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Articles 30781 - 30810 of 302569
Full-Text Articles in Physical Sciences and Mathematics
First Test Of Lepton Flavor Universality In The Charmed Baryon Decays Ωc0 → Ω-ℓ+Νℓ Using Data Of The Belle Experiment, Y. B. Li, C. P. Shen, I. Adachi, H. Aihara, S. Al Said, D. M. Asner, H. Atmacan, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, P. Behera, K. Belous, J. Bennett, F. Bernlochner, M. Bessner, B. Bhuyan, T. Bilka, A. Bobrov
First Test Of Lepton Flavor Universality In The Charmed Baryon Decays Ωc0 → Ω-ℓ+Νℓ Using Data Of The Belle Experiment, Y. B. Li, C. P. Shen, I. Adachi, H. Aihara, S. Al Said, D. M. Asner, H. Atmacan, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, P. Behera, K. Belous, J. Bennett, F. Bernlochner, M. Bessner, B. Bhuyan, T. Bilka, A. Bobrov
Faculty and Student Publications
We present the first observation of the ωc0→ω-μ+νμ decay and present measurements of the branching fraction ratios of the ωc0→ω-ℓ+νℓ decays compared to the reference mode ωc0→ω-π+, (ℓ=e or μ). This analysis is based on 89.5 fb-1, 711 fb-1, and 121.1 fb-1 data samples collected with the Belle detector at the KEKB asymmetric-energy e+e- collider at the center-of-mass energies of 10.52 GeV, 10.58 GeV, and 10.86 GeV, respectively. The ωc0 signal yields are extracted by fitting Mωℓ and Mωπ spectra. The branching fraction ratios B(ωc0→ω-e+νe)/B(ωc0→ω-π+) and B(ωc0→ω-μ+νμ)/B(ωc0→ω-π+) are measured to be 1.98±0.13(stat)±0.08(syst) and 1.94±0.18(stat)±0.10(syst), respectively. The ratio of B(ωc0→ω-e+νe)/B(ωc0→ω-μ+νμ) is …
Alma Discovery Of A Disk Around The Planetary-Mass Companion Sr 12 C, Ya Lin Wu, Brendan P. Bowler, Patrick D. Sheehan, Laird M. Close, Joshua A. Eisner, William M.J. Best, Kimberly Ward-Duong, Zhaohuan Zhu, Adam L. Kraus
Alma Discovery Of A Disk Around The Planetary-Mass Companion Sr 12 C, Ya Lin Wu, Brendan P. Bowler, Patrick D. Sheehan, Laird M. Close, Joshua A. Eisner, William M.J. Best, Kimberly Ward-Duong, Zhaohuan Zhu, Adam L. Kraus
Astronomy: Faculty Publications
We report an Atacama Large Millimeter/submillimeter Array 0.88 mm (Band 7) continuum detection of the accretion disk around SR 12 c, an ∼11 M Jup planetary-mass companion (PMC) orbiting its host binary at 980 au. This is the first submillimeter detection of a circumplanetary disk around a wide PMC. The disk has a flux density of 127 ± 14 μJy and is not resolved by the ∼0.″1 beam, so the dust disk radius is likely less than 5 au and can be much smaller if the dust continuum is optically thick. If, however, the dust emission is optically thin, then …
Nessie Notation: A New Tool In Sequential Substitution Systems And Graph Theory For Summarizing Concatenations, Colton Davis
Nessie Notation: A New Tool In Sequential Substitution Systems And Graph Theory For Summarizing Concatenations, Colton Davis
Student Research
While doing research looking for ways to categorize causal networks generated by Sequential Substitution Systems, I created a new notation to compactly summarize concatenations of integers or strings of integers, including infinite sequences of these, in the same way that sums, products, and unions of sets can be summarized. Using my method, any sequence of integers or strings of integers with a closed-form iterative pattern can be compactly summarized in just one line of mathematical notation, including graphs generated by Sequential Substitution Systems, many Primitive Pythagorean Triplets, and various Lucas sequences including the Fibonacci sequence and the sequence of square …
The Acm/Ais Is2020 Competency Model For Undergraduate Programs In Information Systems: A Joint Acm/Ais Task Force Report, Paul Leidig, Hannu Salmela
The Acm/Ais Is2020 Competency Model For Undergraduate Programs In Information Systems: A Joint Acm/Ais Task Force Report, Paul Leidig, Hannu Salmela
Peer-Reviewed Publications
The Association of Computing Machinery (ACM) and the Association of Information Systems (AIS) along with the ISCAP EDSIG, recently released a joint taskforce report IS2020: A Competency Model for Undergraduate Programs in Information Systems. In this paper, the co-chairs of IS2020, the latest Information Systems curriculum guidelines, provide their insight on the problems presented with existing guidelines, illustrate the issue, and share their opinions that led to the release of these latest guidelines.
