineate the extent of PFAS contamination, numerous site investigations have occurred, which have generated large quantities of investigation-derived wastes (IDW). The commonly used treatment of incinerating PFAS-tainted IDW is costly, and was recently suspended by the Department of Defense. Given long-term IDW storage in warehouses is not sustainable, our objective was to use electrochemical oxidation to degrade PFAS in contaminated water and then scale the technology toward IDW treatment. This was accomplished by conducting a series of laboratory …


2022 Fall Engr333 Project Assignment, Matthew K. Heun Aug 2022

2022 Fall Engr333 Project Assignment, Matthew K. Heun

ENGR 333

The Fall 2022 ENGR333 project focused on sustainable heating for Calvin University.

I asked the students “What would it take to eliminate Calvin’s natural gas-related net CO2 emissions?”

Matt Kucinski (Calvin PR) wrote a story about the project. President Boer wrote a complementary post about the students’ work on LinkedIn.

Customer

The customer for this project was Dr. Wiebe Boer, President of Calvin University.


Hydrogen Behavior At Crystalline/Amorphous Interface Of Transparent Oxide Semiconductor And Its Effects On Carrier Transport And Crystallization, Julia E. Medvedeva, Kapil Sharma, Bishal Bhattarai, Mariana I. Bertoni Aug 2022

Hydrogen Behavior At Crystalline/Amorphous Interface Of Transparent Oxide Semiconductor And Its Effects On Carrier Transport And Crystallization, Julia E. Medvedeva, Kapil Sharma, Bishal Bhattarai, Mariana I. Bertoni

Physics Faculty Research & Creative Works

The role of disorder and particularly of the interfacial region between crystalline and amorphous phases of indium oxide in the formation of hydrogen defects with covalent (In-OH) or ionic (In-H-In) bonding are investigated using ab initio molecular dynamics and hybrid density-functional approaches. The results reveal that disorder stabilizes In-H-In defects even in the stoichiometric amorphous oxide and also promotes the formation of deep electron traps adjacent to In-OH defects. Furthermore, below-room-temperature fluctuations help switch interfacial In-H-In into In-OH, creating a new deep state in the process. This H-defect transformation limits not only the number of free carriers but also the …


Flint Michigan Drinking Water Crisis, J. David Aiken Aug 2022

Flint Michigan Drinking Water Crisis, J. David Aiken

Cornhusker Economics

Briefly covers the Flint, Michigan drinking water crisis including providing some background, a timeline of events, and key takeaways from the perspective of public policy.

This article was originally prepared for distribution to students in Aiken's AECN 357 environmental and natural resources law course.


2022 Final Blacktail Creek Remediation And Contaminated Groundwater Hydraulic Control Site Pumping Test Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc. Aug 2022

2022 Final Blacktail Creek Remediation And Contaminated Groundwater Hydraulic Control Site Pumping Test Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Request For Change (Rfc) To The Butte Priority Soils Operable Unit (Bpsou) 2022 Final Insufficiently Reclaimed Areas Quality Assurance Project Plan (Qapp), Mike Mcanulty Aug 2022

Request For Change (Rfc) To The Butte Priority Soils Operable Unit (Bpsou) 2022 Final Insufficiently Reclaimed Areas Quality Assurance Project Plan (Qapp), Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Towards Ensuring Integrity And Authenticity Of Software Repositories, Sangat Vaidya Aug 2022

Towards Ensuring Integrity And Authenticity Of Software Repositories, Sangat Vaidya

Dissertations

The software development process comprises a series of steps known as a software supply chain. These steps include managing the source code, testing, building and packaging it into a final product, and distributing the product to end users. Along this chain, software repositories are used for different purposes such as source code management (Git, SVN, mercurial), software distribution (PyPI, RubyGems, NPM) or for deploying software based on container images (Harbor, DockerHub, Artifact Hub). In the recent past, different types of repositories have increasingly been the target of attacks. As such, there is a need for mechanisms to ensure integrity and …


Sars-Cov-2 Antibody Seroprevalence In Jakarta, Indonesia, Iwan Ariawan, Hafizah Jusril, Muhammad N Farid, Pandu Riono, Wiji Wahyuningsih, Widyastuti Widyastuti, Dwi Oktavia T L Handayani, Endang Sri Wahyuningsih, Rebekka Daulay, Retno Henderiawati, Safarina G. Malik, Rintis Noviyanti, Leily Trianty, Nadia Fadila, Khin Saw Aye Myint, Frilasita A. Yudhaputri, Neeraja Venkateswaran, Kodumudi Venkateswaran, Venkatachalam Udhayakumar, William A. Hawley, Juliette Morgan, Paul M. Pronyk Aug 2022