Fault-Free Tilings, T. Elise Dettling, Amelia Goetzinger
Fault-Free Tilings, T. Elise Dettling, Amelia Goetzinger
Undergraduate Research
Given a p×q rectangular board (height p and width q), we may fill in the area with 2×1 tiles. We say the board is tileable if the board can be filled with non-overlapping tiles leaving no open space. Not all boards are tileable, for example a 5 × 5 board is not tileable because it has an odd area. A fault-free tiling exists on the board if every line through the board parallel to a side goes through a tile. Previous work on this subject has been completed by Ron Graham in “Fault-Free Tilings of Rectangles" and Emily Montelius in …
A Study Of Machine Learning Techniques For Dynamical System Prediction, Rishi Pawar
A Study Of Machine Learning Techniques For Dynamical System Prediction, Rishi Pawar
Theses and Dissertations
Dynamical Systems are ubiquitous in mathematics and science and have been used to model many important application problems such as population dynamics, fluid flow, and control systems. However, some of them are challenging to construct from the traditional mathematical techniques. To combat such problems, various machine learning techniques exist that attempt to use collected data to form predictions that can approximate the dynamical system of interest. This thesis will study some basic machine learning techniques for predicting system dynamics from the data generated by test systems. In particular, the methods of Dynamic Mode Decomposition (DMD), Sparse Identification of Nonlinear Dynamics …
Seven Years Of Sn 2014c: A Multiwavelength Synthesis Of An Extraordinary Supernova, B. P. Thomas, J. C. Wheeler, V. V. Dwarkadas, C. Stockdale, J. Vinkó, David Pooley, Y. Xu, G. Zeimann, P. Macqueen
Seven Years Of Sn 2014c: A Multiwavelength Synthesis Of An Extraordinary Supernova, B. P. Thomas, J. C. Wheeler, V. V. Dwarkadas, C. Stockdale, J. Vinkó, David Pooley, Y. Xu, G. Zeimann, P. Macqueen
Physics and Astronomy Faculty Research
SN 2014C was originally classified as a Type Ib supernova, but at phase ϕ = 127 days, post-explosion strong Hα emission was observed. SN 2014C has since been observed in radio, infrared, optical and X-ray bands. Here we present new optical spectroscopic and photometric data spanning ϕ = 947–2494 days post-explosion. We address the evolution of the broadened Hα emission line, as well as broad [O iii] emission and other lines. We also conduct a parallel analysis of all publicly available multiwavelength data. From our spectra, we find a nearly constant Hα FWHM velocity width of ∼2000 …
The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen
The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen
Honors College Theses
The percent of people with mental health disorders in the United States have skyrocketed over the past decade. With stigma surrounding the discussion of mental health and the symptoms associated with it, often those that are suffering do not receive sufficient treatment, as they might with a physical illness. The current, common treatment options for common psychological disorders, like depression, anxiety, and post-traumatic stress disorder, are sometimes not effective in patients, due to resistance or poor response outcomes. Consequently, in order to research alternative therapeutic approaches for mental health disorders, scientists are researching the effects of several hallucinogenic drugs in …
Quantum Dimension Polynomials: A Networked-Numbers Game Approach, Nicholas Gaubatz
Quantum Dimension Polynomials: A Networked-Numbers Game Approach, Nicholas Gaubatz
Honors College Theses
The Networked-Numbers Game--a mathematical "game'' played on a simple graph--is incredibly accessible and yet surprisingly rich in content. The Game is known to contain deep connections to the finite-dimensional simple Lie algebras over the complex numbers. On the other hand, Quantum Dimension Polynomials (QDPs)--enumerative expressions traditionally understood through root systems--corresponding to the above Lie algebras are complicated to derive and often inaccessible to undergraduates. In this thesis, the Networked-Numbers Game is defined and some known properties are presented. Next, the significance of the QDPs as a method to count combinatorially interesting structures is relayed. Ultimately, a novel closed-form expression of …
An Exploratory Study On Refactoring Documentation In Issues Handling, Eman Abdullah Alomar, Anthony Peruma, Mohamed Wiem Mkaouer, Christian D. Newman, Ali Ouni
An Exploratory Study On Refactoring Documentation In Issues Handling, Eman Abdullah Alomar, Anthony Peruma, Mohamed Wiem Mkaouer, Christian D. Newman, Ali Ouni
Articles
Understanding the practice of refactoring documentation is of paramount importance in academia and industry. Issue tracking systems are used by most software projects enabling developers, quality assurance, managers, and users to submit feature requests and other tasks such as bug fixing and code review. Although recent studies explored how to document refactoring in commit messages, little is known about how developers describe their refactoring needs in issues. In this study, we aim at exploring developer-reported refactoring changes in issues to better understand what developers consider to be problematic in their code and how they handle it. Our approach relies on …
Identifying The Isotopic Signature Of Lake-Effect Precipitation In Shallow Groundwater, Andrew Brown
Identifying The Isotopic Signature Of Lake-Effect Precipitation In Shallow Groundwater, Andrew Brown
Honors Projects
Three different stable isotopes of water occur in nature, with the majority of water on Earth containing the oxygen isotope 16O. These isotopes have slightly differing physical and chemical properties. H2O with heavier oxygen isotopes should theoretically precipitate earlier than lighter isotope H2O, meaning this natural process should allow for the observation of the magnitude of effects of lake-effect precipitation on the basis of water isotope differences. Furthermore, it may allow for better understanding of the significance lake-effect precipitation plays in recharging shallow aquifers. In this study, patterns of lake-effect precipitation from Lake Michigan were observed in a collection of …
Tackling Chloride Pollution In Southeastern Wisconsin: Halophilic Bacterial Indicators And Policy Alternatives, Elexius Kaitlyn Passante
Tackling Chloride Pollution In Southeastern Wisconsin: Halophilic Bacterial Indicators And Policy Alternatives, Elexius Kaitlyn Passante
Theses and Dissertations
There are few biological indicators for freshwater systems subjected to high chloride levels. Freshwater systems receive many forms of chloride such as road salts (e.g., NaCl, CaCl2, MgCl2), fertilizers (e.g., KCl), and year-round water softener pollution. The goal our study was to investigate Halomonadaceae populations as prospective biological indicators of chloride-impacted freshwaters. The bacterial family Halomonadaceae are halophiles that generally require the presence of salt to survive, which makes them an attractive candidate in determining chloride impaired areas. Field sediment surveys assessed how salt tolerant and halophilic bacteria abundance corresponded to chloride and conductivity measurements. Colony forming unit (CFU) counts …
An Application Of Machine Learning To Analysis Of Packed Mac Malware, Kimo Bumanglag
An Application Of Machine Learning To Analysis Of Packed Mac Malware, Kimo Bumanglag
Masters Theses & Doctoral Dissertations
The macOS operating system is increasingly targeted by malware. Software written for macOS, both benign and malicious, is in the Mach-O executable format. Malware authors may frustrate analysts through obfuscation methods such as packing. The field of malware research on Windows is well-established but is less so on the macOS platform. Thus far, no research has been identified that studies how machine learning can be used to detected packed Mach-O malware. This research applies supervised machine learning techniques to the classification of packed Mach-O malware. This research will answer three research questions. First, whether machine learning can classify packed Mach-O …
Developing And Applying Computational Algorithms To Reveal Health-Related Biomolecular Interactions, Yixin Xie
Developing And Applying Computational Algorithms To Reveal Health-Related Biomolecular Interactions, Yixin Xie
Open Access Theses & Dissertations
Computational biology is an interdisciplinary area that applies computational approaches in biological big data, including protein amino acid sequences, genetic sequences, etc., which is widely used to analyze protein-protein interactions, make predictions in drug discovery, develop vaccines, etc. Popular methods include mathematical modeling, molecular dynamics simulations, data science mythology, etc. With the help of computational algorithms and applications, drug development is much faster than traditional processes, as it reduces risks early on in a drug discovery process and helps researchers select target candidates that have the highest potential for success. In my doctoral research, I applied multi-scale computational approaches to …
Low-Lying Spin-Flip Excitonic States Of ����12��12 (��������)16 [��2��]4 Molecule (Mn12 − ����), Karma Dema
Low-Lying Spin-Flip Excitonic States Of ����12��12 (��������)16 [��2��]4 Molecule (Mn12 − ����), Karma Dema
Open Access Theses & Dissertations