Sars-Cov-2 Antibody Seroprevalence In Jakarta, Indonesia, Iwan Ariawan, Hafizah Jusril, Muhammad N Farid, Pandu Riono, Wiji Wahyuningsih, Widyastuti Widyastuti, Dwi Oktavia T L Handayani, Endang Sri Wahyuningsih, Rebekka Daulay, Retno Henderiawati, Safarina G. Malik, Rintis Noviyanti, Leily Trianty, Nadia Fadila, Khin Saw Aye Myint, Frilasita A. Yudhaputri, Neeraja Venkateswaran, Kodumudi Venkateswaran, Venkatachalam Udhayakumar, William A. Hawley, Juliette Morgan, Paul M. Pronyk

Kesmas

The SARS-CoV-2 transmission dynamics in low- and middle-income countries remain poorly understood. This study aimed to estimate the SARS-CoV-2 antibodies seroprevalence in Jakarta, Indonesia, and to increase knowledge of SARS-CoV-2 transmission in urban settings. A population-based serosurvey among individuals aged one year or older was conducted in Jakarta. Employing a multistage sampling design, samples were stratified by district, slum, and non-slum residency, sex, and age group. Blood samples were tested for IgG against three different SARS-CoV-2 antigens. Seroprevalence was estimated after applying sample weights and adjusting for cluster characteristics. In March 2021, this study collected 4,919 respondents. The weighted estimate …


Model Autonomy Of Self-Finance Management For Primary Health Care To Enhance Workers’ Satisfaction, Ahmad Jet Alamin, Ossama Issac, Lina Teo, Atikah Adyas Aug 2022

Model Autonomy Of Self-Finance Management For Primary Health Care To Enhance Workers’ Satisfaction, Ahmad Jet Alamin, Ossama Issac, Lina Teo, Atikah Adyas

Kesmas

This study aimed to find an appropriate model of autonomous self-finance management in primary health care (PHC) to enhance workers' satisfaction. This was a cross-sectional study in which data were collected through self-administered questionnaires from 204 workers in ten Regional Public Service Agency for Primary Health Care (RPSAPHC)/Badan Layanan Umum Daerah Pusat Kesehatan Masyarakat (BLUD Puskesmas) in Tangerang District, Banten Province, Indonesia using the partial least squares and structural equation model (PLS-SEM). A total of 73 indicators were used to examine the PHC transformation process to enhance workers' satisfaction. The indicators were grouped into three variables depending on workers' satisfaction: …


Predictors Of Anxiety Toward Covid-19 Delta Variant: A Cross- Sectional Study Among Healthcare Providers In Java And Bali, Indonesia, I Ketut Swarjana, I Gede Putu Darma Suyasa, I Kadek Nuryanto Aug 2022

Predictors Of Anxiety Toward Covid-19 Delta Variant: A Cross- Sectional Study Among Healthcare Providers In Java And Bali, Indonesia, I Ketut Swarjana, I Gede Putu Darma Suyasa, I Kadek Nuryanto

Kesmas

Health facilities are experiencing overcapacity, oxygen scarcity, and a limited number of healthcare providers due to the coronavirus disease 2019 (COVID-19), thus impacted on anxiety. This study aimed to determine predictors of anxiety among healthcare providers toward the Delta variant of COVID-19 in Indonesia. A cross-sectional study was conducted with 371 healthcare providers in Java and Bali Islands, and the snowball sampling technique was used. Data were collected using a questionnaire and distributed through social media (WhatsApp), then analyzed using univariate analysis, bivariate analysis (Chi-square test), and multivariate analysis (multiple logistic regression). The results showed that 81 (21.8%) respondents experienced …


Spatial Analysis Of Seven Islands In Indonesia To Determine Stunting Hotspots, Tiopan Sipahutar, Tris Eryando, Meiwita Budiharsana Aug 2022

Spatial Analysis Of Seven Islands In Indonesia To Determine Stunting Hotspots, Tiopan Sipahutar, Tris Eryando, Meiwita Budiharsana

Kesmas

Indonesia is a vast country struggling to reduce its stunting prevalence. Hence, identifying priority areas is urgent. In determining areas to prioritize, one needs to consider geographical issues, particularly correlations among areas. This study aimed to discover whether stunting prevalence in Indonesia occurs randomly or in clusters; and, if it occurs in clusters, which areas are the hotspots. This ecological study used aggregate data from the 2018 National Basic Health Research and Poverty Data and Information Report from the Statistics Indonesia. This study analyzed 514 districts/cities across 34 provinces on seven main islands in Indonesia. The method used was the …


Galaxy And Mass Assembly (Gama): Bulge-Disc Decomposition Of Kids Data In The Nearby Universe, Sarah Casura, Jochen Liske, Aaron S G Robotham, Sarah Brough, Simon P. Driver, Alister W. Graham, Boris Häußler, Benne Holwerda, Andrew M. Hopkins, Lee S. Kelvin, Amanda J. Moffett, Dan S. Taranu, Edward N. Taylor Aug 2022

Galaxy And Mass Assembly (Gama): Bulge-Disc Decomposition Of Kids Data In The Nearby Universe, Sarah Casura, Jochen Liske, Aaron S G Robotham, Sarah Brough, Simon P. Driver, Alister W. Graham, Boris Häußler, Benne Holwerda, Andrew M. Hopkins, Lee S. Kelvin, Amanda J. Moffett, Dan S. Taranu, Edward N. Taylor