Molecules and materials constructed from Mn atoms offer diverse assortments of geomet- rical and spin structures. The diversity of structures, in comparison with other transition metals, along with nature’s decision to use a Mn-based molecule to catalyze solar-driven water splitting and oxygen evolution, suggests that there is indeed something special about the location of Mn valence electrons, both energetically and geometrically, that endows Mn with its multifaceted behaviors that, in turn, provide such chemical, physical and mag- netic diversity. Based upon recent work on the Mn3 monomer and the Mn(taa) there is an expectation that Mn�� �� �� centers can …
A Central Compact Hybrid-Variable Method With Spectral-Like Resolution, Md Mahmudul Hasan
A Central Compact Hybrid-Variable Method With Spectral-Like Resolution, Md Mahmudul Hasan
Open Access Theses & Dissertations
Numerical methods for hyperbolic conservation laws have been a driving force for theresearch in scientific computing and simulation science in the past decades, as many physical, biological, and engineering systems are governed by these equations, such as fluid mechanics, tumor growth, and virtual wind tunnel simulations. Despite the existence of many schemes in the literature, people have never stopped searching for more accurate and efficient methods for these problems. Indeed, the increasing complexity of systems in emerging applications demands better resolution of sub-grid scale phenomenon whereas classical methods usually fail to deliver high-fidelity simulation results of such systems within realistic …
Method Development For Preconcentration And Quantification Of Critical And Valuable Elements In Permian Basin Produced Waters, Joshua Matthew Lewis
Method Development For Preconcentration And Quantification Of Critical And Valuable Elements In Permian Basin Produced Waters, Joshua Matthew Lewis
Open Access Theses & Dissertations
Produced waters are a voluminous byproduct of unconventional oil and gas production. Produced water volumes are primarily addressed by subsurface reinjection through saltwater disposal wells (SWDs) and reuse within the oil and gas industry. Oil and gas operators continue to evaluate and trial novel methods to improve produced water handling, and reduce freshwater use, and disposal volumes. Here, we present results for method development to quantify Critical and Valuable Elements (CVEs; defined here as the lanthanide series, high field strength elements, industrial elements and precious metals in brines. CVE concentrations in produced waters and other high-salinity waters are poorly understood …
Rational Design Of Composite Nanomaterials For Water Treatment Applications, Mariana Marcos-Hernandez
Rational Design Of Composite Nanomaterials For Water Treatment Applications, Mariana Marcos-Hernandez
Open Access Theses & Dissertations
Water quantity and quality have been affected in communities all around the world due to population growth, pollution, changes in land use, and climate change. In order to cope with existing and anticipated water demands and shortages, the use of treated or reclaimed water is an ongoing alternative that has helped communities all over the world address this problem. The adaptation of nanotechnology to traditional water and wastewater treatment processes offers new opportunities in technological developments. Unique size-dependent properties such as: high surface to mass ratio, high reactivity, high sorption capacities, fast dissolution, superparamagnetism, among others, provide high-tech efficient materials …
Material Synthesis And Machine Learning For Additive Manufacturing, Jaime Eduardo Regis
Material Synthesis And Machine Learning For Additive Manufacturing, Jaime Eduardo Regis
Open Access Theses & Dissertations
The goal of this research was to address three key challenges in additive manufacturing (AM), the need for feedstock material, minimal end-use fabrication from lack of functionality in commercially available materials, and the need for qualification and property prediction in printed structures. The near ultraviolet-light assisted green reduction of graphene oxide through L-ascorbic acid was studied with to address the issue of low part strength in additively manufactured parts by providing a functional filler that can strengthen the polymer matrix. The synthesis of self-healing epoxy vitrimers was done to adapt high strength materials with recyclable properties for compatibility with AM …
Covid Synergy: A Machine Learning Approach Uncovering Potential Treatment Combinations For Sars-Cov-2, Jason Eden Sanchez
Covid Synergy: A Machine Learning Approach Uncovering Potential Treatment Combinations For Sars-Cov-2, Jason Eden Sanchez
Open Access Theses & Dissertations
For more than two years, the COVID-19 pandemic has upended the lives of billions of individualsworldwide leading to disruptions in healthcare, the economy and society at large. As the pandemic enters its third year, the human impact cannot be overstated and the need to develop effective pharmaceuticals remains. Though there currently exits FDA-approved medications for COVID-19, the emergence of novel variants, such as Omicron, highlights the importance of discovering new therapies which will continue to be effective regardless of the pandemicâ??s progression. Because discovering new medications is a costly and timeintensive endeavor, my approach entails drug repurposing to test medications …
Acoustic Waves In The Upper Atmosphere, Geoffrey Blayne Schulthess
Acoustic Waves In The Upper Atmosphere, Geoffrey Blayne Schulthess
All Graduate Plan B and other Reports, Spring 1920 to Spring 2023
Atmospheric waves can be generated by tropospheric sources such as earthquakes and explosions, causing significant disturbances in the upper atmosphere and ionosphere, where radio wave communications take place. For this analysis, they will be separated into two sub-groups called acoustic waves and gravity waves. Because each of these waves have unique frequency ranges, they can be observed and measured in order to determine their source type and location. Past studies attempted to build the connections between these waves with severe storms and earthquakes, which have improved our understanding of their complexity. Because of the complex nature of these waves, simplified …
Analyzing Suicidal Text Using Natural Language Processing, Cassandra Barton
Analyzing Suicidal Text Using Natural Language Processing, Cassandra Barton
All Graduate Plan B and other Reports, Spring 1920 to Spring 2023
Using Natural Language Processing (NLP), we are able to analyze text from suicidal individuals. This can be done using a variety of methods. I analyzed a dataset of a girl named Victoria that died by suicide. I used a machine learning method to train a different dataset and tested it on her diary entries to classify her text into two categories: suicidal vs non-suicidal. I used topic modeling to find out unique topics in each subset. I also found a pattern in her diary entries. NLP allows us to help individuals that are suicidal and their family members and close …
A Machine Learning Approach To Stochastic Optimal Control, Pablo Ever Avalos
A Machine Learning Approach To Stochastic Optimal Control, Pablo Ever Avalos
Open Access Theses & Dissertations
Merton's portfolio optimization problem is a well-renowned problem in financial mathematics which seeks to optimize the investment decision for an investor. In the simplest situation, the market consists of a risk-less asset (i.e. a bond) that pays back a relatively low interest rate, and a risky asset (i.e. a stock) that follows a geometric Brownian motion. The optimal allocation strategy of the investor's wealth is found by optimizing the expected utility along the stochastic evolution of the market. This thesis focuses on several different applications of this optimization problem. We look at pre-constructed analytical solutions and showcase the results. We …
Suitability Of Low-Cost Additive Manufacturing For Polymer Electrolyte Fuel Cells, David Alexander
Suitability Of Low-Cost Additive Manufacturing For Polymer Electrolyte Fuel Cells, David Alexander
Open Access Theses & Dissertations
The purpose of this dissertation is to study the feasibility of low-cost additive manufacturing to fabricate polymer electrolyte fuel cell bipolar plate materials. Traditional manufacturing techniques include molding, milling, hollow embossing, hydro-forming, rolling, and electromagnetic forming. These processes are employed when a design has been selected due to higher costs at low volumes. The combination of high initial costs and bipolar plates being the most expensive component of the polymer electrolyte fuel cell creates incentive to mitigate this obstacle. The feasibility of low-cost additive manufactured bipolar plates will be proven by fabrication, post-processing, and characterization of printed test specimen. The …
Tuning Nanoscale Molecular Heterogeneity To Improve Co2 Transport And Binding In Co2 Capture Solvents, Omar Avina
Tuning Nanoscale Molecular Heterogeneity To Improve Co2 Transport And Binding In Co2 Capture Solvents, Omar Avina
Open Access Theses & Dissertations
Aqueous amine-based technology has been considered the most promising carbon capture solution for post-combustion gas from fossil fuel plants. However, solvent degradation and the high energy cost associated with removing CO2 from the solvent, known as regeneration, have hindered its widespread implementation. It has been proposed that utilizing a water lean solvent, in contrast to aqueous amines, can decrease the required heat to regenerate the solvent. Additionally, Malhotra et al. proposed that controlling the viscosity can help increase the mass transport properties of CO2 in the solvent. A recent study on CO2 binding organic liquids (CO2BOLs) found them to exist …