Faculty and Staff Scholarship

We derive single Sérsic fits and bulge-disc decompositions for 13 096 galaxies at redshifts z < 0.08 in the GAMA II equatorial survey regions in the Kilo-Degree Survey (KiDS) g, r, and i bands. The surface brightness fitting is performed using the Bayesian two-dimensional profile fitting code PROFIT. We fit three models to each galaxy in each band independently with a fully automated Markov chain Monte Carlo analysis: a single Sérsic model, a Sérsic plus exponential and a point source plus exponential. After fitting the galaxies, we perform model selection and flag galaxies for which none of our models are appropriate (mainly mergers/Irregular galaxies). The fit quality is assessed by visual inspections, comparison …


System Design For The Quantification Of Microbial Motility In Extreme Environments, Megan Marie Dubay Aug 2022

System Design For The Quantification Of Microbial Motility In Extreme Environments, Megan Marie Dubay

Dissertations and Theses

Motility of microorganisms is understudied but provides useful insights into their behavior. Organisms' ability to move autonomously changes how they interact with their environment--finding nutrients, interacting with other organisms, and avoiding unfavorable conditions. Understanding motility features can also be used to identify specific species, such as the identification of Vibrio cholerae in human samples. Motility might also be used as evidence of life existing in even the most extreme environments on Earth, and possibly beyond. Specialized microscopy systems can be required to examine the motility of microorganisms due to the nature of the environments to which the instruments are exposed. …


Copulas, Maximal Dependence, And Anomaly Detection In Bi-Variate Time Series, Ning Sun Aug 2022

Copulas, Maximal Dependence, And Anomaly Detection In Bi-Variate Time Series, Ning Sun

Electronic Thesis and Dissertation Repository

This thesis focuses on discussing non-parametric estimators and their asymptotic behaviors for indices developed to characterize bi-variate time series. There are typically two types of indices depending on whether the distributional information is involved. For the indices containing the distributional information of the bivariate stationary time series, we particularly focus on the index called the tail order of maximal dependence (TOMD), which is an improvement of the tail order. For the indices without distributional information of the bivariate time series, we focus on an anomaly detection index for univariate input-output systems.

This thesis integrates three articles. The first article (Chapter …


Ai Protein Structure Prediction-Based Modeling And Mutagenesis Of A Protostome Receptor And Peptide Ligands Reveal Key Residues For Their Interaction, Shi-Qi Guo, Ya-Dong Li, Ping Chen, Guo Zhang, Hui-Ying Wang, Hui-Min Jiang, Wei-Jia Liu, Ju-Ping Xu, Xue-Ying Ding, Ping Fu, Ke Yu, Hai-Bo Zhou, James W. Checco, Jian Jing Aug 2022

Ai Protein Structure Prediction-Based Modeling And Mutagenesis Of A Protostome Receptor And Peptide Ligands Reveal Key Residues For Their Interaction, Shi-Qi Guo, Ya-Dong Li, Ping Chen, Guo Zhang, Hui-Ying Wang, Hui-Min Jiang, Wei-Jia Liu, Ju-Ping Xu, Xue-Ying Ding, Ping Fu, Ke Yu, Hai-Bo Zhou, James W. Checco, Jian Jing

Chemistry Department: Faculty Publications

The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide–receptor interactions remain to be elucidated. Previously, we identified a precursor protein for Aplysia leucokinin-like peptides (ALKs) that contains the greatest number of amidated peptides among LK precursors in all species identified so far. Here, we identified the first ALK receptor from Aplysia, ALKR. We used cell-based IP1 activation assays to demonstrate that two ALK peptides with the most copies, ALK1 and ALK2, activated ALKR with high potencies. Other endogenous ALK-derived peptides …


Truncated Matrix Power Iteration For Differentiable Dag Learning, Zhen Zhang, Ignavier Ng, Dong Gong, Yuhang Liu, Ehsan M. Abbasnejad, Mingming Gong, Kun Zhang, Javen Qinfeng Shi Aug 2022

Truncated Matrix Power Iteration For Differentiable Dag Learning, Zhen Zhang, Ignavier Ng, Dong Gong, Yuhang Liu, Ehsan M. Abbasnejad, Mingming Gong, Kun Zhang, Javen Qinfeng Shi

Machine Learning Faculty Publications

Recovering underlying Directed Acyclic Graph structures (DAG) from observational data is highly challenging due to the combinatorial nature of the DAG-constrained optimization problem. Recently, DAG learning has been cast as a continuous optimization problem by characterizing the DAG constraint as a smooth equality one, generally based on polynomials over adjacency matrices. Existing methods place very small coefficients on high-order polynomial terms for stabilization, since they argue that large coefficients on the higher-order terms are harmful due to numeric exploding. On the contrary, we discover that large coefficients on higher-order terms are beneficial for DAG learning, when the spectral radiuses of …