Game-Theoretic Deception Modeling For Distracting Network Adversarie, Mohammad Sujan Miah
Game-Theoretic Deception Modeling For Distracting Network Adversarie, Mohammad Sujan Miah
Open Access Theses & Dissertations
In this day and age, adversaries in the cybersecurity space have become alarmingly capable of identifying network vulnerabilities and work out various targets to attack where deception is becoming an increasingly crucial technique for the defenders to delay these attacks. For securing computer networks, the defenders use various deceptive decoy objects to detect, confuse, and distract attackers. By trapping the attackers, these decoys gather information, waste their time and resources, and potentially prevent future attacks. However, we have to consider that an attacker with the help of smart techniques may detect the decoys and avoid them. One of the well-known …
Managing Risk For Power System Operations And Planning: Applications Of Conditional Value-At-Risk And Uncertainty Quantification To Optimal Power Flow And Distributed Energy Resources Investment, Thanh To
All Dissertations
Renewable energy sources are indispensable components of sustainable electrical systems that reduce human dependence on fossil fuels. However, due to their intermittent nature, there are issues that need to be addressed to ensure the security and resiliency of these power systems. This dissertation formulates several practical problems, from an optimization perspective, stemming from the increasing penetration of intermittent renewable energy to power systems. A number of Optimal Power Flow (OPF) formulations are investigated and new formulations are proposed to control both operations and planning risks by utilizing the Conditional Value–at–Risk (CVaR) measure. Our formulations provide system operators and investors analysis …
Determining The Value Of Ecosystem Services Provided By Green Stormwater Infrastructure In Coastal South Carolina, Joan U. Ureta
Determining The Value Of Ecosystem Services Provided By Green Stormwater Infrastructure In Coastal South Carolina, Joan U. Ureta
All Dissertations
Rapid urbanization changes the natural hydrology of a landscape, making stormwater management a crucial aspect of land development. As the fastest growing ecosystem globally, an innovative way of managing stormwater is needed to address the increase in urban run-off. In coastal South Carolina, stormwater practices have been widely adopted at the neighborhood level, yet threat of flooding is becoming more evident as the urban population and development continue to rise.
To determine the importance of stormwater practices to coastal residents, we assessed perception on stormwater practices and programs at different decision levels— 1) household, 2) neighborhood, and 3) city/county. Results …
Synthesis Of Fluorinated Monomers And Polymers For Various Applications, Cassandra J. Hager
Synthesis Of Fluorinated Monomers And Polymers For Various Applications, Cassandra J. Hager
All Dissertations
The world of industry utilizes a variety of polymers for various applications in many prominent fields. From electronics to food storage, the versatility of this class of chemistry has been widely proven. The Thrasher research group undertook a program dedicated towards the development of a library of fluorinated materials that focused on the synthesis and characterization of perfluoroalkoxy (PFA) copolymers of tetrafluoroethylene (TFE) and perfluoroalkyl trifluorovinyl ethers. One aim of the project was to improve upon the mechanical strength and wearability of commercial PFA resins by incorporating bulkier perfluoroalkoxy trifluorovinyl ether monomers into these copolymers. In addition to focusing on …
Optimization Of Modular, Long-Range, Ultra-Fast Optical Tweezers With Fluorescence Capabilities For Single-Molecule And Single-Cell Based Biophysical Measurements, Subash C. Godar
All Dissertations
An Optical tweezer is a tightly focused laser beam that applies and senses precise and localized optical force to a dielectric microsphere and offers a unique and effective tool for manipulating the single cell or cell components, including nucleotides and dynein motor proteins. Here, I used highly stabilized optomechanical components and ultra-sensitive detection modules to significantly improve the measurement capabilities over a wide range of temporal and spatial scales. I combined the optical tweezer-based force spectroscopy technique with fluorescence microscopy to develop an integrated high-resolution force-fluorescence system capable of measuring displacements at sub-nanometer, forces at sub-piconewton over a temporal range …